Transcriptional control of a whole chromosome: emerging models for dosage compensation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-02

AUTHORS

Francesco Ferrari, Artyom A Alekseyenko, Peter J Park, Mitzi I Kuroda

ABSTRACT

Males and females of many animal species differ in their sex-chromosome karyotype, and this creates imbalances between X-chromosome and autosomal gene products that require compensation. Although distinct molecular mechanisms have evolved in three highly studied systems, they all achieve coordinate regulation of an entire chromosome by differential RNA-polymerase occupancy at X-linked genes. High-throughput genome-wide methods have been pivotal in driving the latest progress in the field. Here we review the emerging models for dosage compensation in mammals, flies and nematodes, with a focus on mechanisms affecting RNA polymerase II activity on the X chromosome. More... »

PAGES

118-125

References to SciGraph publications

  • 2010-12. An evolutionary consequence of dosage compensation on Drosophila melanogaster female X-chromatin structure? in BMC GENOMICS
  • 2003-03. Dosage Dependent Gene Regulation and the Compensation of the X Chromosome in Drosophila Males in GENETICA
  • 2012-09. The long-range interaction landscape of gene promoters in NATURE
  • 2013-12. High-resolution Xist binding maps reveal two-step spreading during X-chromosome inactivation in NATURE
  • 2006-02. Global analysis of X-chromosome dosage compensation in BMC BIOLOGY
  • 2005-08. Steps in the evolution of heteromorphic sex chromosomes in HEREDITY
  • 2006-11. Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture–on-chip (4C) in NATURE GENETICS
  • 2010-12. RNA sequencing shows no dosage compensation of the active X-chromosome in NATURE GENETICS
  • 2009-10. ChIP–seq: advantages and challenges of a maturing technology in NATURE REVIEWS GENETICS
  • 2009-08. Drosophila MSL complex globally acetylates H4K16 on the male X chromosome for dosage compensation in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2007-03. X chromosome repression by localization of the C. elegans dosage compensation machinery to sites of transcription initiation in NATURE GENETICS
  • 2004-09. Gene loops juxtapose promoters and terminators in yeast in NATURE GENETICS
  • 2012-01. Claims and counterclaims of X-chromosome compensation in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2013-06. Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data in NATURE REVIEWS GENETICS
  • 2012-06-21. Sensitive detection of chromatin coassociations using enhanced chromosome conformation capture on chip in NATURE PROTOCOLS
  • 2011-03. X chromosome dosage compensation via enhanced transcriptional elongation in Drosophila in NATURE
  • 2011-12. Relative overexpression of X-linked genes in mouse embryonic stem cells is consistent with Ohno's hypothesis in NATURE GENETICS
  • 2011-12. Evidence for dosage compensation between the X chromosome and autosomes in mammals in NATURE GENETICS
  • 2012-04-11. Spatial partitioning of the regulatory landscape of the X-inactivation centre in NATURE
  • 2012-01. X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2013-05. Human inactive X chromosome is compacted through a PRC2-independent SMCHD1-HBiX1 pathway in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2006-11. Clustered DNA motifs mark X chromosomes for repression by a dosage compensation complex in NATURE
  • 2011-12. Evidence for compensatory upregulation of expressed X-linked genes in mammals, Caenorhabditis elegans and Drosophila melanogaster in NATURE GENETICS
  • 2011-01. Nascent transcript sequencing visualizes transcription at nucleotide resolution in NATURE
  • 2006-01. Dosage compensation of the active X chromosome in mammals in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nsmb.2763

    DOI

    http://dx.doi.org/10.1038/nsmb.2763

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1001012395

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24500429


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