Drosophila MSL complex globally acetylates H4K16 on the male X chromosome for dosage compensation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-08

AUTHORS

Marnie E Gelbart, Erica Larschan, Shouyong Peng, Peter J Park, Mitzi I Kuroda

ABSTRACT

The Drosophila melanogaster male-specific lethal (MSL) complex binds the single male X chromosome to upregulate gene expression to equal that from the two female X chromosomes. However, it has been puzzling that approximately 25% of transcribed genes on the X chromosome do not stably recruit MSL complex. Here we find that almost all active genes on the X chromosome are associated with robust H4 Lys16 acetylation (H4K16ac), the histone modification catalyzed by the MSL complex. The distribution of H4K16ac is much broader than that of the MSL complex, and our results favor the idea that chromosome-wide H4K16ac reflects transient association of the MSL complex, occurring through spreading or chromosomal looping. Our results parallel those of localized Polycomb repressive complex and its more broadly distributed chromatin mark, trimethylated histone H3 Lys27 (H3K27me3), suggesting a common principle for the establishment of active and silenced chromatin domains. More... »

PAGES

825-832

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsmb.1644

DOI

http://dx.doi.org/10.1038/nsmb.1644

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044654423

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19648925


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acetylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blotting, Western", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromatin Immunoprecipitation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dosage Compensation, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drosophila Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drosophila melanogaster", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histone Acetyltransferases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histones", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lysine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA Interference", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "X Chromosome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Division of Genetics, Department of Medicine, Brigham & Women's Hospital, Boston, Massachusetts, USA.", 
            "Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gelbart", 
        "givenName": "Marnie E", 
        "id": "sg:person.0604164204.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604164204.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Division of Genetics, Department of Medicine, Brigham & Women's Hospital, Boston, Massachusetts, USA.", 
            "Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Larschan", 
        "givenName": "Erica", 
        "id": "sg:person.0632310457.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632310457.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Boston Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.2515.3", 
          "name": [
            "Division of Genetics, Department of Medicine, Brigham & Women's Hospital, Boston, Massachusetts, USA.", 
            "Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.", 
            "Children's Hospital Informatics Program, Children's Hospital, Boston, Massachusetts, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peng", 
        "givenName": "Shouyong", 
        "id": "sg:person.01176656634.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176656634.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Boston Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.2515.3", 
          "name": [
            "Division of Genetics, Department of Medicine, Brigham & Women's Hospital, Boston, Massachusetts, USA.", 
            "Children's Hospital Informatics Program, Children's Hospital, Boston, Massachusetts, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Peter J", 
        "id": "sg:person.01024612701.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024612701.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Division of Genetics, Department of Medicine, Brigham & Women's Hospital, Boston, Massachusetts, USA.", 
            "Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuroda", 
        "givenName": "Mitzi I", 
        "id": "sg:person.01347452651.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347452651.31"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1128/mcb.25.15.6798-6810.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001631293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.06.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002951913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.511809", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004061649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m605430200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005122972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005233052", 
          "https://doi.org/10.1038/ng1017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005233052", 
          "https://doi.org/10.1038/ng1017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.02623", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005247942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(00)80430-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005265921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.00006-08", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005718402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/jbiol30", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006105526", 
          "https://doi.org/10.1186/jbiol30"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.02202-07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007667192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(00)80431-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008121454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/30.3.649", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010829026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.0050232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011415110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.8.6.698", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016653064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018442414", 
          "https://doi.org/10.1038/ng.154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00412-005-0020-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022054032", 
          "https://doi.org/10.1007/s00412-005-0020-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00412-005-0020-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022054032", 
          "https://doi.org/10.1007/s00412-005-0020-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/16.8.2054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022855253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2007.08.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024374939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1343705", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024407499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0701538104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025320222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1637", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025423233", 
          "https://doi.org/10.1038/ng1637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1637", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025423233", 
          "https://doi.org/10.1038/ng1637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7601926", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025559718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1817", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026324467", 
          "https://doi.org/10.1038/ng1817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1817", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026324467", 
          "https://doi.org/10.1038/ng1817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2006.11.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026358458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.388706", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026603580"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1399406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026982051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1124000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027661592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1400206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029012312"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1332749100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032155515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.029645", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032682420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-08-0141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034301867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.c100351200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034846799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.04.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035035282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1520-6408(1998)22:1<56::aid-dvg6>3.0.co;2-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035152458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10577-006-1066-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035168731", 
          "https://doi.org/10.1007/s10577-006-1066-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10577-006-1066-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035168731", 
          "https://doi.org/10.1007/s10577-006-1066-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.25.21.9175-9188.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036493072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.1520", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036614550", 
          "https://doi.org/10.1038/nsmb.1520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1082003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037805613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-8-219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038111013", 
          "https://doi.org/10.1186/1471-2105-8-219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.377506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038783857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.01045-07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040981978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2006.02.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041921660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0500136102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042534004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.25.12.5292-5305.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043836564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.3198905", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043935365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1000302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044428545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.20.1.312-318.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044800469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2008.04.050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044949865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(92)90417-b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047731096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/embo-reports/kvf056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048697087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.0030328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049469158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.0030328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049469158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(01)00325-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049750088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.01230-07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050094766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng993", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050594107", 
          "https://doi.org/10.1038/ng993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng993", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050594107", 
          "https://doi.org/10.1038/ng993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.8.1.96", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051785317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.04.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052072342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/19.19.5202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053441354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.6.6.4013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072299323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074365940", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083188227", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-08", 
    "datePublishedReg": "2009-08-01", 
    "description": "The Drosophila melanogaster male-specific lethal (MSL) complex binds the single male X chromosome to upregulate gene expression to equal that from the two female X chromosomes. However, it has been puzzling that approximately 25% of transcribed genes on the X chromosome do not stably recruit MSL complex. Here we find that almost all active genes on the X chromosome are associated with robust H4 Lys16 acetylation (H4K16ac), the histone modification catalyzed by the MSL complex. The distribution of H4K16ac is much broader than that of the MSL complex, and our results favor the idea that chromosome-wide H4K16ac reflects transient association of the MSL complex, occurring through spreading or chromosomal looping. Our results parallel those of localized Polycomb repressive complex and its more broadly distributed chromatin mark, trimethylated histone H3 Lys27 (H3K27me3), suggesting a common principle for the establishment of active and silenced chromatin domains.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nsmb.1644", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2421559", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2635302", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7745289", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2513449", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2519756", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1295033", 
        "issn": [
          "1545-9993", 
          "2331-365X"
        ], 
        "name": "Nature Structural & Molecular Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "16"
      }
    ], 
    "name": "Drosophila MSL complex globally acetylates H4K16 on the male X chromosome for dosage compensation", 
    "pagination": "825-832", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d4b4b63db029185e661fb74284e7078b391fd3ed55bc5382eaa101b1caed11ee"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19648925"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101186374"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nsmb.1644"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1044654423"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nsmb.1644", 
      "https://app.dimensions.ai/details/publication/pub.1044654423"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:22", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000345_0000000345/records_64081_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/nsmb.1644"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nsmb.1644'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nsmb.1644'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nsmb.1644'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nsmb.1644'


 

This table displays all metadata directly associated to this object as RDF triples.

369 TRIPLES      21 PREDICATES      106 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nsmb.1644 schema:about N0fe8a7bb1f064955ae32b2cda9631e42
2 N1af9a9b76cfc4eeeac9f54ae1be4efd5
3 N3cae0b761230471eb12d926384e69bc7
4 N6d638a6d8d104921b2ca4a870502f760
5 N777fd4a380d446f7bddbffd4a3ffcaef
6 N7f044bacd95947faa9710722a31f7e38
7 N80ff86294f6d4c01b6cc427d88704b83
8 N83177123878349f9970ca488c79c9699
9 N8a01f9435c9e44cbbbe70410b6582603
10 N9b25fea3f3ba44ecab9dfefdd02e951d
11 N9f1c42baed1841538090b4a8bb1e5bec
12 Na3b156512f4a4f868268b0257387bdcb
13 Nad08cceb93c642dda5ac102345e1da54
14 Nbe7d846ba26c4e5ea65f3c910937dcb0
15 Ncbf6ef1b2a024883aa291d9c7cdbbf38
16 Ne05cd8a2dbe84346a626255b2c969e76
17 Nf488c747c6564b1791aa9f0ef8493f38
18 anzsrc-for:06
19 anzsrc-for:0604
20 schema:author Ned40c658e812467b8ac207a205c0a4c8
21 schema:citation sg:pub.10.1007/s00412-005-0020-x
22 sg:pub.10.1007/s10577-006-1066-1
23 sg:pub.10.1038/ng.154
24 sg:pub.10.1038/ng1017
25 sg:pub.10.1038/ng1637
26 sg:pub.10.1038/ng1817
27 sg:pub.10.1038/ng993
28 sg:pub.10.1038/nsmb.1520
29 sg:pub.10.1186/1471-2105-8-219
30 sg:pub.10.1186/jbiol30
31 https://app.dimensions.ai/details/publication/pub.1074365940
32 https://app.dimensions.ai/details/publication/pub.1083188227
33 https://doi.org/10.1002/(sici)1520-6408(1998)22:1<56::aid-dvg6>3.0.co;2-6
34 https://doi.org/10.1016/0092-8674(92)90417-b
35 https://doi.org/10.1016/j.cell.2005.04.031
36 https://doi.org/10.1016/j.cell.2008.04.036
37 https://doi.org/10.1016/j.cell.2008.06.033
38 https://doi.org/10.1016/j.jmb.2008.04.050
39 https://doi.org/10.1016/j.molcel.2006.02.007
40 https://doi.org/10.1016/j.molcel.2006.11.026
41 https://doi.org/10.1016/j.molcel.2007.08.011
42 https://doi.org/10.1016/s0092-8674(01)00325-7
43 https://doi.org/10.1016/s1097-2765(00)80430-x
44 https://doi.org/10.1016/s1097-2765(00)80431-1
45 https://doi.org/10.1038/sj.emboj.7601926
46 https://doi.org/10.1073/pnas.0500136102
47 https://doi.org/10.1073/pnas.0701538104
48 https://doi.org/10.1073/pnas.1332749100
49 https://doi.org/10.1074/jbc.c100351200
50 https://doi.org/10.1074/jbc.m605430200
51 https://doi.org/10.1093/embo-reports/kvf056
52 https://doi.org/10.1093/emboj/16.8.2054
53 https://doi.org/10.1093/emboj/19.19.5202
54 https://doi.org/10.1093/nar/30.3.649
55 https://doi.org/10.1101/gad.1082003
56 https://doi.org/10.1101/gad.1343705
57 https://doi.org/10.1101/gad.1399406
58 https://doi.org/10.1101/gad.1400206
59 https://doi.org/10.1101/gad.377506
60 https://doi.org/10.1101/gad.388706
61 https://doi.org/10.1101/gad.511809
62 https://doi.org/10.1101/gad.8.1.96
63 https://doi.org/10.1101/gad.8.6.698
64 https://doi.org/10.1101/gr.3198905
65 https://doi.org/10.1126/science.1124000
66 https://doi.org/10.1128/mcb.00006-08
67 https://doi.org/10.1128/mcb.01045-07
68 https://doi.org/10.1128/mcb.01230-07
69 https://doi.org/10.1128/mcb.02202-07
70 https://doi.org/10.1128/mcb.20.1.312-318.2000
71 https://doi.org/10.1128/mcb.25.12.5292-5305.2005
72 https://doi.org/10.1128/mcb.25.15.6798-6810.2005
73 https://doi.org/10.1128/mcb.25.21.9175-9188.2005
74 https://doi.org/10.1158/0008-5472.can-08-0141
75 https://doi.org/10.1242/dev.029645
76 https://doi.org/10.1242/jcs.02623
77 https://doi.org/10.1371/journal.pbio.0030328
78 https://doi.org/10.1371/journal.pbio.0050232
79 https://doi.org/10.1371/journal.pgen.1000302
80 https://doi.org/10.4161/cc.6.6.4013
81 schema:datePublished 2009-08
82 schema:datePublishedReg 2009-08-01
83 schema:description The Drosophila melanogaster male-specific lethal (MSL) complex binds the single male X chromosome to upregulate gene expression to equal that from the two female X chromosomes. However, it has been puzzling that approximately 25% of transcribed genes on the X chromosome do not stably recruit MSL complex. Here we find that almost all active genes on the X chromosome are associated with robust H4 Lys16 acetylation (H4K16ac), the histone modification catalyzed by the MSL complex. The distribution of H4K16ac is much broader than that of the MSL complex, and our results favor the idea that chromosome-wide H4K16ac reflects transient association of the MSL complex, occurring through spreading or chromosomal looping. Our results parallel those of localized Polycomb repressive complex and its more broadly distributed chromatin mark, trimethylated histone H3 Lys27 (H3K27me3), suggesting a common principle for the establishment of active and silenced chromatin domains.
84 schema:genre research_article
85 schema:inLanguage en
86 schema:isAccessibleForFree true
87 schema:isPartOf N5a7db88c0e6c463481b32b7b968d473c
88 Nc923b783325a4c19b7c158d3c89a4c37
89 sg:journal.1295033
90 schema:name Drosophila MSL complex globally acetylates H4K16 on the male X chromosome for dosage compensation
91 schema:pagination 825-832
92 schema:productId N1e9b9a5db7db4e63b8cffa26375838fa
93 N6c93bbd449e7457792d22364b32ddb72
94 N72182691ce5b40809b2985e73f95cd97
95 N9a106187389447b08119a6638f575e8d
96 Nac30c2464dc84bc785053269d7ad2506
97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044654423
98 https://doi.org/10.1038/nsmb.1644
99 schema:sdDatePublished 2019-04-11T09:22
100 schema:sdLicense https://scigraph.springernature.com/explorer/license/
101 schema:sdPublisher N98af2905b293491394afd2e98463e489
102 schema:url http://www.nature.com/articles/nsmb.1644
103 sgo:license sg:explorer/license/
104 sgo:sdDataset articles
105 rdf:type schema:ScholarlyArticle
106 N0dba583ac4b048168176888d364d8d93 rdf:first sg:person.0632310457.53
107 rdf:rest Ncd49652fdc74416193f7cf10dd638603
108 N0fe8a7bb1f064955ae32b2cda9631e42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Drosophila Proteins
110 rdf:type schema:DefinedTerm
111 N1af9a9b76cfc4eeeac9f54ae1be4efd5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Lysine
113 rdf:type schema:DefinedTerm
114 N1e9b9a5db7db4e63b8cffa26375838fa schema:name doi
115 schema:value 10.1038/nsmb.1644
116 rdf:type schema:PropertyValue
117 N3cae0b761230471eb12d926384e69bc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Chromatin Immunoprecipitation
119 rdf:type schema:DefinedTerm
120 N508fa0debdab4b6cb284f6b4bbac0b1b rdf:first sg:person.01024612701.33
121 rdf:rest Nbe4ed0f4703049c3a6e1884e619f144a
122 N5a7db88c0e6c463481b32b7b968d473c schema:issueNumber 8
123 rdf:type schema:PublicationIssue
124 N6c93bbd449e7457792d22364b32ddb72 schema:name dimensions_id
125 schema:value pub.1044654423
126 rdf:type schema:PropertyValue
127 N6d638a6d8d104921b2ca4a870502f760 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name RNA Interference
129 rdf:type schema:DefinedTerm
130 N72182691ce5b40809b2985e73f95cd97 schema:name nlm_unique_id
131 schema:value 101186374
132 rdf:type schema:PropertyValue
133 N777fd4a380d446f7bddbffd4a3ffcaef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Mutation
135 rdf:type schema:DefinedTerm
136 N7f044bacd95947faa9710722a31f7e38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Animals
138 rdf:type schema:DefinedTerm
139 N80ff86294f6d4c01b6cc427d88704b83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Gene Expression Profiling
141 rdf:type schema:DefinedTerm
142 N83177123878349f9970ca488c79c9699 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Dosage Compensation, Genetic
144 rdf:type schema:DefinedTerm
145 N8a01f9435c9e44cbbbe70410b6582603 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Cell Line
147 rdf:type schema:DefinedTerm
148 N98af2905b293491394afd2e98463e489 schema:name Springer Nature - SN SciGraph project
149 rdf:type schema:Organization
150 N9a106187389447b08119a6638f575e8d schema:name readcube_id
151 schema:value d4b4b63db029185e661fb74284e7078b391fd3ed55bc5382eaa101b1caed11ee
152 rdf:type schema:PropertyValue
153 N9b25fea3f3ba44ecab9dfefdd02e951d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Acetylation
155 rdf:type schema:DefinedTerm
156 N9f1c42baed1841538090b4a8bb1e5bec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Blotting, Western
158 rdf:type schema:DefinedTerm
159 Na3b156512f4a4f868268b0257387bdcb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name X Chromosome
161 rdf:type schema:DefinedTerm
162 Nac30c2464dc84bc785053269d7ad2506 schema:name pubmed_id
163 schema:value 19648925
164 rdf:type schema:PropertyValue
165 Nad08cceb93c642dda5ac102345e1da54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Drosophila melanogaster
167 rdf:type schema:DefinedTerm
168 Nbe4ed0f4703049c3a6e1884e619f144a rdf:first sg:person.01347452651.31
169 rdf:rest rdf:nil
170 Nbe7d846ba26c4e5ea65f3c910937dcb0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Histone Acetyltransferases
172 rdf:type schema:DefinedTerm
173 Nc923b783325a4c19b7c158d3c89a4c37 schema:volumeNumber 16
174 rdf:type schema:PublicationVolume
175 Ncbf6ef1b2a024883aa291d9c7cdbbf38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Female
177 rdf:type schema:DefinedTerm
178 Ncd49652fdc74416193f7cf10dd638603 rdf:first sg:person.01176656634.45
179 rdf:rest N508fa0debdab4b6cb284f6b4bbac0b1b
180 Ne05cd8a2dbe84346a626255b2c969e76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Histones
182 rdf:type schema:DefinedTerm
183 Ned40c658e812467b8ac207a205c0a4c8 rdf:first sg:person.0604164204.42
184 rdf:rest N0dba583ac4b048168176888d364d8d93
185 Nf488c747c6564b1791aa9f0ef8493f38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Male
187 rdf:type schema:DefinedTerm
188 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
189 schema:name Biological Sciences
190 rdf:type schema:DefinedTerm
191 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
192 schema:name Genetics
193 rdf:type schema:DefinedTerm
194 sg:grant.2421559 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.1644
195 rdf:type schema:MonetaryGrant
196 sg:grant.2513449 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.1644
197 rdf:type schema:MonetaryGrant
198 sg:grant.2519756 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.1644
199 rdf:type schema:MonetaryGrant
200 sg:grant.2635302 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.1644
201 rdf:type schema:MonetaryGrant
202 sg:grant.7745289 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.1644
203 rdf:type schema:MonetaryGrant
204 sg:journal.1295033 schema:issn 1545-9993
205 2331-365X
206 schema:name Nature Structural & Molecular Biology
207 rdf:type schema:Periodical
208 sg:person.01024612701.33 schema:affiliation https://www.grid.ac/institutes/grid.2515.3
209 schema:familyName Park
210 schema:givenName Peter J
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024612701.33
212 rdf:type schema:Person
213 sg:person.01176656634.45 schema:affiliation https://www.grid.ac/institutes/grid.2515.3
214 schema:familyName Peng
215 schema:givenName Shouyong
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176656634.45
217 rdf:type schema:Person
218 sg:person.01347452651.31 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
219 schema:familyName Kuroda
220 schema:givenName Mitzi I
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347452651.31
222 rdf:type schema:Person
223 sg:person.0604164204.42 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
224 schema:familyName Gelbart
225 schema:givenName Marnie E
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604164204.42
227 rdf:type schema:Person
228 sg:person.0632310457.53 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
229 schema:familyName Larschan
230 schema:givenName Erica
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632310457.53
232 rdf:type schema:Person
233 sg:pub.10.1007/s00412-005-0020-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022054032
234 https://doi.org/10.1007/s00412-005-0020-x
235 rdf:type schema:CreativeWork
236 sg:pub.10.1007/s10577-006-1066-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035168731
237 https://doi.org/10.1007/s10577-006-1066-1
238 rdf:type schema:CreativeWork
239 sg:pub.10.1038/ng.154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018442414
240 https://doi.org/10.1038/ng.154
241 rdf:type schema:CreativeWork
242 sg:pub.10.1038/ng1017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005233052
243 https://doi.org/10.1038/ng1017
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/ng1637 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025423233
246 https://doi.org/10.1038/ng1637
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/ng1817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026324467
249 https://doi.org/10.1038/ng1817
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/ng993 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050594107
252 https://doi.org/10.1038/ng993
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/nsmb.1520 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036614550
255 https://doi.org/10.1038/nsmb.1520
256 rdf:type schema:CreativeWork
257 sg:pub.10.1186/1471-2105-8-219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038111013
258 https://doi.org/10.1186/1471-2105-8-219
259 rdf:type schema:CreativeWork
260 sg:pub.10.1186/jbiol30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006105526
261 https://doi.org/10.1186/jbiol30
262 rdf:type schema:CreativeWork
263 https://app.dimensions.ai/details/publication/pub.1074365940 schema:CreativeWork
264 https://app.dimensions.ai/details/publication/pub.1083188227 schema:CreativeWork
265 https://doi.org/10.1002/(sici)1520-6408(1998)22:1<56::aid-dvg6>3.0.co;2-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035152458
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/0092-8674(92)90417-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1047731096
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/j.cell.2005.04.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052072342
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/j.cell.2008.04.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035035282
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.cell.2008.06.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002951913
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.jmb.2008.04.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044949865
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.molcel.2006.02.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041921660
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.molcel.2006.11.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026358458
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.molcel.2007.08.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024374939
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/s0092-8674(01)00325-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049750088
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/s1097-2765(00)80430-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005265921
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/s1097-2765(00)80431-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008121454
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1038/sj.emboj.7601926 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025559718
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1073/pnas.0500136102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042534004
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1073/pnas.0701538104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025320222
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1073/pnas.1332749100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032155515
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1074/jbc.c100351200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034846799
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1074/jbc.m605430200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005122972
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1093/embo-reports/kvf056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048697087
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1093/emboj/16.8.2054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022855253
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1093/emboj/19.19.5202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053441354
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1093/nar/30.3.649 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010829026
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1101/gad.1082003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037805613
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1101/gad.1343705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024407499
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1101/gad.1399406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026982051
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1101/gad.1400206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029012312
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1101/gad.377506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038783857
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1101/gad.388706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026603580
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1101/gad.511809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004061649
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1101/gad.8.1.96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051785317
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1101/gad.8.6.698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016653064
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1101/gr.3198905 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043935365
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1126/science.1124000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027661592
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1128/mcb.00006-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005718402
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1128/mcb.01045-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040981978
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1128/mcb.01230-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050094766
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1128/mcb.02202-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007667192
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1128/mcb.20.1.312-318.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044800469
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1128/mcb.25.12.5292-5305.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043836564
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1128/mcb.25.15.6798-6810.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001631293
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1128/mcb.25.21.9175-9188.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036493072
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1158/0008-5472.can-08-0141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034301867
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1242/dev.029645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032682420
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1242/jcs.02623 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005247942
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1371/journal.pbio.0030328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049469158
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1371/journal.pbio.0050232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011415110
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1371/journal.pgen.1000302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044428545
358 rdf:type schema:CreativeWork
359 https://doi.org/10.4161/cc.6.6.4013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072299323
360 rdf:type schema:CreativeWork
361 https://www.grid.ac/institutes/grid.2515.3 schema:alternateName Boston Children's Hospital
362 schema:name Children's Hospital Informatics Program, Children's Hospital, Boston, Massachusetts, USA.
363 Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
364 Division of Genetics, Department of Medicine, Brigham & Women's Hospital, Boston, Massachusetts, USA.
365 rdf:type schema:Organization
366 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
367 schema:name Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
368 Division of Genetics, Department of Medicine, Brigham & Women's Hospital, Boston, Massachusetts, USA.
369 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...