Structural basis for specificity of GRB2-SH2 revealed by a novel ligand binding mode View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-07

AUTHORS

Joseph Rahuel, Brigitte Gay, Dirk Erdmann, André Strauss, Carlos García-Echeverría, Pascal Furet, Giorgio Caravatti, Heinz Fretz, Joseph Schoepfer, Markus G. Grütter

ABSTRACT

The complex of Grb2-SH2 a BCR-Abl target peptide reveals that the peptide binds in a β-turn conformation; Trp 121 closes the binding site C-terminal to the phosphotyrosyl residue of the ligand and prevents it from assuming the expected extended conformation.

PAGES

586-589

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsb0796-586

DOI

http://dx.doi.org/10.1038/nsb0796-586

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003931922

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8673601


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