Promiscuous RNA binding by Polycomb repressive complex 2 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-11

AUTHORS

Chen Davidovich, Leon Zheng, Karen J Goodrich, Thomas R Cech

ABSTRACT

Polycomb repressive complex 2 (PRC2) is a histone methyltransferase required for epigenetic silencing during development and cancer. Long noncoding RNAs (lncRNAs) recruit PRC2 to chromatin, but the general role of RNA in maintaining repressed chromatin is unknown. Here we measure the binding constants of human PRC2 to various RNAs and find comparable affinity for human lncRNAs targeted by PRC2 as for irrelevant transcripts from ciliates and bacteria. PRC2 binding is size dependent, with lower affinity for shorter RNAs. In vivo, PRC2 predominantly occupies repressed genes; PRC2 is also associated with active genes, but most of those are not regulated by PRC2. These findings support a model in which PRC2's promiscuous binding to RNA transcripts allows it to scan for target genes that have escaped repression, thus leading to maintenance of the repressed state. Such RNAs may also provide a decoy for PRC2. More... »

PAGES

1250-1257

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nsmb.2679

    DOI

    http://dx.doi.org/10.1038/nsmb.2679

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1026913602

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24077223


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