A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-07-27

AUTHORS

Jemima Cordle, Steven Johnson, Joyce Zi Yan Tay, Pietro Roversi, Marian B Wilkin, Beatriz Hernández de Madrid, Hideyuki Shimizu, Sacha Jensen, Pat Whiteman, Boquan Jin, Christina Redfield, Martin Baron, Susan M Lea, Penny A Handford

ABSTRACT

The NMR structure of the Notch binding region of one of its ligands, Jagged, gives insight into the binding surface. Subsequent in vivo analysis of mutants indicates that the same surface is likely to be active in signaling within cells as well as to different cells, and modeling indicates how this surface might interact to participate in such distinct functions. More... »

PAGES

849-857

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsmb.1457

DOI

http://dx.doi.org/10.1038/nsmb.1457

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015571304

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18660822


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