High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-08

AUTHORS

Andrea Musacchio, Matti Saraste, Matthias Wilmanns

ABSTRACT

Src-homology 3 (SH3) domains bind to proline-rich motifs in target proteins. We have determined high-resolution crystal structures of the complexes between the SH3 domains of Abl and Fyn tyrosine kinases, and two ten-residue proline-rich peptides derived from the SH3-binding proteins 3BP-1 and 3BP-2. The X-ray data show that the basic mode of binding of both proline-rich peptides is the same. Peptides are bound over their entire length and interact with three major sites on the SH3 molecules by both hydrogen-bonding and van der Waals contacts. Residues 4-10 of the peptide adopt the conformation of a left-handed polyproline helix type II. Binding of the proline at position 2 requires a kink at the non-proline position 3. More... »

PAGES

546-551

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsb0894-546

DOI

http://dx.doi.org/10.1038/nsb0894-546

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037549643

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7664083


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Binding Sites", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemical Phenomena", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemistry, Physical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Crystallography, X-Ray", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydrogen Bonding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Spectroscopy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Chemical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proline", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Structure, Tertiary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-abl", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-fyn", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Alignment", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Homology, Amino Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Substrate Specificity", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "European Molecular Biology Laboratory, Meyerhofstrasse 1, Postfach 102209, D-69012, Heidelberg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.4709.a", 
          "name": [
            "European Molecular Biology Laboratory, Meyerhofstrasse 1, Postfach 102209, D-69012, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Musacchio", 
        "givenName": "Andrea", 
        "id": "sg:person.01367316326.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367316326.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "European Molecular Biology Laboratory, Meyerhofstrasse 1, Postfach 102209, D-69012, Heidelberg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.4709.a", 
          "name": [
            "European Molecular Biology Laboratory, Meyerhofstrasse 1, Postfach 102209, D-69012, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saraste", 
        "givenName": "Matti", 
        "id": "sg:person.01017002062.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017002062.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "European Molecular Biology Laboratory, Meyerhofstrasse 1, Postfach 102209, D-69012, Heidelberg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.4709.a", 
          "name": [
            "European Molecular Biology Laboratory, Meyerhofstrasse 1, Postfach 102209, D-69012, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wilmanns", 
        "givenName": "Matthias", 
        "id": "sg:person.01257465465.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257465465.39"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/359851a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051712088", 
          "https://doi.org/10.1038/359851a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/368215a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000873113", 
          "https://doi.org/10.1038/368215a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsb0494-221", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046713967", 
          "https://doi.org/10.1038/nsb0494-221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/368764a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026759430", 
          "https://doi.org/10.1038/368764a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1994-08", 
    "datePublishedReg": "1994-08-01", 
    "description": "Src-homology 3 (SH3) domains bind to proline-rich motifs in target proteins. We have determined high-resolution crystal structures of the complexes between the SH3 domains of Abl and Fyn tyrosine kinases, and two ten-residue proline-rich peptides derived from the SH3-binding proteins 3BP-1 and 3BP-2. The X-ray data show that the basic mode of binding of both proline-rich peptides is the same. Peptides are bound over their entire length and interact with three major sites on the SH3 molecules by both hydrogen-bonding and van der Waals contacts. Residues 4-10 of the peptide adopt the conformation of a left-handed polyproline helix type II. Binding of the proline at position 2 requires a kink at the non-proline position 3.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/nsb0894-546", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1295033", 
        "issn": [
          "1545-9993", 
          "2331-365X"
        ], 
        "name": "Nature Structural & Molecular Biology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "1"
      }
    ], 
    "keywords": [
      "high-resolution crystal structures", 
      "proline-rich peptides", 
      "crystal structure", 
      "van der Waals contacts", 
      "SH3 molecules", 
      "Waals contacts", 
      "X-ray data", 
      "position 2", 
      "position 3", 
      "target proteins", 
      "residues 4", 
      "peptides", 
      "molecules", 
      "conformation", 
      "structure", 
      "complexes", 
      "binds", 
      "SH3 domain", 
      "motif", 
      "sites", 
      "proline", 
      "mode", 
      "contact", 
      "kinks", 
      "Fyn tyrosine kinase", 
      "protein", 
      "length", 
      "type II", 
      "Src homology 3", 
      "basic modes", 
      "proline-rich motif", 
      "major site", 
      "entire length", 
      "domain", 
      "data", 
      "tyrosine kinase", 
      "ABL", 
      "kinase"
    ], 
    "name": "High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides", 
    "pagination": "546-551", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1037549643"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nsb0894-546"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7664083"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nsb0894-546", 
      "https://app.dimensions.ai/details/publication/pub.1037549643"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-08-04T16:51", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_233.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/nsb0894-546"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nsb0894-546'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nsb0894-546'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nsb0894-546'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nsb0894-546'


 

This table displays all metadata directly associated to this object as RDF triples.

217 TRIPLES      21 PREDICATES      90 URIs      77 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nsb0894-546 schema:about N0aeeb2e19c264ba5ba1b57bbbd54427f
2 N166f4afe856a459382331d08f1172eb8
3 N19a3e81c1e3a4f6cab752314d9d00016
4 N22f9d652930943a5bab4310178effab0
5 N26458cda0fa24841bc336031ac6f4a00
6 N2dc96a97eae44b6e99c50511baeda080
7 N45537bfdd93b4fcaa750fee94db6be0b
8 N4f019a4c374b4dadab7b1d48c5de9808
9 N57d12bb743e047e3af39d80494862515
10 N6060f2e6121a414983a30a8a18d2a5cf
11 N846189e3e9404af78a98aa716cde9c96
12 N86b3a60eb1044fcd8da1b302ba6c8401
13 N8c24b4dbb7d540c68928354fd778b6ac
14 N90e418f29ccb4116aa1a3abc25ec66ac
15 Na7c86854768d4d679472b95f49141e77
16 Nb2ef14d8548d4e67b96ab20a2fbffee5
17 Ncd775b98cbfd48ac9425c42f72c6681a
18 Nde1b9b6f774f43739d0f7b6438d4dcac
19 Ne04fc152e6064c239d37fca7eb63cf7f
20 Ne072e99a220048dab2a841fbd8c2f0a5
21 Ned57b972e6964d4e8b9c1f37aadfcbc6
22 anzsrc-for:03
23 anzsrc-for:06
24 anzsrc-for:11
25 schema:author Nd32924f7a852408c9c868c59d3c25051
26 schema:citation sg:pub.10.1038/359851a0
27 sg:pub.10.1038/368215a0
28 sg:pub.10.1038/368764a0
29 sg:pub.10.1038/nsb0494-221
30 schema:datePublished 1994-08
31 schema:datePublishedReg 1994-08-01
32 schema:description Src-homology 3 (SH3) domains bind to proline-rich motifs in target proteins. We have determined high-resolution crystal structures of the complexes between the SH3 domains of Abl and Fyn tyrosine kinases, and two ten-residue proline-rich peptides derived from the SH3-binding proteins 3BP-1 and 3BP-2. The X-ray data show that the basic mode of binding of both proline-rich peptides is the same. Peptides are bound over their entire length and interact with three major sites on the SH3 molecules by both hydrogen-bonding and van der Waals contacts. Residues 4-10 of the peptide adopt the conformation of a left-handed polyproline helix type II. Binding of the proline at position 2 requires a kink at the non-proline position 3.
33 schema:genre article
34 schema:isAccessibleForFree false
35 schema:isPartOf N9bcb8590c9ac4210acd7bf7a7afccbe1
36 Nbc58592264564db49601cdd0413f83b2
37 sg:journal.1295033
38 schema:keywords ABL
39 Fyn tyrosine kinase
40 SH3 domain
41 SH3 molecules
42 Src homology 3
43 Waals contacts
44 X-ray data
45 basic modes
46 binds
47 complexes
48 conformation
49 contact
50 crystal structure
51 data
52 domain
53 entire length
54 high-resolution crystal structures
55 kinase
56 kinks
57 length
58 major site
59 mode
60 molecules
61 motif
62 peptides
63 position 2
64 position 3
65 proline
66 proline-rich motif
67 proline-rich peptides
68 protein
69 residues 4
70 sites
71 structure
72 target proteins
73 type II
74 tyrosine kinase
75 van der Waals contacts
76 schema:name High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides
77 schema:pagination 546-551
78 schema:productId N1c0928dd85864a12bf956dd2aac9c6e8
79 N862e6d49fbe04c45a8d36cfc061e0d25
80 N96071915117e433e80d69e76a3add071
81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037549643
82 https://doi.org/10.1038/nsb0894-546
83 schema:sdDatePublished 2022-08-04T16:51
84 schema:sdLicense https://scigraph.springernature.com/explorer/license/
85 schema:sdPublisher N19b3e8117ac740b6ba54890f6f4fa509
86 schema:url https://doi.org/10.1038/nsb0894-546
87 sgo:license sg:explorer/license/
88 sgo:sdDataset articles
89 rdf:type schema:ScholarlyArticle
90 N0aeeb2e19c264ba5ba1b57bbbd54427f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Proto-Oncogene Proteins
92 rdf:type schema:DefinedTerm
93 N166f4afe856a459382331d08f1172eb8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Substrate Specificity
95 rdf:type schema:DefinedTerm
96 N19a3e81c1e3a4f6cab752314d9d00016 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Protein Structure, Tertiary
98 rdf:type schema:DefinedTerm
99 N19b3e8117ac740b6ba54890f6f4fa509 schema:name Springer Nature - SN SciGraph project
100 rdf:type schema:Organization
101 N1c0928dd85864a12bf956dd2aac9c6e8 schema:name pubmed_id
102 schema:value 7664083
103 rdf:type schema:PropertyValue
104 N22f9d652930943a5bab4310178effab0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Crystallography, X-Ray
106 rdf:type schema:DefinedTerm
107 N26458cda0fa24841bc336031ac6f4a00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Humans
109 rdf:type schema:DefinedTerm
110 N2dc96a97eae44b6e99c50511baeda080 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Proto-Oncogene Proteins c-abl
112 rdf:type schema:DefinedTerm
113 N31063dc027584f00a1f003935e0358af rdf:first sg:person.01257465465.39
114 rdf:rest rdf:nil
115 N45537bfdd93b4fcaa750fee94db6be0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Models, Molecular
117 rdf:type schema:DefinedTerm
118 N4f019a4c374b4dadab7b1d48c5de9808 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Amino Acid Sequence
120 rdf:type schema:DefinedTerm
121 N57d12bb743e047e3af39d80494862515 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Molecular Sequence Data
123 rdf:type schema:DefinedTerm
124 N6060f2e6121a414983a30a8a18d2a5cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Chemistry, Physical
126 rdf:type schema:DefinedTerm
127 N846189e3e9404af78a98aa716cde9c96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Chemical Phenomena
129 rdf:type schema:DefinedTerm
130 N862e6d49fbe04c45a8d36cfc061e0d25 schema:name dimensions_id
131 schema:value pub.1037549643
132 rdf:type schema:PropertyValue
133 N86b3a60eb1044fcd8da1b302ba6c8401 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Proline
135 rdf:type schema:DefinedTerm
136 N8c24b4dbb7d540c68928354fd778b6ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Sequence Homology, Amino Acid
138 rdf:type schema:DefinedTerm
139 N90e418f29ccb4116aa1a3abc25ec66ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Binding Sites
141 rdf:type schema:DefinedTerm
142 N96071915117e433e80d69e76a3add071 schema:name doi
143 schema:value 10.1038/nsb0894-546
144 rdf:type schema:PropertyValue
145 N9bcb8590c9ac4210acd7bf7a7afccbe1 schema:issueNumber 8
146 rdf:type schema:PublicationIssue
147 Na7c86854768d4d679472b95f49141e77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Hydrogen Bonding
149 rdf:type schema:DefinedTerm
150 Nb2ef14d8548d4e67b96ab20a2fbffee5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Magnetic Resonance Spectroscopy
152 rdf:type schema:DefinedTerm
153 Nbc58592264564db49601cdd0413f83b2 schema:volumeNumber 1
154 rdf:type schema:PublicationVolume
155 Ncd775b98cbfd48ac9425c42f72c6681a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Peptides
157 rdf:type schema:DefinedTerm
158 Nd32924f7a852408c9c868c59d3c25051 rdf:first sg:person.01367316326.03
159 rdf:rest Ndeeb41ef945f43b08f9414f77ae32c84
160 Nde1b9b6f774f43739d0f7b6438d4dcac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Proto-Oncogene Proteins c-fyn
162 rdf:type schema:DefinedTerm
163 Ndeeb41ef945f43b08f9414f77ae32c84 rdf:first sg:person.01017002062.65
164 rdf:rest N31063dc027584f00a1f003935e0358af
165 Ne04fc152e6064c239d37fca7eb63cf7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Models, Chemical
167 rdf:type schema:DefinedTerm
168 Ne072e99a220048dab2a841fbd8c2f0a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Protein Binding
170 rdf:type schema:DefinedTerm
171 Ned57b972e6964d4e8b9c1f37aadfcbc6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Sequence Alignment
173 rdf:type schema:DefinedTerm
174 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
175 schema:name Chemical Sciences
176 rdf:type schema:DefinedTerm
177 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
178 schema:name Biological Sciences
179 rdf:type schema:DefinedTerm
180 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
181 schema:name Medical and Health Sciences
182 rdf:type schema:DefinedTerm
183 sg:journal.1295033 schema:issn 1545-9993
184 2331-365X
185 schema:name Nature Structural & Molecular Biology
186 schema:publisher Springer Nature
187 rdf:type schema:Periodical
188 sg:person.01017002062.65 schema:affiliation grid-institutes:grid.4709.a
189 schema:familyName Saraste
190 schema:givenName Matti
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017002062.65
192 rdf:type schema:Person
193 sg:person.01257465465.39 schema:affiliation grid-institutes:grid.4709.a
194 schema:familyName Wilmanns
195 schema:givenName Matthias
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257465465.39
197 rdf:type schema:Person
198 sg:person.01367316326.03 schema:affiliation grid-institutes:grid.4709.a
199 schema:familyName Musacchio
200 schema:givenName Andrea
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367316326.03
202 rdf:type schema:Person
203 sg:pub.10.1038/359851a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051712088
204 https://doi.org/10.1038/359851a0
205 rdf:type schema:CreativeWork
206 sg:pub.10.1038/368215a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000873113
207 https://doi.org/10.1038/368215a0
208 rdf:type schema:CreativeWork
209 sg:pub.10.1038/368764a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026759430
210 https://doi.org/10.1038/368764a0
211 rdf:type schema:CreativeWork
212 sg:pub.10.1038/nsb0494-221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046713967
213 https://doi.org/10.1038/nsb0494-221
214 rdf:type schema:CreativeWork
215 grid-institutes:grid.4709.a schema:alternateName European Molecular Biology Laboratory, Meyerhofstrasse 1, Postfach 102209, D-69012, Heidelberg, Germany
216 schema:name European Molecular Biology Laboratory, Meyerhofstrasse 1, Postfach 102209, D-69012, Heidelberg, Germany
217 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...