Crystal structure of the trithorax group protein Ash2L reveals a Forkhead-like DNA binding domain View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-06-05

AUTHORS

Sabina Sarvan, Vanja Avdic, Véronique Tremblay, Chandra-Prakash Chaturvedi, Pamela Zhang, Sylvain Lanouette, Alexandre Blais, Joseph S. Brunzelle, Marjorie Brand, Jean-François Couture

ABSTRACT

Absent, small or homeotic discs-like 2 (ASH2L) is a trithorax group (TrxG) protein and a regulatory subunit of the SET1 family of lysine methyltransferases. Here we report that ASH2L binds DNA using a forkhead-like helix-wing-helix (HWH) domain. In vivo, the ASH2L HWH domain is required for binding to the β-globin locus control region, histone H3 Lys4 (H3K4) trimethylation and maximal expression of the β-globin gene (Hbb-1), validating the functional importance of the ASH2L DNA binding domain. More... »

PAGES

857-859

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsmb.2093

DOI

http://dx.doi.org/10.1038/nsmb.2093

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047506745

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21642971


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Motifs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Crystallography, X-Ray", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Structure, Tertiary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H 8M5, Canada", 
          "id": "http://www.grid.ac/institutes/grid.28046.38", 
          "name": [
            "Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H 8M5, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sarvan", 
        "givenName": "Sabina", 
        "id": "sg:person.0601212103.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601212103.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H 8M5, Canada", 
          "id": "http://www.grid.ac/institutes/grid.28046.38", 
          "name": [
            "Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H 8M5, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Avdic", 
        "givenName": "Vanja", 
        "id": "sg:person.01334724075.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334724075.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H 8M5, Canada", 
          "id": "http://www.grid.ac/institutes/grid.28046.38", 
          "name": [
            "Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H 8M5, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tremblay", 
        "givenName": "V\u00e9ronique", 
        "id": "sg:person.0773661575.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773661575.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8L6, Canada", 
          "id": "http://www.grid.ac/institutes/grid.28046.38", 
          "name": [
            "The Sprott Center for Stem cell Research, Regenerative medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario K1H 8L6 Canada", 
            "Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8L6, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chaturvedi", 
        "givenName": "Chandra-Prakash", 
        "id": "sg:person.0766201103.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766201103.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H 8M5, Canada", 
          "id": "http://www.grid.ac/institutes/grid.28046.38", 
          "name": [
            "Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H 8M5, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Pamela", 
        "id": "sg:person.01143041151.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143041151.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H 8M5, Canada", 
          "id": "http://www.grid.ac/institutes/grid.28046.38", 
          "name": [
            "Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H 8M5, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lanouette", 
        "givenName": "Sylvain", 
        "id": "sg:person.0657433175.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657433175.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Sprott Center for Stem cell Research, Regenerative medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario K1H 8L6 Canada", 
          "id": "http://www.grid.ac/institutes/grid.412687.e", 
          "name": [
            "Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H 8M5, Canada", 
            "The Sprott Center for Stem cell Research, Regenerative medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario K1H 8L6 Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blais", 
        "givenName": "Alexandre", 
        "id": "sg:person.01047775206.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047775206.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Feinberg School of Medicine, Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, Chicago, Illinois 60611, USA", 
          "id": "http://www.grid.ac/institutes/grid.16753.36", 
          "name": [
            "Feinberg School of Medicine, Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, Chicago, Illinois 60611, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brunzelle", 
        "givenName": "Joseph S.", 
        "id": "sg:person.0737563257.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737563257.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8L6, Canada", 
          "id": "http://www.grid.ac/institutes/grid.28046.38", 
          "name": [
            "The Sprott Center for Stem cell Research, Regenerative medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario K1H 8L6 Canada", 
            "Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8L6, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brand", 
        "givenName": "Marjorie", 
        "id": "sg:person.0725574274.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725574274.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H 8M5, Canada", 
          "id": "http://www.grid.ac/institutes/grid.28046.38", 
          "name": [
            "Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H 8M5, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Couture", 
        "givenName": "Jean-Fran\u00e7ois", 
        "id": "sg:person.01110110175.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110110175.47"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/onc.2008.20", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038205631", 
          "https://doi.org/10.1038/onc.2008.20"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb1131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034551143", 
          "https://doi.org/10.1038/nsmb1131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb1316", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020559439", 
          "https://doi.org/10.1038/nsmb1316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb1128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047968845", 
          "https://doi.org/10.1038/nsmb1128"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-06-05", 
    "datePublishedReg": "2011-06-05", 
    "description": "Absent, small or homeotic discs-like 2 (ASH2L) is a trithorax group (TrxG) protein and a regulatory subunit of the SET1 family of lysine methyltransferases. Here we report that ASH2L binds DNA using a forkhead-like helix-wing-helix (HWH) domain. In vivo, the ASH2L HWH domain is required for binding to the \u03b2-globin locus control region, histone H3 Lys4 (H3K4) trimethylation and maximal expression of the \u03b2-globin gene (Hbb-1), validating the functional importance of the ASH2L DNA binding domain.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/nsmb.2093", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1295033", 
        "issn": [
          "1545-9993", 
          "2331-365X"
        ], 
        "name": "Nature Structural & Molecular Biology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "keywords": [
      "histone H3 Lys4 trimethylation", 
      "globin locus control region", 
      "trithorax group proteins", 
      "locus control region", 
      "SET1 family", 
      "lysine methyltransferases", 
      "helix domain", 
      "regulatory subunit", 
      "group proteins", 
      "control region", 
      "globin genes", 
      "functional importance", 
      "maximal expression", 
      "ASH2L", 
      "DNA", 
      "domain", 
      "trimethylation", 
      "methyltransferases", 
      "genes", 
      "subunits", 
      "crystal structure", 
      "protein", 
      "expression", 
      "family", 
      "vivo", 
      "region", 
      "importance", 
      "structure", 
      "disk", 
      "homeotic discs", 
      "ASH2L HWH domain", 
      "HWH domain", 
      "H3 Lys4 (H3K4) trimethylation", 
      "Lys4 (H3K4) trimethylation", 
      "ASH2L DNA", 
      "trithorax group protein Ash2L", 
      "group protein Ash2L", 
      "protein Ash2L", 
      "Forkhead-like DNA"
    ], 
    "name": "Crystal structure of the trithorax group protein Ash2L reveals a Forkhead-like DNA binding domain", 
    "pagination": "857-859", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1047506745"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nsmb.2093"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21642971"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nsmb.2093", 
      "https://app.dimensions.ai/details/publication/pub.1047506745"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-11-01T18:17", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_555.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/nsmb.2093"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2093'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2093'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2093'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2093'


 

This table displays all metadata directly associated to this object as RDF triples.

226 TRIPLES      22 PREDICATES      78 URIs      66 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nsmb.2093 schema:about N09d42c6e76df454785825bee3b8f9869
2 N1763b5883a804684b41000ea7b5a8739
3 N19c20770b9674f1fa5650f297bd59617
4 N4144c8d458e84894bfcbbbbec62930f7
5 N4a36c488cb1f4568a9b806f7c98eef2b
6 N52c61ad8a74340478f9953ccff208aec
7 N9b491c9441b04feb8f5f677b6d8b502c
8 Nd79eef8b6275432c8c708f420019e85f
9 Nea301fe3228f4c3aa783a1c45235ef79
10 anzsrc-for:06
11 anzsrc-for:0601
12 schema:author N239a74bebd2540e2843e42ef6d94daba
13 schema:citation sg:pub.10.1038/nsmb1128
14 sg:pub.10.1038/nsmb1131
15 sg:pub.10.1038/nsmb1316
16 sg:pub.10.1038/onc.2008.20
17 schema:datePublished 2011-06-05
18 schema:datePublishedReg 2011-06-05
19 schema:description Absent, small or homeotic discs-like 2 (ASH2L) is a trithorax group (TrxG) protein and a regulatory subunit of the SET1 family of lysine methyltransferases. Here we report that ASH2L binds DNA using a forkhead-like helix-wing-helix (HWH) domain. In vivo, the ASH2L HWH domain is required for binding to the β-globin locus control region, histone H3 Lys4 (H3K4) trimethylation and maximal expression of the β-globin gene (Hbb-1), validating the functional importance of the ASH2L DNA binding domain.
20 schema:genre article
21 schema:inLanguage en
22 schema:isAccessibleForFree true
23 schema:isPartOf N254644032ef74a2187251184926614fe
24 N671046cc5e694304ab956f5dd5b6ccc7
25 sg:journal.1295033
26 schema:keywords ASH2L
27 ASH2L DNA
28 ASH2L HWH domain
29 DNA
30 Forkhead-like DNA
31 H3 Lys4 (H3K4) trimethylation
32 HWH domain
33 Lys4 (H3K4) trimethylation
34 SET1 family
35 control region
36 crystal structure
37 disk
38 domain
39 expression
40 family
41 functional importance
42 genes
43 globin genes
44 globin locus control region
45 group protein Ash2L
46 group proteins
47 helix domain
48 histone H3 Lys4 trimethylation
49 homeotic discs
50 importance
51 locus control region
52 lysine methyltransferases
53 maximal expression
54 methyltransferases
55 protein
56 protein Ash2L
57 region
58 regulatory subunit
59 structure
60 subunits
61 trimethylation
62 trithorax group protein Ash2L
63 trithorax group proteins
64 vivo
65 schema:name Crystal structure of the trithorax group protein Ash2L reveals a Forkhead-like DNA binding domain
66 schema:pagination 857-859
67 schema:productId N26eab4375df645a2a739235faf874322
68 Nde98d61eb96842f195a55a42af3e823e
69 Nfb6c25cebdf1405b8e55b5ba23720d38
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047506745
71 https://doi.org/10.1038/nsmb.2093
72 schema:sdDatePublished 2021-11-01T18:17
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher N10a9f06a16814d0ba3f52815db30435e
75 schema:url https://doi.org/10.1038/nsmb.2093
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N07976a4e9e0e4f4987852b97a431ef4c rdf:first sg:person.0766201103.30
80 rdf:rest Ned5d749326e043a9a38a7bea9239e33d
81 N09d42c6e76df454785825bee3b8f9869 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Amino Acid Motifs
83 rdf:type schema:DefinedTerm
84 N10a9f06a16814d0ba3f52815db30435e schema:name Springer Nature - SN SciGraph project
85 rdf:type schema:Organization
86 N1763b5883a804684b41000ea7b5a8739 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Humans
88 rdf:type schema:DefinedTerm
89 N19c20770b9674f1fa5650f297bd59617 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Nuclear Proteins
91 rdf:type schema:DefinedTerm
92 N239a74bebd2540e2843e42ef6d94daba rdf:first sg:person.0601212103.31
93 rdf:rest Nadd30704d9454951b8d8481775866b91
94 N254644032ef74a2187251184926614fe schema:issueNumber 7
95 rdf:type schema:PublicationIssue
96 N26eab4375df645a2a739235faf874322 schema:name doi
97 schema:value 10.1038/nsmb.2093
98 rdf:type schema:PropertyValue
99 N4144c8d458e84894bfcbbbbec62930f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Crystallography, X-Ray
101 rdf:type schema:DefinedTerm
102 N4a36c488cb1f4568a9b806f7c98eef2b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name DNA-Binding Proteins
104 rdf:type schema:DefinedTerm
105 N4f6bcbc236824f0db8ed20df68cc2251 rdf:first sg:person.0725574274.51
106 rdf:rest N81a71ff3ff154bdcab8e8b56780ea60f
107 N52c61ad8a74340478f9953ccff208aec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Transcription Factors
109 rdf:type schema:DefinedTerm
110 N671046cc5e694304ab956f5dd5b6ccc7 schema:volumeNumber 18
111 rdf:type schema:PublicationVolume
112 N6bd95a66eafd4cf782de9c634e97e7da rdf:first sg:person.01047775206.14
113 rdf:rest Nd3ddecf86e9c405a991bd5e0f8daf60b
114 N81a71ff3ff154bdcab8e8b56780ea60f rdf:first sg:person.01110110175.47
115 rdf:rest rdf:nil
116 N9b491c9441b04feb8f5f677b6d8b502c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name DNA
118 rdf:type schema:DefinedTerm
119 N9f31e7b4b07747f6aad22dffa61c09c2 rdf:first sg:person.0773661575.53
120 rdf:rest N07976a4e9e0e4f4987852b97a431ef4c
121 Nadd30704d9454951b8d8481775866b91 rdf:first sg:person.01334724075.10
122 rdf:rest N9f31e7b4b07747f6aad22dffa61c09c2
123 Nd3ddecf86e9c405a991bd5e0f8daf60b rdf:first sg:person.0737563257.38
124 rdf:rest N4f6bcbc236824f0db8ed20df68cc2251
125 Nd79eef8b6275432c8c708f420019e85f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Protein Structure, Tertiary
127 rdf:type schema:DefinedTerm
128 Nde98d61eb96842f195a55a42af3e823e schema:name dimensions_id
129 schema:value pub.1047506745
130 rdf:type schema:PropertyValue
131 Nea301fe3228f4c3aa783a1c45235ef79 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Models, Molecular
133 rdf:type schema:DefinedTerm
134 Nea3dfcd50abb417f9287871c8196ecf9 rdf:first sg:person.0657433175.16
135 rdf:rest N6bd95a66eafd4cf782de9c634e97e7da
136 Ned5d749326e043a9a38a7bea9239e33d rdf:first sg:person.01143041151.23
137 rdf:rest Nea3dfcd50abb417f9287871c8196ecf9
138 Nfb6c25cebdf1405b8e55b5ba23720d38 schema:name pubmed_id
139 schema:value 21642971
140 rdf:type schema:PropertyValue
141 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
142 schema:name Biological Sciences
143 rdf:type schema:DefinedTerm
144 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
145 schema:name Biochemistry and Cell Biology
146 rdf:type schema:DefinedTerm
147 sg:journal.1295033 schema:issn 1545-9993
148 2331-365X
149 schema:name Nature Structural & Molecular Biology
150 schema:publisher Springer Nature
151 rdf:type schema:Periodical
152 sg:person.01047775206.14 schema:affiliation grid-institutes:grid.412687.e
153 schema:familyName Blais
154 schema:givenName Alexandre
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047775206.14
156 rdf:type schema:Person
157 sg:person.01110110175.47 schema:affiliation grid-institutes:grid.28046.38
158 schema:familyName Couture
159 schema:givenName Jean-François
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110110175.47
161 rdf:type schema:Person
162 sg:person.01143041151.23 schema:affiliation grid-institutes:grid.28046.38
163 schema:familyName Zhang
164 schema:givenName Pamela
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143041151.23
166 rdf:type schema:Person
167 sg:person.01334724075.10 schema:affiliation grid-institutes:grid.28046.38
168 schema:familyName Avdic
169 schema:givenName Vanja
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334724075.10
171 rdf:type schema:Person
172 sg:person.0601212103.31 schema:affiliation grid-institutes:grid.28046.38
173 schema:familyName Sarvan
174 schema:givenName Sabina
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601212103.31
176 rdf:type schema:Person
177 sg:person.0657433175.16 schema:affiliation grid-institutes:grid.28046.38
178 schema:familyName Lanouette
179 schema:givenName Sylvain
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657433175.16
181 rdf:type schema:Person
182 sg:person.0725574274.51 schema:affiliation grid-institutes:grid.28046.38
183 schema:familyName Brand
184 schema:givenName Marjorie
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725574274.51
186 rdf:type schema:Person
187 sg:person.0737563257.38 schema:affiliation grid-institutes:grid.16753.36
188 schema:familyName Brunzelle
189 schema:givenName Joseph S.
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737563257.38
191 rdf:type schema:Person
192 sg:person.0766201103.30 schema:affiliation grid-institutes:grid.28046.38
193 schema:familyName Chaturvedi
194 schema:givenName Chandra-Prakash
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766201103.30
196 rdf:type schema:Person
197 sg:person.0773661575.53 schema:affiliation grid-institutes:grid.28046.38
198 schema:familyName Tremblay
199 schema:givenName Véronique
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773661575.53
201 rdf:type schema:Person
202 sg:pub.10.1038/nsmb1128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047968845
203 https://doi.org/10.1038/nsmb1128
204 rdf:type schema:CreativeWork
205 sg:pub.10.1038/nsmb1131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034551143
206 https://doi.org/10.1038/nsmb1131
207 rdf:type schema:CreativeWork
208 sg:pub.10.1038/nsmb1316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020559439
209 https://doi.org/10.1038/nsmb1316
210 rdf:type schema:CreativeWork
211 sg:pub.10.1038/onc.2008.20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038205631
212 https://doi.org/10.1038/onc.2008.20
213 rdf:type schema:CreativeWork
214 grid-institutes:grid.16753.36 schema:alternateName Feinberg School of Medicine, Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, Chicago, Illinois 60611, USA
215 schema:name Feinberg School of Medicine, Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, Chicago, Illinois 60611, USA
216 rdf:type schema:Organization
217 grid-institutes:grid.28046.38 schema:alternateName Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8L6, Canada
218 Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H 8M5, Canada
219 schema:name Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8L6, Canada
220 Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H 8M5, Canada
221 The Sprott Center for Stem cell Research, Regenerative medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario K1H 8L6 Canada
222 rdf:type schema:Organization
223 grid-institutes:grid.412687.e schema:alternateName The Sprott Center for Stem cell Research, Regenerative medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario K1H 8L6 Canada
224 schema:name Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H 8M5, Canada
225 The Sprott Center for Stem cell Research, Regenerative medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario K1H 8L6 Canada
226 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...