APOBEC3 proteins mediate the clearance of foreign DNA from human cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-02

AUTHORS

Mark D Stenglein, Michael B Burns, Ming Li, Joy Lengyel, Reuben S Harris

ABSTRACT

Bacteria evolved restriction endonucleases to prevent interspecies DNA transmission and bacteriophage infection. Here we show that human cells possess an analogous mechanism. APOBEC3A is induced by interferon following DNA detection, and it deaminates foreign double-stranded DNA cytidines to uridines. These atypical DNA nucleosides are converted by the uracil DNA glycosylase UNG2 to abasic lesions, which lead to foreign DNA degradation. This mechanism is evident in cell lines and primary monocytes, where up to 97% of cytidines in foreign DNA are deaminated. In contrast, cellular genomic DNA appears unaffected. Several other APOBEC3s also restrict foreign gene transfer. Related proteins exist in all vertebrates, indicating that foreign DNA restriction may be a conserved innate immune defense mechanism. The efficiency and fidelity of genetic engineering, gene therapy, and DNA vaccination are likely to be influenced by this anti-DNA defense system. More... »

PAGES

222

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsmb.1744

DOI

http://dx.doi.org/10.1038/nsmb.1744

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002558962

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20062055


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytidine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytidine Deaminase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Glycosylases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA, Bacterial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA, Viral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Deamination", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transfection", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Uridine", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Minnesota", 
          "id": "https://www.grid.ac/institutes/grid.17635.36", 
          "name": [
            "Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stenglein", 
        "givenName": "Mark D", 
        "id": "sg:person.0767635447.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767635447.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Minnesota", 
          "id": "https://www.grid.ac/institutes/grid.17635.36", 
          "name": [
            "Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Burns", 
        "givenName": "Michael B", 
        "id": "sg:person.0640116270.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640116270.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Minnesota", 
          "id": "https://www.grid.ac/institutes/grid.17635.36", 
          "name": [
            "Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Ming", 
        "id": "sg:person.011020612177.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011020612177.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Minnesota", 
          "id": "https://www.grid.ac/institutes/grid.17635.36", 
          "name": [
            "Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lengyel", 
        "givenName": "Joy", 
        "id": "sg:person.01251301004.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251301004.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Minnesota", 
          "id": "https://www.grid.ac/institutes/grid.17635.36", 
          "name": [
            "Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harris", 
        "givenName": "Reuben S", 
        "id": "sg:person.07542533532.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07542533532.03"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/264477a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000145825", 
          "https://doi.org/10.1038/264477a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1169841", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000674389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-2776(06)94002-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000744668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07710", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000921496", 
          "https://doi.org/10.1038/nature07710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.it.2006.09.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000948588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(90)90374-n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001573989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2009.06.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001580370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2006.01.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001980938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(88)90253-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004163084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004311589", 
          "https://doi.org/10.1038/nature06246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.01089-09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004445400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0603313103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007050514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/vir.0.80426-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008503228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/268540a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009521163", 
          "https://doi.org/10.1038/268540a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/geno.2002.6718", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011191861"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature00981", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012417517", 
          "https://doi.org/10.1038/nature00981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature00981", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012417517", 
          "https://doi.org/10.1038/nature00981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20051512", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016822267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chom.2008.04.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019738927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2199-9-104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020631443", 
          "https://doi.org/10.1186/1471-2199-9-104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0004277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021821176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkj416", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021926740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1282", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022597660", 
          "https://doi.org/10.1038/ni1282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1282", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022597660", 
          "https://doi.org/10.1038/ni1282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0408223102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023631355"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0408223102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023631355"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023911990", 
          "https://doi.org/10.1038/nature07725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m706436200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023970523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri2314", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024668704", 
          "https://doi.org/10.1038/nri2314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80436-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025106858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2006-10-051763", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025327903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.06.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028609753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2004.06.050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029556541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coi.2006.01.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029586249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2005.12.192", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031081914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.biochem.76.061705.090740", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033286055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033292640", 
          "https://doi.org/10.1038/nature06013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.21187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034909568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(02)00742-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034916943"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2005.12.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038266827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1000439", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039428425"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chom.2008.03.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039952632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0604524103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042212435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m601716200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044087562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/molbev/msi026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044612085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dnarep.2006.10.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044667234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.r700009200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044883374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0076-6879(08)01414-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045055325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.immunol.26.021607.090350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045653508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.8.3.175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048253030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.1702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048985233", 
          "https://doi.org/10.1038/ni.1702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06553", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050660540", 
          "https://doi.org/10.1038/nature06553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2004.06.057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051940871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20051654", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052075727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/vir.0.83530-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060401722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1153201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062457319"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-02", 
    "datePublishedReg": "2010-02-01", 
    "description": "Bacteria evolved restriction endonucleases to prevent interspecies DNA transmission and bacteriophage infection. Here we show that human cells possess an analogous mechanism. APOBEC3A is induced by interferon following DNA detection, and it deaminates foreign double-stranded DNA cytidines to uridines. These atypical DNA nucleosides are converted by the uracil DNA glycosylase UNG2 to abasic lesions, which lead to foreign DNA degradation. This mechanism is evident in cell lines and primary monocytes, where up to 97% of cytidines in foreign DNA are deaminated. In contrast, cellular genomic DNA appears unaffected. Several other APOBEC3s also restrict foreign gene transfer. Related proteins exist in all vertebrates, indicating that foreign DNA restriction may be a conserved innate immune defense mechanism. The efficiency and fidelity of genetic engineering, gene therapy, and DNA vaccination are likely to be influenced by this anti-DNA defense system.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nsmb.1744", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2383033", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2519519", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4730000", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2682478", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2457053", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2666060", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1295033", 
        "issn": [
          "1545-9993", 
          "2331-365X"
        ], 
        "name": "Nature Structural & Molecular Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "name": "APOBEC3 proteins mediate the clearance of foreign DNA from human cells", 
    "pagination": "222", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "0c2f12a28ebd0cd6c148a63c76793c7bf3776900858d8f0184e66513721b1f65"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20062055"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101186374"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nsmb.1744"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1002558962"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nsmb.1744", 
      "https://app.dimensions.ai/details/publication/pub.1002558962"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:48", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89785_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nsmb.1744"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nsmb.1744'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nsmb.1744'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nsmb.1744'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nsmb.1744'


 

This table displays all metadata directly associated to this object as RDF triples.

336 TRIPLES      21 PREDICATES      96 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nsmb.1744 schema:about N00802c1ac7a74f78b9ccc47b78e12900
2 N0c626f05177f40fabf87deeb16753325
3 N25d7bcfa1bb540dfb87a3aa74b75e811
4 N3a2209636cfb4bb0acd955e69ae7cae1
5 N5fe068fc743c4edeb6804ed6fd9b4c9c
6 N69e09255553940d5a444a9ebbfe87c0f
7 N6f5dfe67851448589f5994e13ced56c9
8 N753b9c5b4af44bcdb882642f95f8ba41
9 N7d42b15280b446dea472563de84ea32d
10 N84fdcc1a17984f50be6f4b5c4fd76381
11 N8a0741fe4da4424996a7f87d3ceb22f2
12 Nc444901458644f4db125d19fa0631c0c
13 Ncdf0e54454764d79abfadc51ae9172a7
14 Ne2d4ea5ffd2546519b5ca9feaa8f4c91
15 anzsrc-for:11
16 anzsrc-for:1107
17 schema:author N9f339f4b51a64d448e0501f7f47bd943
18 schema:citation sg:pub.10.1038/264477a0
19 sg:pub.10.1038/268540a0
20 sg:pub.10.1038/nature00981
21 sg:pub.10.1038/nature06013
22 sg:pub.10.1038/nature06246
23 sg:pub.10.1038/nature06553
24 sg:pub.10.1038/nature07710
25 sg:pub.10.1038/nature07725
26 sg:pub.10.1038/ni.1702
27 sg:pub.10.1038/ni1282
28 sg:pub.10.1038/nri2314
29 sg:pub.10.1186/1471-2199-9-104
30 https://doi.org/10.1002/hep.21187
31 https://doi.org/10.1006/geno.2002.6718
32 https://doi.org/10.1016/0092-8674(88)90253-x
33 https://doi.org/10.1016/0092-8674(90)90374-n
34 https://doi.org/10.1016/j.bbrc.2005.12.192
35 https://doi.org/10.1016/j.cell.2008.06.032
36 https://doi.org/10.1016/j.cell.2009.06.015
37 https://doi.org/10.1016/j.chom.2008.03.001
38 https://doi.org/10.1016/j.chom.2008.04.008
39 https://doi.org/10.1016/j.coi.2006.01.008
40 https://doi.org/10.1016/j.cub.2004.06.050
41 https://doi.org/10.1016/j.cub.2004.06.057
42 https://doi.org/10.1016/j.cub.2006.01.031
43 https://doi.org/10.1016/j.dnarep.2006.10.014
44 https://doi.org/10.1016/j.immuni.2005.12.003
45 https://doi.org/10.1016/j.it.2006.09.002
46 https://doi.org/10.1016/s0065-2776(06)94002-4
47 https://doi.org/10.1016/s0076-6879(08)01414-6
48 https://doi.org/10.1016/s0092-8674(00)80436-5
49 https://doi.org/10.1016/s1097-2765(02)00742-6
50 https://doi.org/10.1073/pnas.0408223102
51 https://doi.org/10.1073/pnas.0603313103
52 https://doi.org/10.1073/pnas.0604524103
53 https://doi.org/10.1074/jbc.m601716200
54 https://doi.org/10.1074/jbc.m706436200
55 https://doi.org/10.1074/jbc.r700009200
56 https://doi.org/10.1084/jem.20051512
57 https://doi.org/10.1084/jem.20051654
58 https://doi.org/10.1093/molbev/msi026
59 https://doi.org/10.1093/nar/gkj416
60 https://doi.org/10.1099/vir.0.80426-0
61 https://doi.org/10.1099/vir.0.83530-0
62 https://doi.org/10.1101/gr.8.3.175
63 https://doi.org/10.1126/science.1153201
64 https://doi.org/10.1126/science.1169841
65 https://doi.org/10.1128/jvi.01089-09
66 https://doi.org/10.1146/annurev.biochem.76.061705.090740
67 https://doi.org/10.1146/annurev.immunol.26.021607.090350
68 https://doi.org/10.1182/blood-2006-10-051763
69 https://doi.org/10.1371/journal.pone.0004277
70 https://doi.org/10.1371/journal.ppat.1000439
71 schema:datePublished 2010-02
72 schema:datePublishedReg 2010-02-01
73 schema:description Bacteria evolved restriction endonucleases to prevent interspecies DNA transmission and bacteriophage infection. Here we show that human cells possess an analogous mechanism. APOBEC3A is induced by interferon following DNA detection, and it deaminates foreign double-stranded DNA cytidines to uridines. These atypical DNA nucleosides are converted by the uracil DNA glycosylase UNG2 to abasic lesions, which lead to foreign DNA degradation. This mechanism is evident in cell lines and primary monocytes, where up to 97% of cytidines in foreign DNA are deaminated. In contrast, cellular genomic DNA appears unaffected. Several other APOBEC3s also restrict foreign gene transfer. Related proteins exist in all vertebrates, indicating that foreign DNA restriction may be a conserved innate immune defense mechanism. The efficiency and fidelity of genetic engineering, gene therapy, and DNA vaccination are likely to be influenced by this anti-DNA defense system.
74 schema:genre research_article
75 schema:inLanguage en
76 schema:isAccessibleForFree true
77 schema:isPartOf N04811611c01643b28205b81206836def
78 Nf60bb9f89f394f0f9557d9555c832321
79 sg:journal.1295033
80 schema:name APOBEC3 proteins mediate the clearance of foreign DNA from human cells
81 schema:pagination 222
82 schema:productId N2bb3dae8e1fd49cb949a11acbaa8bd81
83 N389cd9c9ada34e47b072a0e41b700d2e
84 N4da4d60dd36b4d28b2369698e43f431d
85 N5e537fd00bdf4926ba3130117c2ab5cf
86 N9d49fe64096e46d098d974d732fc3b42
87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002558962
88 https://doi.org/10.1038/nsmb.1744
89 schema:sdDatePublished 2019-04-11T09:48
90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
91 schema:sdPublisher N0aacc4c688b643b9a80a44182e431f1b
92 schema:url https://www.nature.com/articles/nsmb.1744
93 sgo:license sg:explorer/license/
94 sgo:sdDataset articles
95 rdf:type schema:ScholarlyArticle
96 N00802c1ac7a74f78b9ccc47b78e12900 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Cytidine
98 rdf:type schema:DefinedTerm
99 N04811611c01643b28205b81206836def schema:issueNumber 2
100 rdf:type schema:PublicationIssue
101 N0aacc4c688b643b9a80a44182e431f1b schema:name Springer Nature - SN SciGraph project
102 rdf:type schema:Organization
103 N0c626f05177f40fabf87deeb16753325 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Uridine
105 rdf:type schema:DefinedTerm
106 N25d7bcfa1bb540dfb87a3aa74b75e811 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Deamination
108 rdf:type schema:DefinedTerm
109 N2bb3dae8e1fd49cb949a11acbaa8bd81 schema:name pubmed_id
110 schema:value 20062055
111 rdf:type schema:PropertyValue
112 N389cd9c9ada34e47b072a0e41b700d2e schema:name doi
113 schema:value 10.1038/nsmb.1744
114 rdf:type schema:PropertyValue
115 N3a2209636cfb4bb0acd955e69ae7cae1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name DNA
117 rdf:type schema:DefinedTerm
118 N4da4d60dd36b4d28b2369698e43f431d schema:name readcube_id
119 schema:value 0c2f12a28ebd0cd6c148a63c76793c7bf3776900858d8f0184e66513721b1f65
120 rdf:type schema:PropertyValue
121 N5559ec28c93d47cbb9dcbf3f357a8a66 rdf:first sg:person.011020612177.23
122 rdf:rest N6c3e191bd5ad401885eff85b6d723892
123 N5e537fd00bdf4926ba3130117c2ab5cf schema:name dimensions_id
124 schema:value pub.1002558962
125 rdf:type schema:PropertyValue
126 N5fe068fc743c4edeb6804ed6fd9b4c9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Cells, Cultured
128 rdf:type schema:DefinedTerm
129 N69e09255553940d5a444a9ebbfe87c0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name DNA, Bacterial
131 rdf:type schema:DefinedTerm
132 N6c3e191bd5ad401885eff85b6d723892 rdf:first sg:person.01251301004.09
133 rdf:rest Na3f97fb98d96497ab95dbbd8a0c959e5
134 N6f5dfe67851448589f5994e13ced56c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Humans
136 rdf:type schema:DefinedTerm
137 N753b9c5b4af44bcdb882642f95f8ba41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name DNA Glycosylases
139 rdf:type schema:DefinedTerm
140 N7a1f06472451435089e954f69ceaaa45 rdf:first sg:person.0640116270.07
141 rdf:rest N5559ec28c93d47cbb9dcbf3f357a8a66
142 N7d42b15280b446dea472563de84ea32d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name DNA, Viral
144 rdf:type schema:DefinedTerm
145 N84fdcc1a17984f50be6f4b5c4fd76381 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Interferons
147 rdf:type schema:DefinedTerm
148 N8a0741fe4da4424996a7f87d3ceb22f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Cytidine Deaminase
150 rdf:type schema:DefinedTerm
151 N9d49fe64096e46d098d974d732fc3b42 schema:name nlm_unique_id
152 schema:value 101186374
153 rdf:type schema:PropertyValue
154 N9f339f4b51a64d448e0501f7f47bd943 rdf:first sg:person.0767635447.73
155 rdf:rest N7a1f06472451435089e954f69ceaaa45
156 Na3f97fb98d96497ab95dbbd8a0c959e5 rdf:first sg:person.07542533532.03
157 rdf:rest rdf:nil
158 Nc444901458644f4db125d19fa0631c0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Cell Line
160 rdf:type schema:DefinedTerm
161 Ncdf0e54454764d79abfadc51ae9172a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Transfection
163 rdf:type schema:DefinedTerm
164 Ne2d4ea5ffd2546519b5ca9feaa8f4c91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Proteins
166 rdf:type schema:DefinedTerm
167 Nf60bb9f89f394f0f9557d9555c832321 schema:volumeNumber 17
168 rdf:type schema:PublicationVolume
169 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
170 schema:name Medical and Health Sciences
171 rdf:type schema:DefinedTerm
172 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
173 schema:name Immunology
174 rdf:type schema:DefinedTerm
175 sg:grant.2383033 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.1744
176 rdf:type schema:MonetaryGrant
177 sg:grant.2457053 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.1744
178 rdf:type schema:MonetaryGrant
179 sg:grant.2519519 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.1744
180 rdf:type schema:MonetaryGrant
181 sg:grant.2666060 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.1744
182 rdf:type schema:MonetaryGrant
183 sg:grant.2682478 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.1744
184 rdf:type schema:MonetaryGrant
185 sg:grant.4730000 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.1744
186 rdf:type schema:MonetaryGrant
187 sg:journal.1295033 schema:issn 1545-9993
188 2331-365X
189 schema:name Nature Structural & Molecular Biology
190 rdf:type schema:Periodical
191 sg:person.011020612177.23 schema:affiliation https://www.grid.ac/institutes/grid.17635.36
192 schema:familyName Li
193 schema:givenName Ming
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011020612177.23
195 rdf:type schema:Person
196 sg:person.01251301004.09 schema:affiliation https://www.grid.ac/institutes/grid.17635.36
197 schema:familyName Lengyel
198 schema:givenName Joy
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251301004.09
200 rdf:type schema:Person
201 sg:person.0640116270.07 schema:affiliation https://www.grid.ac/institutes/grid.17635.36
202 schema:familyName Burns
203 schema:givenName Michael B
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640116270.07
205 rdf:type schema:Person
206 sg:person.07542533532.03 schema:affiliation https://www.grid.ac/institutes/grid.17635.36
207 schema:familyName Harris
208 schema:givenName Reuben S
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07542533532.03
210 rdf:type schema:Person
211 sg:person.0767635447.73 schema:affiliation https://www.grid.ac/institutes/grid.17635.36
212 schema:familyName Stenglein
213 schema:givenName Mark D
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767635447.73
215 rdf:type schema:Person
216 sg:pub.10.1038/264477a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000145825
217 https://doi.org/10.1038/264477a0
218 rdf:type schema:CreativeWork
219 sg:pub.10.1038/268540a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009521163
220 https://doi.org/10.1038/268540a0
221 rdf:type schema:CreativeWork
222 sg:pub.10.1038/nature00981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012417517
223 https://doi.org/10.1038/nature00981
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/nature06013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033292640
226 https://doi.org/10.1038/nature06013
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/nature06246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004311589
229 https://doi.org/10.1038/nature06246
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/nature06553 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050660540
232 https://doi.org/10.1038/nature06553
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/nature07710 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000921496
235 https://doi.org/10.1038/nature07710
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/nature07725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023911990
238 https://doi.org/10.1038/nature07725
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/ni.1702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048985233
241 https://doi.org/10.1038/ni.1702
242 rdf:type schema:CreativeWork
243 sg:pub.10.1038/ni1282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022597660
244 https://doi.org/10.1038/ni1282
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/nri2314 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024668704
247 https://doi.org/10.1038/nri2314
248 rdf:type schema:CreativeWork
249 sg:pub.10.1186/1471-2199-9-104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020631443
250 https://doi.org/10.1186/1471-2199-9-104
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1002/hep.21187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034909568
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1006/geno.2002.6718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011191861
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/0092-8674(88)90253-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004163084
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/0092-8674(90)90374-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1001573989
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/j.bbrc.2005.12.192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031081914
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/j.cell.2008.06.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028609753
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/j.cell.2009.06.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001580370
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/j.chom.2008.03.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039952632
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/j.chom.2008.04.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019738927
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/j.coi.2006.01.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029586249
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/j.cub.2004.06.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029556541
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/j.cub.2004.06.057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051940871
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/j.cub.2006.01.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001980938
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/j.dnarep.2006.10.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044667234
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/j.immuni.2005.12.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038266827
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/j.it.2006.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000948588
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/s0065-2776(06)94002-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000744668
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/s0076-6879(08)01414-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045055325
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/s0092-8674(00)80436-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025106858
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/s1097-2765(02)00742-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034916943
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1073/pnas.0408223102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023631355
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1073/pnas.0603313103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007050514
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1073/pnas.0604524103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042212435
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1074/jbc.m601716200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044087562
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1074/jbc.m706436200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023970523
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1074/jbc.r700009200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044883374
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1084/jem.20051512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016822267
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1084/jem.20051654 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052075727
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1093/molbev/msi026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044612085
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1093/nar/gkj416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021926740
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1099/vir.0.80426-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008503228
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1099/vir.0.83530-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060401722
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1101/gr.8.3.175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048253030
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1126/science.1153201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062457319
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1126/science.1169841 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000674389
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1128/jvi.01089-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004445400
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1146/annurev.biochem.76.061705.090740 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033286055
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1146/annurev.immunol.26.021607.090350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045653508
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1182/blood-2006-10-051763 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025327903
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1371/journal.pone.0004277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021821176
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1371/journal.ppat.1000439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039428425
333 rdf:type schema:CreativeWork
334 https://www.grid.ac/institutes/grid.17635.36 schema:alternateName University of Minnesota
335 schema:name Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, USA.
336 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...