Functional convergence of two lysyl-tRNA synthetases with unrelated topologies View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-04-01

AUTHORS

Takaho Terada, Osamu Nureki, Ryuichiro Ishitani, Alexandre Ambrogelly, Michael Ibba, Dieter Söll, Shigeyuki Yokoyama

ABSTRACT

Lysyl-tRNA can be synthesized by both a class I (LysRS-I) and a class II (LysRS-II) lysyl-tRNA synthetase. The crystal structure of LysRS-I from Pyrococcus horikoshii at 2.6 A resolution reveals extensive similarity with glutamyl-tRNA synthetase (GluRS). A comparison of the structures of LysRS-I and LysRS-II in complex with lysine shows that both enzymes use similar strategies for substrate recognition within unrelated active site topologies. A docking model based upon the GluRS-tRNA complex suggests how LysRS-I and LysRS-II can recognize the same molecular determinants in tRNALys, as shown by biochemical results, while approaching the acceptor helix of the tRNA from opposite sides. More... »

PAGES

257-262

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsb777

DOI

http://dx.doi.org/10.1038/nsb777

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046859980

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11887185


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