APOBEC3 proteins mediate the clearance of foreign DNA from human cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-01-10

AUTHORS

Mark D Stenglein, Michael B Burns, Ming Li, Joy Lengyel, Reuben S Harris

ABSTRACT

APOBEC3 cytidine deaminases have been implicated in restriction of retroviruses and retrotransposons in mammalian cells. Now human APOBEC3A is shown to be upregulated by interferon and to catalyze the deamination of foreign double-stranded DNA transfected into primary cells or cell lines, with no detectable effect on genomic DNA.

PAGES

222-229

Journal

TITLE

Nature Structural & Molecular Biology

ISSUE

2

VOLUME

17

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsmb.1744

DOI

http://dx.doi.org/10.1038/nsmb.1744

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002558962

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20062055


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