A trimeric structural domain of the HIV-1 transmembrane glycoprotein View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-12

AUTHORS

M Lu, S C Blacklow, P S Kim

ABSTRACT

Infection with HIV-1 is initiated by fusion of cellular and viral membranes. The gp41 subunit of the HIV-1 envelope plays a major role in this process, but the structure of gp41 is unknown. We have identified a stable, proteinase-resistant structure comprising two peptides, N-51 and C-43, derived from a recombinant protein fragment of the gp41 ectodomain. In isolation, N-51 is predominantly aggregated and C-43 is unfolded. When mixed, however, these peptides associate to form a stable, alpha-helical, discrete trimer of heterodimers. Proteolysis experiments indicate that the relative orientation of the N-51 and C-43 helices in the complex is antiparallel. We propose that N-51 forms an interior, parallel, homotrimeric, coiled-coil core, against which three C-43 helices pack in an antiparallel fashion. We suggest that this alpha-helical, trimeric complex is the core of the fusion-competent state of the HIV-1 envelope. More... »

PAGES

1075-1082

Journal

TITLE

Nature Structural & Molecular Biology

ISSUE

12

VOLUME

2

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsb1295-1075

DOI

http://dx.doi.org/10.1038/nsb1295-1075

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049045339

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8846219


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cloning, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endopeptidases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Giant Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Envelope Protein gp120", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Glycoproteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Weight", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proline", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Conformation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombinant Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Viral Envelope Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Massachusetts Institute of Technology", 
          "id": "https://www.grid.ac/institutes/grid.116068.8", 
          "name": [
            "Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lu", 
        "givenName": "M", 
        "type": "Person"
      }, 
      {
        "familyName": "Blacklow", 
        "givenName": "S C", 
        "type": "Person"
      }, 
      {
        "familyName": "Kim", 
        "givenName": "P S", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.88.6.2189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001563131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.174.2.407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003948596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0042-6822(89)90142-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004963240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90260-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005067432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/329219a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005321784", 
          "https://doi.org/10.1038/329219a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.89.21.10537", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008570940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0076-6879(87)54085-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012349220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0076-6879(86)31043-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013641920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.21.9770", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015809885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/289366a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016242659", 
          "https://doi.org/10.1038/289366a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0739-6260(88)90039-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017079453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0739-6260(88)90039-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017079453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(87)90485-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020094846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(95)00057-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020631936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/312767a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028751316", 
          "https://doi.org/10.1038/312767a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(87)90587-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034483257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.87.2.648", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035899108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/365113a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037709060", 
          "https://doi.org/10.1038/365113a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(95)00275-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040252256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1993.2078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043461926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/371037a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046282624", 
          "https://doi.org/10.1038/371037a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-2836(75)80119-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048630266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/371080a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050245813", 
          "https://doi.org/10.1038/371080a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.18.8259", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051517626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00046a001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055158637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00174a021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055163787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00859a010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055191349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/aid.1989.5.431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059223036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/aid.1990.6.703", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059223186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/aid.1995.11.189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059224081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/aid.1995.11.323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059224099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/aid.1995.11.687", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059224138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/0022-1317-71-12-3075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060357433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/sqb.1973.037.01.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060404251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1439803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062482253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1925547", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062513720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1948029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062514556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2251501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062529249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2309120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062531720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.252.5009.1162", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062542077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.252.5010.1322-a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062542116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2911757", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062573457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2992081", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062580028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3001934", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062582015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7939658", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062650677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8248779", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062653809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076183005", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077143807", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fasebj.5.10.1712328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077327812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077842973", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078148814", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078484191", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082404016", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082831671", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1995-12", 
    "datePublishedReg": "1995-12-01", 
    "description": "Infection with HIV-1 is initiated by fusion of cellular and viral membranes. The gp41 subunit of the HIV-1 envelope plays a major role in this process, but the structure of gp41 is unknown. We have identified a stable, proteinase-resistant structure comprising two peptides, N-51 and C-43, derived from a recombinant protein fragment of the gp41 ectodomain. In isolation, N-51 is predominantly aggregated and C-43 is unfolded. When mixed, however, these peptides associate to form a stable, alpha-helical, discrete trimer of heterodimers. Proteolysis experiments indicate that the relative orientation of the N-51 and C-43 helices in the complex is antiparallel. We propose that N-51 forms an interior, parallel, homotrimeric, coiled-coil core, against which three C-43 helices pack in an antiparallel fashion. We suggest that this alpha-helical, trimeric complex is the core of the fusion-competent state of the HIV-1 envelope.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nsb1295-1075", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1295033", 
        "issn": [
          "1545-9993", 
          "2331-365X"
        ], 
        "name": "Nature Structural & Molecular Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "2"
      }
    ], 
    "name": "A trimeric structural domain of the HIV-1 transmembrane glycoprotein", 
    "pagination": "1075-1082", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e9a4a7f81428ed5925738a0479914b86f53c438a96f6eb429ff3cce9837bd9f6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8846219"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9421566"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nsb1295-1075"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1049045339"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nsb1295-1075", 
      "https://app.dimensions.ai/details/publication/pub.1049045339"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:09", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000434.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/nsmb/journal/v2/n12/full/nsb1295-1075.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nsb1295-1075'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nsb1295-1075'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nsb1295-1075'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nsb1295-1075'


 

This table displays all metadata directly associated to this object as RDF triples.

292 TRIPLES      21 PREDICATES      96 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nsb1295-1075 schema:about N0f5e6080747c4af8824b1e48a11bbd9e
2 N4568c0c821ac461fa4e496c131ea512d
3 N55bff0d2d14148b09cda0ac04a621ed4
4 N7b535801a6df4d57a5a7a28eaf8ecf80
5 N83819bba23fd41638843991b84788dea
6 Naff490429d3b49d48ff546708100742f
7 Nc082085c19e34080977729fa3c997035
8 Ncde841806a1c41acb2eb065aa521588c
9 Nd052774635014db49e25a24dae68b0d1
10 Nd3c2cce5eb2a45a3a248eb882f9327f4
11 Nd82f48c57bd4470a876f42132ee74dbf
12 Ne5a9152fbd3949ac8dbe39d84f1188da
13 Ne75e2972f2444e38b1e7a1b22c71baf7
14 Nffde8c9fff7d42cc9e0dfe73c2e72158
15 anzsrc-for:06
16 anzsrc-for:0601
17 schema:author Nfbf44577064b4b1691497362dd07346e
18 schema:citation sg:pub.10.1038/289366a0
19 sg:pub.10.1038/312767a0
20 sg:pub.10.1038/329219a0
21 sg:pub.10.1038/365113a0
22 sg:pub.10.1038/371037a0
23 sg:pub.10.1038/371080a0
24 https://app.dimensions.ai/details/publication/pub.1076183005
25 https://app.dimensions.ai/details/publication/pub.1077143807
26 https://app.dimensions.ai/details/publication/pub.1077842973
27 https://app.dimensions.ai/details/publication/pub.1078148814
28 https://app.dimensions.ai/details/publication/pub.1078484191
29 https://app.dimensions.ai/details/publication/pub.1082404016
30 https://app.dimensions.ai/details/publication/pub.1082831671
31 https://doi.org/10.1006/bbrc.1993.2078
32 https://doi.org/10.1016/0003-2697(87)90587-2
33 https://doi.org/10.1016/0042-6822(89)90142-6
34 https://doi.org/10.1016/0076-6879(86)31043-7
35 https://doi.org/10.1016/0076-6879(87)54085-x
36 https://doi.org/10.1016/0092-8674(87)90485-5
37 https://doi.org/10.1016/0092-8674(93)90260-w
38 https://doi.org/10.1016/0739-6260(88)90039-1
39 https://doi.org/10.1016/s0022-2836(75)80119-7
40 https://doi.org/10.1016/s0960-9822(95)00057-1
41 https://doi.org/10.1016/s0960-9822(95)00275-2
42 https://doi.org/10.1021/bi00046a001
43 https://doi.org/10.1021/bi00174a021
44 https://doi.org/10.1021/bi00859a010
45 https://doi.org/10.1073/pnas.87.2.648
46 https://doi.org/10.1073/pnas.88.6.2189
47 https://doi.org/10.1073/pnas.89.21.10537
48 https://doi.org/10.1073/pnas.91.21.9770
49 https://doi.org/10.1073/pnas.92.18.8259
50 https://doi.org/10.1084/jem.174.2.407
51 https://doi.org/10.1089/aid.1989.5.431
52 https://doi.org/10.1089/aid.1990.6.703
53 https://doi.org/10.1089/aid.1995.11.189
54 https://doi.org/10.1089/aid.1995.11.323
55 https://doi.org/10.1089/aid.1995.11.687
56 https://doi.org/10.1096/fasebj.5.10.1712328
57 https://doi.org/10.1099/0022-1317-71-12-3075
58 https://doi.org/10.1101/sqb.1973.037.01.040
59 https://doi.org/10.1126/science.1439803
60 https://doi.org/10.1126/science.1925547
61 https://doi.org/10.1126/science.1948029
62 https://doi.org/10.1126/science.2251501
63 https://doi.org/10.1126/science.2309120
64 https://doi.org/10.1126/science.252.5009.1162
65 https://doi.org/10.1126/science.252.5010.1322-a
66 https://doi.org/10.1126/science.2911757
67 https://doi.org/10.1126/science.2992081
68 https://doi.org/10.1126/science.3001934
69 https://doi.org/10.1126/science.7939658
70 https://doi.org/10.1126/science.8248779
71 schema:datePublished 1995-12
72 schema:datePublishedReg 1995-12-01
73 schema:description Infection with HIV-1 is initiated by fusion of cellular and viral membranes. The gp41 subunit of the HIV-1 envelope plays a major role in this process, but the structure of gp41 is unknown. We have identified a stable, proteinase-resistant structure comprising two peptides, N-51 and C-43, derived from a recombinant protein fragment of the gp41 ectodomain. In isolation, N-51 is predominantly aggregated and C-43 is unfolded. When mixed, however, these peptides associate to form a stable, alpha-helical, discrete trimer of heterodimers. Proteolysis experiments indicate that the relative orientation of the N-51 and C-43 helices in the complex is antiparallel. We propose that N-51 forms an interior, parallel, homotrimeric, coiled-coil core, against which three C-43 helices pack in an antiparallel fashion. We suggest that this alpha-helical, trimeric complex is the core of the fusion-competent state of the HIV-1 envelope.
74 schema:genre research_article
75 schema:inLanguage en
76 schema:isAccessibleForFree false
77 schema:isPartOf N12be1ecb8fc9428ba46d7e5ea12f42e4
78 N68ac152880d340a9b0aa3e56330a9009
79 sg:journal.1295033
80 schema:name A trimeric structural domain of the HIV-1 transmembrane glycoprotein
81 schema:pagination 1075-1082
82 schema:productId N0e3a6505d0a54f05805eb95bceed16bc
83 N50d939257ea141d6811b4fa6e5a1579d
84 N783483ce0ca84ec88c7fe23b3a1b38c5
85 Nc8f1b40d19f54f039e985a742689578e
86 Ndbd7b878c87b4fa5b79d09caab9382dd
87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049045339
88 https://doi.org/10.1038/nsb1295-1075
89 schema:sdDatePublished 2019-04-10T18:09
90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
91 schema:sdPublisher N445941d2fb8c43fda862a4d97cebc60b
92 schema:url http://www.nature.com/nsmb/journal/v2/n12/full/nsb1295-1075.html
93 sgo:license sg:explorer/license/
94 sgo:sdDataset articles
95 rdf:type schema:ScholarlyArticle
96 N0e3a6505d0a54f05805eb95bceed16bc schema:name nlm_unique_id
97 schema:value 9421566
98 rdf:type schema:PropertyValue
99 N0f5e6080747c4af8824b1e48a11bbd9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Protein Conformation
101 rdf:type schema:DefinedTerm
102 N12be1ecb8fc9428ba46d7e5ea12f42e4 schema:volumeNumber 2
103 rdf:type schema:PublicationVolume
104 N1327551844f84c9a9a4d1fbd779b9195 schema:familyName Kim
105 schema:givenName P S
106 rdf:type schema:Person
107 N445941d2fb8c43fda862a4d97cebc60b schema:name Springer Nature - SN SciGraph project
108 rdf:type schema:Organization
109 N4568c0c821ac461fa4e496c131ea512d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Membrane Glycoproteins
111 rdf:type schema:DefinedTerm
112 N50d939257ea141d6811b4fa6e5a1579d schema:name doi
113 schema:value 10.1038/nsb1295-1075
114 rdf:type schema:PropertyValue
115 N55bff0d2d14148b09cda0ac04a621ed4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Viral Envelope Proteins
117 rdf:type schema:DefinedTerm
118 N68ac152880d340a9b0aa3e56330a9009 schema:issueNumber 12
119 rdf:type schema:PublicationIssue
120 N783483ce0ca84ec88c7fe23b3a1b38c5 schema:name pubmed_id
121 schema:value 8846219
122 rdf:type schema:PropertyValue
123 N7b535801a6df4d57a5a7a28eaf8ecf80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Molecular Sequence Data
125 rdf:type schema:DefinedTerm
126 N83819bba23fd41638843991b84788dea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name HIV Envelope Protein gp120
128 rdf:type schema:DefinedTerm
129 Naff490429d3b49d48ff546708100742f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Peptides
131 rdf:type schema:DefinedTerm
132 Nc082085c19e34080977729fa3c997035 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Recombinant Proteins
134 rdf:type schema:DefinedTerm
135 Nc8c9470330f74b43836a13b68a6c7416 rdf:first N1327551844f84c9a9a4d1fbd779b9195
136 rdf:rest rdf:nil
137 Nc8f1b40d19f54f039e985a742689578e schema:name readcube_id
138 schema:value e9a4a7f81428ed5925738a0479914b86f53c438a96f6eb429ff3cce9837bd9f6
139 rdf:type schema:PropertyValue
140 Ncd3049ce1ad5412ea86a4741203eae30 schema:affiliation https://www.grid.ac/institutes/grid.116068.8
141 schema:familyName Lu
142 schema:givenName M
143 rdf:type schema:Person
144 Ncde841806a1c41acb2eb065aa521588c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name HIV-1
146 rdf:type schema:DefinedTerm
147 Nd052774635014db49e25a24dae68b0d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Amino Acid Sequence
149 rdf:type schema:DefinedTerm
150 Nd3c2cce5eb2a45a3a248eb882f9327f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Endopeptidases
152 rdf:type schema:DefinedTerm
153 Nd82f48c57bd4470a876f42132ee74dbf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Giant Cells
155 rdf:type schema:DefinedTerm
156 Ndbd7b878c87b4fa5b79d09caab9382dd schema:name dimensions_id
157 schema:value pub.1049045339
158 rdf:type schema:PropertyValue
159 Ne544ad12702f440788ef3d5d17f949f7 schema:familyName Blacklow
160 schema:givenName S C
161 rdf:type schema:Person
162 Ne5a9152fbd3949ac8dbe39d84f1188da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Proline
164 rdf:type schema:DefinedTerm
165 Ne75e2972f2444e38b1e7a1b22c71baf7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Cloning, Molecular
167 rdf:type schema:DefinedTerm
168 Nf97d8ce2d7b546aa8591960a550d1489 rdf:first Ne544ad12702f440788ef3d5d17f949f7
169 rdf:rest Nc8c9470330f74b43836a13b68a6c7416
170 Nfbf44577064b4b1691497362dd07346e rdf:first Ncd3049ce1ad5412ea86a4741203eae30
171 rdf:rest Nf97d8ce2d7b546aa8591960a550d1489
172 Nffde8c9fff7d42cc9e0dfe73c2e72158 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Molecular Weight
174 rdf:type schema:DefinedTerm
175 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
176 schema:name Biological Sciences
177 rdf:type schema:DefinedTerm
178 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
179 schema:name Biochemistry and Cell Biology
180 rdf:type schema:DefinedTerm
181 sg:journal.1295033 schema:issn 1545-9993
182 2331-365X
183 schema:name Nature Structural & Molecular Biology
184 rdf:type schema:Periodical
185 sg:pub.10.1038/289366a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016242659
186 https://doi.org/10.1038/289366a0
187 rdf:type schema:CreativeWork
188 sg:pub.10.1038/312767a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028751316
189 https://doi.org/10.1038/312767a0
190 rdf:type schema:CreativeWork
191 sg:pub.10.1038/329219a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005321784
192 https://doi.org/10.1038/329219a0
193 rdf:type schema:CreativeWork
194 sg:pub.10.1038/365113a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037709060
195 https://doi.org/10.1038/365113a0
196 rdf:type schema:CreativeWork
197 sg:pub.10.1038/371037a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046282624
198 https://doi.org/10.1038/371037a0
199 rdf:type schema:CreativeWork
200 sg:pub.10.1038/371080a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050245813
201 https://doi.org/10.1038/371080a0
202 rdf:type schema:CreativeWork
203 https://app.dimensions.ai/details/publication/pub.1076183005 schema:CreativeWork
204 https://app.dimensions.ai/details/publication/pub.1077143807 schema:CreativeWork
205 https://app.dimensions.ai/details/publication/pub.1077842973 schema:CreativeWork
206 https://app.dimensions.ai/details/publication/pub.1078148814 schema:CreativeWork
207 https://app.dimensions.ai/details/publication/pub.1078484191 schema:CreativeWork
208 https://app.dimensions.ai/details/publication/pub.1082404016 schema:CreativeWork
209 https://app.dimensions.ai/details/publication/pub.1082831671 schema:CreativeWork
210 https://doi.org/10.1006/bbrc.1993.2078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043461926
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/0003-2697(87)90587-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034483257
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/0042-6822(89)90142-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004963240
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/0076-6879(86)31043-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013641920
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/0076-6879(87)54085-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012349220
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/0092-8674(87)90485-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020094846
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/0092-8674(93)90260-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1005067432
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/0739-6260(88)90039-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017079453
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/s0022-2836(75)80119-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048630266
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/s0960-9822(95)00057-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020631936
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/s0960-9822(95)00275-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040252256
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1021/bi00046a001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055158637
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1021/bi00174a021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055163787
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1021/bi00859a010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055191349
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1073/pnas.87.2.648 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035899108
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1073/pnas.88.6.2189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001563131
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1073/pnas.89.21.10537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008570940
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1073/pnas.91.21.9770 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015809885
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1073/pnas.92.18.8259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051517626
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1084/jem.174.2.407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003948596
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1089/aid.1989.5.431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059223036
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1089/aid.1990.6.703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059223186
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1089/aid.1995.11.189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059224081
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1089/aid.1995.11.323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059224099
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1089/aid.1995.11.687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059224138
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1096/fasebj.5.10.1712328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077327812
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1099/0022-1317-71-12-3075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060357433
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1101/sqb.1973.037.01.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060404251
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1126/science.1439803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062482253
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1126/science.1925547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062513720
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1126/science.1948029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062514556
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1126/science.2251501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062529249
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1126/science.2309120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062531720
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1126/science.252.5009.1162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062542077
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1126/science.252.5010.1322-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1062542116
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1126/science.2911757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062573457
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1126/science.2992081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062580028
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1126/science.3001934 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062582015
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1126/science.7939658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062650677
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1126/science.8248779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062653809
289 rdf:type schema:CreativeWork
290 https://www.grid.ac/institutes/grid.116068.8 schema:alternateName Massachusetts Institute of Technology
291 schema:name Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA.
292 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...