Promiscuous RNA binding by Polycomb repressive complex 2 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-11

AUTHORS

Chen Davidovich, Leon Zheng, Karen J Goodrich, Thomas R Cech

ABSTRACT

Polycomb repressive complex 2 (PRC2) is a histone methyltransferase required for epigenetic silencing during development and cancer. Long noncoding RNAs (lncRNAs) recruit PRC2 to chromatin, but the general role of RNA in maintaining repressed chromatin is unknown. Here we measure the binding constants of human PRC2 to various RNAs and find comparable affinity for human lncRNAs targeted by PRC2 as for irrelevant transcripts from ciliates and bacteria. PRC2 binding is size dependent, with lower affinity for shorter RNAs. In vivo, PRC2 predominantly occupies repressed genes; PRC2 is also associated with active genes, but most of those are not regulated by PRC2. These findings support a model in which PRC2's promiscuous binding to RNA transcripts allows it to scan for target genes that have escaped repression, thus leading to maintenance of the repressed state. Such RNAs may also provide a decoy for PRC2. More... »

PAGES

1250-1257

References to SciGraph publications

  • 2012-12. Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2012-09. An integrated encyclopedia of DNA elements in the human genome in NATURE
  • 2008-11. Model-based Analysis of ChIP-Seq (MACS) in GENOME BIOLOGY
  • 2012-12. Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2013-03. Crystal structure of an RNA-bound 11-subunit eukaryotic exosome complex in NATURE
  • 2011-09. lincRNAs act in the circuitry controlling pluripotency and differentiation in NATURE
  • 2007-01. Polycomb silencing mechanisms and the management of genomic programmes in NATURE REVIEWS GENETICS
  • 2009-10-08. Role of the polycomb protein EED in the propagation of repressive histone marks in NATURE
  • 2008-07. Mapping and quantifying mammalian transcriptomes by RNA-Seq in NATURE METHODS
  • 2006-05. Chromatin signatures of pluripotent cell lines in NATURE CELL BIOLOGY
  • 2010-04-15. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis in NATURE
  • 2006-05. Polycomb complexes repress developmental regulators in murine embryonic stem cells in NATURE
  • 2011-01. The Polycomb complex PRC2 and its mark in life in NATURE
  • 2008-11. A model for transmission of the H3K27me3 epigenetic mark in NATURE CELL BIOLOGY
  • 2011-01. Integrative genomics viewer in NATURE BIOTECHNOLOGY
  • 2009-03. Ultrafast and memory-efficient alignment of short DNA sequences to the human genome in GENOME BIOLOGY
  • 2012-12. Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1 in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nsmb.2679

    DOI

    http://dx.doi.org/10.1038/nsmb.2679

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1026913602

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24077223


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bacteria", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ciliophora", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Profiling", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polycomb Repressive Complex 2", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Binding", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA, Messenger", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA-Binding Proteins", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Colorado Boulder", 
              "id": "https://www.grid.ac/institutes/grid.266190.a", 
              "name": [
                "Department of Chemistry & Biochemistry, Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, Colorado, USA.", 
                "BioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Davidovich", 
            "givenName": "Chen", 
            "id": "sg:person.01147327545.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147327545.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Colorado Anschutz Medical Campus", 
              "id": "https://www.grid.ac/institutes/grid.430503.1", 
              "name": [
                "Medical Scientist Training Program, University of Colorado School of Medicine, Aurora, Colorado, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zheng", 
            "givenName": "Leon", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Colorado Boulder", 
              "id": "https://www.grid.ac/institutes/grid.266190.a", 
              "name": [
                "Department of Chemistry & Biochemistry, Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, Colorado, USA.", 
                "BioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Goodrich", 
            "givenName": "Karen J", 
            "id": "sg:person.01341066344.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341066344.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Colorado Boulder", 
              "id": "https://www.grid.ac/institutes/grid.266190.a", 
              "name": [
                "Department of Chemistry & Biochemistry, Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, Colorado, USA.", 
                "BioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cech", 
            "givenName": "Thomas R", 
            "id": "sg:person.01211064044.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211064044.70"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.cell.2011.09.057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000476330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkm226", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001245785"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1192002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002615413"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1192002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002615413"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.02.043", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004307083"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1787", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005538911", 
              "https://doi.org/10.1038/ncb1787"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2010.03.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006770285"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.01-0995fje", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009396098"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2011.03.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013778335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08398", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014254479", 
              "https://doi.org/10.1038/nature08398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08398", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014254479", 
              "https://doi.org/10.1038/nature08398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08975", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017276958", 
              "https://doi.org/10.1038/nature08975"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08975", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017276958", 
              "https://doi.org/10.1038/nature08975"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08975", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017276958", 
              "https://doi.org/10.1038/nature08975"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2011.11.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017735696"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10398", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018204822", 
              "https://doi.org/10.1038/nature10398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m110.194027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018230923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11870", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018452167", 
              "https://doi.org/10.1038/nature11870"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2011.08.027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018828999"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2011.08.027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018828999"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019307928", 
              "https://doi.org/10.1038/nbt.1754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.03.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020648288"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2010.12.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020894025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.08.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021778552"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0904715106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022579887"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btp352", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023014918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg1981", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023847549", 
              "https://doi.org/10.1038/nrg1981"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg1981", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023847549", 
              "https://doi.org/10.1038/nrg1981"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-biochem-030409-143718", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026396443"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.05.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027005696"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0036365", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027411716"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2008-9-9-r137", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027608848", 
              "https://doi.org/10.1186/gb-2008-9-9-r137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.12.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027791026"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.1000276", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028215756"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029065430", 
              "https://doi.org/10.1038/nature11247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.02.041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030427346"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09784", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030505833", 
              "https://doi.org/10.1038/nature09784"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2011.12.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031111768"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.1001046", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031377769"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1225237", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034018193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btq033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036892131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.2434", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037002974", 
              "https://doi.org/10.1038/nsmb.2434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2004.06.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037193790"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-2836(76)80023-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038590344"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1163045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038655698"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04733", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038720785", 
              "https://doi.org/10.1038/nature04733"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04733", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038720785", 
              "https://doi.org/10.1038/nature04733"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04733", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038720785", 
              "https://doi.org/10.1038/nature04733"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1008937107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040079173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1983810", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040100685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bip.1979.360180815", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041830224"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1226", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045381177", 
              "https://doi.org/10.1038/nmeth.1226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1261/rna.2747411", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046325549"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0607617103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046714190"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1261/rna.2778911", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047684583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.204602.112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048519217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.06503-11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048933543"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.2435", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049135533", 
              "https://doi.org/10.1038/nsmb.2435"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2009-10-3-r25", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049583368", 
              "https://doi.org/10.1186/gb-2009-10-3-r25"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.05.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051644950"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1403", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053217564", 
              "https://doi.org/10.1038/ncb1403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1403", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053217564", 
              "https://doi.org/10.1038/ncb1403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.2449", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053258244", 
              "https://doi.org/10.1038/nsmb.2449"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1000242", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053736080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1000242", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053736080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi00354a006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055171611"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.8085157", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062652200"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-11", 
        "datePublishedReg": "2013-11-01", 
        "description": "Polycomb repressive complex 2 (PRC2) is a histone methyltransferase required for epigenetic silencing during development and cancer. Long noncoding RNAs (lncRNAs) recruit PRC2 to chromatin, but the general role of RNA in maintaining repressed chromatin is unknown. Here we measure the binding constants of human PRC2 to various RNAs and find comparable affinity for human lncRNAs targeted by PRC2 as for irrelevant transcripts from ciliates and bacteria. PRC2 binding is size dependent, with lower affinity for shorter RNAs. In vivo, PRC2 predominantly occupies repressed genes; PRC2 is also associated with active genes, but most of those are not regulated by PRC2. These findings support a model in which PRC2's promiscuous binding to RNA transcripts allows it to scan for target genes that have escaped repression, thus leading to maintenance of the repressed state. Such RNAs may also provide a decoy for PRC2. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nsmb.2679", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2683979", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1295033", 
            "issn": [
              "1545-9993", 
              "2331-365X"
            ], 
            "name": "Nature Structural & Molecular Biology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "11", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "20"
          }
        ], 
        "name": "Promiscuous RNA binding by Polycomb repressive complex 2", 
        "pagination": "1250-1257", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "8036139141fd01b19b94eb69030ce8aa4c84a2b71861a8dce8bcacdf7a4cb5cf"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "24077223"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101186374"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nsmb.2679"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1026913602"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nsmb.2679", 
          "https://app.dimensions.ai/details/publication/pub.1026913602"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T15:39", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000428.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/nsmb/journal/v20/n11/full/nsmb.2679.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2679'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2679'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2679'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2679'


     

    This table displays all metadata directly associated to this object as RDF triples.

    315 TRIPLES      21 PREDICATES      94 URIs      29 LITERALS      17 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nsmb.2679 schema:about N0b17373946e741fb9d8cfc94e4c37598
    2 N2f71f81d419644bdbd0787d0233aec1a
    3 N308831f6e2af4f54982a287189c39b24
    4 N5d4f3c04ecda4800a996cd420f6661a0
    5 N9c0c17c2004a42f890dbc982ca8d3000
    6 N9e1201d434a04865ab1285e601acc0ef
    7 Nb5b5e66c0a814e03a920bcd664b1c688
    8 Ned00375ab8894e2384cf3652b615fb1e
    9 anzsrc-for:06
    10 anzsrc-for:0604
    11 schema:author N7bf8d4bc341f4bfe949dabfec9c944c3
    12 schema:citation sg:pub.10.1038/nature04733
    13 sg:pub.10.1038/nature08398
    14 sg:pub.10.1038/nature08975
    15 sg:pub.10.1038/nature09784
    16 sg:pub.10.1038/nature10398
    17 sg:pub.10.1038/nature11247
    18 sg:pub.10.1038/nature11870
    19 sg:pub.10.1038/nbt.1754
    20 sg:pub.10.1038/ncb1403
    21 sg:pub.10.1038/ncb1787
    22 sg:pub.10.1038/nmeth.1226
    23 sg:pub.10.1038/nrg1981
    24 sg:pub.10.1038/nsmb.2434
    25 sg:pub.10.1038/nsmb.2435
    26 sg:pub.10.1038/nsmb.2449
    27 sg:pub.10.1186/gb-2008-9-9-r137
    28 sg:pub.10.1186/gb-2009-10-3-r25
    29 https://doi.org/10.1002/bip.1979.360180815
    30 https://doi.org/10.1016/j.cell.2006.02.041
    31 https://doi.org/10.1016/j.cell.2006.02.043
    32 https://doi.org/10.1016/j.cell.2007.05.022
    33 https://doi.org/10.1016/j.cell.2009.08.020
    34 https://doi.org/10.1016/j.cell.2009.12.022
    35 https://doi.org/10.1016/j.cell.2011.09.057
    36 https://doi.org/10.1016/j.cell.2012.03.026
    37 https://doi.org/10.1016/j.cell.2013.05.028
    38 https://doi.org/10.1016/j.molcel.2004.06.020
    39 https://doi.org/10.1016/j.molcel.2010.03.019
    40 https://doi.org/10.1016/j.molcel.2010.12.011
    41 https://doi.org/10.1016/j.molcel.2011.03.025
    42 https://doi.org/10.1016/j.molcel.2011.08.027
    43 https://doi.org/10.1016/j.molcel.2011.11.019
    44 https://doi.org/10.1016/j.stem.2011.12.017
    45 https://doi.org/10.1016/s0022-2836(76)80023-x
    46 https://doi.org/10.1021/bi00354a006
    47 https://doi.org/10.1073/pnas.0607617103
    48 https://doi.org/10.1073/pnas.0904715106
    49 https://doi.org/10.1073/pnas.1008937107
    50 https://doi.org/10.1074/jbc.m110.194027
    51 https://doi.org/10.1093/bioinformatics/btp352
    52 https://doi.org/10.1093/bioinformatics/btq033
    53 https://doi.org/10.1093/nar/gkm226
    54 https://doi.org/10.1096/fj.01-0995fje
    55 https://doi.org/10.1101/gad.1983810
    56 https://doi.org/10.1101/gad.204602.112
    57 https://doi.org/10.1126/science.1163045
    58 https://doi.org/10.1126/science.1192002
    59 https://doi.org/10.1126/science.1225237
    60 https://doi.org/10.1126/science.8085157
    61 https://doi.org/10.1128/mcb.06503-11
    62 https://doi.org/10.1146/annurev-biochem-030409-143718
    63 https://doi.org/10.1261/rna.2747411
    64 https://doi.org/10.1261/rna.2778911
    65 https://doi.org/10.1371/journal.pbio.1000276
    66 https://doi.org/10.1371/journal.pbio.1001046
    67 https://doi.org/10.1371/journal.pgen.1000242
    68 https://doi.org/10.1371/journal.pone.0036365
    69 schema:datePublished 2013-11
    70 schema:datePublishedReg 2013-11-01
    71 schema:description Polycomb repressive complex 2 (PRC2) is a histone methyltransferase required for epigenetic silencing during development and cancer. Long noncoding RNAs (lncRNAs) recruit PRC2 to chromatin, but the general role of RNA in maintaining repressed chromatin is unknown. Here we measure the binding constants of human PRC2 to various RNAs and find comparable affinity for human lncRNAs targeted by PRC2 as for irrelevant transcripts from ciliates and bacteria. PRC2 binding is size dependent, with lower affinity for shorter RNAs. In vivo, PRC2 predominantly occupies repressed genes; PRC2 is also associated with active genes, but most of those are not regulated by PRC2. These findings support a model in which PRC2's promiscuous binding to RNA transcripts allows it to scan for target genes that have escaped repression, thus leading to maintenance of the repressed state. Such RNAs may also provide a decoy for PRC2.
    72 schema:genre research_article
    73 schema:inLanguage en
    74 schema:isAccessibleForFree true
    75 schema:isPartOf N9d799859928343869d4edff0e6613d9d
    76 Neaf75d0754bf46d9a357cf5149c7d285
    77 sg:journal.1295033
    78 schema:name Promiscuous RNA binding by Polycomb repressive complex 2
    79 schema:pagination 1250-1257
    80 schema:productId N64dc3bf0b52441438e153d2eac69cd00
    81 Naf0e726ea38c4692b5da5744f76ff866
    82 Nc6b6d8b73f6e4690bc37efdbfcc55515
    83 Nc9130e8a6df24140925a48ab9246aa21
    84 Nfc7cd2f9ea90453da822cfc599196800
    85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026913602
    86 https://doi.org/10.1038/nsmb.2679
    87 schema:sdDatePublished 2019-04-10T15:39
    88 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    89 schema:sdPublisher N9e24a3864c684fd397ab13fbd7e32856
    90 schema:url http://www.nature.com/nsmb/journal/v20/n11/full/nsmb.2679.html
    91 sgo:license sg:explorer/license/
    92 sgo:sdDataset articles
    93 rdf:type schema:ScholarlyArticle
    94 N0b17373946e741fb9d8cfc94e4c37598 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    95 schema:name Humans
    96 rdf:type schema:DefinedTerm
    97 N2f71f81d419644bdbd0787d0233aec1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    98 schema:name Bacteria
    99 rdf:type schema:DefinedTerm
    100 N308831f6e2af4f54982a287189c39b24 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    101 schema:name Ciliophora
    102 rdf:type schema:DefinedTerm
    103 N5d4f3c04ecda4800a996cd420f6661a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name RNA, Messenger
    105 rdf:type schema:DefinedTerm
    106 N63b20af776ad48cea5b9b4485e7a97a1 rdf:first sg:person.01211064044.70
    107 rdf:rest rdf:nil
    108 N64dc3bf0b52441438e153d2eac69cd00 schema:name dimensions_id
    109 schema:value pub.1026913602
    110 rdf:type schema:PropertyValue
    111 N7bf8d4bc341f4bfe949dabfec9c944c3 rdf:first sg:person.01147327545.11
    112 rdf:rest N83b3f3d1dd5a49e29146d197a531e412
    113 N7dc0148a86fb4f01be31f92fed262e22 rdf:first sg:person.01341066344.66
    114 rdf:rest N63b20af776ad48cea5b9b4485e7a97a1
    115 N83b3f3d1dd5a49e29146d197a531e412 rdf:first Ne40d59c19f304ca9bee02524061cfbd4
    116 rdf:rest N7dc0148a86fb4f01be31f92fed262e22
    117 N9c0c17c2004a42f890dbc982ca8d3000 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Gene Expression Profiling
    119 rdf:type schema:DefinedTerm
    120 N9d799859928343869d4edff0e6613d9d schema:volumeNumber 20
    121 rdf:type schema:PublicationVolume
    122 N9e1201d434a04865ab1285e601acc0ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name RNA-Binding Proteins
    124 rdf:type schema:DefinedTerm
    125 N9e24a3864c684fd397ab13fbd7e32856 schema:name Springer Nature - SN SciGraph project
    126 rdf:type schema:Organization
    127 Naf0e726ea38c4692b5da5744f76ff866 schema:name doi
    128 schema:value 10.1038/nsmb.2679
    129 rdf:type schema:PropertyValue
    130 Nb5b5e66c0a814e03a920bcd664b1c688 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Protein Binding
    132 rdf:type schema:DefinedTerm
    133 Nc6b6d8b73f6e4690bc37efdbfcc55515 schema:name pubmed_id
    134 schema:value 24077223
    135 rdf:type schema:PropertyValue
    136 Nc9130e8a6df24140925a48ab9246aa21 schema:name nlm_unique_id
    137 schema:value 101186374
    138 rdf:type schema:PropertyValue
    139 Ne40d59c19f304ca9bee02524061cfbd4 schema:affiliation https://www.grid.ac/institutes/grid.430503.1
    140 schema:familyName Zheng
    141 schema:givenName Leon
    142 rdf:type schema:Person
    143 Neaf75d0754bf46d9a357cf5149c7d285 schema:issueNumber 11
    144 rdf:type schema:PublicationIssue
    145 Ned00375ab8894e2384cf3652b615fb1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Polycomb Repressive Complex 2
    147 rdf:type schema:DefinedTerm
    148 Nfc7cd2f9ea90453da822cfc599196800 schema:name readcube_id
    149 schema:value 8036139141fd01b19b94eb69030ce8aa4c84a2b71861a8dce8bcacdf7a4cb5cf
    150 rdf:type schema:PropertyValue
    151 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    152 schema:name Biological Sciences
    153 rdf:type schema:DefinedTerm
    154 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    155 schema:name Genetics
    156 rdf:type schema:DefinedTerm
    157 sg:grant.2683979 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.2679
    158 rdf:type schema:MonetaryGrant
    159 sg:journal.1295033 schema:issn 1545-9993
    160 2331-365X
    161 schema:name Nature Structural & Molecular Biology
    162 rdf:type schema:Periodical
    163 sg:person.01147327545.11 schema:affiliation https://www.grid.ac/institutes/grid.266190.a
    164 schema:familyName Davidovich
    165 schema:givenName Chen
    166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147327545.11
    167 rdf:type schema:Person
    168 sg:person.01211064044.70 schema:affiliation https://www.grid.ac/institutes/grid.266190.a
    169 schema:familyName Cech
    170 schema:givenName Thomas R
    171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211064044.70
    172 rdf:type schema:Person
    173 sg:person.01341066344.66 schema:affiliation https://www.grid.ac/institutes/grid.266190.a
    174 schema:familyName Goodrich
    175 schema:givenName Karen J
    176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341066344.66
    177 rdf:type schema:Person
    178 sg:pub.10.1038/nature04733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038720785
    179 https://doi.org/10.1038/nature04733
    180 rdf:type schema:CreativeWork
    181 sg:pub.10.1038/nature08398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014254479
    182 https://doi.org/10.1038/nature08398
    183 rdf:type schema:CreativeWork
    184 sg:pub.10.1038/nature08975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017276958
    185 https://doi.org/10.1038/nature08975
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1038/nature09784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030505833
    188 https://doi.org/10.1038/nature09784
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1038/nature10398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018204822
    191 https://doi.org/10.1038/nature10398
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1038/nature11247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029065430
    194 https://doi.org/10.1038/nature11247
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1038/nature11870 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018452167
    197 https://doi.org/10.1038/nature11870
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1038/nbt.1754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019307928
    200 https://doi.org/10.1038/nbt.1754
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1038/ncb1403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053217564
    203 https://doi.org/10.1038/ncb1403
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1038/ncb1787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005538911
    206 https://doi.org/10.1038/ncb1787
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1038/nmeth.1226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045381177
    209 https://doi.org/10.1038/nmeth.1226
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1038/nrg1981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023847549
    212 https://doi.org/10.1038/nrg1981
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1038/nsmb.2434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037002974
    215 https://doi.org/10.1038/nsmb.2434
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1038/nsmb.2435 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049135533
    218 https://doi.org/10.1038/nsmb.2435
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1038/nsmb.2449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053258244
    221 https://doi.org/10.1038/nsmb.2449
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1186/gb-2008-9-9-r137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027608848
    224 https://doi.org/10.1186/gb-2008-9-9-r137
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1186/gb-2009-10-3-r25 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049583368
    227 https://doi.org/10.1186/gb-2009-10-3-r25
    228 rdf:type schema:CreativeWork
    229 https://doi.org/10.1002/bip.1979.360180815 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041830224
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1016/j.cell.2006.02.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030427346
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1016/j.cell.2006.02.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004307083
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1016/j.cell.2007.05.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051644950
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1016/j.cell.2009.08.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021778552
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1016/j.cell.2009.12.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027791026
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1016/j.cell.2011.09.057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000476330
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1016/j.cell.2012.03.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020648288
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1016/j.cell.2013.05.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027005696
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1016/j.molcel.2004.06.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037193790
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1016/j.molcel.2010.03.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006770285
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1016/j.molcel.2010.12.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020894025
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1016/j.molcel.2011.03.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013778335
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1016/j.molcel.2011.08.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018828999
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1016/j.molcel.2011.11.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017735696
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1016/j.stem.2011.12.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031111768
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1016/s0022-2836(76)80023-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038590344
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1021/bi00354a006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055171611
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1073/pnas.0607617103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046714190
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1073/pnas.0904715106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022579887
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1073/pnas.1008937107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040079173
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1074/jbc.m110.194027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018230923
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1093/bioinformatics/btp352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023014918
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1093/bioinformatics/btq033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036892131
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1093/nar/gkm226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001245785
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1096/fj.01-0995fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1009396098
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1101/gad.1983810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040100685
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1101/gad.204602.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048519217
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1126/science.1163045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038655698
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1126/science.1192002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002615413
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1126/science.1225237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034018193
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1126/science.8085157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062652200
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1128/mcb.06503-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048933543
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1146/annurev-biochem-030409-143718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026396443
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1261/rna.2747411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046325549
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1261/rna.2778911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047684583
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1371/journal.pbio.1000276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028215756
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1371/journal.pbio.1001046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031377769
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1371/journal.pgen.1000242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053736080
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1371/journal.pone.0036365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027411716
    308 rdf:type schema:CreativeWork
    309 https://www.grid.ac/institutes/grid.266190.a schema:alternateName University of Colorado Boulder
    310 schema:name BioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, USA.
    311 Department of Chemistry & Biochemistry, Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, Colorado, USA.
    312 rdf:type schema:Organization
    313 https://www.grid.ac/institutes/grid.430503.1 schema:alternateName University of Colorado Anschutz Medical Campus
    314 schema:name Medical Scientist Training Program, University of Colorado School of Medicine, Aurora, Colorado, USA.
    315 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...