Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-12

AUTHORS

Gerard L Brien, Guillermo Gambero, David J O'Connell, Emilia Jerman, Siobhán A Turner, Chris M Egan, Eiseart J Dunne, Maike C Jurgens, Kieran Wynne, Lianhua Piao, Amanda J Lohan, Neil Ferguson, Xiaobing Shi, Krishna M Sinha, Brendan J Loftus, Gerard Cagney, Adrian P Bracken

ABSTRACT

Polycomb group proteins are repressive chromatin modifiers with essential roles in metazoan development, cellular differentiation and cell fate maintenance. How Polycomb proteins access active chromatin to confer transcriptional silencing during lineage transitions remains unclear. Here we show that the Polycomb repressive complex 2 (PRC2) component PHF19 binds trimethylated histone H3 Lys36 (H3K36me3), a mark of active chromatin, via its Tudor domain. PHF19 associates with the H3K36me3 demethylase NO66, and it is required to recruit the PRC2 complex and NO66 to stem cell genes during differentiation, leading to PRC2-mediated trimethylation of histone H3 Lys27 (H3K27), loss of H3K36me3 and transcriptional silencing. We propose a model whereby PHF19 functions during mouse embryonic stem cell differentiation to transiently bind the H3K36me3 mark via its Tudor domain, forming essential contact points that allow recruitment of PRC2 and H3K36me3 demethylase activity to active gene loci during their transition to a Polycomb-repressed state. More... »

PAGES

1273

References to SciGraph publications

  • 2004-10. Role of histone H2A ubiquitination in Polycomb silencing in NATURE
  • 2008-11. Model-based Analysis of ChIP-Seq (MACS) in GENOME BIOLOGY
  • 2009-10. Mechanisms of Polycomb gene silencing: knowns and unknowns in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2006-07. A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling in NATURE
  • 2010-03. JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells in NATURE
  • 2008-12. MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification in NATURE BIOTECHNOLOGY
  • 2008-11. A model for transmission of the H3K27me3 epigenetic mark in NATURE CELL BIOLOGY
  • 2009-11. Polycomb group proteins: navigators of lineage pathways led astray in cancer in NATURE REVIEWS CANCER
  • 2012-05. Functional genomics: Complexities of occupancy and sequence in NATURE REVIEWS GENETICS
  • 2011-01. The Polycomb complex PRC2 and its mark in life in NATURE
  • 2012-05. Molecular mechanisms and potential functions of histone demethylases in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2007-08. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells in NATURE
  • 2010-06. Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators in NATURE CELL BIOLOGY
  • 2011-01. Charting histone modifications and the functional organization of mammalian genomes in NATURE REVIEWS GENETICS
  • 2009-10. In Brief in NATURE REVIEWS NEUROSCIENCE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nsmb.2449

    DOI

    http://dx.doi.org/10.1038/nsmb.2449

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1053258244

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23160351


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Differentiation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Embryonic Stem Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Histones", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polycomb Repressive Complex 2", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Trinity College Dublin", 
              "id": "https://www.grid.ac/institutes/grid.8217.c", 
              "name": [
                "The Smurfit Institute of Genetics, Trinity College Dublin, Ireland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brien", 
            "givenName": "Gerard L", 
            "id": "sg:person.01226600003.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226600003.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University College Dublin", 
              "id": "https://www.grid.ac/institutes/grid.7886.1", 
              "name": [
                "Conway Institute, University College Dublin, Ireland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gambero", 
            "givenName": "Guillermo", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University College Dublin", 
              "id": "https://www.grid.ac/institutes/grid.7886.1", 
              "name": [
                "Conway Institute, University College Dublin, Ireland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "O'Connell", 
            "givenName": "David J", 
            "id": "sg:person.01215436403.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215436403.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Trinity College Dublin", 
              "id": "https://www.grid.ac/institutes/grid.8217.c", 
              "name": [
                "The Smurfit Institute of Genetics, Trinity College Dublin, Ireland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jerman", 
            "givenName": "Emilia", 
            "id": "sg:person.01254020664.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254020664.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Trinity College Dublin", 
              "id": "https://www.grid.ac/institutes/grid.8217.c", 
              "name": [
                "The Smurfit Institute of Genetics, Trinity College Dublin, Ireland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Turner", 
            "givenName": "Siobh\u00e1n A", 
            "id": "sg:person.01322134064.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322134064.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Trinity College Dublin", 
              "id": "https://www.grid.ac/institutes/grid.8217.c", 
              "name": [
                "The Smurfit Institute of Genetics, Trinity College Dublin, Ireland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Egan", 
            "givenName": "Chris M", 
            "id": "sg:person.01051312046.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051312046.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Trinity College Dublin", 
              "id": "https://www.grid.ac/institutes/grid.8217.c", 
              "name": [
                "The Smurfit Institute of Genetics, Trinity College Dublin, Ireland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dunne", 
            "givenName": "Eiseart J", 
            "id": "sg:person.0577033224.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577033224.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University College Dublin", 
              "id": "https://www.grid.ac/institutes/grid.7886.1", 
              "name": [
                "Conway Institute, University College Dublin, Ireland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jurgens", 
            "givenName": "Maike C", 
            "id": "sg:person.0764572763.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764572763.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University College Dublin", 
              "id": "https://www.grid.ac/institutes/grid.7886.1", 
              "name": [
                "Conway Institute, University College Dublin, Ireland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wynne", 
            "givenName": "Kieran", 
            "id": "sg:person.01056412062.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056412062.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Piao", 
            "givenName": "Lianhua", 
            "id": "sg:person.010310124073.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010310124073.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University College Dublin", 
              "id": "https://www.grid.ac/institutes/grid.7886.1", 
              "name": [
                "Conway Institute, University College Dublin, Ireland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lohan", 
            "givenName": "Amanda J", 
            "id": "sg:person.0607006142.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607006142.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University College Dublin", 
              "id": "https://www.grid.ac/institutes/grid.7886.1", 
              "name": [
                "Conway Institute, University College Dublin, Ireland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ferguson", 
            "givenName": "Neil", 
            "id": "sg:person.0655710722.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655710722.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shi", 
            "givenName": "Xiaobing", 
            "id": "sg:person.01032232641.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032232641.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sinha", 
            "givenName": "Krishna M", 
            "id": "sg:person.01242110435.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242110435.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University College Dublin", 
              "id": "https://www.grid.ac/institutes/grid.7886.1", 
              "name": [
                "Conway Institute, University College Dublin, Ireland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Loftus", 
            "givenName": "Brendan J", 
            "id": "sg:person.01052650052.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052650052.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University College Dublin", 
              "id": "https://www.grid.ac/institutes/grid.7886.1", 
              "name": [
                "Conway Institute, University College Dublin, Ireland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cagney", 
            "givenName": "Gerard", 
            "id": "sg:person.01014656545.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014656545.85"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tallaght Hospital", 
              "id": "https://www.grid.ac/institutes/grid.413305.0", 
              "name": [
                "The Smurfit Institute of Genetics, Trinity College Dublin, Ireland.", 
                "The Adelaide & Meath Hospital, including the National Children's Hospital, Dublin, Ireland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bracken", 
            "givenName": "Adrian P", 
            "id": "sg:person.0720264620.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720264620.31"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.ceb.2008.01.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000287938"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/emboj.2009.332", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001591836"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.emboj.7600402", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002391009"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pmic.200800600", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003115835"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pmic.200800600", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003115835"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn2731", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003593041", 
              "https://doi.org/10.1038/nrn2731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn2731", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003593041", 
              "https://doi.org/10.1038/nrn2731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2763", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004980736", 
              "https://doi.org/10.1038/nrm2763"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2763", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004980736", 
              "https://doi.org/10.1038/nrm2763"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1787", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005538911", 
              "https://doi.org/10.1038/ncb1787"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0968-0004(03)00004-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006918144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0968-0004(03)00004-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006918144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2005.04.051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006935847"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2065", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009835974", 
              "https://doi.org/10.1038/ncb2065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2065", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009835974", 
              "https://doi.org/10.1038/ncb2065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.10.1.14389", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012782521"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2011.03.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013778335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80604-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014526993"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2008.10.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014750873"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m110.194027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018230923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20100944", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019444475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20100944", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019444475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1100576", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020733240"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.053652", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021044560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.00259-10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022418617"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.02.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022937373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.470008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024814718"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.23.9.3352-3362.2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024830315"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1002576", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025930163"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2905", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026386976", 
              "https://doi.org/10.1038/nrg2905"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2905", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026386976", 
              "https://doi.org/10.1038/nrg2905"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2010.04.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027466820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2008-9-9-r137", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027608848", 
              "https://doi.org/10.1186/gb-2008-9-9-r137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/cdg542", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029576413"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/emboj.2011.383", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030065978"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09784", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030505833", 
              "https://doi.org/10.1038/nature09784"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.09.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030661380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m104294200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032772166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1035902", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033394366"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2004.10.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033618192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-09-0270", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034573739"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.12.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035129976"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.484208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036116799"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036216819", 
              "https://doi.org/10.1038/nature06008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.02017-07", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036575885"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.016006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041510018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.12.029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041907573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.415507", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042100087"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.emboj.7601837", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044794985"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08788", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045150487", 
              "https://doi.org/10.1038/nature08788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08788", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045150487", 
              "https://doi.org/10.1038/nature08788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2010.08.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046752737"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2736", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047038730", 
              "https://doi.org/10.1038/nrc2736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.01432-06", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047362471"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm3327", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047915532", 
              "https://doi.org/10.1038/nrm3327"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.381706", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048643612"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049469421", 
              "https://doi.org/10.1038/nbt.1511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02985", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049709002", 
              "https://doi.org/10.1038/nature02985"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02985", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049709002", 
              "https://doi.org/10.1038/nature02985"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1076997", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050318758"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04815", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051379136", 
              "https://doi.org/10.1038/nature04815"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04815", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051379136", 
              "https://doi.org/10.1038/nature04815"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04815", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051379136", 
              "https://doi.org/10.1038/nature04815"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2012.01.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051615565"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg3219", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052283167", 
              "https://doi.org/10.1038/nrg3219"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1000242", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053736080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1000242", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053736080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac950914h", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055072376"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac950914h", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055072376"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2012-12", 
        "datePublishedReg": "2012-12-01", 
        "description": "Polycomb group proteins are repressive chromatin modifiers with essential roles in metazoan development, cellular differentiation and cell fate maintenance. How Polycomb proteins access active chromatin to confer transcriptional silencing during lineage transitions remains unclear. Here we show that the Polycomb repressive complex 2 (PRC2) component PHF19 binds trimethylated histone H3 Lys36 (H3K36me3), a mark of active chromatin, via its Tudor domain. PHF19 associates with the H3K36me3 demethylase NO66, and it is required to recruit the PRC2 complex and NO66 to stem cell genes during differentiation, leading to PRC2-mediated trimethylation of histone H3 Lys27 (H3K27), loss of H3K36me3 and transcriptional silencing. We propose a model whereby PHF19 functions during mouse embryonic stem cell differentiation to transiently bind the H3K36me3 mark via its Tudor domain, forming essential contact points that allow recruitment of PRC2 and H3K36me3 demethylase activity to active gene loci during their transition to a Polycomb-repressed state.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nsmb.2449", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.3983111", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2567927", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1295033", 
            "issn": [
              "1545-9993", 
              "2331-365X"
            ], 
            "name": "Nature Structural & Molecular Biology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "12", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "19"
          }
        ], 
        "name": "Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation", 
        "pagination": "1273", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "fdae1052844fc77046a7abc8288ec11a2f13a992fbb80bd4d28bbc187cd9c111"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "23160351"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101186374"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nsmb.2449"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1053258244"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nsmb.2449", 
          "https://app.dimensions.ai/details/publication/pub.1053258244"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T20:36", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000436.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/nsmb.2449"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2449'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2449'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2449'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2449'


     

    This table displays all metadata directly associated to this object as RDF triples.

    402 TRIPLES      21 PREDICATES      91 URIs      27 LITERALS      15 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nsmb.2449 schema:about N03e0d8aadcfd40c28eb0fb079ddc57d9
    2 N448b8a148f38461dbc2225cdc39c5ef8
    3 N69421b1a27b045d8802626b82951d4ec
    4 N85793132b24740cd85d5386dcbd8efd8
    5 N99b4c735413548d88d016c8ae8d7a628
    6 Na9c7f431855041d4a05e66ef8aa669a8
    7 anzsrc-for:06
    8 anzsrc-for:0601
    9 schema:author N2af09ab443154519926e1780689bdcbe
    10 schema:citation sg:pub.10.1038/nature02985
    11 sg:pub.10.1038/nature04815
    12 sg:pub.10.1038/nature06008
    13 sg:pub.10.1038/nature08788
    14 sg:pub.10.1038/nature09784
    15 sg:pub.10.1038/nbt.1511
    16 sg:pub.10.1038/ncb1787
    17 sg:pub.10.1038/ncb2065
    18 sg:pub.10.1038/nrc2736
    19 sg:pub.10.1038/nrg2905
    20 sg:pub.10.1038/nrg3219
    21 sg:pub.10.1038/nrm2763
    22 sg:pub.10.1038/nrm3327
    23 sg:pub.10.1038/nrn2731
    24 sg:pub.10.1186/gb-2008-9-9-r137
    25 https://doi.org/10.1002/pmic.200800600
    26 https://doi.org/10.1016/j.ceb.2008.01.004
    27 https://doi.org/10.1016/j.cell.2007.02.005
    28 https://doi.org/10.1016/j.cell.2009.12.002
    29 https://doi.org/10.1016/j.cell.2011.12.029
    30 https://doi.org/10.1016/j.cell.2012.09.002
    31 https://doi.org/10.1016/j.cub.2005.04.051
    32 https://doi.org/10.1016/j.devcel.2004.10.005
    33 https://doi.org/10.1016/j.molcel.2008.10.016
    34 https://doi.org/10.1016/j.molcel.2010.04.009
    35 https://doi.org/10.1016/j.molcel.2011.03.025
    36 https://doi.org/10.1016/j.molcel.2012.01.002
    37 https://doi.org/10.1016/j.stem.2010.08.002
    38 https://doi.org/10.1016/s0092-8674(00)80604-2
    39 https://doi.org/10.1016/s0968-0004(03)00004-5
    40 https://doi.org/10.1021/ac950914h
    41 https://doi.org/10.1038/emboj.2009.332
    42 https://doi.org/10.1038/emboj.2011.383
    43 https://doi.org/10.1038/sj.emboj.7600402
    44 https://doi.org/10.1038/sj.emboj.7601837
    45 https://doi.org/10.1042/bj20100944
    46 https://doi.org/10.1074/jbc.m104294200
    47 https://doi.org/10.1074/jbc.m110.194027
    48 https://doi.org/10.1093/emboj/cdg542
    49 https://doi.org/10.1101/gad.1035902
    50 https://doi.org/10.1101/gad.381706
    51 https://doi.org/10.1101/gad.415507
    52 https://doi.org/10.1101/gad.470008
    53 https://doi.org/10.1101/gad.484208
    54 https://doi.org/10.1126/science.1076997
    55 https://doi.org/10.1126/science.1100576
    56 https://doi.org/10.1128/mcb.00259-10
    57 https://doi.org/10.1128/mcb.01432-06
    58 https://doi.org/10.1128/mcb.02017-07
    59 https://doi.org/10.1128/mcb.23.9.3352-3362.2003
    60 https://doi.org/10.1158/0008-5472.can-09-0270
    61 https://doi.org/10.1242/dev.016006
    62 https://doi.org/10.1242/dev.053652
    63 https://doi.org/10.1371/journal.pgen.1000242
    64 https://doi.org/10.1371/journal.pgen.1002576
    65 https://doi.org/10.4161/cc.10.1.14389
    66 schema:datePublished 2012-12
    67 schema:datePublishedReg 2012-12-01
    68 schema:description Polycomb group proteins are repressive chromatin modifiers with essential roles in metazoan development, cellular differentiation and cell fate maintenance. How Polycomb proteins access active chromatin to confer transcriptional silencing during lineage transitions remains unclear. Here we show that the Polycomb repressive complex 2 (PRC2) component PHF19 binds trimethylated histone H3 Lys36 (H3K36me3), a mark of active chromatin, via its Tudor domain. PHF19 associates with the H3K36me3 demethylase NO66, and it is required to recruit the PRC2 complex and NO66 to stem cell genes during differentiation, leading to PRC2-mediated trimethylation of histone H3 Lys27 (H3K27), loss of H3K36me3 and transcriptional silencing. We propose a model whereby PHF19 functions during mouse embryonic stem cell differentiation to transiently bind the H3K36me3 mark via its Tudor domain, forming essential contact points that allow recruitment of PRC2 and H3K36me3 demethylase activity to active gene loci during their transition to a Polycomb-repressed state.
    69 schema:genre research_article
    70 schema:inLanguage en
    71 schema:isAccessibleForFree false
    72 schema:isPartOf Nb4ba9f114c074f1e92d4fab8078d2584
    73 Nd5b1c1d25dc04fba891dca327ca5031e
    74 sg:journal.1295033
    75 schema:name Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation
    76 schema:pagination 1273
    77 schema:productId N382f05858bf846ad8686eb5b045a60e3
    78 N7b45650a46c9463d81a55170403c0b49
    79 N861a50da35f34ff494be8a578722a7c4
    80 Nd177e45511e54698af9ccba6e5b33e5e
    81 Nfc675fb9f37c4eb7830c81aa17287650
    82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053258244
    83 https://doi.org/10.1038/nsmb.2449
    84 schema:sdDatePublished 2019-04-10T20:36
    85 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    86 schema:sdPublisher N27d4097d643e4ea996cc4c1b4aa6647a
    87 schema:url https://www.nature.com/articles/nsmb.2449
    88 sgo:license sg:explorer/license/
    89 sgo:sdDataset articles
    90 rdf:type schema:ScholarlyArticle
    91 N02dcc9596e984367ba992edabff6a1f1 rdf:first sg:person.0607006142.55
    92 rdf:rest Nb35e6369403e4de2bf284f99f54a5384
    93 N03e0d8aadcfd40c28eb0fb079ddc57d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    94 schema:name Polycomb Repressive Complex 2
    95 rdf:type schema:DefinedTerm
    96 N0558a4ef234d4621818b16c9273cb93d rdf:first sg:person.01032232641.91
    97 rdf:rest N2e3b515c31f340c1a7e44dc80bfc2d6e
    98 N15deb75cf2dc4524a337c68ed0ee5dec rdf:first sg:person.01215436403.22
    99 rdf:rest Nd6332e36c44149178740f6f7d2f20654
    100 N1a1c20f46ba0482482916a60f0ad8962 rdf:first N6361063b8c9843a8a4deda704cf21435
    101 rdf:rest N15deb75cf2dc4524a337c68ed0ee5dec
    102 N27d4097d643e4ea996cc4c1b4aa6647a schema:name Springer Nature - SN SciGraph project
    103 rdf:type schema:Organization
    104 N2af09ab443154519926e1780689bdcbe rdf:first sg:person.01226600003.78
    105 rdf:rest N1a1c20f46ba0482482916a60f0ad8962
    106 N2e3b515c31f340c1a7e44dc80bfc2d6e rdf:first sg:person.01242110435.65
    107 rdf:rest Ndc923dcdb93c488bb3a424c9d5a2ab47
    108 N356b093d817b4b199a7e367ccde89fd3 rdf:first sg:person.01322134064.44
    109 rdf:rest N8004e5fa0537481e9df7810380cbddfe
    110 N382f05858bf846ad8686eb5b045a60e3 schema:name dimensions_id
    111 schema:value pub.1053258244
    112 rdf:type schema:PropertyValue
    113 N448b8a148f38461dbc2225cdc39c5ef8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Animals
    115 rdf:type schema:DefinedTerm
    116 N48f1622b05de4664bf646cdf663acb65 rdf:first sg:person.01056412062.25
    117 rdf:rest N8389d02dd15a45e881989872bf09c8a5
    118 N5ebe44d7cafd4bf8b25a8245afb8260d rdf:first sg:person.0720264620.31
    119 rdf:rest rdf:nil
    120 N6361063b8c9843a8a4deda704cf21435 schema:affiliation https://www.grid.ac/institutes/grid.7886.1
    121 schema:familyName Gambero
    122 schema:givenName Guillermo
    123 rdf:type schema:Person
    124 N6927b38eeb514675898957818608ae3b rdf:first sg:person.01014656545.85
    125 rdf:rest N5ebe44d7cafd4bf8b25a8245afb8260d
    126 N69421b1a27b045d8802626b82951d4ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Cell Differentiation
    128 rdf:type schema:DefinedTerm
    129 N7b45650a46c9463d81a55170403c0b49 schema:name nlm_unique_id
    130 schema:value 101186374
    131 rdf:type schema:PropertyValue
    132 N8004e5fa0537481e9df7810380cbddfe rdf:first sg:person.01051312046.46
    133 rdf:rest Nd4811c06cd6a43a285d123421c2bb55a
    134 N8389d02dd15a45e881989872bf09c8a5 rdf:first sg:person.010310124073.74
    135 rdf:rest N02dcc9596e984367ba992edabff6a1f1
    136 N85793132b24740cd85d5386dcbd8efd8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Embryonic Stem Cells
    138 rdf:type schema:DefinedTerm
    139 N861a50da35f34ff494be8a578722a7c4 schema:name pubmed_id
    140 schema:value 23160351
    141 rdf:type schema:PropertyValue
    142 N99b4c735413548d88d016c8ae8d7a628 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Mice
    144 rdf:type schema:DefinedTerm
    145 Na9c7f431855041d4a05e66ef8aa669a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Histones
    147 rdf:type schema:DefinedTerm
    148 Nb35e6369403e4de2bf284f99f54a5384 rdf:first sg:person.0655710722.12
    149 rdf:rest N0558a4ef234d4621818b16c9273cb93d
    150 Nb4ba9f114c074f1e92d4fab8078d2584 schema:volumeNumber 19
    151 rdf:type schema:PublicationVolume
    152 Nc1a5aa2d07b24b5a841ad841cde3e105 rdf:first sg:person.0764572763.08
    153 rdf:rest N48f1622b05de4664bf646cdf663acb65
    154 Nd177e45511e54698af9ccba6e5b33e5e schema:name doi
    155 schema:value 10.1038/nsmb.2449
    156 rdf:type schema:PropertyValue
    157 Nd4811c06cd6a43a285d123421c2bb55a rdf:first sg:person.0577033224.20
    158 rdf:rest Nc1a5aa2d07b24b5a841ad841cde3e105
    159 Nd5b1c1d25dc04fba891dca327ca5031e schema:issueNumber 12
    160 rdf:type schema:PublicationIssue
    161 Nd6332e36c44149178740f6f7d2f20654 rdf:first sg:person.01254020664.28
    162 rdf:rest N356b093d817b4b199a7e367ccde89fd3
    163 Ndc923dcdb93c488bb3a424c9d5a2ab47 rdf:first sg:person.01052650052.48
    164 rdf:rest N6927b38eeb514675898957818608ae3b
    165 Nfc675fb9f37c4eb7830c81aa17287650 schema:name readcube_id
    166 schema:value fdae1052844fc77046a7abc8288ec11a2f13a992fbb80bd4d28bbc187cd9c111
    167 rdf:type schema:PropertyValue
    168 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    169 schema:name Biological Sciences
    170 rdf:type schema:DefinedTerm
    171 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    172 schema:name Biochemistry and Cell Biology
    173 rdf:type schema:DefinedTerm
    174 sg:grant.2567927 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.2449
    175 rdf:type schema:MonetaryGrant
    176 sg:grant.3983111 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.2449
    177 rdf:type schema:MonetaryGrant
    178 sg:journal.1295033 schema:issn 1545-9993
    179 2331-365X
    180 schema:name Nature Structural & Molecular Biology
    181 rdf:type schema:Periodical
    182 sg:person.01014656545.85 schema:affiliation https://www.grid.ac/institutes/grid.7886.1
    183 schema:familyName Cagney
    184 schema:givenName Gerard
    185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014656545.85
    186 rdf:type schema:Person
    187 sg:person.010310124073.74 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    188 schema:familyName Piao
    189 schema:givenName Lianhua
    190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010310124073.74
    191 rdf:type schema:Person
    192 sg:person.01032232641.91 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    193 schema:familyName Shi
    194 schema:givenName Xiaobing
    195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032232641.91
    196 rdf:type schema:Person
    197 sg:person.01051312046.46 schema:affiliation https://www.grid.ac/institutes/grid.8217.c
    198 schema:familyName Egan
    199 schema:givenName Chris M
    200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051312046.46
    201 rdf:type schema:Person
    202 sg:person.01052650052.48 schema:affiliation https://www.grid.ac/institutes/grid.7886.1
    203 schema:familyName Loftus
    204 schema:givenName Brendan J
    205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052650052.48
    206 rdf:type schema:Person
    207 sg:person.01056412062.25 schema:affiliation https://www.grid.ac/institutes/grid.7886.1
    208 schema:familyName Wynne
    209 schema:givenName Kieran
    210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056412062.25
    211 rdf:type schema:Person
    212 sg:person.01215436403.22 schema:affiliation https://www.grid.ac/institutes/grid.7886.1
    213 schema:familyName O'Connell
    214 schema:givenName David J
    215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215436403.22
    216 rdf:type schema:Person
    217 sg:person.01226600003.78 schema:affiliation https://www.grid.ac/institutes/grid.8217.c
    218 schema:familyName Brien
    219 schema:givenName Gerard L
    220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226600003.78
    221 rdf:type schema:Person
    222 sg:person.01242110435.65 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    223 schema:familyName Sinha
    224 schema:givenName Krishna M
    225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242110435.65
    226 rdf:type schema:Person
    227 sg:person.01254020664.28 schema:affiliation https://www.grid.ac/institutes/grid.8217.c
    228 schema:familyName Jerman
    229 schema:givenName Emilia
    230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254020664.28
    231 rdf:type schema:Person
    232 sg:person.01322134064.44 schema:affiliation https://www.grid.ac/institutes/grid.8217.c
    233 schema:familyName Turner
    234 schema:givenName Siobhán A
    235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322134064.44
    236 rdf:type schema:Person
    237 sg:person.0577033224.20 schema:affiliation https://www.grid.ac/institutes/grid.8217.c
    238 schema:familyName Dunne
    239 schema:givenName Eiseart J
    240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577033224.20
    241 rdf:type schema:Person
    242 sg:person.0607006142.55 schema:affiliation https://www.grid.ac/institutes/grid.7886.1
    243 schema:familyName Lohan
    244 schema:givenName Amanda J
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607006142.55
    246 rdf:type schema:Person
    247 sg:person.0655710722.12 schema:affiliation https://www.grid.ac/institutes/grid.7886.1
    248 schema:familyName Ferguson
    249 schema:givenName Neil
    250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655710722.12
    251 rdf:type schema:Person
    252 sg:person.0720264620.31 schema:affiliation https://www.grid.ac/institutes/grid.413305.0
    253 schema:familyName Bracken
    254 schema:givenName Adrian P
    255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720264620.31
    256 rdf:type schema:Person
    257 sg:person.0764572763.08 schema:affiliation https://www.grid.ac/institutes/grid.7886.1
    258 schema:familyName Jurgens
    259 schema:givenName Maike C
    260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764572763.08
    261 rdf:type schema:Person
    262 sg:pub.10.1038/nature02985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049709002
    263 https://doi.org/10.1038/nature02985
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1038/nature04815 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051379136
    266 https://doi.org/10.1038/nature04815
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1038/nature06008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036216819
    269 https://doi.org/10.1038/nature06008
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1038/nature08788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045150487
    272 https://doi.org/10.1038/nature08788
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1038/nature09784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030505833
    275 https://doi.org/10.1038/nature09784
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1038/nbt.1511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049469421
    278 https://doi.org/10.1038/nbt.1511
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1038/ncb1787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005538911
    281 https://doi.org/10.1038/ncb1787
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1038/ncb2065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009835974
    284 https://doi.org/10.1038/ncb2065
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1038/nrc2736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047038730
    287 https://doi.org/10.1038/nrc2736
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1038/nrg2905 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026386976
    290 https://doi.org/10.1038/nrg2905
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1038/nrg3219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052283167
    293 https://doi.org/10.1038/nrg3219
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1038/nrm2763 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004980736
    296 https://doi.org/10.1038/nrm2763
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1038/nrm3327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047915532
    299 https://doi.org/10.1038/nrm3327
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1038/nrn2731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003593041
    302 https://doi.org/10.1038/nrn2731
    303 rdf:type schema:CreativeWork
    304 sg:pub.10.1186/gb-2008-9-9-r137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027608848
    305 https://doi.org/10.1186/gb-2008-9-9-r137
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1002/pmic.200800600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003115835
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1016/j.ceb.2008.01.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000287938
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1016/j.cell.2007.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022937373
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1016/j.cell.2009.12.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035129976
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1016/j.cell.2011.12.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041907573
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1016/j.cell.2012.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030661380
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1016/j.cub.2005.04.051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006935847
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1016/j.devcel.2004.10.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033618192
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1016/j.molcel.2008.10.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014750873
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1016/j.molcel.2010.04.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027466820
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1016/j.molcel.2011.03.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013778335
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1016/j.molcel.2012.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051615565
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1016/j.stem.2010.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046752737
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1016/s0092-8674(00)80604-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014526993
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1016/s0968-0004(03)00004-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006918144
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1021/ac950914h schema:sameAs https://app.dimensions.ai/details/publication/pub.1055072376
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1038/emboj.2009.332 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001591836
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1038/emboj.2011.383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030065978
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1038/sj.emboj.7600402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002391009
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1038/sj.emboj.7601837 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044794985
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1042/bj20100944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019444475
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1074/jbc.m104294200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032772166
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1074/jbc.m110.194027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018230923
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1093/emboj/cdg542 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029576413
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1101/gad.1035902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033394366
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1101/gad.381706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048643612
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1101/gad.415507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042100087
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1101/gad.470008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024814718
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1101/gad.484208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036116799
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1126/science.1076997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050318758
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1126/science.1100576 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020733240
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1128/mcb.00259-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022418617
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1128/mcb.01432-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047362471
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1128/mcb.02017-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036575885
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1128/mcb.23.9.3352-3362.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024830315
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1158/0008-5472.can-09-0270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034573739
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1242/dev.016006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041510018
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1242/dev.053652 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021044560
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1371/journal.pgen.1000242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053736080
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1371/journal.pgen.1002576 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025930163
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.4161/cc.10.1.14389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012782521
    388 rdf:type schema:CreativeWork
    389 https://www.grid.ac/institutes/grid.240145.6 schema:alternateName The University of Texas MD Anderson Cancer Center
    390 schema:name Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
    391 Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
    392 rdf:type schema:Organization
    393 https://www.grid.ac/institutes/grid.413305.0 schema:alternateName Tallaght Hospital
    394 schema:name The Adelaide & Meath Hospital, including the National Children's Hospital, Dublin, Ireland.
    395 The Smurfit Institute of Genetics, Trinity College Dublin, Ireland.
    396 rdf:type schema:Organization
    397 https://www.grid.ac/institutes/grid.7886.1 schema:alternateName University College Dublin
    398 schema:name Conway Institute, University College Dublin, Ireland.
    399 rdf:type schema:Organization
    400 https://www.grid.ac/institutes/grid.8217.c schema:alternateName Trinity College Dublin
    401 schema:name The Smurfit Institute of Genetics, Trinity College Dublin, Ireland.
    402 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...