Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-05

AUTHORS

Mary D Holdom, Anna M Davies, Joanne E Nettleship, Sarah C Bagby, Balvinder Dhaliwal, Enrico Girardi, James Hunt, Hannah J Gould, Andrew J Beavil, James M McDonnell, Ray J Owens, Brian J Sutton

ABSTRACT

Among antibody classes, IgE has a uniquely slow dissociation rate from, and high affinity for, its cell surface receptor FcɛRI. We show the structural basis for these key determinants of the ability of IgE to mediate allergic hypersensitivity through the 3.4-Å-resolution crystal structure of human IgE-Fc (consisting of the Cɛ2, Cɛ3 and Cɛ4 domains) bound to the extracellular domains of the FcɛRI α chain. Comparison with the structure of free IgE-Fc (reported here at a resolution of 1.9 Å) shows that the antibody, which has a compact, bent structure before receptor engagement, becomes even more acutely bent in the complex. Thermodynamic analysis indicates that the interaction is entropically driven, which explains how the noncontacting Cɛ2 domains, in place of the flexible hinge region of IgG antibodies, contribute together with the conformational changes to the unique binding properties of IgE. More... »

PAGES

571

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsmb.2044

DOI

http://dx.doi.org/10.1038/nsmb.2044

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047835195

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21516097


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Substitution", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Binding Sites", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin E", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Folding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Interaction Domains and Motifs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Structure, Tertiary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, IgE", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thermodynamics", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Medical Research Council", 
          "id": "https://www.grid.ac/institutes/grid.14105.31", 
          "name": [
            "King's College London, Randall Division of Cell and Molecular Biophysics, London, UK.", 
            "Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Holdom", 
        "givenName": "Mary D", 
        "id": "sg:person.01371571771.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371571771.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical Research Council", 
          "id": "https://www.grid.ac/institutes/grid.14105.31", 
          "name": [
            "King's College London, Randall Division of Cell and Molecular Biophysics, London, UK.", 
            "Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Davies", 
        "givenName": "Anna M", 
        "id": "sg:person.0755563552.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755563552.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Complex at Harwell", 
          "id": "https://www.grid.ac/institutes/grid.465239.f", 
          "name": [
            "University of Oxford, The Oxford Protein Production Facility, Division of Structural Biology, Oxford, UK.", 
            "Oxford Protein Production Facility UK, The Research Complex at Harwell, Rutherford Appleton Laboratory, Harwell Science & Innovation Centre, Harwell, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nettleship", 
        "givenName": "Joanne E", 
        "id": "sg:person.0753555511.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753555511.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "University of Oxford, Laboratory of Molecular Biophysics, Department of Biochemistry, Oxford, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bagby", 
        "givenName": "Sarah C", 
        "id": "sg:person.01005461447.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005461447.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical Research Council", 
          "id": "https://www.grid.ac/institutes/grid.14105.31", 
          "name": [
            "King's College London, Randall Division of Cell and Molecular Biophysics, London, UK.", 
            "Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dhaliwal", 
        "givenName": "Balvinder", 
        "id": "sg:person.01372705717.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372705717.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical Research Council", 
          "id": "https://www.grid.ac/institutes/grid.14105.31", 
          "name": [
            "King's College London, Randall Division of Cell and Molecular Biophysics, London, UK.", 
            "Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Girardi", 
        "givenName": "Enrico", 
        "id": "sg:person.01274501703.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274501703.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "King's College London", 
          "id": "https://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "King's College London, Randall Division of Cell and Molecular Biophysics, London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hunt", 
        "givenName": "James", 
        "id": "sg:person.0751331302.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751331302.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical Research Council", 
          "id": "https://www.grid.ac/institutes/grid.14105.31", 
          "name": [
            "King's College London, Randall Division of Cell and Molecular Biophysics, London, UK.", 
            "Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gould", 
        "givenName": "Hannah J", 
        "id": "sg:person.01041421406.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041421406.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical Research Council", 
          "id": "https://www.grid.ac/institutes/grid.14105.31", 
          "name": [
            "King's College London, Randall Division of Cell and Molecular Biophysics, London, UK.", 
            "Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beavil", 
        "givenName": "Andrew J", 
        "id": "sg:person.01205647402.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205647402.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical Research Council", 
          "id": "https://www.grid.ac/institutes/grid.14105.31", 
          "name": [
            "King's College London, Randall Division of Cell and Molecular Biophysics, London, UK.", 
            "Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "McDonnell", 
        "givenName": "James M", 
        "id": "sg:person.0662147671.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662147671.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Complex at Harwell", 
          "id": "https://www.grid.ac/institutes/grid.465239.f", 
          "name": [
            "University of Oxford, The Oxford Protein Production Facility, Division of Structural Biology, Oxford, UK.", 
            "Oxford Protein Production Facility UK, The Research Complex at Harwell, Rutherford Appleton Laboratory, Harwell Science & Innovation Centre, Harwell, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Owens", 
        "givenName": "Ray J", 
        "id": "sg:person.012722400377.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012722400377.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical Research Council", 
          "id": "https://www.grid.ac/institutes/grid.14105.31", 
          "name": [
            "King's College London, Randall Division of Cell and Molecular Biophysics, London, UK.", 
            "Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sutton", 
        "givenName": "Brian J", 
        "id": "sg:person.01062203557.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062203557.39"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1074/jbc.m800937200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000409427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m804742200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002620407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.0803018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002792450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(00)00037-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002951401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m409458200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002970419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tibs.2007.03.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004487444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m605190200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004874353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0076-6879(97)76066-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004907170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri2273", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006625763", 
          "https://doi.org/10.1038/nri2273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcc.20084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008225564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-59745-196-3_16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011331930", 
          "https://doi.org/10.1007/978-1-59745-196-3_16"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-59745-196-3_16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011331930", 
          "https://doi.org/10.1007/978-1-59745-196-3_16"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81719-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011849640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0134(19980201)30:2<144::aid-prot4>3.0.co;2-n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012036233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio0306-112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015718784", 
          "https://doi.org/10.1038/nchembio0306-112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio0306-112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015718784", 
          "https://doi.org/10.1038/nchembio0306-112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmbi.2001.4670", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017160761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2009.08.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018195234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0021889897006766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019562892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444998003254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019779527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444904019158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020281098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0021889800018227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020452683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/87603", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022271339", 
          "https://doi.org/10.1038/87603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1093-3263(02)00140-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023562177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35018508", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024812761", 
          "https://doi.org/10.1038/35018508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35018508", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024812761", 
          "https://doi.org/10.1038/35018508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444994003112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025573949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0021889805038987", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025674621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.rmed.2009.03.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026955993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.immunol.21.120601.141103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032251036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmbi.2001.4929", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033695999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0009037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035286988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m500965200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035832726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci6551", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036721301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2007.02.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038492026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m100350200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039196701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35018500", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040384935", 
          "https://doi.org/10.1038/35018500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35018500", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040384935", 
          "https://doi.org/10.1038/35018500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2007.05.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042204379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444998006684", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044366173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1099-1352(199909/10)12:5<279::aid-jmr473>3.0.co;2-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045752856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni811", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046652146", 
          "https://doi.org/10.1038/ni811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni811", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046652146", 
          "https://doi.org/10.1038/ni811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsb0596-419", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047252894", 
          "https://doi.org/10.1038/nsb0596-419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.str.2007.09.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048977627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m106819200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049049427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444906016076", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049706631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkm216", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052481822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(06)69283-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053132149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00044a023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055158564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00148a004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055162630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi971299+", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055214218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi971299+", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055214218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi9713005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055214219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi9713005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055214219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi9928391", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055219038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi9928391", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055219038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/protein/8.2.193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059981199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.165.1.331", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074656383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.173.11.6831", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076969454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080144554", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082465093", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083332958", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-05", 
    "datePublishedReg": "2011-05-01", 
    "description": "Among antibody classes, IgE has a uniquely slow dissociation rate from, and high affinity for, its cell surface receptor Fc\u025bRI. We show the structural basis for these key determinants of the ability of IgE to mediate allergic hypersensitivity through the 3.4-\u00c5-resolution crystal structure of human IgE-Fc (consisting of the C\u025b2, C\u025b3 and C\u025b4 domains) bound to the extracellular domains of the Fc\u025bRI \u03b1 chain. Comparison with the structure of free IgE-Fc (reported here at a resolution of 1.9 \u00c5) shows that the antibody, which has a compact, bent structure before receptor engagement, becomes even more acutely bent in the complex. Thermodynamic analysis indicates that the interaction is entropically driven, which explains how the noncontacting C\u025b2 domains, in place of the flexible hinge region of IgG antibodies, contribute together with the conformational changes to the unique binding properties of IgE.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nsmb.2044", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3636942", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2777535", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2756095", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2758825", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3628305", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2757631", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2775873", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2752163", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2787176", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1295033", 
        "issn": [
          "1545-9993", 
          "2331-365X"
        ], 
        "name": "Nature Structural & Molecular Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "name": "Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor Fc\u025bRI", 
    "pagination": "571", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e3dff206e41226fc6528d73ab2d073188653a2c3cf20761dad48352bbb65a860"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21516097"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101186374"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nsmb.2044"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1047835195"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nsmb.2044", 
      "https://app.dimensions.ai/details/publication/pub.1047835195"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:09", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000437.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nsmb.2044"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2044'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2044'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2044'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2044'


 

This table displays all metadata directly associated to this object as RDF triples.

385 TRIPLES      21 PREDICATES      94 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nsmb.2044 schema:about N3fb3e007686c447590038dc3759e3d9b
2 N4a444a24bfcd461ea4837ee475ca33cc
3 N511d0fa6228d48f396533221f3797158
4 N5dcd60267a53401aa4ea0c1d3b933115
5 N5ed95768e9154c5382e9f23d569bd9e1
6 N979926bae61e47a4b1f4dc97d72cdd09
7 Nba6eb13a7da64e32bfa1b57b09fbf0d5
8 Nd2a35f0283de4a3ebb4e5de413763d26
9 Nd564be85dc9b401c871e328098224028
10 Ndac1cda6f6f246e280e488a6465e67e6
11 anzsrc-for:11
12 anzsrc-for:1107
13 schema:author N9dd44a4b17e84b8fbf82758a26dbab0b
14 schema:citation sg:pub.10.1007/978-1-59745-196-3_16
15 sg:pub.10.1038/35018500
16 sg:pub.10.1038/35018508
17 sg:pub.10.1038/87603
18 sg:pub.10.1038/nchembio0306-112
19 sg:pub.10.1038/ni811
20 sg:pub.10.1038/nri2273
21 sg:pub.10.1038/nsb0596-419
22 https://app.dimensions.ai/details/publication/pub.1080144554
23 https://app.dimensions.ai/details/publication/pub.1082465093
24 https://app.dimensions.ai/details/publication/pub.1083332958
25 https://doi.org/10.1002/(sici)1097-0134(19980201)30:2<144::aid-prot4>3.0.co;2-n
26 https://doi.org/10.1002/(sici)1099-1352(199909/10)12:5<279::aid-jmr473>3.0.co;2-3
27 https://doi.org/10.1002/jcc.20084
28 https://doi.org/10.1006/jmbi.2001.4670
29 https://doi.org/10.1006/jmbi.2001.4929
30 https://doi.org/10.1016/j.jmb.2007.02.036
31 https://doi.org/10.1016/j.jmb.2007.05.022
32 https://doi.org/10.1016/j.jmb.2009.08.012
33 https://doi.org/10.1016/j.rmed.2009.03.008
34 https://doi.org/10.1016/j.str.2007.09.012
35 https://doi.org/10.1016/j.tibs.2007.03.008
36 https://doi.org/10.1016/s0076-6879(97)76066-x
37 https://doi.org/10.1016/s0092-8674(00)81719-5
38 https://doi.org/10.1016/s0140-6736(06)69283-0
39 https://doi.org/10.1016/s1074-7613(00)00037-6
40 https://doi.org/10.1016/s1093-3263(02)00140-7
41 https://doi.org/10.1021/bi00044a023
42 https://doi.org/10.1021/bi00148a004
43 https://doi.org/10.1021/bi971299+
44 https://doi.org/10.1021/bi9713005
45 https://doi.org/10.1021/bi9928391
46 https://doi.org/10.1074/jbc.m100350200
47 https://doi.org/10.1074/jbc.m106819200
48 https://doi.org/10.1074/jbc.m409458200
49 https://doi.org/10.1074/jbc.m500965200
50 https://doi.org/10.1074/jbc.m605190200
51 https://doi.org/10.1074/jbc.m800937200
52 https://doi.org/10.1074/jbc.m804742200
53 https://doi.org/10.1093/nar/gkm216
54 https://doi.org/10.1093/protein/8.2.193
55 https://doi.org/10.1107/s0021889800018227
56 https://doi.org/10.1107/s0021889805038987
57 https://doi.org/10.1107/s0021889897006766
58 https://doi.org/10.1107/s0907444904019158
59 https://doi.org/10.1107/s0907444906016076
60 https://doi.org/10.1107/s0907444994003112
61 https://doi.org/10.1107/s0907444998003254
62 https://doi.org/10.1107/s0907444998006684
63 https://doi.org/10.1146/annurev.immunol.21.120601.141103
64 https://doi.org/10.1172/jci6551
65 https://doi.org/10.1371/journal.pone.0009037
66 https://doi.org/10.4049/jimmunol.0803018
67 https://doi.org/10.4049/jimmunol.165.1.331
68 https://doi.org/10.4049/jimmunol.173.11.6831
69 schema:datePublished 2011-05
70 schema:datePublishedReg 2011-05-01
71 schema:description Among antibody classes, IgE has a uniquely slow dissociation rate from, and high affinity for, its cell surface receptor FcɛRI. We show the structural basis for these key determinants of the ability of IgE to mediate allergic hypersensitivity through the 3.4-Å-resolution crystal structure of human IgE-Fc (consisting of the Cɛ2, Cɛ3 and Cɛ4 domains) bound to the extracellular domains of the FcɛRI α chain. Comparison with the structure of free IgE-Fc (reported here at a resolution of 1.9 Å) shows that the antibody, which has a compact, bent structure before receptor engagement, becomes even more acutely bent in the complex. Thermodynamic analysis indicates that the interaction is entropically driven, which explains how the noncontacting Cɛ2 domains, in place of the flexible hinge region of IgG antibodies, contribute together with the conformational changes to the unique binding properties of IgE.
72 schema:genre research_article
73 schema:inLanguage en
74 schema:isAccessibleForFree true
75 schema:isPartOf N37e15f6b5edd49f8b3c1362cc70b2e6e
76 N9eedc9a1e4d84bc9887bf9631a4e3d49
77 sg:journal.1295033
78 schema:name Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI
79 schema:pagination 571
80 schema:productId N1de7ecca7d234b1284c4acbdc790ae5e
81 N1fe853bd616e4bf98b6bbfe33a7e28e0
82 N30457cab355b41f79bb218f4912c7f68
83 N392a921701154ba681c1c6644c61554c
84 N9ec84ab99e234698bccee958ff22c1c6
85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047835195
86 https://doi.org/10.1038/nsmb.2044
87 schema:sdDatePublished 2019-04-10T18:09
88 schema:sdLicense https://scigraph.springernature.com/explorer/license/
89 schema:sdPublisher N53496e093fad4f69a9b8b60f0d1362b1
90 schema:url https://www.nature.com/articles/nsmb.2044
91 sgo:license sg:explorer/license/
92 sgo:sdDataset articles
93 rdf:type schema:ScholarlyArticle
94 N0a4dbd2df566456185fca5e4002193a0 rdf:first sg:person.01062203557.39
95 rdf:rest rdf:nil
96 N1de7ecca7d234b1284c4acbdc790ae5e schema:name doi
97 schema:value 10.1038/nsmb.2044
98 rdf:type schema:PropertyValue
99 N1fe853bd616e4bf98b6bbfe33a7e28e0 schema:name nlm_unique_id
100 schema:value 101186374
101 rdf:type schema:PropertyValue
102 N2de56d59c08946629ec4979d96c0d48a rdf:first sg:person.01274501703.78
103 rdf:rest N82a1ff135af9419a9354f0e70fd0eb6f
104 N30457cab355b41f79bb218f4912c7f68 schema:name readcube_id
105 schema:value e3dff206e41226fc6528d73ab2d073188653a2c3cf20761dad48352bbb65a860
106 rdf:type schema:PropertyValue
107 N37e15f6b5edd49f8b3c1362cc70b2e6e schema:issueNumber 5
108 rdf:type schema:PublicationIssue
109 N392a921701154ba681c1c6644c61554c schema:name pubmed_id
110 schema:value 21516097
111 rdf:type schema:PropertyValue
112 N3ce70608b0434096a702924c0ad0b47f rdf:first sg:person.0755563552.71
113 rdf:rest N8ad37f65022644148544a07f34c5cb2e
114 N3fb3e007686c447590038dc3759e3d9b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Protein Interaction Domains and Motifs
116 rdf:type schema:DefinedTerm
117 N4a444a24bfcd461ea4837ee475ca33cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Protein Folding
119 rdf:type schema:DefinedTerm
120 N511d0fa6228d48f396533221f3797158 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Immunoglobulin E
122 rdf:type schema:DefinedTerm
123 N53496e093fad4f69a9b8b60f0d1362b1 schema:name Springer Nature - SN SciGraph project
124 rdf:type schema:Organization
125 N5dcd60267a53401aa4ea0c1d3b933115 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Models, Molecular
127 rdf:type schema:DefinedTerm
128 N5ed95768e9154c5382e9f23d569bd9e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Receptors, IgE
130 rdf:type schema:DefinedTerm
131 N644f579cbcb24eb088089947350adecc rdf:first sg:person.01372705717.75
132 rdf:rest N2de56d59c08946629ec4979d96c0d48a
133 N82a1ff135af9419a9354f0e70fd0eb6f rdf:first sg:person.0751331302.11
134 rdf:rest Nc4625dbaf8c94de0bd2823bce46d32d4
135 N8ad37f65022644148544a07f34c5cb2e rdf:first sg:person.0753555511.53
136 rdf:rest N9f26254185e244bcb037b3100a7cb43c
137 N979926bae61e47a4b1f4dc97d72cdd09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Binding Sites
139 rdf:type schema:DefinedTerm
140 N9dd44a4b17e84b8fbf82758a26dbab0b rdf:first sg:person.01371571771.04
141 rdf:rest N3ce70608b0434096a702924c0ad0b47f
142 N9e92401fd5a44896bf56d0721d82492a rdf:first sg:person.01205647402.96
143 rdf:rest Neb5f9491243c418896365873b219fbe9
144 N9ec84ab99e234698bccee958ff22c1c6 schema:name dimensions_id
145 schema:value pub.1047835195
146 rdf:type schema:PropertyValue
147 N9eedc9a1e4d84bc9887bf9631a4e3d49 schema:volumeNumber 18
148 rdf:type schema:PublicationVolume
149 N9f26254185e244bcb037b3100a7cb43c rdf:first sg:person.01005461447.34
150 rdf:rest N644f579cbcb24eb088089947350adecc
151 Nba6eb13a7da64e32bfa1b57b09fbf0d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Protein Structure, Tertiary
153 rdf:type schema:DefinedTerm
154 Nc4625dbaf8c94de0bd2823bce46d32d4 rdf:first sg:person.01041421406.36
155 rdf:rest N9e92401fd5a44896bf56d0721d82492a
156 Nd2a35f0283de4a3ebb4e5de413763d26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Amino Acid Substitution
158 rdf:type schema:DefinedTerm
159 Nd564be85dc9b401c871e328098224028 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Thermodynamics
161 rdf:type schema:DefinedTerm
162 Nda57fb9bc123442cbbd041befb4670b0 rdf:first sg:person.012722400377.84
163 rdf:rest N0a4dbd2df566456185fca5e4002193a0
164 Ndac1cda6f6f246e280e488a6465e67e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Humans
166 rdf:type schema:DefinedTerm
167 Neb5f9491243c418896365873b219fbe9 rdf:first sg:person.0662147671.90
168 rdf:rest Nda57fb9bc123442cbbd041befb4670b0
169 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
170 schema:name Medical and Health Sciences
171 rdf:type schema:DefinedTerm
172 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
173 schema:name Immunology
174 rdf:type schema:DefinedTerm
175 sg:grant.2752163 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.2044
176 rdf:type schema:MonetaryGrant
177 sg:grant.2756095 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.2044
178 rdf:type schema:MonetaryGrant
179 sg:grant.2757631 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.2044
180 rdf:type schema:MonetaryGrant
181 sg:grant.2758825 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.2044
182 rdf:type schema:MonetaryGrant
183 sg:grant.2775873 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.2044
184 rdf:type schema:MonetaryGrant
185 sg:grant.2777535 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.2044
186 rdf:type schema:MonetaryGrant
187 sg:grant.2787176 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.2044
188 rdf:type schema:MonetaryGrant
189 sg:grant.3628305 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.2044
190 rdf:type schema:MonetaryGrant
191 sg:grant.3636942 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.2044
192 rdf:type schema:MonetaryGrant
193 sg:journal.1295033 schema:issn 1545-9993
194 2331-365X
195 schema:name Nature Structural & Molecular Biology
196 rdf:type schema:Periodical
197 sg:person.01005461447.34 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
198 schema:familyName Bagby
199 schema:givenName Sarah C
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005461447.34
201 rdf:type schema:Person
202 sg:person.01041421406.36 schema:affiliation https://www.grid.ac/institutes/grid.14105.31
203 schema:familyName Gould
204 schema:givenName Hannah J
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041421406.36
206 rdf:type schema:Person
207 sg:person.01062203557.39 schema:affiliation https://www.grid.ac/institutes/grid.14105.31
208 schema:familyName Sutton
209 schema:givenName Brian J
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062203557.39
211 rdf:type schema:Person
212 sg:person.01205647402.96 schema:affiliation https://www.grid.ac/institutes/grid.14105.31
213 schema:familyName Beavil
214 schema:givenName Andrew J
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205647402.96
216 rdf:type schema:Person
217 sg:person.012722400377.84 schema:affiliation https://www.grid.ac/institutes/grid.465239.f
218 schema:familyName Owens
219 schema:givenName Ray J
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012722400377.84
221 rdf:type schema:Person
222 sg:person.01274501703.78 schema:affiliation https://www.grid.ac/institutes/grid.14105.31
223 schema:familyName Girardi
224 schema:givenName Enrico
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274501703.78
226 rdf:type schema:Person
227 sg:person.01371571771.04 schema:affiliation https://www.grid.ac/institutes/grid.14105.31
228 schema:familyName Holdom
229 schema:givenName Mary D
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371571771.04
231 rdf:type schema:Person
232 sg:person.01372705717.75 schema:affiliation https://www.grid.ac/institutes/grid.14105.31
233 schema:familyName Dhaliwal
234 schema:givenName Balvinder
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372705717.75
236 rdf:type schema:Person
237 sg:person.0662147671.90 schema:affiliation https://www.grid.ac/institutes/grid.14105.31
238 schema:familyName McDonnell
239 schema:givenName James M
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662147671.90
241 rdf:type schema:Person
242 sg:person.0751331302.11 schema:affiliation https://www.grid.ac/institutes/grid.13097.3c
243 schema:familyName Hunt
244 schema:givenName James
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751331302.11
246 rdf:type schema:Person
247 sg:person.0753555511.53 schema:affiliation https://www.grid.ac/institutes/grid.465239.f
248 schema:familyName Nettleship
249 schema:givenName Joanne E
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753555511.53
251 rdf:type schema:Person
252 sg:person.0755563552.71 schema:affiliation https://www.grid.ac/institutes/grid.14105.31
253 schema:familyName Davies
254 schema:givenName Anna M
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755563552.71
256 rdf:type schema:Person
257 sg:pub.10.1007/978-1-59745-196-3_16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011331930
258 https://doi.org/10.1007/978-1-59745-196-3_16
259 rdf:type schema:CreativeWork
260 sg:pub.10.1038/35018500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040384935
261 https://doi.org/10.1038/35018500
262 rdf:type schema:CreativeWork
263 sg:pub.10.1038/35018508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024812761
264 https://doi.org/10.1038/35018508
265 rdf:type schema:CreativeWork
266 sg:pub.10.1038/87603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022271339
267 https://doi.org/10.1038/87603
268 rdf:type schema:CreativeWork
269 sg:pub.10.1038/nchembio0306-112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015718784
270 https://doi.org/10.1038/nchembio0306-112
271 rdf:type schema:CreativeWork
272 sg:pub.10.1038/ni811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046652146
273 https://doi.org/10.1038/ni811
274 rdf:type schema:CreativeWork
275 sg:pub.10.1038/nri2273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006625763
276 https://doi.org/10.1038/nri2273
277 rdf:type schema:CreativeWork
278 sg:pub.10.1038/nsb0596-419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047252894
279 https://doi.org/10.1038/nsb0596-419
280 rdf:type schema:CreativeWork
281 https://app.dimensions.ai/details/publication/pub.1080144554 schema:CreativeWork
282 https://app.dimensions.ai/details/publication/pub.1082465093 schema:CreativeWork
283 https://app.dimensions.ai/details/publication/pub.1083332958 schema:CreativeWork
284 https://doi.org/10.1002/(sici)1097-0134(19980201)30:2<144::aid-prot4>3.0.co;2-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1012036233
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1002/(sici)1099-1352(199909/10)12:5<279::aid-jmr473>3.0.co;2-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045752856
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1002/jcc.20084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008225564
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1006/jmbi.2001.4670 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017160761
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1006/jmbi.2001.4929 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033695999
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/j.jmb.2007.02.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038492026
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/j.jmb.2007.05.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042204379
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/j.jmb.2009.08.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018195234
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/j.rmed.2009.03.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026955993
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/j.str.2007.09.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048977627
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1016/j.tibs.2007.03.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004487444
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1016/s0076-6879(97)76066-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004907170
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/s0092-8674(00)81719-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011849640
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/s0140-6736(06)69283-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053132149
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/s1074-7613(00)00037-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002951401
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/s1093-3263(02)00140-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023562177
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1021/bi00044a023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055158564
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1021/bi00148a004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055162630
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1021/bi971299+ schema:sameAs https://app.dimensions.ai/details/publication/pub.1055214218
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1021/bi9713005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055214219
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1021/bi9928391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055219038
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1074/jbc.m100350200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039196701
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1074/jbc.m106819200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049049427
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1074/jbc.m409458200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002970419
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1074/jbc.m500965200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035832726
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1074/jbc.m605190200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004874353
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1074/jbc.m800937200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000409427
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1074/jbc.m804742200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002620407
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1093/nar/gkm216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052481822
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1093/protein/8.2.193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059981199
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1107/s0021889800018227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020452683
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1107/s0021889805038987 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025674621
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1107/s0021889897006766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019562892
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1107/s0907444904019158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020281098
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1107/s0907444906016076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049706631
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1107/s0907444994003112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025573949
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1107/s0907444998003254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019779527
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1107/s0907444998006684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044366173
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1146/annurev.immunol.21.120601.141103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032251036
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1172/jci6551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036721301
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1371/journal.pone.0009037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035286988
365 rdf:type schema:CreativeWork
366 https://doi.org/10.4049/jimmunol.0803018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002792450
367 rdf:type schema:CreativeWork
368 https://doi.org/10.4049/jimmunol.165.1.331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074656383
369 rdf:type schema:CreativeWork
370 https://doi.org/10.4049/jimmunol.173.11.6831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076969454
371 rdf:type schema:CreativeWork
372 https://www.grid.ac/institutes/grid.13097.3c schema:alternateName King's College London
373 schema:name King's College London, Randall Division of Cell and Molecular Biophysics, London, UK.
374 rdf:type schema:Organization
375 https://www.grid.ac/institutes/grid.14105.31 schema:alternateName Medical Research Council
376 schema:name King's College London, Randall Division of Cell and Molecular Biophysics, London, UK.
377 Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK.
378 rdf:type schema:Organization
379 https://www.grid.ac/institutes/grid.465239.f schema:alternateName Research Complex at Harwell
380 schema:name Oxford Protein Production Facility UK, The Research Complex at Harwell, Rutherford Appleton Laboratory, Harwell Science & Innovation Centre, Harwell, UK.
381 University of Oxford, The Oxford Protein Production Facility, Division of Structural Biology, Oxford, UK.
382 rdf:type schema:Organization
383 https://www.grid.ac/institutes/grid.4991.5 schema:alternateName University of Oxford
384 schema:name University of Oxford, Laboratory of Molecular Biophysics, Department of Biochemistry, Oxford, UK.
385 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...