Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-02

AUTHORS

Jeffrey Buis, Trina Stoneham, Elizabeth Spehalski, David O Ferguson

ABSTRACT

Homologous recombination facilitates accurate repair of DNA double-strand breaks (DSBs) during the S and G2 phases of the cell cycle by using intact sister chromatids as sequence templates. Homologous recombination capacity is maximized in S and G2 by cyclin-dependent kinase (CDK) phosphorylation of CtIP, which subsequently interacts with BRCA1 and the Mre11-Rad50-NBS1 (MRN) complex. Here we show that, in human and mouse, Mre11 controls these events through a direct interaction with CDK2 that is required for CtIP phosphorylation and BRCA1 interaction in normally dividing cells. CDK2 binds the C terminus of Mre11, which is absent in an inherited allele causing ataxia telangiectasia-like disorder. This newly uncovered role for Mre11 does not require ATM activation or nuclease activities. Therefore, functions of MRN are not restricted to DNA damage responses but include regulating homologous recombination capacity during the normal mammalian cell cycle. More... »

PAGES

246

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsmb.2212

DOI

http://dx.doi.org/10.1038/nsmb.2212

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007242691

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22231403


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carrier Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclin-Dependent Kinase 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Breaks, Double-Stranded", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Repair", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Repair Enzymes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MRE11 Homologue Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Interaction Mapping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombination, Genetic", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Buis", 
        "givenName": "Jeffrey", 
        "id": "sg:person.01261224645.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261224645.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stoneham", 
        "givenName": "Trina", 
        "id": "sg:person.01327340045.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327340045.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Spehalski", 
        "givenName": "Elizabeth", 
        "id": "sg:person.01352606321.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352606321.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ferguson", 
        "givenName": "David O", 
        "id": "sg:person.0667652043.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667652043.20"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/emboj/18.23.6619", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000406992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.biochem.77.061306.125255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000560477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07955", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000929920", 
          "https://doi.org/10.1038/nature07955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07955", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000929920", 
          "https://doi.org/10.1038/nature07955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.24.20.8917-8928.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001315381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1373705", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001654709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2009.07.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001977111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002815475", 
          "https://doi.org/10.1038/nature01368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002815475", 
          "https://doi.org/10.1038/nature01368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m710245200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003143847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dnarep.2010.12.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005487602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1108297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005911474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.01525-08", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006541482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.88.21.9578", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006969540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.24.21.9478-9486.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013148122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.2003811", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013673802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0803520105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014275836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2009.07.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014624883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2004.08.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016486212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200903033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018116872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-3945", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021113411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(01)00335-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021688273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.13.20.2633", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022595499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81547-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024972519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025635345", 
          "https://doi.org/10.1038/sj.onc.1206994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025635345", 
          "https://doi.org/10.1038/sj.onc.1206994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025699748", 
          "https://doi.org/10.1038/ncb1270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025699748", 
          "https://doi.org/10.1038/ncb1270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.genom.7.080505.115648", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026196063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(03)00455-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026769640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20081326", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030102810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dnarep.2010.10.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030217771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031468320", 
          "https://doi.org/10.1038/nature07215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2003.09.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032868154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2003.09.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032868154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2958.2001.02553.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032989671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2009.170", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035307232", 
          "https://doi.org/10.1038/onc.2009.170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2009.170", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035307232", 
          "https://doi.org/10.1038/onc.2009.170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.21.1.281-288.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035805910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.08.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036363563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m808906200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036458410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037045843", 
          "https://doi.org/10.1038/nature06046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(01)00381-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038799913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2009.12.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039765810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(02)00763-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042779681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1140321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043601744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.08.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044995368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.1639", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046183915", 
          "https://doi.org/10.1038/nsmb.1639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.1639", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046183915", 
          "https://doi.org/10.1038/nsmb.1639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2007.10.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046724885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jb.182.21.6036-6041.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048692973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1385/nmm:8:4:495", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050105423", 
          "https://doi.org/10.1385/nmm:8:4:495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00412-009-0242-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050381210", 
          "https://doi.org/10.1007/s00412-009-0242-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00412-009-0242-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050381210", 
          "https://doi.org/10.1007/s00412-009-0242-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00412-009-0242-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050381210", 
          "https://doi.org/10.1007/s00412-009-0242-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051713472", 
          "https://doi.org/10.1038/nature06337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08467", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052581766", 
          "https://doi.org/10.1038/nature08467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08467", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052581766", 
          "https://doi.org/10.1038/nature08467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ar0201198", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055149647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ar0201198", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055149647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1091496", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062449100"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-02", 
    "datePublishedReg": "2012-02-01", 
    "description": "Homologous recombination facilitates accurate repair of DNA double-strand breaks (DSBs) during the S and G2 phases of the cell cycle by using intact sister chromatids as sequence templates. Homologous recombination capacity is maximized in S and G2 by cyclin-dependent kinase (CDK) phosphorylation of CtIP, which subsequently interacts with BRCA1 and the Mre11-Rad50-NBS1 (MRN) complex. Here we show that, in human and mouse, Mre11 controls these events through a direct interaction with CDK2 that is required for CtIP phosphorylation and BRCA1 interaction in normally dividing cells. CDK2 binds the C terminus of Mre11, which is absent in an inherited allele causing ataxia telangiectasia-like disorder. This newly uncovered role for Mre11 does not require ATM activation or nuclease activities. Therefore, functions of MRN are not restricted to DNA damage responses but include regulating homologous recombination capacity during the normal mammalian cell cycle.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nsmb.2212", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2682669", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2681870", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2382912", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2540229", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438854", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1295033", 
        "issn": [
          "1545-9993", 
          "2331-365X"
        ], 
        "name": "Nature Structural & Molecular Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "name": "Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2", 
    "pagination": "246", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "227fb0d746c93fc2da333499d02ce151d4bc2ead32f4262942e2b8b3ed47a64b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22231403"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101186374"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nsmb.2212"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1007242691"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nsmb.2212", 
      "https://app.dimensions.ai/details/publication/pub.1007242691"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:48", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000436.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nsmb.2212"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2212'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2212'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2212'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2212'


 

This table displays all metadata directly associated to this object as RDF triples.

330 TRIPLES      21 PREDICATES      96 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nsmb.2212 schema:about N30e023dd830c49aa8bef6b78361cc8cf
2 N42d2f4de45dd46d89f1888cccaab1b9e
3 N4dfcf8bf126a4ceeb6b1de026a4e7eec
4 N793102eb36f1481bbe96493797e5bcbd
5 N7955f684e5514db0b81953ae7366629b
6 N8587d564f51442c59c4860a9fb97e75a
7 N8fb252b9368b415e93ad8d76af5aad93
8 N93a13ed4cbe44bd192ec0e5de0f54d90
9 Nac99e8f5d7744ffd9c506b76f3c4accd
10 Nae5b34badd9849ad90d023810c253f33
11 Nb1846afd6a9947d0bfe023ff202cbfe3
12 Nb5b487a6f0de47dfb7b67665af5c32b6
13 Nb62414ca0b3b4535960bac65b828e49e
14 Nbcf8960208b3420d9f61c758d9ec4e51
15 Nbf2c717d88594fe1ac2d04bf2da98b45
16 Nbf7167c568db44d68d3ba803e6aaea85
17 Nd216bce24bae41be875b190398e58aff
18 anzsrc-for:06
19 anzsrc-for:0601
20 schema:author N4e3f1774a03d4477b43b84ea799c7e76
21 schema:citation sg:pub.10.1007/s00412-009-0242-4
22 sg:pub.10.1038/nature01368
23 sg:pub.10.1038/nature06046
24 sg:pub.10.1038/nature06337
25 sg:pub.10.1038/nature07215
26 sg:pub.10.1038/nature07955
27 sg:pub.10.1038/nature08467
28 sg:pub.10.1038/ncb1270
29 sg:pub.10.1038/nsmb.1639
30 sg:pub.10.1038/onc.2009.170
31 sg:pub.10.1038/sj.onc.1206994
32 sg:pub.10.1385/nmm:8:4:495
33 https://doi.org/10.1016/j.cell.2004.08.015
34 https://doi.org/10.1016/j.cell.2008.08.015
35 https://doi.org/10.1016/j.cell.2008.08.017
36 https://doi.org/10.1016/j.cell.2009.07.033
37 https://doi.org/10.1016/j.cell.2009.07.043
38 https://doi.org/10.1016/j.cub.2003.09.024
39 https://doi.org/10.1016/j.dnarep.2010.10.001
40 https://doi.org/10.1016/j.dnarep.2010.12.004
41 https://doi.org/10.1016/j.molcel.2007.10.016
42 https://doi.org/10.1016/j.molcel.2009.12.002
43 https://doi.org/10.1016/s0092-8674(00)81547-0
44 https://doi.org/10.1016/s0092-8674(01)00335-x
45 https://doi.org/10.1016/s0960-9822(02)00763-7
46 https://doi.org/10.1016/s1097-2765(01)00381-1
47 https://doi.org/10.1016/s1097-2765(03)00455-6
48 https://doi.org/10.1021/ar0201198
49 https://doi.org/10.1046/j.1365-2958.2001.02553.x
50 https://doi.org/10.1073/pnas.0803520105
51 https://doi.org/10.1073/pnas.88.21.9578
52 https://doi.org/10.1074/jbc.m710245200
53 https://doi.org/10.1074/jbc.m808906200
54 https://doi.org/10.1083/jcb.200903033
55 https://doi.org/10.1084/jem.20081326
56 https://doi.org/10.1093/emboj/18.23.6619
57 https://doi.org/10.1101/gad.13.20.2633
58 https://doi.org/10.1101/gad.1373705
59 https://doi.org/10.1101/gad.2003811
60 https://doi.org/10.1126/science.1091496
61 https://doi.org/10.1126/science.1108297
62 https://doi.org/10.1126/science.1140321
63 https://doi.org/10.1128/jb.182.21.6036-6041.2000
64 https://doi.org/10.1128/mcb.01525-08
65 https://doi.org/10.1128/mcb.21.1.281-288.2001
66 https://doi.org/10.1128/mcb.24.20.8917-8928.2004
67 https://doi.org/10.1128/mcb.24.21.9478-9486.2004
68 https://doi.org/10.1146/annurev.biochem.77.061306.125255
69 https://doi.org/10.1146/annurev.genom.7.080505.115648
70 https://doi.org/10.1158/0008-5472.can-05-3945
71 schema:datePublished 2012-02
72 schema:datePublishedReg 2012-02-01
73 schema:description Homologous recombination facilitates accurate repair of DNA double-strand breaks (DSBs) during the S and G2 phases of the cell cycle by using intact sister chromatids as sequence templates. Homologous recombination capacity is maximized in S and G2 by cyclin-dependent kinase (CDK) phosphorylation of CtIP, which subsequently interacts with BRCA1 and the Mre11-Rad50-NBS1 (MRN) complex. Here we show that, in human and mouse, Mre11 controls these events through a direct interaction with CDK2 that is required for CtIP phosphorylation and BRCA1 interaction in normally dividing cells. CDK2 binds the C terminus of Mre11, which is absent in an inherited allele causing ataxia telangiectasia-like disorder. This newly uncovered role for Mre11 does not require ATM activation or nuclease activities. Therefore, functions of MRN are not restricted to DNA damage responses but include regulating homologous recombination capacity during the normal mammalian cell cycle.
74 schema:genre research_article
75 schema:inLanguage en
76 schema:isAccessibleForFree true
77 schema:isPartOf Ne41003adf29347aa9d1f92ef2d6778d6
78 Nf8d18096ad3c41fa8e076531d3d4cd7d
79 sg:journal.1295033
80 schema:name Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2
81 schema:pagination 246
82 schema:productId N436f0f14b897448489559c5635737e18
83 N44e7d01c6b7142fbb86dfc8ff4de48f7
84 N4d841438d3d447b9b3c726812750eb28
85 N6b0f8f01ba0845d9bad63f62cd46334a
86 Nb61cb55e7dae4ca38fa258f6df81ea6b
87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007242691
88 https://doi.org/10.1038/nsmb.2212
89 schema:sdDatePublished 2019-04-11T01:48
90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
91 schema:sdPublisher N6ff5a9de7bbe4fd6bba1544d6507f675
92 schema:url https://www.nature.com/articles/nsmb.2212
93 sgo:license sg:explorer/license/
94 sgo:sdDataset articles
95 rdf:type schema:ScholarlyArticle
96 N30e023dd830c49aa8bef6b78361cc8cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Humans
98 rdf:type schema:DefinedTerm
99 N42d2f4de45dd46d89f1888cccaab1b9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name MRE11 Homologue Protein
101 rdf:type schema:DefinedTerm
102 N436f0f14b897448489559c5635737e18 schema:name dimensions_id
103 schema:value pub.1007242691
104 rdf:type schema:PropertyValue
105 N44e7d01c6b7142fbb86dfc8ff4de48f7 schema:name readcube_id
106 schema:value 227fb0d746c93fc2da333499d02ce151d4bc2ead32f4262942e2b8b3ed47a64b
107 rdf:type schema:PropertyValue
108 N4d841438d3d447b9b3c726812750eb28 schema:name doi
109 schema:value 10.1038/nsmb.2212
110 rdf:type schema:PropertyValue
111 N4dfcf8bf126a4ceeb6b1de026a4e7eec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Protein Interaction Mapping
113 rdf:type schema:DefinedTerm
114 N4e3f1774a03d4477b43b84ea799c7e76 rdf:first sg:person.01261224645.12
115 rdf:rest N5eb133642e6448a7ae54d8f143f6da61
116 N5eb133642e6448a7ae54d8f143f6da61 rdf:first sg:person.01327340045.44
117 rdf:rest Nf75f4c1618114ade8a1163b544e06752
118 N6b0f8f01ba0845d9bad63f62cd46334a schema:name pubmed_id
119 schema:value 22231403
120 rdf:type schema:PropertyValue
121 N6ff5a9de7bbe4fd6bba1544d6507f675 schema:name Springer Nature - SN SciGraph project
122 rdf:type schema:Organization
123 N793102eb36f1481bbe96493797e5bcbd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name DNA Repair Enzymes
125 rdf:type schema:DefinedTerm
126 N7955f684e5514db0b81953ae7366629b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name DNA-Binding Proteins
128 rdf:type schema:DefinedTerm
129 N818b19facb87435cb4a7123b5b21af11 rdf:first sg:person.0667652043.20
130 rdf:rest rdf:nil
131 N8587d564f51442c59c4860a9fb97e75a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Mice
133 rdf:type schema:DefinedTerm
134 N8fb252b9368b415e93ad8d76af5aad93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Recombination, Genetic
136 rdf:type schema:DefinedTerm
137 N93a13ed4cbe44bd192ec0e5de0f54d90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Cell Cycle Proteins
139 rdf:type schema:DefinedTerm
140 Nac99e8f5d7744ffd9c506b76f3c4accd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Carrier Proteins
142 rdf:type schema:DefinedTerm
143 Nae5b34badd9849ad90d023810c253f33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Nuclear Proteins
145 rdf:type schema:DefinedTerm
146 Nb1846afd6a9947d0bfe023ff202cbfe3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Phosphorylation
148 rdf:type schema:DefinedTerm
149 Nb5b487a6f0de47dfb7b67665af5c32b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Cyclin-Dependent Kinase 2
151 rdf:type schema:DefinedTerm
152 Nb61cb55e7dae4ca38fa258f6df81ea6b schema:name nlm_unique_id
153 schema:value 101186374
154 rdf:type schema:PropertyValue
155 Nb62414ca0b3b4535960bac65b828e49e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name DNA Breaks, Double-Stranded
157 rdf:type schema:DefinedTerm
158 Nbcf8960208b3420d9f61c758d9ec4e51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Animals
160 rdf:type schema:DefinedTerm
161 Nbf2c717d88594fe1ac2d04bf2da98b45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Protein Binding
163 rdf:type schema:DefinedTerm
164 Nbf7167c568db44d68d3ba803e6aaea85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Mice, Knockout
166 rdf:type schema:DefinedTerm
167 Nd216bce24bae41be875b190398e58aff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name DNA Repair
169 rdf:type schema:DefinedTerm
170 Ne41003adf29347aa9d1f92ef2d6778d6 schema:volumeNumber 19
171 rdf:type schema:PublicationVolume
172 Nf75f4c1618114ade8a1163b544e06752 rdf:first sg:person.01352606321.12
173 rdf:rest N818b19facb87435cb4a7123b5b21af11
174 Nf8d18096ad3c41fa8e076531d3d4cd7d schema:issueNumber 2
175 rdf:type schema:PublicationIssue
176 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
177 schema:name Biological Sciences
178 rdf:type schema:DefinedTerm
179 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
180 schema:name Biochemistry and Cell Biology
181 rdf:type schema:DefinedTerm
182 sg:grant.2382912 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.2212
183 rdf:type schema:MonetaryGrant
184 sg:grant.2438854 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.2212
185 rdf:type schema:MonetaryGrant
186 sg:grant.2540229 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.2212
187 rdf:type schema:MonetaryGrant
188 sg:grant.2681870 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.2212
189 rdf:type schema:MonetaryGrant
190 sg:grant.2682669 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.2212
191 rdf:type schema:MonetaryGrant
192 sg:journal.1295033 schema:issn 1545-9993
193 2331-365X
194 schema:name Nature Structural & Molecular Biology
195 rdf:type schema:Periodical
196 sg:person.01261224645.12 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
197 schema:familyName Buis
198 schema:givenName Jeffrey
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261224645.12
200 rdf:type schema:Person
201 sg:person.01327340045.44 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
202 schema:familyName Stoneham
203 schema:givenName Trina
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327340045.44
205 rdf:type schema:Person
206 sg:person.01352606321.12 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
207 schema:familyName Spehalski
208 schema:givenName Elizabeth
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352606321.12
210 rdf:type schema:Person
211 sg:person.0667652043.20 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
212 schema:familyName Ferguson
213 schema:givenName David O
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667652043.20
215 rdf:type schema:Person
216 sg:pub.10.1007/s00412-009-0242-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050381210
217 https://doi.org/10.1007/s00412-009-0242-4
218 rdf:type schema:CreativeWork
219 sg:pub.10.1038/nature01368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002815475
220 https://doi.org/10.1038/nature01368
221 rdf:type schema:CreativeWork
222 sg:pub.10.1038/nature06046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037045843
223 https://doi.org/10.1038/nature06046
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/nature06337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051713472
226 https://doi.org/10.1038/nature06337
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/nature07215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031468320
229 https://doi.org/10.1038/nature07215
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/nature07955 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000929920
232 https://doi.org/10.1038/nature07955
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/nature08467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052581766
235 https://doi.org/10.1038/nature08467
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/ncb1270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025699748
238 https://doi.org/10.1038/ncb1270
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/nsmb.1639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046183915
241 https://doi.org/10.1038/nsmb.1639
242 rdf:type schema:CreativeWork
243 sg:pub.10.1038/onc.2009.170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035307232
244 https://doi.org/10.1038/onc.2009.170
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/sj.onc.1206994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025635345
247 https://doi.org/10.1038/sj.onc.1206994
248 rdf:type schema:CreativeWork
249 sg:pub.10.1385/nmm:8:4:495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050105423
250 https://doi.org/10.1385/nmm:8:4:495
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/j.cell.2004.08.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016486212
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/j.cell.2008.08.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044995368
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/j.cell.2008.08.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036363563
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/j.cell.2009.07.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001977111
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/j.cell.2009.07.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014624883
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/j.cub.2003.09.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032868154
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/j.dnarep.2010.10.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030217771
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/j.dnarep.2010.12.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005487602
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/j.molcel.2007.10.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046724885
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/j.molcel.2009.12.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039765810
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/s0092-8674(00)81547-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024972519
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/s0092-8674(01)00335-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021688273
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/s0960-9822(02)00763-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042779681
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/s1097-2765(01)00381-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038799913
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/s1097-2765(03)00455-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026769640
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1021/ar0201198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055149647
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1046/j.1365-2958.2001.02553.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032989671
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1073/pnas.0803520105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014275836
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1073/pnas.88.21.9578 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006969540
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1074/jbc.m710245200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003143847
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1074/jbc.m808906200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036458410
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1083/jcb.200903033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018116872
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1084/jem.20081326 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030102810
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1093/emboj/18.23.6619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000406992
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1101/gad.13.20.2633 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022595499
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1101/gad.1373705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001654709
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1101/gad.2003811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013673802
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1126/science.1091496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062449100
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1126/science.1108297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005911474
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1126/science.1140321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043601744
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1128/jb.182.21.6036-6041.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048692973
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1128/mcb.01525-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006541482
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1128/mcb.21.1.281-288.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035805910
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1128/mcb.24.20.8917-8928.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001315381
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1128/mcb.24.21.9478-9486.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013148122
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1146/annurev.biochem.77.061306.125255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000560477
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1146/annurev.genom.7.080505.115648 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026196063
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1158/0008-5472.can-05-3945 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021113411
327 rdf:type schema:CreativeWork
328 https://www.grid.ac/institutes/grid.214458.e schema:alternateName University of Michigan–Ann Arbor
329 schema:name Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan, USA.
330 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...