Ontology type: schema:ScholarlyArticle Open Access: True
2010-08-29
AUTHORSKyle M Miller, Jorrit V Tjeertes, Julia Coates, Gaëlle Legube, Sophie E Polo, Sébastien Britton, Stephen P Jackson
ABSTRACTHow changes in chromatin can modulate the repair pathway of DNA double-strand breaks is now investigated. The work shows that histone deacetylases HDAC1 and HDAC2 are recruited to sites of DNA damage, where they mediate the removal of H3K56 acetyl marks, and their activity is important for repair via non-homologous end-joining. More... »
PAGES1144-1151
http://scigraph.springernature.com/pub.10.1038/nsmb.1899
DOIhttp://dx.doi.org/10.1038/nsmb.1899
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1019375204
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/20802485
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Genetics",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Line, Tumor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "DNA Breaks, Double-Stranded",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "DNA Repair",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Histone Deacetylase 1",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Histone Deacetylase 2",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Histones",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "RNA, Small Interfering",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "The Gurdon Institute, University of Cambridge, Cambridge, UK",
"id": "http://www.grid.ac/institutes/grid.450000.1",
"name": [
"The Gurdon Institute, University of Cambridge, Cambridge, UK"
],
"type": "Organization"
},
"familyName": "Miller",
"givenName": "Kyle M",
"id": "sg:person.0626452612.74",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626452612.74"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The Gurdon Institute, University of Cambridge, Cambridge, UK",
"id": "http://www.grid.ac/institutes/grid.450000.1",
"name": [
"The Gurdon Institute, University of Cambridge, Cambridge, UK"
],
"type": "Organization"
},
"familyName": "Tjeertes",
"givenName": "Jorrit V",
"id": "sg:person.01252717574.20",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252717574.20"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The Gurdon Institute, University of Cambridge, Cambridge, UK",
"id": "http://www.grid.ac/institutes/grid.450000.1",
"name": [
"The Gurdon Institute, University of Cambridge, Cambridge, UK"
],
"type": "Organization"
},
"familyName": "Coates",
"givenName": "Julia",
"id": "sg:person.01300124131.62",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300124131.62"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Laboratoire de biologie cellulaire et mol\u00e9culaire du contr\u00f4le de la prolif\u00e9ration, Centre National de la Recherche Scientifique and Universit\u00e9 de Toulouse, Toulouse, France",
"id": "http://www.grid.ac/institutes/grid.463884.5",
"name": [
"Laboratoire de biologie cellulaire et mol\u00e9culaire du contr\u00f4le de la prolif\u00e9ration, Centre National de la Recherche Scientifique and Universit\u00e9 de Toulouse, Toulouse, France"
],
"type": "Organization"
},
"familyName": "Legube",
"givenName": "Ga\u00eblle",
"id": "sg:person.01002524357.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002524357.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The Gurdon Institute, University of Cambridge, Cambridge, UK",
"id": "http://www.grid.ac/institutes/grid.450000.1",
"name": [
"The Gurdon Institute, University of Cambridge, Cambridge, UK"
],
"type": "Organization"
},
"familyName": "Polo",
"givenName": "Sophie E",
"id": "sg:person.0713315773.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713315773.50"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The Gurdon Institute, University of Cambridge, Cambridge, UK",
"id": "http://www.grid.ac/institutes/grid.450000.1",
"name": [
"The Gurdon Institute, University of Cambridge, Cambridge, UK"
],
"type": "Organization"
},
"familyName": "Britton",
"givenName": "S\u00e9bastien",
"id": "sg:person.0701774075.33",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701774075.33"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The Gurdon Institute, University of Cambridge, Cambridge, UK",
"id": "http://www.grid.ac/institutes/grid.450000.1",
"name": [
"The Gurdon Institute, University of Cambridge, Cambridge, UK"
],
"type": "Organization"
},
"familyName": "Jackson",
"givenName": "Stephen P",
"id": "sg:person.010347035222.99",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010347035222.99"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/nature08657",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046919299",
"https://doi.org/10.1038/nature08657"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng1531",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029978023",
"https://doi.org/10.1038/ng1531"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrm2651",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038110714",
"https://doi.org/10.1038/nrm2651"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature08467",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052581766",
"https://doi.org/10.1038/nature08467"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature03485",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005294665",
"https://doi.org/10.1038/nature03485"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrm2346",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037857855",
"https://doi.org/10.1038/nrm2346"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc2440",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046307420",
"https://doi.org/10.1038/nrc2440"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature07861",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042273422",
"https://doi.org/10.1038/nature07861"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature05268",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039813470",
"https://doi.org/10.1038/nature05268"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc2523",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034798234",
"https://doi.org/10.1038/nrc2523"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature02118",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014616827",
"https://doi.org/10.1038/nature02118"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature05327",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007876716",
"https://doi.org/10.1038/nature05327"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature03482",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037091000",
"https://doi.org/10.1038/nature03482"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1210610",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023418889",
"https://doi.org/10.1038/sj.onc.1210610"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncb1343",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001861805",
"https://doi.org/10.1038/ncb1343"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature01035",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050812143",
"https://doi.org/10.1038/nature01035"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature05980",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018481990",
"https://doi.org/10.1038/nature05980"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nsmb.1710",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044567755",
"https://doi.org/10.1038/nsmb.1710"
],
"type": "CreativeWork"
}
],
"datePublished": "2010-08-29",
"datePublishedReg": "2010-08-29",
"description": "How changes in chromatin can modulate the repair pathway of DNA double-strand breaks is now investigated. The work shows that histone deacetylases HDAC1 and HDAC2 are recruited to sites of DNA damage, where they mediate the removal of H3K56 acetyl marks, and their activity is important for repair via non-homologous end-joining.",
"genre": "article",
"id": "sg:pub.10.1038/nsmb.1899",
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.3639161",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.5136987",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1295033",
"issn": [
"1545-9993",
"2331-365X"
],
"name": "Nature Structural & Molecular Biology",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "9",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "17"
}
],
"keywords": [
"HDAC2 function",
"human HDAC1",
"DNA damage",
"HDAC1",
"DNA damage response",
"DNA double-strand breaks",
"repair pathways",
"HDAC2",
"repair",
"double-strand breaks",
"pathway",
"damage",
"response",
"activity",
"changes",
"DNA",
"function",
"histones",
"acetyl marks",
"sites",
"removal",
"breaks",
"chromatin",
"marks",
"work"
],
"name": "Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining",
"pagination": "1144-1151",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1019375204"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/nsmb.1899"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"20802485"
]
}
],
"sameAs": [
"https://doi.org/10.1038/nsmb.1899",
"https://app.dimensions.ai/details/publication/pub.1019375204"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T16:58",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_518.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/nsmb.1899"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nsmb.1899'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nsmb.1899'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nsmb.1899'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nsmb.1899'
This table displays all metadata directly associated to this object as RDF triples.
239 TRIPLES
21 PREDICATES
76 URIs
50 LITERALS
15 BLANK NODES