Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-09

AUTHORS

Xuefeng Chen, Hengyao Niu, Woo-Hyun Chung, Zhu Zhu, Alma Papusha, Eun Yong Shim, Sang Eun Lee, Patrick Sung, Grzegorz Ira

ABSTRACT

DNA recombination pathways are regulated by the cell cycle to coordinate with replication. Cyclin-dependent kinase (Cdk1) promotes efficient 5' strand resection at DNA double-strand breaks (DSBs), the initial step of homologous recombination and damage checkpoint activation. The Mre11-Rad50-Xrs2 complex with Sae2 initiates resection, whereas two nucleases, Exo1 and Dna2, and the DNA helicase-topoisomerase complex Sgs1-Top3-Rmi1 generate longer ssDNA at DSBs. Using Saccharomyces cerevisiae, we provide evidence for Cdk1-dependent phosphorylation of the resection nuclease Dna2 at Thr4, Ser17 and Ser237 that stimulates its recruitment to DSBs, resection and subsequent Mec1-dependent phosphorylation. Poorly recruited dna2T4A S17A S237A and dna2ΔN248 mutant proteins promote resection only in the presence of Exo1, suggesting cross-talk between Dna2- and Exo1-dependent resection pathways. More... »

PAGES

1015

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsmb.2105

DOI

http://dx.doi.org/10.1038/nsmb.2105

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013853290

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21841787


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CDC2 Protein Kinase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Breaks, Double-Stranded", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Helicases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Exodeoxyribonucleases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intracellular Signaling Peptides and Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Serine-Threonine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombination, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Saccharomyces cerevisiae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Saccharomyces cerevisiae Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Baylor College of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.39382.33", 
          "name": [
            "Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, Texas, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Xuefeng", 
        "id": "sg:person.0602643340.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602643340.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Molecular Biophysics & Biochemistry, Yale University School of Medicine, New Haven, Connecticut, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Niu", 
        "givenName": "Hengyao", 
        "id": "sg:person.0704406550.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704406550.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Baylor College of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.39382.33", 
          "name": [
            "Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, Texas, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chung", 
        "givenName": "Woo-Hyun", 
        "id": "sg:person.01074000711.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074000711.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Baylor College of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.39382.33", 
          "name": [
            "Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, Texas, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhu", 
        "givenName": "Zhu", 
        "id": "sg:person.0646661277.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646661277.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Baylor College of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.39382.33", 
          "name": [
            "Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, Texas, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Papusha", 
        "givenName": "Alma", 
        "id": "sg:person.015406150417.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015406150417.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Health Science Center at San Antonio", 
          "id": "https://www.grid.ac/institutes/grid.267309.9", 
          "name": [
            "Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shim", 
        "givenName": "Eun Yong", 
        "id": "sg:person.01104145410.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104145410.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Health Science Center at San Antonio", 
          "id": "https://www.grid.ac/institutes/grid.267309.9", 
          "name": [
            "Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Sang Eun", 
        "id": "sg:person.01255235266.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255235266.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Molecular Biophysics & Biochemistry, Yale University School of Medicine, New Haven, Connecticut, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sung", 
        "givenName": "Patrick", 
        "id": "sg:person.01050151473.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050151473.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Baylor College of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.39382.33", 
          "name": [
            "Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, Texas, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ira", 
        "givenName": "Grzegorz", 
        "id": "sg:person.01371463666.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371463666.31"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature07955", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000929920", 
          "https://doi.org/10.1038/nature07955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07955", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000929920", 
          "https://doi.org/10.1038/nature07955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.221402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001698552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2010.09.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002511682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7600469", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003921076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m109.048157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004311873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35030148", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007129994", 
          "https://doi.org/10.1038/35030148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35030148", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007129994", 
          "https://doi.org/10.1038/35030148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008867916", 
          "https://doi.org/10.1038/nrc2602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2010.11.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009685773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2007.09.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010694452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0900604106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013516159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.2003811", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013673802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015857765", 
          "https://doi.org/10.1038/nature02062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015857765", 
          "https://doi.org/10.1038/nature02062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.503108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017396089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1747-1028-5-11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018220065", 
          "https://doi.org/10.1186/1747-1028-5-11"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/emboj.2010.219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018874548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkp1222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019018691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.26.7.2490-2500.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019507761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.0010061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020721324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.1957", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021023013", 
          "https://doi.org/10.1038/nsmb.1957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.1957", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021023013", 
          "https://doi.org/10.1038/nsmb.1957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07312", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021228402", 
          "https://doi.org/10.1038/nature07312"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03329", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022719089", 
          "https://doi.org/10.1038/nature03329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03329", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022719089", 
          "https://doi.org/10.1038/nature03329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/embor.2008.121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024735349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1000858", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027470364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09318", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027803050", 
          "https://doi.org/10.1038/nature09318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09318", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027803050", 
          "https://doi.org/10.1038/nature09318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(03)00886-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029137741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.08.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029629280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029720893", 
          "https://doi.org/10.1038/ncb1337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029720893", 
          "https://doi.org/10.1038/ncb1337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031468320", 
          "https://doi.org/10.1038/nature07215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.81.7.1991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034589758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dnarep.2010.09.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035511291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m808906200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036458410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/emboj.2008.111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036540030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(03)00269-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037672509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/emboj.2010.193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042032181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043753182", 
          "https://doi.org/10.1038/nature03404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043753182", 
          "https://doi.org/10.1038/nature03404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb1261", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046650048", 
          "https://doi.org/10.1038/nsmb1261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2008.01.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047183571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2009.05.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048664954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1001047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049417766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09355", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049775672", 
          "https://doi.org/10.1038/nature09355"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09355", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049775672", 
          "https://doi.org/10.1038/nature09355"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02964", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050476890", 
          "https://doi.org/10.1038/nature02964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02964", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050476890", 
          "https://doi.org/10.1038/nature02964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dnarep.2010.11.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051051180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dnarep.2010.11.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051051180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.315804", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052190302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.4.6.968", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052278170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2004.11.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052688064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.9.2.10448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072301122"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-09", 
    "datePublishedReg": "2011-09-01", 
    "description": "DNA recombination pathways are regulated by the cell cycle to coordinate with replication. Cyclin-dependent kinase (Cdk1) promotes efficient 5' strand resection at DNA double-strand breaks (DSBs), the initial step of homologous recombination and damage checkpoint activation. The Mre11-Rad50-Xrs2 complex with Sae2 initiates resection, whereas two nucleases, Exo1 and Dna2, and the DNA helicase-topoisomerase complex Sgs1-Top3-Rmi1 generate longer ssDNA at DSBs. Using Saccharomyces cerevisiae, we provide evidence for Cdk1-dependent phosphorylation of the resection nuclease Dna2 at Thr4, Ser17 and Ser237 that stimulates its recruitment to DSBs, resection and subsequent Mec1-dependent phosphorylation. Poorly recruited dna2T4A S17A S237A and dna2\u0394N248 mutant proteins promote resection only in the presence of Exo1, suggesting cross-talk between Dna2- and Exo1-dependent resection pathways.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nsmb.2105", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2503035", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2515778", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2518389", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2519555", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1295033", 
        "issn": [
          "1545-9993", 
          "2331-365X"
        ], 
        "name": "Nature Structural & Molecular Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "name": "Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation", 
    "pagination": "1015", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "41fe8bed3b89316f4dfb2809a4c57586f68e54b2267c5bce452c3821811e9cfe"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21841787"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101186374"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nsmb.2105"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1013853290"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nsmb.2105", 
      "https://app.dimensions.ai/details/publication/pub.1013853290"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:40", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000436.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nsmb.2105"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2105'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2105'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2105'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2105'


 

This table displays all metadata directly associated to this object as RDF triples.

336 TRIPLES      21 PREDICATES      86 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nsmb.2105 schema:about N06d9f4f279064a69bac9076f65c72502
2 N314eafb6b7af4f41914bc5c821809973
3 N724af6e514114f4789a2bc2944d3ea6c
4 N787fb9004d13457bb51bd5c422c82ddd
5 Na27f778d99094ca89d45086abd1473ed
6 Nac5117026b6b400ca637174dd1e60740
7 Naf7dd55002e04ffc9bacfb687a1f37ce
8 Nb9107aa58ba24edb84276a36f8f6fcbf
9 Nd28c896a2b774e258685f23c8a67e126
10 Nddef80880b41491c90682bccf3f8ab67
11 Nf2a419ec83aa48f7b8e5899bcf0bda60
12 anzsrc-for:06
13 anzsrc-for:0601
14 schema:author N9fd644fcd21d4600aec5594e9bf654fa
15 schema:citation sg:pub.10.1038/35030148
16 sg:pub.10.1038/nature02062
17 sg:pub.10.1038/nature02964
18 sg:pub.10.1038/nature03329
19 sg:pub.10.1038/nature03404
20 sg:pub.10.1038/nature07215
21 sg:pub.10.1038/nature07312
22 sg:pub.10.1038/nature07955
23 sg:pub.10.1038/nature09318
24 sg:pub.10.1038/nature09355
25 sg:pub.10.1038/ncb1337
26 sg:pub.10.1038/nrc2602
27 sg:pub.10.1038/nsmb.1957
28 sg:pub.10.1038/nsmb1261
29 sg:pub.10.1186/1747-1028-5-11
30 https://doi.org/10.1016/j.cell.2008.08.037
31 https://doi.org/10.1016/j.dnarep.2010.09.024
32 https://doi.org/10.1016/j.dnarep.2010.11.008
33 https://doi.org/10.1016/j.molcel.2004.11.032
34 https://doi.org/10.1016/j.molcel.2007.09.009
35 https://doi.org/10.1016/j.molcel.2008.01.016
36 https://doi.org/10.1016/j.molcel.2009.05.015
37 https://doi.org/10.1016/j.molcel.2010.09.004
38 https://doi.org/10.1016/j.molcel.2010.11.032
39 https://doi.org/10.1016/s0092-8674(03)00886-9
40 https://doi.org/10.1016/s1097-2765(03)00269-7
41 https://doi.org/10.1038/emboj.2008.111
42 https://doi.org/10.1038/emboj.2010.193
43 https://doi.org/10.1038/emboj.2010.219
44 https://doi.org/10.1038/embor.2008.121
45 https://doi.org/10.1038/sj.emboj.7600469
46 https://doi.org/10.1073/pnas.0900604106
47 https://doi.org/10.1073/pnas.81.7.1991
48 https://doi.org/10.1074/jbc.m109.048157
49 https://doi.org/10.1074/jbc.m808906200
50 https://doi.org/10.1093/nar/gkp1222
51 https://doi.org/10.1101/gad.2003811
52 https://doi.org/10.1101/gad.221402
53 https://doi.org/10.1101/gad.315804
54 https://doi.org/10.1101/gad.4.6.968
55 https://doi.org/10.1101/gad.503108
56 https://doi.org/10.1128/mcb.26.7.2490-2500.2006
57 https://doi.org/10.1371/journal.pgen.0010061
58 https://doi.org/10.1371/journal.pgen.1000858
59 https://doi.org/10.1371/journal.pgen.1001047
60 https://doi.org/10.4161/cc.9.2.10448
61 schema:datePublished 2011-09
62 schema:datePublishedReg 2011-09-01
63 schema:description DNA recombination pathways are regulated by the cell cycle to coordinate with replication. Cyclin-dependent kinase (Cdk1) promotes efficient 5' strand resection at DNA double-strand breaks (DSBs), the initial step of homologous recombination and damage checkpoint activation. The Mre11-Rad50-Xrs2 complex with Sae2 initiates resection, whereas two nucleases, Exo1 and Dna2, and the DNA helicase-topoisomerase complex Sgs1-Top3-Rmi1 generate longer ssDNA at DSBs. Using Saccharomyces cerevisiae, we provide evidence for Cdk1-dependent phosphorylation of the resection nuclease Dna2 at Thr4, Ser17 and Ser237 that stimulates its recruitment to DSBs, resection and subsequent Mec1-dependent phosphorylation. Poorly recruited dna2T4A S17A S237A and dna2ΔN248 mutant proteins promote resection only in the presence of Exo1, suggesting cross-talk between Dna2- and Exo1-dependent resection pathways.
64 schema:genre research_article
65 schema:inLanguage en
66 schema:isAccessibleForFree true
67 schema:isPartOf N1f6c61bb2cf64b34a537f7d89b7f793a
68 N2f21e3c3964a42de97cede66b85dcadc
69 sg:journal.1295033
70 schema:name Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation
71 schema:pagination 1015
72 schema:productId N21677290175644e29371debee3baa5b7
73 N560a7fc50ee243a2be25e0a882681ce0
74 N94f3e2e1eab14e7e9f2b56e9633eea53
75 Na56f1b3ed283408ab5ae207d3e05408e
76 Nd65320f884ce463894421b22e6742be1
77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013853290
78 https://doi.org/10.1038/nsmb.2105
79 schema:sdDatePublished 2019-04-10T15:40
80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
81 schema:sdPublisher N8b2ac6706cfc4d4d84ef6607740b7e58
82 schema:url https://www.nature.com/articles/nsmb.2105
83 sgo:license sg:explorer/license/
84 sgo:sdDataset articles
85 rdf:type schema:ScholarlyArticle
86 N06d9f4f279064a69bac9076f65c72502 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Intracellular Signaling Peptides and Proteins
88 rdf:type schema:DefinedTerm
89 N1f6c61bb2cf64b34a537f7d89b7f793a schema:volumeNumber 18
90 rdf:type schema:PublicationVolume
91 N21677290175644e29371debee3baa5b7 schema:name dimensions_id
92 schema:value pub.1013853290
93 rdf:type schema:PropertyValue
94 N2f21e3c3964a42de97cede66b85dcadc schema:issueNumber 9
95 rdf:type schema:PublicationIssue
96 N314eafb6b7af4f41914bc5c821809973 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name CDC2 Protein Kinase
98 rdf:type schema:DefinedTerm
99 N4def95774b654f82991be979e3e3a26f rdf:first sg:person.0646661277.11
100 rdf:rest N4ef674e10760440fbf435ed3a7ef6e1c
101 N4ef674e10760440fbf435ed3a7ef6e1c rdf:first sg:person.015406150417.19
102 rdf:rest Nbe948f2cd646443980abc540fb36b99e
103 N5577137b345d45fcb7cfaaa5b4452052 rdf:first sg:person.01074000711.13
104 rdf:rest N4def95774b654f82991be979e3e3a26f
105 N560a7fc50ee243a2be25e0a882681ce0 schema:name readcube_id
106 schema:value 41fe8bed3b89316f4dfb2809a4c57586f68e54b2267c5bce452c3821811e9cfe
107 rdf:type schema:PropertyValue
108 N724af6e514114f4789a2bc2944d3ea6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name DNA Breaks, Double-Stranded
110 rdf:type schema:DefinedTerm
111 N7337ea6fd4a94de794e371867d6dd069 rdf:first sg:person.01255235266.68
112 rdf:rest N7717c6ac34e1407984f8497f71042ace
113 N75748e691a3d45fc991e4baa8ff37744 rdf:first sg:person.0704406550.05
114 rdf:rest N5577137b345d45fcb7cfaaa5b4452052
115 N7717c6ac34e1407984f8497f71042ace rdf:first sg:person.01050151473.86
116 rdf:rest Nd61e8522a5d340259fc2534011ff4f87
117 N787fb9004d13457bb51bd5c422c82ddd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Exodeoxyribonucleases
119 rdf:type schema:DefinedTerm
120 N8b2ac6706cfc4d4d84ef6607740b7e58 schema:name Springer Nature - SN SciGraph project
121 rdf:type schema:Organization
122 N94f3e2e1eab14e7e9f2b56e9633eea53 schema:name pubmed_id
123 schema:value 21841787
124 rdf:type schema:PropertyValue
125 N9fd644fcd21d4600aec5594e9bf654fa rdf:first sg:person.0602643340.16
126 rdf:rest N75748e691a3d45fc991e4baa8ff37744
127 Na27f778d99094ca89d45086abd1473ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name DNA Helicases
129 rdf:type schema:DefinedTerm
130 Na56f1b3ed283408ab5ae207d3e05408e schema:name nlm_unique_id
131 schema:value 101186374
132 rdf:type schema:PropertyValue
133 Nac5117026b6b400ca637174dd1e60740 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Saccharomyces cerevisiae
135 rdf:type schema:DefinedTerm
136 Naf7dd55002e04ffc9bacfb687a1f37ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Phosphorylation
138 rdf:type schema:DefinedTerm
139 Nb9107aa58ba24edb84276a36f8f6fcbf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Models, Genetic
141 rdf:type schema:DefinedTerm
142 Nbe948f2cd646443980abc540fb36b99e rdf:first sg:person.01104145410.43
143 rdf:rest N7337ea6fd4a94de794e371867d6dd069
144 Nd28c896a2b774e258685f23c8a67e126 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Saccharomyces cerevisiae Proteins
146 rdf:type schema:DefinedTerm
147 Nd61e8522a5d340259fc2534011ff4f87 rdf:first sg:person.01371463666.31
148 rdf:rest rdf:nil
149 Nd65320f884ce463894421b22e6742be1 schema:name doi
150 schema:value 10.1038/nsmb.2105
151 rdf:type schema:PropertyValue
152 Nddef80880b41491c90682bccf3f8ab67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Protein-Serine-Threonine Kinases
154 rdf:type schema:DefinedTerm
155 Nf2a419ec83aa48f7b8e5899bcf0bda60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Recombination, Genetic
157 rdf:type schema:DefinedTerm
158 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
159 schema:name Biological Sciences
160 rdf:type schema:DefinedTerm
161 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
162 schema:name Biochemistry and Cell Biology
163 rdf:type schema:DefinedTerm
164 sg:grant.2503035 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.2105
165 rdf:type schema:MonetaryGrant
166 sg:grant.2515778 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.2105
167 rdf:type schema:MonetaryGrant
168 sg:grant.2518389 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.2105
169 rdf:type schema:MonetaryGrant
170 sg:grant.2519555 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.2105
171 rdf:type schema:MonetaryGrant
172 sg:journal.1295033 schema:issn 1545-9993
173 2331-365X
174 schema:name Nature Structural & Molecular Biology
175 rdf:type schema:Periodical
176 sg:person.01050151473.86 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
177 schema:familyName Sung
178 schema:givenName Patrick
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050151473.86
180 rdf:type schema:Person
181 sg:person.01074000711.13 schema:affiliation https://www.grid.ac/institutes/grid.39382.33
182 schema:familyName Chung
183 schema:givenName Woo-Hyun
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074000711.13
185 rdf:type schema:Person
186 sg:person.01104145410.43 schema:affiliation https://www.grid.ac/institutes/grid.267309.9
187 schema:familyName Shim
188 schema:givenName Eun Yong
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104145410.43
190 rdf:type schema:Person
191 sg:person.01255235266.68 schema:affiliation https://www.grid.ac/institutes/grid.267309.9
192 schema:familyName Lee
193 schema:givenName Sang Eun
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255235266.68
195 rdf:type schema:Person
196 sg:person.01371463666.31 schema:affiliation https://www.grid.ac/institutes/grid.39382.33
197 schema:familyName Ira
198 schema:givenName Grzegorz
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371463666.31
200 rdf:type schema:Person
201 sg:person.015406150417.19 schema:affiliation https://www.grid.ac/institutes/grid.39382.33
202 schema:familyName Papusha
203 schema:givenName Alma
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015406150417.19
205 rdf:type schema:Person
206 sg:person.0602643340.16 schema:affiliation https://www.grid.ac/institutes/grid.39382.33
207 schema:familyName Chen
208 schema:givenName Xuefeng
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602643340.16
210 rdf:type schema:Person
211 sg:person.0646661277.11 schema:affiliation https://www.grid.ac/institutes/grid.39382.33
212 schema:familyName Zhu
213 schema:givenName Zhu
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646661277.11
215 rdf:type schema:Person
216 sg:person.0704406550.05 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
217 schema:familyName Niu
218 schema:givenName Hengyao
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704406550.05
220 rdf:type schema:Person
221 sg:pub.10.1038/35030148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007129994
222 https://doi.org/10.1038/35030148
223 rdf:type schema:CreativeWork
224 sg:pub.10.1038/nature02062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015857765
225 https://doi.org/10.1038/nature02062
226 rdf:type schema:CreativeWork
227 sg:pub.10.1038/nature02964 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050476890
228 https://doi.org/10.1038/nature02964
229 rdf:type schema:CreativeWork
230 sg:pub.10.1038/nature03329 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022719089
231 https://doi.org/10.1038/nature03329
232 rdf:type schema:CreativeWork
233 sg:pub.10.1038/nature03404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043753182
234 https://doi.org/10.1038/nature03404
235 rdf:type schema:CreativeWork
236 sg:pub.10.1038/nature07215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031468320
237 https://doi.org/10.1038/nature07215
238 rdf:type schema:CreativeWork
239 sg:pub.10.1038/nature07312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021228402
240 https://doi.org/10.1038/nature07312
241 rdf:type schema:CreativeWork
242 sg:pub.10.1038/nature07955 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000929920
243 https://doi.org/10.1038/nature07955
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/nature09318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027803050
246 https://doi.org/10.1038/nature09318
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/nature09355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049775672
249 https://doi.org/10.1038/nature09355
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/ncb1337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029720893
252 https://doi.org/10.1038/ncb1337
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/nrc2602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008867916
255 https://doi.org/10.1038/nrc2602
256 rdf:type schema:CreativeWork
257 sg:pub.10.1038/nsmb.1957 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021023013
258 https://doi.org/10.1038/nsmb.1957
259 rdf:type schema:CreativeWork
260 sg:pub.10.1038/nsmb1261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046650048
261 https://doi.org/10.1038/nsmb1261
262 rdf:type schema:CreativeWork
263 sg:pub.10.1186/1747-1028-5-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018220065
264 https://doi.org/10.1186/1747-1028-5-11
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/j.cell.2008.08.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029629280
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/j.dnarep.2010.09.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035511291
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/j.dnarep.2010.11.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051051180
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/j.molcel.2004.11.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052688064
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/j.molcel.2007.09.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010694452
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/j.molcel.2008.01.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047183571
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/j.molcel.2009.05.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048664954
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/j.molcel.2010.09.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002511682
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/j.molcel.2010.11.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009685773
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/s0092-8674(03)00886-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029137741
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/s1097-2765(03)00269-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037672509
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1038/emboj.2008.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036540030
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1038/emboj.2010.193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042032181
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1038/emboj.2010.219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018874548
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1038/embor.2008.121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024735349
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1038/sj.emboj.7600469 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003921076
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1073/pnas.0900604106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013516159
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1073/pnas.81.7.1991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034589758
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1074/jbc.m109.048157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004311873
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1074/jbc.m808906200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036458410
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1093/nar/gkp1222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019018691
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1101/gad.2003811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013673802
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1101/gad.221402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001698552
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1101/gad.315804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052190302
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1101/gad.4.6.968 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052278170
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1101/gad.503108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017396089
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1128/mcb.26.7.2490-2500.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019507761
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1371/journal.pgen.0010061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020721324
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1371/journal.pgen.1000858 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027470364
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1371/journal.pgen.1001047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049417766
325 rdf:type schema:CreativeWork
326 https://doi.org/10.4161/cc.9.2.10448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072301122
327 rdf:type schema:CreativeWork
328 https://www.grid.ac/institutes/grid.267309.9 schema:alternateName The University of Texas Health Science Center at San Antonio
329 schema:name Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
330 rdf:type schema:Organization
331 https://www.grid.ac/institutes/grid.39382.33 schema:alternateName Baylor College of Medicine
332 schema:name Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, Texas, USA.
333 rdf:type schema:Organization
334 https://www.grid.ac/institutes/grid.47100.32 schema:alternateName Yale University
335 schema:name Department of Molecular Biophysics & Biochemistry, Yale University School of Medicine, New Haven, Connecticut, USA.
336 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...