Structure of the DLM-1–Z-DNA complex reveals a conserved family of Z-DNA-binding proteins View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-09-01

AUTHORS

T Schwartz, J Behlke, K Lowenhaupt, U Heinemann, A Rich

ABSTRACT

The first crystal structure of a protein, the Z alpha high affinity binding domain of the RNA editing enzyme ADAR1, bound to left-handed Z-DNA was recently described. The essential set of residues determined from this structure to be critical for Z-DNA recognition was used to search the database for other proteins with the potential for Z-DNA binding. We found that the tumor-associated protein DLM-1 contains a domain with remarkable sequence similarities to Z alpha(ADAR). Here we report the crystal structure of this DLM-1 domain bound to left-handed Z-DNA at 1.85 A resolution. Comparison of Z-DNA binding by DLM-1 and ADAR1 reveals a common structure-specific recognition core within the binding domain. However, the domains differ in certain residues peripheral to the protein-DNA interface. These structures reveal a general mechanism of Z-DNA recognition, suggesting the existence of a family of winged-helix proteins sharing a common Z-DNA binding motif. More... »

PAGES

761-765

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsb0901-761

DOI

http://dx.doi.org/10.1038/nsb0901-761

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025587071

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11524677


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenosine Deaminase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Conserved Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Crystallography, X-Ray", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glycoproteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nucleic Acid Conformation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Conformation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Structure, Tertiary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Alignment", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ultracentrifugation", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Max Delbr\u00fcck Center for Molecular Medicine", 
          "id": "https://www.grid.ac/institutes/grid.419491.0", 
          "name": [
            "Max-Delbr\u00fcck-Centrum f\u00fcr Molekulare Medizin, Robert-R\u00f6ssle-Str. 10, D-13125 Berlin, Germany. Thomas.Schwartz@mail.rockefeller.edu"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schwartz", 
        "givenName": "T", 
        "id": "sg:person.01014652272.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014652272.92"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Behlke", 
        "givenName": "J", 
        "id": "sg:person.0612010162.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612010162.36"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Lowenhaupt", 
        "givenName": "K", 
        "id": "sg:person.01301756602.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301756602.47"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Heinemann", 
        "givenName": "U", 
        "id": "sg:person.01000563275.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000563275.06"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Rich", 
        "givenName": "A", 
        "id": "sg:person.01140155362.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140155362.98"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/emboj/18.2.470", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001337385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-440x(99)00057-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004480596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/362219a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006902089", 
          "https://doi.org/10.1038/362219a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(99)01119-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010863321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-1119(00)00368-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014557098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444998012517", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017819492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444998003254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019779527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.44.27788", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024067037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444994003112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025573949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s090744499900582x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028970138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/364412a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029108674", 
          "https://doi.org/10.1038/364412a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444900014736", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033401324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.16.8421", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035785688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0955-0674(97)80006-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040895267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.5.2899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041988268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444999011853", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043332648"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-1119(99)00419-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044824602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmbi.2000.4473", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047319567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0962-8924(98)01382-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052062034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.75.2.850-856.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052250740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi962755h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055213176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi962755h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055213176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.284.5421.1841", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062565546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1992.tb05567.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075625396"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2001-09-01", 
    "datePublishedReg": "2001-09-01", 
    "description": "The first crystal structure of a protein, the Z alpha high affinity binding domain of the RNA editing enzyme ADAR1, bound to left-handed Z-DNA was recently described. The essential set of residues determined from this structure to be critical for Z-DNA recognition was used to search the database for other proteins with the potential for Z-DNA binding. We found that the tumor-associated protein DLM-1 contains a domain with remarkable sequence similarities to Z alpha(ADAR). Here we report the crystal structure of this DLM-1 domain bound to left-handed Z-DNA at 1.85 A resolution. Comparison of Z-DNA binding by DLM-1 and ADAR1 reveals a common structure-specific recognition core within the binding domain. However, the domains differ in certain residues peripheral to the protein-DNA interface. These structures reveal a general mechanism of Z-DNA recognition, suggesting the existence of a family of winged-helix proteins sharing a common Z-DNA binding motif.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nsb0901-761", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1295033", 
        "issn": [
          "1545-9993", 
          "2331-365X"
        ], 
        "name": "Nature Structural & Molecular Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "Structure of the DLM-1\u2013Z-DNA complex reveals a conserved family of Z-DNA-binding proteins", 
    "pagination": "761-765", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "79e604116109b5e3eb634bf4938c9b2762b8f634aff244f1dd18d7d026a3ffb4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11524677"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9421566"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nsb0901-761"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1025587071"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nsb0901-761", 
      "https://app.dimensions.ai/details/publication/pub.1025587071"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:34", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000424.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/nsmb/journal/v8/n9/full/nsb0901-761.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nsb0901-761'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nsb0901-761'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nsb0901-761'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nsb0901-761'


 

This table displays all metadata directly associated to this object as RDF triples.

232 TRIPLES      21 PREDICATES      68 URIs      37 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nsb0901-761 schema:about N0471c98d5ecd4e909e00a68a70216e20
2 N28842b0ae75e47e493f0b0543804ce5d
3 N3a65c6c0b2d345898580941c4300c15d
4 N45e732f96a7b4acdba5ecf4d895fd8c0
5 N4ab2ef0929d64e5cb7cf1f92f4f4d175
6 N4d3ea03bfad741dd8184ebd9b0aa8d08
7 N514b8b78d1674be79d6bde30297e124e
8 N57af49bb39334b4797b2fb98004bbd75
9 N661964567e3c428b9f099abb9720b72f
10 N67e98500f1784b11971fe316146d933d
11 N89d9bf1c242c4617b6676bd144139235
12 N94075075e0814d399eb43e5e25340eb6
13 Nbf644bd6b2be4679a3ffe679d3a2b7cb
14 Ncc2155520d0c440d8d35d26d20fc4f89
15 Nd849cc2878e54ef7a6c9a79186217adf
16 Ne3fa0ceaaa2e44edb103d35b4245f9cd
17 Neb315ec1f169414f97175c2f81bd2d80
18 anzsrc-for:06
19 anzsrc-for:0601
20 schema:author N8bdaaa411a7f4eb58333cd4b2850e2bc
21 schema:citation sg:pub.10.1038/362219a0
22 sg:pub.10.1038/364412a0
23 https://doi.org/10.1002/j.1460-2075.1992.tb05567.x
24 https://doi.org/10.1006/jmbi.2000.4473
25 https://doi.org/10.1016/s0014-5793(99)01119-9
26 https://doi.org/10.1016/s0378-1119(00)00368-1
27 https://doi.org/10.1016/s0378-1119(99)00419-9
28 https://doi.org/10.1016/s0955-0674(97)80006-3
29 https://doi.org/10.1016/s0959-440x(99)00057-3
30 https://doi.org/10.1016/s0962-8924(98)01382-8
31 https://doi.org/10.1021/bi962755h
32 https://doi.org/10.1073/pnas.94.16.8421
33 https://doi.org/10.1074/jbc.271.44.27788
34 https://doi.org/10.1074/jbc.274.5.2899
35 https://doi.org/10.1093/emboj/18.2.470
36 https://doi.org/10.1107/s0907444900014736
37 https://doi.org/10.1107/s0907444994003112
38 https://doi.org/10.1107/s0907444998003254
39 https://doi.org/10.1107/s0907444998012517
40 https://doi.org/10.1107/s090744499900582x
41 https://doi.org/10.1107/s0907444999011853
42 https://doi.org/10.1126/science.284.5421.1841
43 https://doi.org/10.1128/jvi.75.2.850-856.2001
44 schema:datePublished 2001-09-01
45 schema:datePublishedReg 2001-09-01
46 schema:description The first crystal structure of a protein, the Z alpha high affinity binding domain of the RNA editing enzyme ADAR1, bound to left-handed Z-DNA was recently described. The essential set of residues determined from this structure to be critical for Z-DNA recognition was used to search the database for other proteins with the potential for Z-DNA binding. We found that the tumor-associated protein DLM-1 contains a domain with remarkable sequence similarities to Z alpha(ADAR). Here we report the crystal structure of this DLM-1 domain bound to left-handed Z-DNA at 1.85 A resolution. Comparison of Z-DNA binding by DLM-1 and ADAR1 reveals a common structure-specific recognition core within the binding domain. However, the domains differ in certain residues peripheral to the protein-DNA interface. These structures reveal a general mechanism of Z-DNA recognition, suggesting the existence of a family of winged-helix proteins sharing a common Z-DNA binding motif.
47 schema:genre research_article
48 schema:inLanguage en
49 schema:isAccessibleForFree false
50 schema:isPartOf N08316b9fa59f4d96b0bc929bcf64f6b3
51 Na30b66d6ec4b467bb52b06ce817cd675
52 sg:journal.1295033
53 schema:name Structure of the DLM-1–Z-DNA complex reveals a conserved family of Z-DNA-binding proteins
54 schema:pagination 761-765
55 schema:productId N213cb0746e0d4601bcb5abc2d5e0f45f
56 N437d1f4027974f36a18ce5d491080bc9
57 N66b33aac15004fef837f92921d08de96
58 N70569a3bf9834e128df5a0a769a1f8e5
59 N7f1ce0f9cc1740ef86c6b1f01b938344
60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025587071
61 https://doi.org/10.1038/nsb0901-761
62 schema:sdDatePublished 2019-04-10T20:34
63 schema:sdLicense https://scigraph.springernature.com/explorer/license/
64 schema:sdPublisher N8b05b5283bed44488231300a3156329d
65 schema:url http://www.nature.com/nsmb/journal/v8/n9/full/nsb0901-761.html
66 sgo:license sg:explorer/license/
67 sgo:sdDataset articles
68 rdf:type schema:ScholarlyArticle
69 N02ee3ff73046407ea0e8b2ee363f134c rdf:first sg:person.0612010162.36
70 rdf:rest N9e92306973c6446aa0b8946580a62f44
71 N0471c98d5ecd4e909e00a68a70216e20 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Molecular Sequence Data
73 rdf:type schema:DefinedTerm
74 N08316b9fa59f4d96b0bc929bcf64f6b3 schema:issueNumber 9
75 rdf:type schema:PublicationIssue
76 N1b840732e46a4762906c2455eade2684 rdf:first sg:person.01000563275.06
77 rdf:rest N53e8b1d44f3f47f08520d9e748311b91
78 N213cb0746e0d4601bcb5abc2d5e0f45f schema:name readcube_id
79 schema:value 79e604116109b5e3eb634bf4938c9b2762b8f634aff244f1dd18d7d026a3ffb4
80 rdf:type schema:PropertyValue
81 N28842b0ae75e47e493f0b0543804ce5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Models, Molecular
83 rdf:type schema:DefinedTerm
84 N3a65c6c0b2d345898580941c4300c15d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Adenosine Deaminase
86 rdf:type schema:DefinedTerm
87 N437d1f4027974f36a18ce5d491080bc9 schema:name nlm_unique_id
88 schema:value 9421566
89 rdf:type schema:PropertyValue
90 N45e732f96a7b4acdba5ecf4d895fd8c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Amino Acid Sequence
92 rdf:type schema:DefinedTerm
93 N4ab2ef0929d64e5cb7cf1f92f4f4d175 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Nucleic Acid Conformation
95 rdf:type schema:DefinedTerm
96 N4d3ea03bfad741dd8184ebd9b0aa8d08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Crystallography, X-Ray
98 rdf:type schema:DefinedTerm
99 N514b8b78d1674be79d6bde30297e124e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name DNA-Binding Proteins
101 rdf:type schema:DefinedTerm
102 N53e8b1d44f3f47f08520d9e748311b91 rdf:first sg:person.01140155362.98
103 rdf:rest rdf:nil
104 N57af49bb39334b4797b2fb98004bbd75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Sequence Alignment
106 rdf:type schema:DefinedTerm
107 N661964567e3c428b9f099abb9720b72f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name RNA-Binding Proteins
109 rdf:type schema:DefinedTerm
110 N66b33aac15004fef837f92921d08de96 schema:name pubmed_id
111 schema:value 11524677
112 rdf:type schema:PropertyValue
113 N67e98500f1784b11971fe316146d933d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Ultracentrifugation
115 rdf:type schema:DefinedTerm
116 N70569a3bf9834e128df5a0a769a1f8e5 schema:name dimensions_id
117 schema:value pub.1025587071
118 rdf:type schema:PropertyValue
119 N7f1ce0f9cc1740ef86c6b1f01b938344 schema:name doi
120 schema:value 10.1038/nsb0901-761
121 rdf:type schema:PropertyValue
122 N89d9bf1c242c4617b6676bd144139235 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Glycoproteins
124 rdf:type schema:DefinedTerm
125 N8b05b5283bed44488231300a3156329d schema:name Springer Nature - SN SciGraph project
126 rdf:type schema:Organization
127 N8bdaaa411a7f4eb58333cd4b2850e2bc rdf:first sg:person.01014652272.92
128 rdf:rest N02ee3ff73046407ea0e8b2ee363f134c
129 N94075075e0814d399eb43e5e25340eb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name DNA
131 rdf:type schema:DefinedTerm
132 N9e92306973c6446aa0b8946580a62f44 rdf:first sg:person.01301756602.47
133 rdf:rest N1b840732e46a4762906c2455eade2684
134 Na30b66d6ec4b467bb52b06ce817cd675 schema:volumeNumber 8
135 rdf:type schema:PublicationVolume
136 Nbf644bd6b2be4679a3ffe679d3a2b7cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Mice
138 rdf:type schema:DefinedTerm
139 Ncc2155520d0c440d8d35d26d20fc4f89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Protein Conformation
141 rdf:type schema:DefinedTerm
142 Nd849cc2878e54ef7a6c9a79186217adf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Protein Structure, Tertiary
144 rdf:type schema:DefinedTerm
145 Ne3fa0ceaaa2e44edb103d35b4245f9cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Animals
147 rdf:type schema:DefinedTerm
148 Neb315ec1f169414f97175c2f81bd2d80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Conserved Sequence
150 rdf:type schema:DefinedTerm
151 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
152 schema:name Biological Sciences
153 rdf:type schema:DefinedTerm
154 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
155 schema:name Biochemistry and Cell Biology
156 rdf:type schema:DefinedTerm
157 sg:journal.1295033 schema:issn 1545-9993
158 2331-365X
159 schema:name Nature Structural & Molecular Biology
160 rdf:type schema:Periodical
161 sg:person.01000563275.06 schema:familyName Heinemann
162 schema:givenName U
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000563275.06
164 rdf:type schema:Person
165 sg:person.01014652272.92 schema:affiliation https://www.grid.ac/institutes/grid.419491.0
166 schema:familyName Schwartz
167 schema:givenName T
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014652272.92
169 rdf:type schema:Person
170 sg:person.01140155362.98 schema:familyName Rich
171 schema:givenName A
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140155362.98
173 rdf:type schema:Person
174 sg:person.01301756602.47 schema:familyName Lowenhaupt
175 schema:givenName K
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301756602.47
177 rdf:type schema:Person
178 sg:person.0612010162.36 schema:familyName Behlke
179 schema:givenName J
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612010162.36
181 rdf:type schema:Person
182 sg:pub.10.1038/362219a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006902089
183 https://doi.org/10.1038/362219a0
184 rdf:type schema:CreativeWork
185 sg:pub.10.1038/364412a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029108674
186 https://doi.org/10.1038/364412a0
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1002/j.1460-2075.1992.tb05567.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1075625396
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1006/jmbi.2000.4473 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047319567
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/s0014-5793(99)01119-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010863321
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/s0378-1119(00)00368-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014557098
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/s0378-1119(99)00419-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044824602
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/s0955-0674(97)80006-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040895267
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/s0959-440x(99)00057-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004480596
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/s0962-8924(98)01382-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052062034
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1021/bi962755h schema:sameAs https://app.dimensions.ai/details/publication/pub.1055213176
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1073/pnas.94.16.8421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035785688
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1074/jbc.271.44.27788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024067037
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1074/jbc.274.5.2899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041988268
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1093/emboj/18.2.470 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001337385
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1107/s0907444900014736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033401324
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1107/s0907444994003112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025573949
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1107/s0907444998003254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019779527
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1107/s0907444998012517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017819492
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1107/s090744499900582x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028970138
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1107/s0907444999011853 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043332648
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1126/science.284.5421.1841 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062565546
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1128/jvi.75.2.850-856.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052250740
229 rdf:type schema:CreativeWork
230 https://www.grid.ac/institutes/grid.419491.0 schema:alternateName Max Delbrück Center for Molecular Medicine
231 schema:name Max-Delbrück-Centrum für Molekulare Medizin, Robert-Rössle-Str. 10, D-13125 Berlin, Germany. Thomas.Schwartz@mail.rockefeller.edu
232 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...