The structure and binding mode of interleukin-18 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-11

AUTHORS

Zenichiro Kato, JunGoo Jee, Hiroaki Shikano, Masaki Mishima, Izuru Ohki, Hidenori Ohnishi, Ailian Li, Kazuyuki Hashimoto, Eiji Matsukuma, Kentaro Omoya, Yutaka Yamamoto, Teruyo Yoneda, Takane Hara, Naomi Kondo, Masahiro Shirakawa

ABSTRACT

Interleukin-18 (IL-18), a cytokine formerly known as interferon-gamma- (IFN-gamma-) inducing factor, has pleiotropic immunoregulatory functions, including augmentation of IFN-gamma production, Fas-mediated cytotoxicity and developmental regulation of T-lymphocyte helper type I. We determined the solution structure of IL-18 as a first step toward understanding its receptor activation mechanism. It folds into a beta-trefoil structure that resembles that of IL-1. Extensive mutagenesis revealed the presence of three sites that are important for receptor activation: two serve as binding sites for IL-18 receptor alpha (IL-18Ralpha), located at positions similar to those of IL-1 for IL-1 receptor type I (IL-1RI), whereas the third site may be involved in IL-18 receptor beta (IL-18Rbeta) binding. The structure and mutagenesis data provide a basis for understanding the IL-18-induced heterodimerization of receptor subunits, which is necessary for receptor activation. More... »

PAGES

966-971

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsb993

DOI

http://dx.doi.org/10.1038/nsb993

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041513834

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14528293


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Binding Sites", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-18", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-18 Receptor alpha Subunit", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Interleukin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Interleukin-18", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Gifu University", 
          "id": "https://www.grid.ac/institutes/grid.256342.4", 
          "name": [
            "Department of Pediatrics, Gifu University School of Medicine, Tsukasa 40, Gifu 500-8705, Japan. zen-k@cc.gifu-u.ac.jp"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kato", 
        "givenName": "Zenichiro", 
        "id": "sg:person.01144342273.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144342273.77"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Jee", 
        "givenName": "JunGoo", 
        "id": "sg:person.01045264141.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045264141.55"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Shikano", 
        "givenName": "Hiroaki", 
        "id": "sg:person.0713700577.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713700577.30"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Mishima", 
        "givenName": "Masaki", 
        "id": "sg:person.016463535161.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016463535161.36"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Ohki", 
        "givenName": "Izuru", 
        "id": "sg:person.01165326073.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165326073.13"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Ohnishi", 
        "givenName": "Hidenori", 
        "id": "sg:person.01247315165.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247315165.68"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Li", 
        "givenName": "Ailian", 
        "id": "sg:person.0640156362.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640156362.12"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Hashimoto", 
        "givenName": "Kazuyuki", 
        "id": "sg:person.0662735603.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662735603.00"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Matsukuma", 
        "givenName": "Eiji", 
        "id": "sg:person.0760245704.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760245704.35"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Omoya", 
        "givenName": "Kentaro", 
        "id": "sg:person.01026361104.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026361104.86"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Yamamoto", 
        "givenName": "Yutaka", 
        "id": "sg:person.01266054444.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266054444.19"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Yoneda", 
        "givenName": "Teruyo", 
        "type": "Person"
      }, 
      {
        "familyName": "Hara", 
        "givenName": "Takane", 
        "type": "Person"
      }, 
      {
        "familyName": "Kondo", 
        "givenName": "Naomi", 
        "id": "sg:person.010646645343.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010646645343.50"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Shirakawa", 
        "givenName": "Masahiro", 
        "id": "sg:person.0766606626.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766606626.66"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.152337799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000520637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1359-6101(98)00018-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002650315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2222.2001.01141.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002827067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m004077200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008850403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmbi.1997.1284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011642887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-2836(02)00241-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011905922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m009581200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013468646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1067/mai.2002.122158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014887719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.bi.65.070196.003141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019674626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444998003254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019779527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/386190a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020917326", 
          "https://doi.org/10.1038/386190a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/378088a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021750623", 
          "https://doi.org/10.1038/378088a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/386194a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024315584", 
          "https://doi.org/10.1038/386194a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.275.14.10308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027358595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0263-7855(96)00009-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028069795"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1359-6101(00)00015-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029699118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/379591a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031549041", 
          "https://doi.org/10.1038/379591a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00228148", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037775127", 
          "https://doi.org/10.1007/bf00228148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00228148", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037775127", 
          "https://doi.org/10.1007/bf00228148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1008392405740", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038767937", 
          "https://doi.org/10.1023/a:1008392405740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.270.19.11477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040494344"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m108311200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042785651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.97.3.1190", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043832209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmrb.1996.0157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045922337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/75825", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046569481", 
          "https://doi.org/10.1038/75825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80736-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046650642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(00)00073-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051403307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.45.29445", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053313376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja963625z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055866258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja963625z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055866258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1549776", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062490342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074766107", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.169.8.4467", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075172337"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-11", 
    "datePublishedReg": "2003-11-01", 
    "description": "Interleukin-18 (IL-18), a cytokine formerly known as interferon-gamma- (IFN-gamma-) inducing factor, has pleiotropic immunoregulatory functions, including augmentation of IFN-gamma production, Fas-mediated cytotoxicity and developmental regulation of T-lymphocyte helper type I. We determined the solution structure of IL-18 as a first step toward understanding its receptor activation mechanism. It folds into a beta-trefoil structure that resembles that of IL-1. Extensive mutagenesis revealed the presence of three sites that are important for receptor activation: two serve as binding sites for IL-18 receptor alpha (IL-18Ralpha), located at positions similar to those of IL-1 for IL-1 receptor type I (IL-1RI), whereas the third site may be involved in IL-18 receptor beta (IL-18Rbeta) binding. The structure and mutagenesis data provide a basis for understanding the IL-18-induced heterodimerization of receptor subunits, which is necessary for receptor activation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nsb993", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1295033", 
        "issn": [
          "1545-9993", 
          "2331-365X"
        ], 
        "name": "Nature Structural & Molecular Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "11", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "name": "The structure and binding mode of interleukin-18", 
    "pagination": "966-971", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c5c279e9e75e1a7271d466e7a2f3b9a403d45bba21cd31899ce128ac65f74ddd"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "14528293"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9421566"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nsb993"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1041513834"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nsb993", 
      "https://app.dimensions.ai/details/publication/pub.1041513834"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:14", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_54002_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/nsmb/journal/v10/n11/full/nsb993.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nsb993'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nsb993'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nsb993'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nsb993'


 

This table displays all metadata directly associated to this object as RDF triples.

282 TRIPLES      21 PREDICATES      68 URIs      29 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nsb993 schema:about N1be5f5be61cf43c28c2ba1af15da008e
2 N40696fd828914613b39b840bf844c59d
3 N819144b9f37c4ec1a2689c29db39dfb8
4 N954c3371a03041b09736ed09fab26d73
5 N992de7a6086441088b8bffc0d68b1a06
6 Nc21ed87a36fd4e968950952aa04bb674
7 Ne389ac66aa9c4612bca2017e6d03b2a4
8 Nf004be27571f4e8ebcfbb3a65cdd9e5e
9 anzsrc-for:06
10 anzsrc-for:0601
11 schema:author N02378d03187a485b998148be01bdd195
12 schema:citation sg:pub.10.1007/bf00228148
13 sg:pub.10.1023/a:1008392405740
14 sg:pub.10.1038/378088a0
15 sg:pub.10.1038/379591a0
16 sg:pub.10.1038/386190a0
17 sg:pub.10.1038/386194a0
18 sg:pub.10.1038/75825
19 https://app.dimensions.ai/details/publication/pub.1074766107
20 https://doi.org/10.1006/jmbi.1997.1284
21 https://doi.org/10.1006/jmrb.1996.0157
22 https://doi.org/10.1016/0263-7855(96)00009-4
23 https://doi.org/10.1016/s0022-2836(02)00241-3
24 https://doi.org/10.1016/s0092-8674(00)80736-9
25 https://doi.org/10.1016/s1097-2765(00)00073-3
26 https://doi.org/10.1016/s1359-6101(00)00015-0
27 https://doi.org/10.1016/s1359-6101(98)00018-5
28 https://doi.org/10.1021/ja963625z
29 https://doi.org/10.1046/j.1365-2222.2001.01141.x
30 https://doi.org/10.1067/mai.2002.122158
31 https://doi.org/10.1073/pnas.152337799
32 https://doi.org/10.1073/pnas.97.3.1190
33 https://doi.org/10.1074/jbc.270.19.11477
34 https://doi.org/10.1074/jbc.273.45.29445
35 https://doi.org/10.1074/jbc.275.14.10308
36 https://doi.org/10.1074/jbc.m004077200
37 https://doi.org/10.1074/jbc.m009581200
38 https://doi.org/10.1074/jbc.m108311200
39 https://doi.org/10.1107/s0907444998003254
40 https://doi.org/10.1126/science.1549776
41 https://doi.org/10.1146/annurev.bi.65.070196.003141
42 https://doi.org/10.4049/jimmunol.169.8.4467
43 schema:datePublished 2003-11
44 schema:datePublishedReg 2003-11-01
45 schema:description Interleukin-18 (IL-18), a cytokine formerly known as interferon-gamma- (IFN-gamma-) inducing factor, has pleiotropic immunoregulatory functions, including augmentation of IFN-gamma production, Fas-mediated cytotoxicity and developmental regulation of T-lymphocyte helper type I. We determined the solution structure of IL-18 as a first step toward understanding its receptor activation mechanism. It folds into a beta-trefoil structure that resembles that of IL-1. Extensive mutagenesis revealed the presence of three sites that are important for receptor activation: two serve as binding sites for IL-18 receptor alpha (IL-18Ralpha), located at positions similar to those of IL-1 for IL-1 receptor type I (IL-1RI), whereas the third site may be involved in IL-18 receptor beta (IL-18Rbeta) binding. The structure and mutagenesis data provide a basis for understanding the IL-18-induced heterodimerization of receptor subunits, which is necessary for receptor activation.
46 schema:genre research_article
47 schema:inLanguage en
48 schema:isAccessibleForFree false
49 schema:isPartOf Nbd54fa4aba374cc0a83f73f8bb6a6a49
50 Nd7e74e10db2d475c854ef6fd61da9d2d
51 sg:journal.1295033
52 schema:name The structure and binding mode of interleukin-18
53 schema:pagination 966-971
54 schema:productId N23ccc54931794c82851d58cecff36bbf
55 N9799a2b096a84d11bdb6791fd6d85907
56 Nc25674b9084c4091a7521095605365c9
57 Neef60824c2b14305886722da797f625b
58 Nf372584834ca4ac5a8f98473cebdf574
59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041513834
60 https://doi.org/10.1038/nsb993
61 schema:sdDatePublished 2019-04-11T12:14
62 schema:sdLicense https://scigraph.springernature.com/explorer/license/
63 schema:sdPublisher Nf7cdd1cb1f6e41d0a66410b1dece341e
64 schema:url http://www.nature.com/nsmb/journal/v10/n11/full/nsb993.html
65 sgo:license sg:explorer/license/
66 sgo:sdDataset articles
67 rdf:type schema:ScholarlyArticle
68 N02378d03187a485b998148be01bdd195 rdf:first sg:person.01144342273.77
69 rdf:rest Nb7ff8b23078c4217890886dee152913e
70 N059433b988e44fb591a3ba2c476c3485 rdf:first sg:person.01266054444.19
71 rdf:rest Nfad91beb929547d49ba669c7dae594d5
72 N1be5f5be61cf43c28c2ba1af15da008e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Molecular Sequence Data
74 rdf:type schema:DefinedTerm
75 N1ed297365fef4fbc9197d5890704b52b schema:familyName Hara
76 schema:givenName Takane
77 rdf:type schema:Person
78 N23ccc54931794c82851d58cecff36bbf schema:name pubmed_id
79 schema:value 14528293
80 rdf:type schema:PropertyValue
81 N24c7d8f984bf4373a172485442bcbefc rdf:first sg:person.01165326073.13
82 rdf:rest N7ab8576ebcb4463d85dd2282a6f48946
83 N2832bb2bc8e44a03a780eeb373b3486d rdf:first N1ed297365fef4fbc9197d5890704b52b
84 rdf:rest Ndcfbee7d30114e4991f35a4904ecf5f5
85 N389adf03048a4993b4bf508d6b8e35e9 rdf:first sg:person.0760245704.35
86 rdf:rest N83d28d1513c5485994a8c9f3bc82caf0
87 N3942119157b2438a911228f2eb7d5cc7 rdf:first sg:person.016463535161.36
88 rdf:rest N24c7d8f984bf4373a172485442bcbefc
89 N40696fd828914613b39b840bf844c59d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Humans
91 rdf:type schema:DefinedTerm
92 N6cc8caf89df64c62afd17440d9e6cd80 rdf:first sg:person.0640156362.12
93 rdf:rest Nfdef89a1e07c4a32bffeb2cc04b469a6
94 N7ab8576ebcb4463d85dd2282a6f48946 rdf:first sg:person.01247315165.68
95 rdf:rest N6cc8caf89df64c62afd17440d9e6cd80
96 N819144b9f37c4ec1a2689c29db39dfb8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Receptors, Interleukin
98 rdf:type schema:DefinedTerm
99 N83d28d1513c5485994a8c9f3bc82caf0 rdf:first sg:person.01026361104.86
100 rdf:rest N059433b988e44fb591a3ba2c476c3485
101 N898ee41f5a8f40db8ac7466068fef2e5 rdf:first sg:person.0766606626.66
102 rdf:rest rdf:nil
103 N919f792633a44c17b88f037e5a85dd7d schema:familyName Yoneda
104 schema:givenName Teruyo
105 rdf:type schema:Person
106 N954c3371a03041b09736ed09fab26d73 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Interleukin-18
108 rdf:type schema:DefinedTerm
109 N9799a2b096a84d11bdb6791fd6d85907 schema:name nlm_unique_id
110 schema:value 9421566
111 rdf:type schema:PropertyValue
112 N992de7a6086441088b8bffc0d68b1a06 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Amino Acid Sequence
114 rdf:type schema:DefinedTerm
115 Nb34fa35e84924feb99943b65fc1300dc rdf:first sg:person.0713700577.30
116 rdf:rest N3942119157b2438a911228f2eb7d5cc7
117 Nb7ff8b23078c4217890886dee152913e rdf:first sg:person.01045264141.55
118 rdf:rest Nb34fa35e84924feb99943b65fc1300dc
119 Nbd54fa4aba374cc0a83f73f8bb6a6a49 schema:issueNumber 11
120 rdf:type schema:PublicationIssue
121 Nc21ed87a36fd4e968950952aa04bb674 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Receptors, Interleukin-18
123 rdf:type schema:DefinedTerm
124 Nc25674b9084c4091a7521095605365c9 schema:name dimensions_id
125 schema:value pub.1041513834
126 rdf:type schema:PropertyValue
127 Nd7e74e10db2d475c854ef6fd61da9d2d schema:volumeNumber 10
128 rdf:type schema:PublicationVolume
129 Ndcfbee7d30114e4991f35a4904ecf5f5 rdf:first sg:person.010646645343.50
130 rdf:rest N898ee41f5a8f40db8ac7466068fef2e5
131 Ne389ac66aa9c4612bca2017e6d03b2a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Binding Sites
133 rdf:type schema:DefinedTerm
134 Neef60824c2b14305886722da797f625b schema:name doi
135 schema:value 10.1038/nsb993
136 rdf:type schema:PropertyValue
137 Nf004be27571f4e8ebcfbb3a65cdd9e5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Interleukin-18 Receptor alpha Subunit
139 rdf:type schema:DefinedTerm
140 Nf372584834ca4ac5a8f98473cebdf574 schema:name readcube_id
141 schema:value c5c279e9e75e1a7271d466e7a2f3b9a403d45bba21cd31899ce128ac65f74ddd
142 rdf:type schema:PropertyValue
143 Nf7cdd1cb1f6e41d0a66410b1dece341e schema:name Springer Nature - SN SciGraph project
144 rdf:type schema:Organization
145 Nfad91beb929547d49ba669c7dae594d5 rdf:first N919f792633a44c17b88f037e5a85dd7d
146 rdf:rest N2832bb2bc8e44a03a780eeb373b3486d
147 Nfdef89a1e07c4a32bffeb2cc04b469a6 rdf:first sg:person.0662735603.00
148 rdf:rest N389adf03048a4993b4bf508d6b8e35e9
149 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
150 schema:name Biological Sciences
151 rdf:type schema:DefinedTerm
152 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
153 schema:name Biochemistry and Cell Biology
154 rdf:type schema:DefinedTerm
155 sg:journal.1295033 schema:issn 1545-9993
156 2331-365X
157 schema:name Nature Structural & Molecular Biology
158 rdf:type schema:Periodical
159 sg:person.01026361104.86 schema:familyName Omoya
160 schema:givenName Kentaro
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026361104.86
162 rdf:type schema:Person
163 sg:person.01045264141.55 schema:familyName Jee
164 schema:givenName JunGoo
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045264141.55
166 rdf:type schema:Person
167 sg:person.010646645343.50 schema:familyName Kondo
168 schema:givenName Naomi
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010646645343.50
170 rdf:type schema:Person
171 sg:person.01144342273.77 schema:affiliation https://www.grid.ac/institutes/grid.256342.4
172 schema:familyName Kato
173 schema:givenName Zenichiro
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144342273.77
175 rdf:type schema:Person
176 sg:person.01165326073.13 schema:familyName Ohki
177 schema:givenName Izuru
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165326073.13
179 rdf:type schema:Person
180 sg:person.01247315165.68 schema:familyName Ohnishi
181 schema:givenName Hidenori
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247315165.68
183 rdf:type schema:Person
184 sg:person.01266054444.19 schema:familyName Yamamoto
185 schema:givenName Yutaka
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266054444.19
187 rdf:type schema:Person
188 sg:person.016463535161.36 schema:familyName Mishima
189 schema:givenName Masaki
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016463535161.36
191 rdf:type schema:Person
192 sg:person.0640156362.12 schema:familyName Li
193 schema:givenName Ailian
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640156362.12
195 rdf:type schema:Person
196 sg:person.0662735603.00 schema:familyName Hashimoto
197 schema:givenName Kazuyuki
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662735603.00
199 rdf:type schema:Person
200 sg:person.0713700577.30 schema:familyName Shikano
201 schema:givenName Hiroaki
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713700577.30
203 rdf:type schema:Person
204 sg:person.0760245704.35 schema:familyName Matsukuma
205 schema:givenName Eiji
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760245704.35
207 rdf:type schema:Person
208 sg:person.0766606626.66 schema:familyName Shirakawa
209 schema:givenName Masahiro
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766606626.66
211 rdf:type schema:Person
212 sg:pub.10.1007/bf00228148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037775127
213 https://doi.org/10.1007/bf00228148
214 rdf:type schema:CreativeWork
215 sg:pub.10.1023/a:1008392405740 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038767937
216 https://doi.org/10.1023/a:1008392405740
217 rdf:type schema:CreativeWork
218 sg:pub.10.1038/378088a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021750623
219 https://doi.org/10.1038/378088a0
220 rdf:type schema:CreativeWork
221 sg:pub.10.1038/379591a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031549041
222 https://doi.org/10.1038/379591a0
223 rdf:type schema:CreativeWork
224 sg:pub.10.1038/386190a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020917326
225 https://doi.org/10.1038/386190a0
226 rdf:type schema:CreativeWork
227 sg:pub.10.1038/386194a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024315584
228 https://doi.org/10.1038/386194a0
229 rdf:type schema:CreativeWork
230 sg:pub.10.1038/75825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046569481
231 https://doi.org/10.1038/75825
232 rdf:type schema:CreativeWork
233 https://app.dimensions.ai/details/publication/pub.1074766107 schema:CreativeWork
234 https://doi.org/10.1006/jmbi.1997.1284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011642887
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1006/jmrb.1996.0157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045922337
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/0263-7855(96)00009-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028069795
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/s0022-2836(02)00241-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011905922
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/s0092-8674(00)80736-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046650642
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/s1097-2765(00)00073-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051403307
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/s1359-6101(00)00015-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029699118
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/s1359-6101(98)00018-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002650315
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1021/ja963625z schema:sameAs https://app.dimensions.ai/details/publication/pub.1055866258
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1046/j.1365-2222.2001.01141.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002827067
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1067/mai.2002.122158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014887719
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1073/pnas.152337799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000520637
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1073/pnas.97.3.1190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043832209
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1074/jbc.270.19.11477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040494344
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1074/jbc.273.45.29445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053313376
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1074/jbc.275.14.10308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027358595
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1074/jbc.m004077200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008850403
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1074/jbc.m009581200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013468646
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1074/jbc.m108311200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042785651
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1107/s0907444998003254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019779527
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1126/science.1549776 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062490342
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1146/annurev.bi.65.070196.003141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019674626
277 rdf:type schema:CreativeWork
278 https://doi.org/10.4049/jimmunol.169.8.4467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075172337
279 rdf:type schema:CreativeWork
280 https://www.grid.ac/institutes/grid.256342.4 schema:alternateName Gifu University
281 schema:name Department of Pediatrics, Gifu University School of Medicine, Tsukasa 40, Gifu 500-8705, Japan. zen-k@cc.gifu-u.ac.jp
282 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...