Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-08

AUTHORS

Gracjan Michlewski, Javier F Cáceres

ABSTRACT

The pluripotency-promoting proteins Lin28a and Lin28b act as post-transcriptional repressors of let-7 miRNA biogenesis in undifferentiated embryonic stem cells. The levels of mature let-7a differ substantially in cells lacking Lin28 expression, indicating the existence of additional mechanism(s) of post-transcriptional regulation. Here, we present evidence supporting a role for heteronuclear ribonucleoprotein A1 (hnRNP A1) as a negative regulator of let-7a. HnRNP A1 binds the conserved terminal loop of pri-let-7a-1 and inhibits its processing by Drosha. Levels of mature let-7a negatively correlate with hnRNP A1 levels in somatic cell lines. Furthermore, hnRNP A1 depletion increased pri-let-7a-1 processing by cell extracts, whereas its ectopic expression decreased let-7a production in vivo. Finally, hnRNP A1 binding to let-7a interferes with the binding of KSRP, which is known to promote let-7a biogenesis. We propose that hnRNP A1 and KSRP have antagonistic roles in the post-transcriptional regulation of let-7a expression. More... »

PAGES

1011

References to SciGraph publications

  • 2008-09. Primary microRNA transcripts are processed co-transcriptionally in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2009-11. Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2007. hnRNP proteins and splicing control. in ALTERNATIVE SPLICING IN THE POSTGENOMIC ERA
  • 2009-07. Lin28 promotes transformation and is associated with advanced human malignancies in NATURE GENETICS
  • 2007-05. Impaired microRNA processing enhances cellular transformation and tumorigenesis in NATURE GENETICS
  • 2007-07. The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2007-12. Identification of a set of KSRP target transcripts upregulated by PI3K-AKT signaling in BMC MOLECULAR BIOLOGY
  • 2009-06. The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs in NATURE
  • 2008-07-03. SMAD proteins control DROSHA-mediated microRNA maturation in NATURE
  • 1997-03. Crystal structure of the two RNA binding domains of human hnRNP A1 at 1.75 Å resolution in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2009-03. Many roads to maturity: microRNA biogenesis pathways and their regulation in NATURE CELL BIOLOGY
  • 2008-08. A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment in NATURE CELL BIOLOGY
  • 2009-02. Biogenesis of small RNAs in animals in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2007-05. DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs in NATURE CELL BIOLOGY
  • 2009-07. Modulation of microRNA processing by p53 in NATURE
  • 2002-04. Listening to silence and understanding nonsense: exonic mutations that affect splicing in NATURE REVIEWS GENETICS
  • 2009-10. Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2009-10. LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2004-11. Processing of primary microRNAs by the Microprocessor complex in NATURE
  • 2004-11. The Microprocessor complex mediates the genesis of microRNAs in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nsmb.1874

    DOI

    http://dx.doi.org/10.1038/nsmb.1874

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1043004854

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20639884


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Base Sequence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Binding, Competitive", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Footprinting", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Green Fluorescent Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Heterogeneous Nuclear Ribonucleoprotein A1", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Heterogeneous-Nuclear Ribonucleoprotein Group A-B", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "MicroRNAs", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Models, Biological", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Sequence Data", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nucleic Acid Conformation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Binding", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA Processing, Post-Transcriptional", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA-Binding Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Recombinant Fusion Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ribonuclease III", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Trans-Activators", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Western General Hospital", 
              "id": "https://www.grid.ac/institutes/grid.417068.c", 
              "name": [
                "Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Michlewski", 
            "givenName": "Gracjan", 
            "id": "sg:person.01170674735.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170674735.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Western General Hospital", 
              "id": "https://www.grid.ac/institutes/grid.417068.c", 
              "name": [
                "Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "C\u00e1ceres", 
            "givenName": "Javier F", 
            "id": "sg:person.01020646115.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020646115.18"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature08025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000219429", 
              "https://doi.org/10.1038/nature08025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000219429", 
              "https://doi.org/10.1038/nature08025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.emboj.7600491", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001286805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.c800108200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001921959"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.1475", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002708827", 
              "https://doi.org/10.1038/nsmb.1475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.08.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006762664"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkg766", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006802316"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.1675", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007633803", 
              "https://doi.org/10.1038/nsmb.1675"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.1675", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007633803", 
              "https://doi.org/10.1038/nsmb.1675"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2004.05.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009536533"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2632", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009902558", 
              "https://doi.org/10.1038/nrm2632"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.89.3.895", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010402343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg775", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011644042", 
              "https://doi.org/10.1038/nrg775"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg775", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011644042", 
              "https://doi.org/10.1038/nrg775"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-291x(03)00554-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012591222"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-291x(03)00554-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012591222"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.09-131342", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012596601"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.bi.62.070193.001445", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013542110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015411207", 
              "https://doi.org/10.1038/nature03120"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015411207", 
              "https://doi.org/10.1038/nature03120"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0712321105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015424504"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08199", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017973498", 
              "https://doi.org/10.1038/nature08199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08199", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017973498", 
              "https://doi.org/10.1038/nature08199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tibtech.2008.09.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019893310"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb1250", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023067946", 
              "https://doi.org/10.1038/nsmb1250"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.01.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023682432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1444406", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025405827"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsb0397-215", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026316469", 
              "https://doi.org/10.1038/nsb0397-215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.01836-08", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027147468"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027442042", 
              "https://doi.org/10.1038/nature03049"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027442042", 
              "https://doi.org/10.1038/nature03049"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2199-8-28", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027768228", 
              "https://doi.org/10.1186/1471-2199-8-28"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1759", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028865043", 
              "https://doi.org/10.1038/ncb1759"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2004.11.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030853194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200803111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031463074"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0969-2126(97)00211-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032750780"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032756706", 
              "https://doi.org/10.1038/nature07086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.138.2.225", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033489832"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/mcp.r800013-mcp200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033822158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-2836(03)00885-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034407851"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-2836(03)00885-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034407851"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb0309-228", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035086053", 
              "https://doi.org/10.1038/ncb0309-228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036221931", 
              "https://doi.org/10.1038/ng2003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036221931", 
              "https://doi.org/10.1038/ng2003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1261/rna.2322506", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036696023"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2009.08.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038253761"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.87.21.8403", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038285660"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.emboj.7601512", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039589401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.392", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039771504", 
              "https://doi.org/10.1038/ng.392"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.11.8.1023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041137808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1262504", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042334541"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.1676", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042948549", 
              "https://doi.org/10.1038/nsmb.1676"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tcb.2008.07.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044009500"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1577", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044486475", 
              "https://doi.org/10.1038/ncb1577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.04.040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045454894"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.01678-08", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046468901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2008.10.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046485773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2777", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047095255", 
              "https://doi.org/10.1038/nrm2777"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2777", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047095255", 
              "https://doi.org/10.1038/nrm2777"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2008.09.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047698038"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1261/rna.1155108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048224171"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pep.2005.03.035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053708620"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi00500a001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055178345"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1154040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062457451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-0-387-77374-2_8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077626947", 
              "https://doi.org/10.1007/978-0-387-77374-2_8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-0-387-77374-2_8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077626947", 
              "https://doi.org/10.1007/978-0-387-77374-2_8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-0-387-77374-2_8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077626947", 
              "https://doi.org/10.1007/978-0-387-77374-2_8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1994.tb06369.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082392304"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083347073", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083366826", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2010-08", 
        "datePublishedReg": "2010-08-01", 
        "description": "The pluripotency-promoting proteins Lin28a and Lin28b act as post-transcriptional repressors of let-7 miRNA biogenesis in undifferentiated embryonic stem cells. The levels of mature let-7a differ substantially in cells lacking Lin28 expression, indicating the existence of additional mechanism(s) of post-transcriptional regulation. Here, we present evidence supporting a role for heteronuclear ribonucleoprotein A1 (hnRNP A1) as a negative regulator of let-7a. HnRNP A1 binds the conserved terminal loop of pri-let-7a-1 and inhibits its processing by Drosha. Levels of mature let-7a negatively correlate with hnRNP A1 levels in somatic cell lines. Furthermore, hnRNP A1 depletion increased pri-let-7a-1 processing by cell extracts, whereas its ectopic expression decreased let-7a production in vivo. Finally, hnRNP A1 binding to let-7a interferes with the binding of KSRP, which is known to promote let-7a biogenesis. We propose that hnRNP A1 and KSRP have antagonistic roles in the post-transcriptional regulation of let-7a expression.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nsmb.1874", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2773448", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3638773", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1295033", 
            "issn": [
              "1545-9993", 
              "2331-365X"
            ], 
            "name": "Nature Structural & Molecular Biology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "8", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "17"
          }
        ], 
        "name": "Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis", 
        "pagination": "1011", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "ccd8ee8a7a5e1812438f504592488dab03879c7ea47a12fade77dca3b928638a"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "20639884"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101186374"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nsmb.1874"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1043004854"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nsmb.1874", 
          "https://app.dimensions.ai/details/publication/pub.1043004854"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T23:13", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000437.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/nsmb.1874"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nsmb.1874'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nsmb.1874'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nsmb.1874'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nsmb.1874'


     

    This table displays all metadata directly associated to this object as RDF triples.

    348 TRIPLES      21 PREDICATES      106 URIs      40 LITERALS      28 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nsmb.1874 schema:about N1178d67522af4ef9a5e39e0b52da3d41
    2 N144529009d2646c698a092d95a5d3eee
    3 N2e6913b0f1184d8f908b0ff00e2f589f
    4 N3b17bb8ac4db47999353cc8f8a0828af
    5 N413de0f12060489c8fccdfd107bf849b
    6 N52cd0dbcfd304ac5aa849f88660c7e28
    7 N69caf1cb9c534e8e8174746f89df7743
    8 N6b4cf6afbb874709b24475042e8285e7
    9 N76ef760e52724a76b7ad3a40f588e9ac
    10 N78a0767e537d4d029dcb44b7cf48d505
    11 N8fb4d744bb6a43c4860b7c3b49181d14
    12 N918194d001f54623a8f10221cdbc82d2
    13 N9f49bc408f8a4260920cc9d376767f63
    14 Na435f3f868b8499a8b35fec4b25b348c
    15 Nc0d4fc3d12db4bb4adb6a72f938920f3
    16 Nc55a7398554f4c0c9348e1fe0db8ea07
    17 Nc5f65ebc2d614f9fb8728da734d8be57
    18 Nda4eb5844b844805a9eaf52937aaafb5
    19 Neb3b3dd9dab04907aa1380a5cf4e3911
    20 anzsrc-for:06
    21 anzsrc-for:0601
    22 schema:author Nf7e6c2b202864d81af1bd270e7373164
    23 schema:citation sg:pub.10.1007/978-0-387-77374-2_8
    24 sg:pub.10.1038/nature03049
    25 sg:pub.10.1038/nature03120
    26 sg:pub.10.1038/nature07086
    27 sg:pub.10.1038/nature08025
    28 sg:pub.10.1038/nature08199
    29 sg:pub.10.1038/ncb0309-228
    30 sg:pub.10.1038/ncb1577
    31 sg:pub.10.1038/ncb1759
    32 sg:pub.10.1038/ng.392
    33 sg:pub.10.1038/ng2003
    34 sg:pub.10.1038/nrg775
    35 sg:pub.10.1038/nrm2632
    36 sg:pub.10.1038/nrm2777
    37 sg:pub.10.1038/nsb0397-215
    38 sg:pub.10.1038/nsmb.1475
    39 sg:pub.10.1038/nsmb.1675
    40 sg:pub.10.1038/nsmb.1676
    41 sg:pub.10.1038/nsmb1250
    42 sg:pub.10.1186/1471-2199-8-28
    43 https://app.dimensions.ai/details/publication/pub.1083347073
    44 https://app.dimensions.ai/details/publication/pub.1083366826
    45 https://doi.org/10.1002/j.1460-2075.1994.tb06369.x
    46 https://doi.org/10.1016/j.cell.2007.04.040
    47 https://doi.org/10.1016/j.cell.2009.01.002
    48 https://doi.org/10.1016/j.cell.2009.08.002
    49 https://doi.org/10.1016/j.cub.2004.11.001
    50 https://doi.org/10.1016/j.jmb.2004.05.021
    51 https://doi.org/10.1016/j.molcel.2008.09.014
    52 https://doi.org/10.1016/j.molcel.2008.10.013
    53 https://doi.org/10.1016/j.molcel.2009.08.017
    54 https://doi.org/10.1016/j.pep.2005.03.035
    55 https://doi.org/10.1016/j.tcb.2008.07.007
    56 https://doi.org/10.1016/j.tibtech.2008.09.006
    57 https://doi.org/10.1016/s0006-291x(03)00554-0
    58 https://doi.org/10.1016/s0022-2836(03)00885-4
    59 https://doi.org/10.1016/s0969-2126(97)00211-6
    60 https://doi.org/10.1021/bi00500a001
    61 https://doi.org/10.1038/sj.emboj.7600491
    62 https://doi.org/10.1038/sj.emboj.7601512
    63 https://doi.org/10.1073/pnas.0712321105
    64 https://doi.org/10.1073/pnas.87.21.8403
    65 https://doi.org/10.1073/pnas.89.3.895
    66 https://doi.org/10.1074/jbc.c800108200
    67 https://doi.org/10.1074/mcp.r800013-mcp200
    68 https://doi.org/10.1083/jcb.138.2.225
    69 https://doi.org/10.1083/jcb.200803111
    70 https://doi.org/10.1093/nar/gkg766
    71 https://doi.org/10.1096/fj.09-131342
    72 https://doi.org/10.1101/gad.11.8.1023
    73 https://doi.org/10.1101/gad.1262504
    74 https://doi.org/10.1101/gad.1444406
    75 https://doi.org/10.1126/science.1154040
    76 https://doi.org/10.1128/mcb.01678-08
    77 https://doi.org/10.1128/mcb.01836-08
    78 https://doi.org/10.1146/annurev.bi.62.070193.001445
    79 https://doi.org/10.1261/rna.1155108
    80 https://doi.org/10.1261/rna.2322506
    81 schema:datePublished 2010-08
    82 schema:datePublishedReg 2010-08-01
    83 schema:description The pluripotency-promoting proteins Lin28a and Lin28b act as post-transcriptional repressors of let-7 miRNA biogenesis in undifferentiated embryonic stem cells. The levels of mature let-7a differ substantially in cells lacking Lin28 expression, indicating the existence of additional mechanism(s) of post-transcriptional regulation. Here, we present evidence supporting a role for heteronuclear ribonucleoprotein A1 (hnRNP A1) as a negative regulator of let-7a. HnRNP A1 binds the conserved terminal loop of pri-let-7a-1 and inhibits its processing by Drosha. Levels of mature let-7a negatively correlate with hnRNP A1 levels in somatic cell lines. Furthermore, hnRNP A1 depletion increased pri-let-7a-1 processing by cell extracts, whereas its ectopic expression decreased let-7a production in vivo. Finally, hnRNP A1 binding to let-7a interferes with the binding of KSRP, which is known to promote let-7a biogenesis. We propose that hnRNP A1 and KSRP have antagonistic roles in the post-transcriptional regulation of let-7a expression.
    84 schema:genre research_article
    85 schema:inLanguage en
    86 schema:isAccessibleForFree true
    87 schema:isPartOf N616f49820be2400581d5e8dfc8c23194
    88 Nea6826d4def646c484d823db1c9cf3c0
    89 sg:journal.1295033
    90 schema:name Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis
    91 schema:pagination 1011
    92 schema:productId N58561b9e39a44f5d8a043a77cb4147d1
    93 N76aa847bed9846a9919903eea39d66ff
    94 Na131f4829c044ab696e974e2041660ec
    95 Nce12ada48a934cc4a8125c46c1ec3c09
    96 Nf948b0114ac1443e8cbc99b8d0465161
    97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043004854
    98 https://doi.org/10.1038/nsmb.1874
    99 schema:sdDatePublished 2019-04-10T23:13
    100 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    101 schema:sdPublisher N6a5af798a46d4bc1a6c24da9572d6f74
    102 schema:url https://www.nature.com/articles/nsmb.1874
    103 sgo:license sg:explorer/license/
    104 sgo:sdDataset articles
    105 rdf:type schema:ScholarlyArticle
    106 N1178d67522af4ef9a5e39e0b52da3d41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Humans
    108 rdf:type schema:DefinedTerm
    109 N144529009d2646c698a092d95a5d3eee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    110 schema:name Ribonuclease III
    111 rdf:type schema:DefinedTerm
    112 N2e6913b0f1184d8f908b0ff00e2f589f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name Green Fluorescent Proteins
    114 rdf:type schema:DefinedTerm
    115 N3b17bb8ac4db47999353cc8f8a0828af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name Binding, Competitive
    117 rdf:type schema:DefinedTerm
    118 N413de0f12060489c8fccdfd107bf849b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name DNA Footprinting
    120 rdf:type schema:DefinedTerm
    121 N52cd0dbcfd304ac5aa849f88660c7e28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name MicroRNAs
    123 rdf:type schema:DefinedTerm
    124 N58561b9e39a44f5d8a043a77cb4147d1 schema:name nlm_unique_id
    125 schema:value 101186374
    126 rdf:type schema:PropertyValue
    127 N59a9fdf8f1044d93b07e093af1caeb76 rdf:first sg:person.01020646115.18
    128 rdf:rest rdf:nil
    129 N616f49820be2400581d5e8dfc8c23194 schema:issueNumber 8
    130 rdf:type schema:PublicationIssue
    131 N69caf1cb9c534e8e8174746f89df7743 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Trans-Activators
    133 rdf:type schema:DefinedTerm
    134 N6a5af798a46d4bc1a6c24da9572d6f74 schema:name Springer Nature - SN SciGraph project
    135 rdf:type schema:Organization
    136 N6b4cf6afbb874709b24475042e8285e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Recombinant Fusion Proteins
    138 rdf:type schema:DefinedTerm
    139 N76aa847bed9846a9919903eea39d66ff schema:name pubmed_id
    140 schema:value 20639884
    141 rdf:type schema:PropertyValue
    142 N76ef760e52724a76b7ad3a40f588e9ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Protein Binding
    144 rdf:type schema:DefinedTerm
    145 N78a0767e537d4d029dcb44b7cf48d505 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Molecular Sequence Data
    147 rdf:type schema:DefinedTerm
    148 N8fb4d744bb6a43c4860b7c3b49181d14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Models, Biological
    150 rdf:type schema:DefinedTerm
    151 N918194d001f54623a8f10221cdbc82d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Base Sequence
    153 rdf:type schema:DefinedTerm
    154 N9f49bc408f8a4260920cc9d376767f63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Gene Expression Regulation, Neoplastic
    156 rdf:type schema:DefinedTerm
    157 Na131f4829c044ab696e974e2041660ec schema:name dimensions_id
    158 schema:value pub.1043004854
    159 rdf:type schema:PropertyValue
    160 Na435f3f868b8499a8b35fec4b25b348c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Heterogeneous-Nuclear Ribonucleoprotein Group A-B
    162 rdf:type schema:DefinedTerm
    163 Nc0d4fc3d12db4bb4adb6a72f938920f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name RNA-Binding Proteins
    165 rdf:type schema:DefinedTerm
    166 Nc55a7398554f4c0c9348e1fe0db8ea07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Nucleic Acid Conformation
    168 rdf:type schema:DefinedTerm
    169 Nc5f65ebc2d614f9fb8728da734d8be57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Heterogeneous Nuclear Ribonucleoprotein A1
    171 rdf:type schema:DefinedTerm
    172 Nce12ada48a934cc4a8125c46c1ec3c09 schema:name readcube_id
    173 schema:value ccd8ee8a7a5e1812438f504592488dab03879c7ea47a12fade77dca3b928638a
    174 rdf:type schema:PropertyValue
    175 Nda4eb5844b844805a9eaf52937aaafb5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Cell Line, Tumor
    177 rdf:type schema:DefinedTerm
    178 Nea6826d4def646c484d823db1c9cf3c0 schema:volumeNumber 17
    179 rdf:type schema:PublicationVolume
    180 Neb3b3dd9dab04907aa1380a5cf4e3911 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name RNA Processing, Post-Transcriptional
    182 rdf:type schema:DefinedTerm
    183 Nf7e6c2b202864d81af1bd270e7373164 rdf:first sg:person.01170674735.26
    184 rdf:rest N59a9fdf8f1044d93b07e093af1caeb76
    185 Nf948b0114ac1443e8cbc99b8d0465161 schema:name doi
    186 schema:value 10.1038/nsmb.1874
    187 rdf:type schema:PropertyValue
    188 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    189 schema:name Biological Sciences
    190 rdf:type schema:DefinedTerm
    191 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    192 schema:name Biochemistry and Cell Biology
    193 rdf:type schema:DefinedTerm
    194 sg:grant.2773448 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.1874
    195 rdf:type schema:MonetaryGrant
    196 sg:grant.3638773 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.1874
    197 rdf:type schema:MonetaryGrant
    198 sg:journal.1295033 schema:issn 1545-9993
    199 2331-365X
    200 schema:name Nature Structural & Molecular Biology
    201 rdf:type schema:Periodical
    202 sg:person.01020646115.18 schema:affiliation https://www.grid.ac/institutes/grid.417068.c
    203 schema:familyName Cáceres
    204 schema:givenName Javier F
    205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020646115.18
    206 rdf:type schema:Person
    207 sg:person.01170674735.26 schema:affiliation https://www.grid.ac/institutes/grid.417068.c
    208 schema:familyName Michlewski
    209 schema:givenName Gracjan
    210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170674735.26
    211 rdf:type schema:Person
    212 sg:pub.10.1007/978-0-387-77374-2_8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077626947
    213 https://doi.org/10.1007/978-0-387-77374-2_8
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1038/nature03049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027442042
    216 https://doi.org/10.1038/nature03049
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1038/nature03120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015411207
    219 https://doi.org/10.1038/nature03120
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1038/nature07086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032756706
    222 https://doi.org/10.1038/nature07086
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1038/nature08025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000219429
    225 https://doi.org/10.1038/nature08025
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1038/nature08199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017973498
    228 https://doi.org/10.1038/nature08199
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1038/ncb0309-228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035086053
    231 https://doi.org/10.1038/ncb0309-228
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1038/ncb1577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044486475
    234 https://doi.org/10.1038/ncb1577
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1038/ncb1759 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028865043
    237 https://doi.org/10.1038/ncb1759
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1038/ng.392 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039771504
    240 https://doi.org/10.1038/ng.392
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/ng2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036221931
    243 https://doi.org/10.1038/ng2003
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/nrg775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011644042
    246 https://doi.org/10.1038/nrg775
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1038/nrm2632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009902558
    249 https://doi.org/10.1038/nrm2632
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1038/nrm2777 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047095255
    252 https://doi.org/10.1038/nrm2777
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1038/nsb0397-215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026316469
    255 https://doi.org/10.1038/nsb0397-215
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1038/nsmb.1475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002708827
    258 https://doi.org/10.1038/nsmb.1475
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1038/nsmb.1675 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007633803
    261 https://doi.org/10.1038/nsmb.1675
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1038/nsmb.1676 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042948549
    264 https://doi.org/10.1038/nsmb.1676
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1038/nsmb1250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023067946
    267 https://doi.org/10.1038/nsmb1250
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1186/1471-2199-8-28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027768228
    270 https://doi.org/10.1186/1471-2199-8-28
    271 rdf:type schema:CreativeWork
    272 https://app.dimensions.ai/details/publication/pub.1083347073 schema:CreativeWork
    273 https://app.dimensions.ai/details/publication/pub.1083366826 schema:CreativeWork
    274 https://doi.org/10.1002/j.1460-2075.1994.tb06369.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082392304
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1016/j.cell.2007.04.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045454894
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1016/j.cell.2009.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023682432
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1016/j.cell.2009.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006762664
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1016/j.cub.2004.11.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030853194
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1016/j.jmb.2004.05.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009536533
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1016/j.molcel.2008.09.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047698038
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1016/j.molcel.2008.10.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046485773
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1016/j.molcel.2009.08.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038253761
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1016/j.pep.2005.03.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053708620
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1016/j.tcb.2008.07.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044009500
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1016/j.tibtech.2008.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019893310
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1016/s0006-291x(03)00554-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012591222
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1016/s0022-2836(03)00885-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034407851
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1016/s0969-2126(97)00211-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032750780
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1021/bi00500a001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055178345
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1038/sj.emboj.7600491 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001286805
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1038/sj.emboj.7601512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039589401
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1073/pnas.0712321105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015424504
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1073/pnas.87.21.8403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038285660
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1073/pnas.89.3.895 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010402343
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1074/jbc.c800108200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001921959
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1074/mcp.r800013-mcp200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033822158
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1083/jcb.138.2.225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033489832
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1083/jcb.200803111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031463074
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1093/nar/gkg766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006802316
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1096/fj.09-131342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012596601
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1101/gad.11.8.1023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041137808
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1101/gad.1262504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042334541
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1101/gad.1444406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025405827
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1126/science.1154040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062457451
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1128/mcb.01678-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046468901
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1128/mcb.01836-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027147468
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1146/annurev.bi.62.070193.001445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013542110
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1261/rna.1155108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048224171
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1261/rna.2322506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036696023
    345 rdf:type schema:CreativeWork
    346 https://www.grid.ac/institutes/grid.417068.c schema:alternateName Western General Hospital
    347 schema:name Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK.
    348 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...