Outline structures for the extracellular domains of the fibroblast growth factor receptors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-12

AUTHORS

A Bateman, C Chothia

ABSTRACT

Fibroblast growth factor receptors (FGFRs) have three extracellular domains that belong to the immunoglobulin superfamily. We have determined the outline structures for these domains on the basis of their homology to the I set molecule telokin. The outline structures describe the relative positions of residues in each domain; their major secondary structures, and the extent to which residues are accessible to the solvent. They also provide the basis of a coherent description of the change in recognition properties that occur when the IIIb and IIIc exons are switched and of the effects of mutations in FGFRs that cause genetic diseases. More... »

PAGES

1068-1074

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsb1295-1068

DOI

http://dx.doi.org/10.1038/nsb1295-1068

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005311803

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8846218


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