Determinants of nucleosome positioning View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-03

AUTHORS

Kevin Struhl, Eran Segal

ABSTRACT

Nucleosome positioning is critical for gene expression and most DNA-related processes. Here we review the dominant patterns of nucleosome positioning that have been observed and summarize the current understanding of their underlying determinants. The genome-wide pattern of nucleosome positioning is determined by the combination of DNA sequence, ATP-dependent nucleosome remodeling enzymes and transcription factors that include activators, components of the preinitiation complex and elongating RNA polymerase II. These determinants influence each other such that the resulting nucleosome positioning patterns are likely to differ among genes and among cells in a population, with consequent effects on gene expression. More... »

PAGES

267

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nsmb.2506

    DOI

    http://dx.doi.org/10.1038/nsmb.2506

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1044431626

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23463311


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