Ontology type: schema:ScholarlyArticle
1995-12-01
AUTHORSKerstin Braig, Paul D. Adams, Axel T. Brünger
ABSTRACTImproved refinement of the crystal structure of GroEL from Escherichia coli has resulted in a complete atomic model for the first 524 residues. A new torsion-angle dynamics method and non-crystallographic symmetry restraints were used in the refinement. The model indicates that conformational variability exists due to rigid-body movements between the apical and intermediate domains of GroEL, resulting in deviations from strict seven-fold symmetry. The regions of the protein involved in polypeptide and GroES binding show unusually high B factors; these values may indicate mobility or discrete disorder. The variability of these regions may play a role in the ability of GroEL to bind a wide variety of substrates. More... »
PAGES1083-1094
http://scigraph.springernature.com/pub.10.1038/nsb1295-1083
DOIhttp://dx.doi.org/10.1038/nsb1295-1083
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/8846220
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