The structural basis for MCM2–7 helicase activation by GINS and Cdc45 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-04

AUTHORS

Alessandro Costa, Ivar Ilves, Nele Tamberg, Tatjana Petojevic, Eva Nogales, Michael R Botchan, James M Berger

ABSTRACT

Two central steps for initiating eukaryotic DNA replication involve loading of the Mcm2-7 helicase onto double-stranded DNA and its activation by GINS-Cdc45. To better understand these events, we determined the structures of Mcm2-7 and the CMG complex by using single-particle electron microscopy. Mcm2-7 adopts two conformations--a lock-washer-shaped spiral state and a planar, gapped-ring form--in which Mcm2 and Mcm5 flank a breach in the helicase perimeter. GINS and Cdc45 bridge this gap, forming a topologically closed assembly with a large interior channel; nucleotide binding further seals off the discontinuity between Mcm2 and Mcm5, partitioning the channel into two smaller pores. Together, our data help explain how GINS and Cdc45 activate Mcm2-7, indicate that Mcm2-7 loading may be assisted by a natural predisposition of the hexamer to form open rings, and suggest a mechanism by which the CMG complex assists DNA strand separation. More... »

PAGES

471

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsmb.2004

DOI

http://dx.doi.org/10.1038/nsmb.2004

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038111337

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21378962


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomal Proteins, Non-Histone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drosophila Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Minichromosome Maintenance Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Conformation", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of California, Berkeley", 
          "id": "https://www.grid.ac/institutes/grid.47840.3f", 
          "name": [
            "Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.", 
            "California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, California, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Costa", 
        "givenName": "Alessandro", 
        "id": "sg:person.0766340761.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766340761.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, Berkeley", 
          "id": "https://www.grid.ac/institutes/grid.47840.3f", 
          "name": [
            "Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ilves", 
        "givenName": "Ivar", 
        "id": "sg:person.01253144231.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253144231.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, Berkeley", 
          "id": "https://www.grid.ac/institutes/grid.47840.3f", 
          "name": [
            "Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tamberg", 
        "givenName": "Nele", 
        "id": "sg:person.01343454437.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343454437.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Freie Universit\u00e4t Berlin", 
          "id": "https://www.grid.ac/institutes/grid.14095.39", 
          "name": [
            "Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.", 
            "Department of Biology, Chemistry and Pharmacy, Institute of Chemistry and Biochemistry, Freie Universit\u00e4t Berlin, Berlin, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Petojevic", 
        "givenName": "Tatjana", 
        "id": "sg:person.01321257431.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321257431.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lawrence Berkeley National Laboratory", 
          "id": "https://www.grid.ac/institutes/grid.184769.5", 
          "name": [
            "Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.", 
            "California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, California, USA.", 
            "Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, California, USA.", 
            "Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nogales", 
        "givenName": "Eva", 
        "id": "sg:person.01310210650.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310210650.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, Berkeley", 
          "id": "https://www.grid.ac/institutes/grid.47840.3f", 
          "name": [
            "Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.", 
            "California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, California, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Botchan", 
        "givenName": "Michael R", 
        "id": "sg:person.0747447154.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747447154.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, Berkeley", 
          "id": "https://www.grid.ac/institutes/grid.47840.3f", 
          "name": [
            "Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.", 
            "California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, California, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berger", 
        "givenName": "James M", 
        "id": "sg:person.01171110072.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171110072.45"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.molcel.2005.09.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000376918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2005.09.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000376918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01692", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002035791", 
          "https://doi.org/10.1038/nature01692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01692", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002035791", 
          "https://doi.org/10.1038/nature01692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.337205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003242492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2010.11.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003604838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gki775", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004446263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.00161-08", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006976948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcc.20084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008225564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m703824200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008452939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0602400103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009060164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2009.12.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013948145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2009.12.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013948145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2009.12.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013948145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2009.12.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013948145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2009.10.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014449249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.20.1.34-41.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014584285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1548107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016356166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ceb.2009.08.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016459873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tcb.2007.04.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018570608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1382", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020448729", 
          "https://doi.org/10.1038/ncb1382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1382", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020448729", 
          "https://doi.org/10.1038/ncb1382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.embor.7401002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021833273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsb.2009.01.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021992126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/cdf308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022682389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2009.10.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023146263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.embor.7400649", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024753851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.embor.7400649", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024753851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jsbi.1996.0004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025955952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.embor.7400010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026897971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jsbi.1999.4174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028456646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsb.2003.10.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028892343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/bti770", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031081661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0808037105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031297632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2004.11.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032128252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(03)00523-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032341751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(03)00523-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032341751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.str.2008.11.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032819508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb1231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033117161", 
          "https://doi.org/10.1038/nsmb1231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb1231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033117161", 
          "https://doi.org/10.1038/nsmb1231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.7.4447", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033497277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m509760200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034364113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb974", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034811191", 
          "https://doi.org/10.1038/nsmb974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb974", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034811191", 
          "https://doi.org/10.1038/nsmb974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsb893", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035997182", 
          "https://doi.org/10.1038/nsb893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsb893", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035997182", 
          "https://doi.org/10.1038/nsb893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/29.23.4834", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036011261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444904026460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036575621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.02451-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036834973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m210511200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037812245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tibs.2005.06.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039798142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tibs.2005.06.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039798142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m109.089078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040704232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkl708", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041480814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.26.14783", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041808243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2008.05.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042577158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0911500106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044523994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04943", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045376961", 
          "https://doi.org/10.1038/nature04943"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04943", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045376961", 
          "https://doi.org/10.1038/nature04943"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04943", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045376961", 
          "https://doi.org/10.1038/nature04943"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1065903", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046475412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20091531", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047797588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20091531", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047797588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20091531", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047797588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2006.01.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047999181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0908039106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048642513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0908039106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048642513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jsbi.1996.0030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049328776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/embo-reports/kvf160", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049572444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0705558104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051158549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.str.2005.11.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051294169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.030539597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052994185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2728(86)90071-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053591727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2728(86)90071-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053591727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0033583500003644", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053903844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075548654", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079518998", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-04", 
    "datePublishedReg": "2011-04-01", 
    "description": "Two central steps for initiating eukaryotic DNA replication involve loading of the Mcm2-7 helicase onto double-stranded DNA and its activation by GINS-Cdc45. To better understand these events, we determined the structures of Mcm2-7 and the CMG complex by using single-particle electron microscopy. Mcm2-7 adopts two conformations--a lock-washer-shaped spiral state and a planar, gapped-ring form--in which Mcm2 and Mcm5 flank a breach in the helicase perimeter. GINS and Cdc45 bridge this gap, forming a topologically closed assembly with a large interior channel; nucleotide binding further seals off the discontinuity between Mcm2 and Mcm5, partitioning the channel into two smaller pores. Together, our data help explain how GINS and Cdc45 activate Mcm2-7, indicate that Mcm2-7 loading may be assisted by a natural predisposition of the hexamer to form open rings, and suggest a mechanism by which the CMG complex assists DNA strand separation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nsmb.2004", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2634233", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2466846", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2518481", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7169857", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1295033", 
        "issn": [
          "1545-9993", 
          "2331-365X"
        ], 
        "name": "Nature Structural & Molecular Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "name": "The structural basis for MCM2\u20137 helicase activation by GINS and Cdc45", 
    "pagination": "471", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b58d1ebc15f6f703a885d1d33def8d6a1fa800938f5611f3eca1e1beba5fd2fa"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21378962"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101186374"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nsmb.2004"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1038111337"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nsmb.2004", 
      "https://app.dimensions.ai/details/publication/pub.1038111337"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000436.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nsmb.2004"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2004'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2004'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2004'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nsmb.2004'


 

This table displays all metadata directly associated to this object as RDF triples.

343 TRIPLES      21 PREDICATES      96 URIs      29 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nsmb.2004 schema:about N592be97099b94659be85a03ab81dd193
2 N63f99b2fb79e4e58b4bd07cc328d8b47
3 N6aa867116f4d41f3bea71d42628545d6
4 N6fd3edaafb674c32a626883172183652
5 N7e12047b20fc4f28ba0689c9ead11bce
6 N86d4d3b4cc48415a833e5056778f2072
7 N99fb74e3cfaf4c7ab9f1e10bd7f7ec58
8 Ne1274cb8d6ae43d8a0bcee80d0eca147
9 anzsrc-for:06
10 anzsrc-for:0601
11 schema:author N25f604822c5d4a3b86a9db7bc0291545
12 schema:citation sg:pub.10.1038/nature01692
13 sg:pub.10.1038/nature04943
14 sg:pub.10.1038/ncb1382
15 sg:pub.10.1038/nsb893
16 sg:pub.10.1038/nsmb1231
17 sg:pub.10.1038/nsmb974
18 https://app.dimensions.ai/details/publication/pub.1075548654
19 https://app.dimensions.ai/details/publication/pub.1079518998
20 https://doi.org/10.1002/jcc.20084
21 https://doi.org/10.1006/jsbi.1996.0004
22 https://doi.org/10.1006/jsbi.1996.0030
23 https://doi.org/10.1006/jsbi.1999.4174
24 https://doi.org/10.1016/0005-2728(86)90071-x
25 https://doi.org/10.1016/j.ceb.2009.08.002
26 https://doi.org/10.1016/j.cell.2009.10.015
27 https://doi.org/10.1016/j.cell.2009.10.037
28 https://doi.org/10.1016/j.jsb.2003.10.010
29 https://doi.org/10.1016/j.jsb.2009.01.004
30 https://doi.org/10.1016/j.molcel.2004.11.038
31 https://doi.org/10.1016/j.molcel.2005.09.020
32 https://doi.org/10.1016/j.molcel.2006.01.030
33 https://doi.org/10.1016/j.molcel.2008.05.020
34 https://doi.org/10.1016/j.molcel.2009.12.030
35 https://doi.org/10.1016/j.molcel.2010.11.027
36 https://doi.org/10.1016/j.str.2005.11.020
37 https://doi.org/10.1016/j.str.2008.11.010
38 https://doi.org/10.1016/j.tcb.2007.04.002
39 https://doi.org/10.1016/j.tibs.2005.06.007
40 https://doi.org/10.1016/s0960-9822(03)00523-2
41 https://doi.org/10.1017/s0033583500003644
42 https://doi.org/10.1038/sj.embor.7400010
43 https://doi.org/10.1038/sj.embor.7400649
44 https://doi.org/10.1038/sj.embor.7401002
45 https://doi.org/10.1042/bj20091531
46 https://doi.org/10.1073/pnas.030539597
47 https://doi.org/10.1073/pnas.0602400103
48 https://doi.org/10.1073/pnas.0705558104
49 https://doi.org/10.1073/pnas.0808037105
50 https://doi.org/10.1073/pnas.0908039106
51 https://doi.org/10.1073/pnas.0911500106
52 https://doi.org/10.1073/pnas.96.26.14783
53 https://doi.org/10.1074/jbc.274.7.4447
54 https://doi.org/10.1074/jbc.m109.089078
55 https://doi.org/10.1074/jbc.m210511200
56 https://doi.org/10.1074/jbc.m509760200
57 https://doi.org/10.1074/jbc.m703824200
58 https://doi.org/10.1093/bioinformatics/bti770
59 https://doi.org/10.1093/embo-reports/kvf160
60 https://doi.org/10.1093/emboj/cdf308
61 https://doi.org/10.1093/nar/29.23.4834
62 https://doi.org/10.1093/nar/gki775
63 https://doi.org/10.1093/nar/gkl708
64 https://doi.org/10.1101/gad.1065903
65 https://doi.org/10.1101/gad.1548107
66 https://doi.org/10.1101/gad.337205
67 https://doi.org/10.1107/s0907444904026460
68 https://doi.org/10.1128/jvi.02451-06
69 https://doi.org/10.1128/mcb.00161-08
70 https://doi.org/10.1128/mcb.20.1.34-41.2000
71 schema:datePublished 2011-04
72 schema:datePublishedReg 2011-04-01
73 schema:description Two central steps for initiating eukaryotic DNA replication involve loading of the Mcm2-7 helicase onto double-stranded DNA and its activation by GINS-Cdc45. To better understand these events, we determined the structures of Mcm2-7 and the CMG complex by using single-particle electron microscopy. Mcm2-7 adopts two conformations--a lock-washer-shaped spiral state and a planar, gapped-ring form--in which Mcm2 and Mcm5 flank a breach in the helicase perimeter. GINS and Cdc45 bridge this gap, forming a topologically closed assembly with a large interior channel; nucleotide binding further seals off the discontinuity between Mcm2 and Mcm5, partitioning the channel into two smaller pores. Together, our data help explain how GINS and Cdc45 activate Mcm2-7, indicate that Mcm2-7 loading may be assisted by a natural predisposition of the hexamer to form open rings, and suggest a mechanism by which the CMG complex assists DNA strand separation.
74 schema:genre research_article
75 schema:inLanguage en
76 schema:isAccessibleForFree true
77 schema:isPartOf Nd0a68810a82c477b8651bdadb6e8dabc
78 Ndb0f4f7d71f3445594873d996cec3928
79 sg:journal.1295033
80 schema:name The structural basis for MCM2–7 helicase activation by GINS and Cdc45
81 schema:pagination 471
82 schema:productId N2ac2fea8016b45d3b1153aaaf1166817
83 N3577b3bb47b149dc83491dd8fd9ed739
84 N421d217b6d3c4b1daf5ec90c6a944521
85 N6167e64f15be48b99cc3eeedff7f9de9
86 N8eacb87e526c497da5e5c163c07a2e03
87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038111337
88 https://doi.org/10.1038/nsmb.2004
89 schema:sdDatePublished 2019-04-10T22:20
90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
91 schema:sdPublisher Ne22201c5d4d44aa69e4551312b46533a
92 schema:url https://www.nature.com/articles/nsmb.2004
93 sgo:license sg:explorer/license/
94 sgo:sdDataset articles
95 rdf:type schema:ScholarlyArticle
96 N25f604822c5d4a3b86a9db7bc0291545 rdf:first sg:person.0766340761.42
97 rdf:rest N82c7178f92b2468cab6f75b69c922389
98 N2ac2fea8016b45d3b1153aaaf1166817 schema:name nlm_unique_id
99 schema:value 101186374
100 rdf:type schema:PropertyValue
101 N3577b3bb47b149dc83491dd8fd9ed739 schema:name doi
102 schema:value 10.1038/nsmb.2004
103 rdf:type schema:PropertyValue
104 N421d217b6d3c4b1daf5ec90c6a944521 schema:name readcube_id
105 schema:value b58d1ebc15f6f703a885d1d33def8d6a1fa800938f5611f3eca1e1beba5fd2fa
106 rdf:type schema:PropertyValue
107 N592be97099b94659be85a03ab81dd193 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Minichromosome Maintenance Proteins
109 rdf:type schema:DefinedTerm
110 N5a91ad60f40440b1ae4237b9c00bf662 rdf:first sg:person.01343454437.62
111 rdf:rest N87fdafbefcdc4566b9cf3d21eeb8b343
112 N6167e64f15be48b99cc3eeedff7f9de9 schema:name pubmed_id
113 schema:value 21378962
114 rdf:type schema:PropertyValue
115 N63f99b2fb79e4e58b4bd07cc328d8b47 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Cell Cycle Proteins
117 rdf:type schema:DefinedTerm
118 N6aa867116f4d41f3bea71d42628545d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Drosophila Proteins
120 rdf:type schema:DefinedTerm
121 N6fd3edaafb674c32a626883172183652 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Chromosomal Proteins, Non-Histone
123 rdf:type schema:DefinedTerm
124 N7e12047b20fc4f28ba0689c9ead11bce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Models, Molecular
126 rdf:type schema:DefinedTerm
127 N82c7178f92b2468cab6f75b69c922389 rdf:first sg:person.01253144231.54
128 rdf:rest N5a91ad60f40440b1ae4237b9c00bf662
129 N86d4d3b4cc48415a833e5056778f2072 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Enzyme Activation
131 rdf:type schema:DefinedTerm
132 N87fdafbefcdc4566b9cf3d21eeb8b343 rdf:first sg:person.01321257431.99
133 rdf:rest N9bba2d6ae44840259098066f89817193
134 N8eacb87e526c497da5e5c163c07a2e03 schema:name dimensions_id
135 schema:value pub.1038111337
136 rdf:type schema:PropertyValue
137 N99fb74e3cfaf4c7ab9f1e10bd7f7ec58 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Protein Conformation
139 rdf:type schema:DefinedTerm
140 N9bba2d6ae44840259098066f89817193 rdf:first sg:person.01310210650.71
141 rdf:rest Ne02bbcb4d0bf4c77a69286246c0ee3b6
142 Nd0a68810a82c477b8651bdadb6e8dabc schema:volumeNumber 18
143 rdf:type schema:PublicationVolume
144 Nd370c881e4f049ed87bb7f67c74a4822 rdf:first sg:person.01171110072.45
145 rdf:rest rdf:nil
146 Ndb0f4f7d71f3445594873d996cec3928 schema:issueNumber 4
147 rdf:type schema:PublicationIssue
148 Ne02bbcb4d0bf4c77a69286246c0ee3b6 rdf:first sg:person.0747447154.91
149 rdf:rest Nd370c881e4f049ed87bb7f67c74a4822
150 Ne1274cb8d6ae43d8a0bcee80d0eca147 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Animals
152 rdf:type schema:DefinedTerm
153 Ne22201c5d4d44aa69e4551312b46533a schema:name Springer Nature - SN SciGraph project
154 rdf:type schema:Organization
155 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
156 schema:name Biological Sciences
157 rdf:type schema:DefinedTerm
158 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
159 schema:name Biochemistry and Cell Biology
160 rdf:type schema:DefinedTerm
161 sg:grant.2466846 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.2004
162 rdf:type schema:MonetaryGrant
163 sg:grant.2518481 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.2004
164 rdf:type schema:MonetaryGrant
165 sg:grant.2634233 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.2004
166 rdf:type schema:MonetaryGrant
167 sg:grant.7169857 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.2004
168 rdf:type schema:MonetaryGrant
169 sg:journal.1295033 schema:issn 1545-9993
170 2331-365X
171 schema:name Nature Structural & Molecular Biology
172 rdf:type schema:Periodical
173 sg:person.01171110072.45 schema:affiliation https://www.grid.ac/institutes/grid.47840.3f
174 schema:familyName Berger
175 schema:givenName James M
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171110072.45
177 rdf:type schema:Person
178 sg:person.01253144231.54 schema:affiliation https://www.grid.ac/institutes/grid.47840.3f
179 schema:familyName Ilves
180 schema:givenName Ivar
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253144231.54
182 rdf:type schema:Person
183 sg:person.01310210650.71 schema:affiliation https://www.grid.ac/institutes/grid.184769.5
184 schema:familyName Nogales
185 schema:givenName Eva
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310210650.71
187 rdf:type schema:Person
188 sg:person.01321257431.99 schema:affiliation https://www.grid.ac/institutes/grid.14095.39
189 schema:familyName Petojevic
190 schema:givenName Tatjana
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321257431.99
192 rdf:type schema:Person
193 sg:person.01343454437.62 schema:affiliation https://www.grid.ac/institutes/grid.47840.3f
194 schema:familyName Tamberg
195 schema:givenName Nele
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343454437.62
197 rdf:type schema:Person
198 sg:person.0747447154.91 schema:affiliation https://www.grid.ac/institutes/grid.47840.3f
199 schema:familyName Botchan
200 schema:givenName Michael R
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747447154.91
202 rdf:type schema:Person
203 sg:person.0766340761.42 schema:affiliation https://www.grid.ac/institutes/grid.47840.3f
204 schema:familyName Costa
205 schema:givenName Alessandro
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766340761.42
207 rdf:type schema:Person
208 sg:pub.10.1038/nature01692 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002035791
209 https://doi.org/10.1038/nature01692
210 rdf:type schema:CreativeWork
211 sg:pub.10.1038/nature04943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045376961
212 https://doi.org/10.1038/nature04943
213 rdf:type schema:CreativeWork
214 sg:pub.10.1038/ncb1382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020448729
215 https://doi.org/10.1038/ncb1382
216 rdf:type schema:CreativeWork
217 sg:pub.10.1038/nsb893 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035997182
218 https://doi.org/10.1038/nsb893
219 rdf:type schema:CreativeWork
220 sg:pub.10.1038/nsmb1231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033117161
221 https://doi.org/10.1038/nsmb1231
222 rdf:type schema:CreativeWork
223 sg:pub.10.1038/nsmb974 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034811191
224 https://doi.org/10.1038/nsmb974
225 rdf:type schema:CreativeWork
226 https://app.dimensions.ai/details/publication/pub.1075548654 schema:CreativeWork
227 https://app.dimensions.ai/details/publication/pub.1079518998 schema:CreativeWork
228 https://doi.org/10.1002/jcc.20084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008225564
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1006/jsbi.1996.0004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025955952
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1006/jsbi.1996.0030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049328776
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1006/jsbi.1999.4174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028456646
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/0005-2728(86)90071-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053591727
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/j.ceb.2009.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016459873
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/j.cell.2009.10.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014449249
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/j.cell.2009.10.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023146263
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/j.jsb.2003.10.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028892343
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/j.jsb.2009.01.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021992126
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/j.molcel.2004.11.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032128252
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.molcel.2005.09.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000376918
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/j.molcel.2006.01.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047999181
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/j.molcel.2008.05.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042577158
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/j.molcel.2009.12.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013948145
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/j.molcel.2010.11.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003604838
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/j.str.2005.11.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051294169
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/j.str.2008.11.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032819508
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/j.tcb.2007.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018570608
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/j.tibs.2005.06.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039798142
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/s0960-9822(03)00523-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032341751
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1017/s0033583500003644 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053903844
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1038/sj.embor.7400010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026897971
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1038/sj.embor.7400649 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024753851
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1038/sj.embor.7401002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021833273
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1042/bj20091531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047797588
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1073/pnas.030539597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052994185
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1073/pnas.0602400103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009060164
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1073/pnas.0705558104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051158549
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1073/pnas.0808037105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031297632
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1073/pnas.0908039106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048642513
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1073/pnas.0911500106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044523994
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1073/pnas.96.26.14783 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041808243
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1074/jbc.274.7.4447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033497277
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1074/jbc.m109.089078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040704232
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1074/jbc.m210511200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037812245
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1074/jbc.m509760200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034364113
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1074/jbc.m703824200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008452939
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1093/bioinformatics/bti770 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031081661
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1093/embo-reports/kvf160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049572444
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1093/emboj/cdf308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022682389
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1093/nar/29.23.4834 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036011261
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1093/nar/gki775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004446263
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1093/nar/gkl708 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041480814
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1101/gad.1065903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046475412
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1101/gad.1548107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016356166
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1101/gad.337205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003242492
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1107/s0907444904026460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036575621
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1128/jvi.02451-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036834973
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1128/mcb.00161-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006976948
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1128/mcb.20.1.34-41.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014584285
329 rdf:type schema:CreativeWork
330 https://www.grid.ac/institutes/grid.14095.39 schema:alternateName Freie Universität Berlin
331 schema:name Department of Biology, Chemistry and Pharmacy, Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.
332 Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.
333 rdf:type schema:Organization
334 https://www.grid.ac/institutes/grid.184769.5 schema:alternateName Lawrence Berkeley National Laboratory
335 schema:name California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, California, USA.
336 Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.
337 Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, California, USA.
338 Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA.
339 rdf:type schema:Organization
340 https://www.grid.ac/institutes/grid.47840.3f schema:alternateName University of California, Berkeley
341 schema:name California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, California, USA.
342 Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.
343 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...