Crystal structure of human CDC7 kinase in complex with its activator DBF4 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-11

AUTHORS

Siobhan Hughes, Frédéric Elustondo, Andrea Di Fonzo, Frédéric G Leroux, Ai C Wong, Ambrosius P Snijders, Stephen J Matthews, Peter Cherepanov

ABSTRACT

CDC7 is a serine/threonine kinase that is essential for the initiation of eukaryotic DNA replication. CDC7 activity is controlled by its activator, DBF4. Here we present crystal structures of human CDC7-DBF4 in complex with a nucleotide or ATP-competing small molecules, revealing the active and inhibited forms of the kinase, respectively. DBF4 wraps around CDC7, burying approximately 6,000 Å(2) of hydrophobic molecular surface in a bipartite interface. The effector domain of DBF4, containing conserved motif C, is essential and sufficient to support CDC7 kinase activity by binding to the kinase N-terminal lobe and stabilizing its canonical αC helix. DBF4 motif M latches onto the C-terminal lobe of the kinase, acting as a tethering domain. Our results elucidate the structural basis for binding to and activation of CDC7 by DBF4 and provide a framework for the design of more potent and specific CDC7 inhibitors. More... »

PAGES

1101

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsmb.2404

DOI

http://dx.doi.org/10.1038/nsmb.2404

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019162678

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23064647


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Crystallization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Spectroscopy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multiprotein Complexes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Conformation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Serine-Threonine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "X-Ray Diffraction", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Cancer Research UK, London Research Institute, Clare Hall Laboratories, Potters Bar, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hughes", 
        "givenName": "Siobhan", 
        "id": "sg:person.012303004457.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012303004457.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Research Technology", 
          "id": "https://www.grid.ac/institutes/grid.432780.a", 
          "name": [
            "Cancer Research Technology Discovery Laboratories, Wolfson Institute for Biomedical Research, London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Elustondo", 
        "givenName": "Fr\u00e9d\u00e9ric", 
        "id": "sg:person.01203201407.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203201407.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Cancer Research UK, London Research Institute, Clare Hall Laboratories, Potters Bar, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Di Fonzo", 
        "givenName": "Andrea", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Research Technology", 
          "id": "https://www.grid.ac/institutes/grid.432780.a", 
          "name": [
            "Cancer Research Technology Discovery Laboratories, Wolfson Institute for Biomedical Research, London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leroux", 
        "givenName": "Fr\u00e9d\u00e9ric G", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Research Technology", 
          "id": "https://www.grid.ac/institutes/grid.432780.a", 
          "name": [
            "Cancer Research Technology Discovery Laboratories, Wolfson Institute for Biomedical Research, London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wong", 
        "givenName": "Ai C", 
        "id": "sg:person.01210025105.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210025105.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Cancer Research UK, London Research Institute, Clare Hall Laboratories, Potters Bar, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Snijders", 
        "givenName": "Ambrosius P", 
        "id": "sg:person.01341405243.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341405243.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Imperial College London", 
          "id": "https://www.grid.ac/institutes/grid.7445.2", 
          "name": [
            "Division of Molecular Biosciences, Imperial College London, South Kensington Campus, London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matthews", 
        "givenName": "Stephen J", 
        "id": "sg:person.012675741117.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012675741117.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Cancer Research UK, London Research Institute, Clare Hall Laboratories, Potters Bar, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cherepanov", 
        "givenName": "Peter", 
        "id": "sg:person.01130065235.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130065235.18"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/376313a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002475687", 
          "https://doi.org/10.1038/376313a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80351-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002494692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2008.91", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003221462", 
          "https://doi.org/10.1038/nprot.2008.91"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/18.19.5334", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003790111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2006.02.050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004357614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.2000.3281", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007179039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsb0896-696", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007402396", 
          "https://doi.org/10.1038/nsb0896-696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1000498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009778566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444905036693", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013232159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1339805", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014111679"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(03)00392-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014444081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-1547", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016938435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.13.5.2899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018252824"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444909042073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018458004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444909042073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018458004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444907050172", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019095775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444904019158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020281098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444996012255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020405374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(02)00741-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020670930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08647", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022812644", 
          "https://doi.org/10.1038/nature08647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08647", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022812644", 
          "https://doi.org/10.1038/nature08647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2012.04.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023539296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(02)00550-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023654371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio.90", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024174782", 
          "https://doi.org/10.1038/nchembio.90"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1626608", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024325007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2010.10.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024536945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.10.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024928304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.19.7.4888", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025071616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m608935200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026939157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444904011679", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027804289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m309322200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027941688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028254057", 
          "https://doi.org/10.1038/ncb1069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028254057", 
          "https://doi.org/10.1038/ncb1069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/15674", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028305284", 
          "https://doi.org/10.1038/15674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/15674", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028305284", 
          "https://doi.org/10.1038/15674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.11.24.3365", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028548738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444909047337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032162623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444909047337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032162623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1933010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035610853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m109.036491", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036469957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pro.5560030203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037295466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pro.5560030203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037295466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkg556", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037373225"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1593/neo.08216", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037593382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0021889809045701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038911089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0021889809045701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038911089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2007.01.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038918866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/cdf290", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040997077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1683308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042983580"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0604990103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043501647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2005.03.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044868767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2011.06.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044927218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m102197200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046042295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-10-0185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046877582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444906022116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048359585"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0610251104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048556248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m111.243311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049078460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1759609", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049980699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m512921200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051278565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.9.10.11752", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072300790"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-11", 
    "datePublishedReg": "2012-11-01", 
    "description": "CDC7 is a serine/threonine kinase that is essential for the initiation of eukaryotic DNA replication. CDC7 activity is controlled by its activator, DBF4. Here we present crystal structures of human CDC7-DBF4 in complex with a nucleotide or ATP-competing small molecules, revealing the active and inhibited forms of the kinase, respectively. DBF4 wraps around CDC7, burying approximately 6,000 \u00c5(2) of hydrophobic molecular surface in a bipartite interface. The effector domain of DBF4, containing conserved motif C, is essential and sufficient to support CDC7 kinase activity by binding to the kinase N-terminal lobe and stabilizing its canonical \u03b1C helix. DBF4 motif M latches onto the C-terminal lobe of the kinase, acting as a tethering domain. Our results elucidate the structural basis for binding to and activation of CDC7 by DBF4 and provide a framework for the design of more potent and specific CDC7 inhibitors.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nsmb.2404", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2782031", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1295033", 
        "issn": [
          "1545-9993", 
          "2331-365X"
        ], 
        "name": "Nature Structural & Molecular Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "11", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "name": "Crystal structure of human CDC7 kinase in complex with its activator DBF4", 
    "pagination": "1101", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5b4d8cf5eea2f6d3f321bc58b0c69ef1afba83556b1fd4fc9cc80abc1fe222b2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23064647"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101186374"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nsmb.2404"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1019162678"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nsmb.2404", 
      "https://app.dimensions.ai/details/publication/pub.1019162678"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000435.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nsmb.2404"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2404'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2404'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2404'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2404'


 

This table displays all metadata directly associated to this object as RDF triples.

339 TRIPLES      21 PREDICATES      93 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nsmb.2404 schema:about N41ea62b7da644d0abb95d501fdccf976
2 N4f17c61f16ac42fba1f74a15bfd60421
3 N5e670afdf8fc478ca2f5d44e144b2adb
4 N647fe73920674102b889bb9b56d9faf1
5 N7f4d7464cb7a4aa8b287a0d4f9588480
6 N83eab3bbd6a847529e7568b9ad537a24
7 N892f830d3da1419ca58dcc1836d87b19
8 N8cc13c774f6d4fd2a2f1d9c64b56d19b
9 Ndd42af2ef73244a6afcef6743f7fe77b
10 Ndee62c5ca9564f4db6a89767aa669beb
11 Ne428fda3674247f296a1384bebfb6695
12 anzsrc-for:06
13 anzsrc-for:0601
14 schema:author N391d8f8f663c48e9a6a0ae96a85367b1
15 schema:citation sg:pub.10.1038/15674
16 sg:pub.10.1038/376313a0
17 sg:pub.10.1038/nature08647
18 sg:pub.10.1038/ncb1069
19 sg:pub.10.1038/nchembio.90
20 sg:pub.10.1038/nprot.2008.91
21 sg:pub.10.1038/nsb0896-696
22 https://doi.org/10.1002/pro.5560030203
23 https://doi.org/10.1006/bbrc.2000.3281
24 https://doi.org/10.1016/j.bmcl.2012.04.024
25 https://doi.org/10.1016/j.cell.2008.10.026
26 https://doi.org/10.1016/j.cell.2011.06.012
27 https://doi.org/10.1016/j.febslet.2006.02.050
28 https://doi.org/10.1016/j.jmb.2007.01.004
29 https://doi.org/10.1016/j.molcel.2005.03.031
30 https://doi.org/10.1016/j.molcel.2010.10.017
31 https://doi.org/10.1016/s0092-8674(00)80351-7
32 https://doi.org/10.1016/s0092-8674(02)00741-9
33 https://doi.org/10.1016/s1097-2765(02)00550-6
34 https://doi.org/10.1016/s1097-2765(03)00392-7
35 https://doi.org/10.1073/pnas.0604990103
36 https://doi.org/10.1073/pnas.0610251104
37 https://doi.org/10.1074/jbc.m102197200
38 https://doi.org/10.1074/jbc.m109.036491
39 https://doi.org/10.1074/jbc.m111.243311
40 https://doi.org/10.1074/jbc.m309322200
41 https://doi.org/10.1074/jbc.m512921200
42 https://doi.org/10.1074/jbc.m608935200
43 https://doi.org/10.1093/emboj/18.19.5334
44 https://doi.org/10.1093/emboj/cdf290
45 https://doi.org/10.1093/nar/gkg556
46 https://doi.org/10.1101/gad.11.24.3365
47 https://doi.org/10.1101/gad.1339805
48 https://doi.org/10.1101/gad.1626608
49 https://doi.org/10.1101/gad.1683308
50 https://doi.org/10.1101/gad.1759609
51 https://doi.org/10.1101/gad.1933010
52 https://doi.org/10.1107/s0021889809045701
53 https://doi.org/10.1107/s0907444904011679
54 https://doi.org/10.1107/s0907444904019158
55 https://doi.org/10.1107/s0907444905036693
56 https://doi.org/10.1107/s0907444906022116
57 https://doi.org/10.1107/s0907444907050172
58 https://doi.org/10.1107/s0907444909042073
59 https://doi.org/10.1107/s0907444909047337
60 https://doi.org/10.1107/s0907444996012255
61 https://doi.org/10.1128/mcb.13.5.2899
62 https://doi.org/10.1128/mcb.19.7.4888
63 https://doi.org/10.1158/0008-5472.can-04-1547
64 https://doi.org/10.1158/1078-0432.ccr-10-0185
65 https://doi.org/10.1371/journal.pgen.1000498
66 https://doi.org/10.1593/neo.08216
67 https://doi.org/10.4161/cc.9.10.11752
68 schema:datePublished 2012-11
69 schema:datePublishedReg 2012-11-01
70 schema:description CDC7 is a serine/threonine kinase that is essential for the initiation of eukaryotic DNA replication. CDC7 activity is controlled by its activator, DBF4. Here we present crystal structures of human CDC7-DBF4 in complex with a nucleotide or ATP-competing small molecules, revealing the active and inhibited forms of the kinase, respectively. DBF4 wraps around CDC7, burying approximately 6,000 Å(2) of hydrophobic molecular surface in a bipartite interface. The effector domain of DBF4, containing conserved motif C, is essential and sufficient to support CDC7 kinase activity by binding to the kinase N-terminal lobe and stabilizing its canonical αC helix. DBF4 motif M latches onto the C-terminal lobe of the kinase, acting as a tethering domain. Our results elucidate the structural basis for binding to and activation of CDC7 by DBF4 and provide a framework for the design of more potent and specific CDC7 inhibitors.
71 schema:genre research_article
72 schema:inLanguage en
73 schema:isAccessibleForFree false
74 schema:isPartOf N430cdb2452a94964b9b3aca4cc83f871
75 N9589237d74b542349ca6f2ea7a421c3e
76 sg:journal.1295033
77 schema:name Crystal structure of human CDC7 kinase in complex with its activator DBF4
78 schema:pagination 1101
79 schema:productId N5b1455dfbc9f461f9f59d2cdeeb660d6
80 N9f0c0887bfb64edd9c6508148f59aa30
81 Nb68ce8d061294b3f8981b2af78c63995
82 Nbcee8a509e144ff5ac16dc46ad0dab03
83 Ndb785091d9994ef8aff475515ba95ddc
84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019162678
85 https://doi.org/10.1038/nsmb.2404
86 schema:sdDatePublished 2019-04-11T00:56
87 schema:sdLicense https://scigraph.springernature.com/explorer/license/
88 schema:sdPublisher Nb980827df46d49aa9712a849d5388191
89 schema:url https://www.nature.com/articles/nsmb.2404
90 sgo:license sg:explorer/license/
91 sgo:sdDataset articles
92 rdf:type schema:ScholarlyArticle
93 N0ebdfca8c4b14ac1833d50a521539e91 rdf:first sg:person.01130065235.18
94 rdf:rest rdf:nil
95 N19ba3dfb661c48f2bdb5d16cc27a7dd7 schema:affiliation https://www.grid.ac/institutes/grid.432780.a
96 schema:familyName Leroux
97 schema:givenName Frédéric G
98 rdf:type schema:Person
99 N391d8f8f663c48e9a6a0ae96a85367b1 rdf:first sg:person.012303004457.91
100 rdf:rest Nec2bffd5134f4197ac98f123b2f52924
101 N41ea62b7da644d0abb95d501fdccf976 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Molecular Sequence Data
103 rdf:type schema:DefinedTerm
104 N430cdb2452a94964b9b3aca4cc83f871 schema:volumeNumber 19
105 rdf:type schema:PublicationVolume
106 N4f17c61f16ac42fba1f74a15bfd60421 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Protein Conformation
108 rdf:type schema:DefinedTerm
109 N5b1455dfbc9f461f9f59d2cdeeb660d6 schema:name pubmed_id
110 schema:value 23064647
111 rdf:type schema:PropertyValue
112 N5d361667bbf24923807f7db3b9ab7bd9 rdf:first sg:person.012675741117.68
113 rdf:rest N0ebdfca8c4b14ac1833d50a521539e91
114 N5e670afdf8fc478ca2f5d44e144b2adb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name X-Ray Diffraction
116 rdf:type schema:DefinedTerm
117 N647fe73920674102b889bb9b56d9faf1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Models, Molecular
119 rdf:type schema:DefinedTerm
120 N6867100f2ec54585859621e109ad660b schema:name Cancer Research UK, London Research Institute, Clare Hall Laboratories, Potters Bar, UK.
121 rdf:type schema:Organization
122 N7f4d7464cb7a4aa8b287a0d4f9588480 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Multiprotein Complexes
124 rdf:type schema:DefinedTerm
125 N83eab3bbd6a847529e7568b9ad537a24 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Crystallization
127 rdf:type schema:DefinedTerm
128 N892f830d3da1419ca58dcc1836d87b19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Protein-Serine-Threonine Kinases
130 rdf:type schema:DefinedTerm
131 N8cc13c774f6d4fd2a2f1d9c64b56d19b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Humans
133 rdf:type schema:DefinedTerm
134 N8e3345da3f6e4271b474681fc1f847f0 schema:affiliation N6867100f2ec54585859621e109ad660b
135 schema:familyName Di Fonzo
136 schema:givenName Andrea
137 rdf:type schema:Person
138 N904d65693ae3495a958ed835cea971ef rdf:first sg:person.01341405243.01
139 rdf:rest N5d361667bbf24923807f7db3b9ab7bd9
140 N9589237d74b542349ca6f2ea7a421c3e schema:issueNumber 11
141 rdf:type schema:PublicationIssue
142 N9f0c0887bfb64edd9c6508148f59aa30 schema:name nlm_unique_id
143 schema:value 101186374
144 rdf:type schema:PropertyValue
145 Nb68ce8d061294b3f8981b2af78c63995 schema:name doi
146 schema:value 10.1038/nsmb.2404
147 rdf:type schema:PropertyValue
148 Nb980827df46d49aa9712a849d5388191 schema:name Springer Nature - SN SciGraph project
149 rdf:type schema:Organization
150 Nbcee8a509e144ff5ac16dc46ad0dab03 schema:name readcube_id
151 schema:value 5b4d8cf5eea2f6d3f321bc58b0c69ef1afba83556b1fd4fc9cc80abc1fe222b2
152 rdf:type schema:PropertyValue
153 Nc69a4259785d479cadaa1ca010f5b3bd rdf:first N8e3345da3f6e4271b474681fc1f847f0
154 rdf:rest Nff99d86d8b924978b33761224d5c4e29
155 Nd0199398f5f54899b9db695e3d1293cb schema:name Cancer Research UK, London Research Institute, Clare Hall Laboratories, Potters Bar, UK.
156 rdf:type schema:Organization
157 Nd01a373bae1e4ec5ae123364bdde309e schema:name Cancer Research UK, London Research Institute, Clare Hall Laboratories, Potters Bar, UK.
158 rdf:type schema:Organization
159 Nd61c463ae95a4ddf99c586b05c26d34b rdf:first sg:person.01210025105.37
160 rdf:rest N904d65693ae3495a958ed835cea971ef
161 Ndb785091d9994ef8aff475515ba95ddc schema:name dimensions_id
162 schema:value pub.1019162678
163 rdf:type schema:PropertyValue
164 Ndd42af2ef73244a6afcef6743f7fe77b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Cell Cycle Proteins
166 rdf:type schema:DefinedTerm
167 Ndee62c5ca9564f4db6a89767aa669beb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Amino Acid Sequence
169 rdf:type schema:DefinedTerm
170 Ne428fda3674247f296a1384bebfb6695 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Magnetic Resonance Spectroscopy
172 rdf:type schema:DefinedTerm
173 Nec2bffd5134f4197ac98f123b2f52924 rdf:first sg:person.01203201407.54
174 rdf:rest Nc69a4259785d479cadaa1ca010f5b3bd
175 Nf113817774dc423e862d7525feda7f17 schema:name Cancer Research UK, London Research Institute, Clare Hall Laboratories, Potters Bar, UK.
176 rdf:type schema:Organization
177 Nff99d86d8b924978b33761224d5c4e29 rdf:first N19ba3dfb661c48f2bdb5d16cc27a7dd7
178 rdf:rest Nd61c463ae95a4ddf99c586b05c26d34b
179 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
180 schema:name Biological Sciences
181 rdf:type schema:DefinedTerm
182 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
183 schema:name Biochemistry and Cell Biology
184 rdf:type schema:DefinedTerm
185 sg:grant.2782031 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.2404
186 rdf:type schema:MonetaryGrant
187 sg:journal.1295033 schema:issn 1545-9993
188 2331-365X
189 schema:name Nature Structural & Molecular Biology
190 rdf:type schema:Periodical
191 sg:person.01130065235.18 schema:affiliation Nf113817774dc423e862d7525feda7f17
192 schema:familyName Cherepanov
193 schema:givenName Peter
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130065235.18
195 rdf:type schema:Person
196 sg:person.01203201407.54 schema:affiliation https://www.grid.ac/institutes/grid.432780.a
197 schema:familyName Elustondo
198 schema:givenName Frédéric
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203201407.54
200 rdf:type schema:Person
201 sg:person.01210025105.37 schema:affiliation https://www.grid.ac/institutes/grid.432780.a
202 schema:familyName Wong
203 schema:givenName Ai C
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210025105.37
205 rdf:type schema:Person
206 sg:person.012303004457.91 schema:affiliation Nd01a373bae1e4ec5ae123364bdde309e
207 schema:familyName Hughes
208 schema:givenName Siobhan
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012303004457.91
210 rdf:type schema:Person
211 sg:person.012675741117.68 schema:affiliation https://www.grid.ac/institutes/grid.7445.2
212 schema:familyName Matthews
213 schema:givenName Stephen J
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012675741117.68
215 rdf:type schema:Person
216 sg:person.01341405243.01 schema:affiliation Nd0199398f5f54899b9db695e3d1293cb
217 schema:familyName Snijders
218 schema:givenName Ambrosius P
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341405243.01
220 rdf:type schema:Person
221 sg:pub.10.1038/15674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028305284
222 https://doi.org/10.1038/15674
223 rdf:type schema:CreativeWork
224 sg:pub.10.1038/376313a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002475687
225 https://doi.org/10.1038/376313a0
226 rdf:type schema:CreativeWork
227 sg:pub.10.1038/nature08647 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022812644
228 https://doi.org/10.1038/nature08647
229 rdf:type schema:CreativeWork
230 sg:pub.10.1038/ncb1069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028254057
231 https://doi.org/10.1038/ncb1069
232 rdf:type schema:CreativeWork
233 sg:pub.10.1038/nchembio.90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024174782
234 https://doi.org/10.1038/nchembio.90
235 rdf:type schema:CreativeWork
236 sg:pub.10.1038/nprot.2008.91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003221462
237 https://doi.org/10.1038/nprot.2008.91
238 rdf:type schema:CreativeWork
239 sg:pub.10.1038/nsb0896-696 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007402396
240 https://doi.org/10.1038/nsb0896-696
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1002/pro.5560030203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037295466
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1006/bbrc.2000.3281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007179039
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/j.bmcl.2012.04.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023539296
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/j.cell.2008.10.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024928304
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.cell.2011.06.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044927218
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/j.febslet.2006.02.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004357614
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/j.jmb.2007.01.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038918866
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/j.molcel.2005.03.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044868767
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/j.molcel.2010.10.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024536945
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/s0092-8674(00)80351-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002494692
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/s0092-8674(02)00741-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020670930
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/s1097-2765(02)00550-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023654371
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/s1097-2765(03)00392-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014444081
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1073/pnas.0604990103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043501647
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1073/pnas.0610251104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048556248
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1074/jbc.m102197200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046042295
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1074/jbc.m109.036491 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036469957
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1074/jbc.m111.243311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049078460
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1074/jbc.m309322200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027941688
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1074/jbc.m512921200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051278565
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1074/jbc.m608935200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026939157
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1093/emboj/18.19.5334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003790111
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1093/emboj/cdf290 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040997077
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1093/nar/gkg556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037373225
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1101/gad.11.24.3365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028548738
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1101/gad.1339805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014111679
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1101/gad.1626608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024325007
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1101/gad.1683308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042983580
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1101/gad.1759609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049980699
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1101/gad.1933010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035610853
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1107/s0021889809045701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038911089
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1107/s0907444904011679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027804289
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1107/s0907444904019158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020281098
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1107/s0907444905036693 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013232159
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1107/s0907444906022116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048359585
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1107/s0907444907050172 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019095775
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1107/s0907444909042073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018458004
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1107/s0907444909047337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032162623
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1107/s0907444996012255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020405374
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1128/mcb.13.5.2899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018252824
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1128/mcb.19.7.4888 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025071616
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1158/0008-5472.can-04-1547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016938435
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1158/1078-0432.ccr-10-0185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046877582
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1371/journal.pgen.1000498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009778566
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1593/neo.08216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037593382
331 rdf:type schema:CreativeWork
332 https://doi.org/10.4161/cc.9.10.11752 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072300790
333 rdf:type schema:CreativeWork
334 https://www.grid.ac/institutes/grid.432780.a schema:alternateName Cancer Research Technology
335 schema:name Cancer Research Technology Discovery Laboratories, Wolfson Institute for Biomedical Research, London, UK.
336 rdf:type schema:Organization
337 https://www.grid.ac/institutes/grid.7445.2 schema:alternateName Imperial College London
338 schema:name Division of Molecular Biosciences, Imperial College London, South Kensington Campus, London, UK.
339 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...