Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-05

AUTHORS

Mary D Holdom, Anna M Davies, Joanne E Nettleship, Sarah C Bagby, Balvinder Dhaliwal, Enrico Girardi, James Hunt, Hannah J Gould, Andrew J Beavil, James M McDonnell, Ray J Owens, Brian J Sutton

ABSTRACT

Among antibody classes, IgE has a uniquely slow dissociation rate from, and high affinity for, its cell surface receptor FcɛRI. We show the structural basis for these key determinants of the ability of IgE to mediate allergic hypersensitivity through the 3.4-Å-resolution crystal structure of human IgE-Fc (consisting of the Cɛ2, Cɛ3 and Cɛ4 domains) bound to the extracellular domains of the FcɛRI α chain. Comparison with the structure of free IgE-Fc (reported here at a resolution of 1.9 Å) shows that the antibody, which has a compact, bent structure before receptor engagement, becomes even more acutely bent in the complex. Thermodynamic analysis indicates that the interaction is entropically driven, which explains how the noncontacting Cɛ2 domains, in place of the flexible hinge region of IgG antibodies, contribute together with the conformational changes to the unique binding properties of IgE. More... »

PAGES

571

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsmb.2044

DOI

http://dx.doi.org/10.1038/nsmb.2044

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047835195

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21516097


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