Divergent evolution of protein conformational dynamics in dihydrofolate reductase View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-11

AUTHORS

Gira Bhabha, Damian C Ekiert, Madeleine Jennewein, Christian M Zmasek, Lisa M Tuttle, Gerard Kroon, H Jane Dyson, Adam Godzik, Ian A Wilson, Peter E Wright

ABSTRACT

Molecular evolution is driven by mutations, which may affect the fitness of an organism and are then subject to natural selection or genetic drift. Analysis of primary protein sequences and tertiary structures has yielded valuable insights into the evolution of protein function, but little is known about the evolution of functional mechanisms, protein dynamics and conformational plasticity essential for activity. We characterized the atomic-level motions across divergent members of the dihydrofolate reductase (DHFR) family. Despite structural similarity, Escherichia coli and human DHFRs use different dynamic mechanisms to perform the same function, and human DHFR cannot complement DHFR-deficient E. coli cells. Identification of the primary-sequence determinants of flexibility in DHFRs from several species allowed us to propose a likely scenario for the evolution of functionally important DHFR dynamics following a pattern of divergent evolution that is tuned by cellular environment. More... »

PAGES

1243-1249

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsmb.2676

DOI

http://dx.doi.org/10.1038/nsmb.2676

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040029266

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24077226


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