Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-11-18

AUTHORS

Gerard L Brien, Guillermo Gambero, David J O'Connell, Emilia Jerman, Siobhán A Turner, Chris M Egan, Eiseart J Dunne, Maike C Jurgens, Kieran Wynne, Lianhua Piao, Amanda J Lohan, Neil Ferguson, Xiaobing Shi, Krishna M Sinha, Brendan J Loftus, Gerard Cagney, Adrian P Bracken

ABSTRACT

How Polycomb repressive complex 2 (PRC2) is recruited to active chromatin to mediate transcriptional silencing during lineage specification in metazoans has been unclear. New findings now show that PRC2 component PHF19, which associates with the H3K36me3 demethylase NO66, binds the active chromatin mark H3K36me3 through its Tudor domain, leading to PRC2-mediated H3K27 trimethylation, loss of H3K36me3 and transcriptional silencing. More... »

PAGES

1273-1281

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsmb.2449

DOI

http://dx.doi.org/10.1038/nsmb.2449

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053258244

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23160351


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