Apolipoprotein A-I structural organization in high-density lipoproteins isolated from human plasma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-04

AUTHORS

Rong Huang, R A Gangani D Silva, W Gray Jerome, Anatol Kontush, M John Chapman, Linda K Curtiss, Timothy J Hodges, W Sean Davidson

ABSTRACT

High-density lipoproteins (HDLs) mediate cholesterol transport and protection from cardiovascular disease. Although synthetic HDLs have been studied for 30 years, the structures of human plasma-derived HDL and its major protein apolipoprotein apoA-I are unknown. We separated normal human HDL into five density subfractions and then further isolated those containing predominantly apoA-I (LpA-I). Using cross-linking chemistry and mass spectrometry, we found that apoA-I adopts a structural framework in these particles that closely mirrors that in synthetic HDL. We adapted established structures for synthetic HDL to generate the first detailed models of authentic human plasma HDL in which apoA-I adopts a symmetrical cage-like structure. The models suggest that HDL particle size is modulated by means of a twisting motion of the resident apoA-I molecules. This understanding offers insights into how apoA-I structure modulates HDL function and its interactions with other apolipoproteins. More... »

PAGES

416

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsmb.2028

DOI

http://dx.doi.org/10.1038/nsmb.2028

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020634624

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21399642


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2028'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2028'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2028'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2028'


 

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297 schema:name Assistance Publique–Hopitaux de Paris, Groupe hospitalier Pitié-Salpétrière, Paris, France.
298 National Institute of Health and Medical Research, Dyslipoproteinemia and Atherosclerosis Research Unit, Paris, France.
299 Université Pierre et Marie Curie-Paris 6, Paris, France.
300 rdf:type schema:Organization
301 https://www.grid.ac/institutes/grid.412807.8 schema:alternateName Vanderbilt University Medical Center
302 schema:name Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
303 rdf:type schema:Organization
 




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