Structure based design and characterization of peptides that inhibit IgE binding to its high-affinity receptor View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-05

AUTHORS

J M McDonnell, A J Beavil, G A Mackay, B A Jameson, R Korngold, H J Gould, B J Sutton

ABSTRACT

We have designed synthetic peptide inhibitors of the interaction between IgE and its high affinity receptor, Fc epsilon RI. The structure of the second domain of CD2 was used as a modelling template for the second alpha-chain domain of Fc epsilon RI, the C-C' loop of which has been implicated in the interaction with IgE. An L-amino acid peptide and a retro-enantiomeric D-amino acid peptide were designed to mimic the conformation of the C-C' region. Both peptides were cyclized by disulphide bond formation between terminal cysteine residues, and show mirror image symmetry by circular dichroism analysis. The C-C' peptide mimics act as competitive inhibitors of IgE binding. The cyclic L- and retro D-peptides exhibited KDs of approximately 3 microM and 11 microM, respectively, for IgE. Further, the peptides inhibit IgE-mediated mast cell degranulation, an in vitro model of an allergic response. More... »

PAGES

419

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsb0596-419

DOI

http://dx.doi.org/10.1038/nsb0596-419

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047252894

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8612071


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Allergic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biosensing Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Degranulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Computer Simulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Design", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypersensitivity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin E", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mast Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Mimicry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptides, Cyclic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Conformation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, IgE", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "King's College London", 
          "id": "https://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "The Randall Institute, King's College London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "McDonnell", 
        "givenName": "J M", 
        "id": "sg:person.0662147671.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662147671.90"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Beavil", 
        "givenName": "A J", 
        "id": "sg:person.01205647402.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205647402.96"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Mackay", 
        "givenName": "G A", 
        "id": "sg:person.01055705537.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055705537.78"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Jameson", 
        "givenName": "B A", 
        "id": "sg:person.01072606406.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072606406.40"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Korngold", 
        "givenName": "R", 
        "id": "sg:person.01365227327.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365227327.84"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Gould", 
        "givenName": "H J", 
        "id": "sg:person.01041421406.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041421406.36"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Sutton", 
        "givenName": "B J", 
        "id": "sg:person.01062203557.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062203557.39"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/368744a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000663713", 
          "https://doi.org/10.1038/368744a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0263-7855(93)87009-t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001021383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0021889892009944", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003451988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(92)81333-h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004498760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bip.1978.360170606", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004798764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-3233(08)60375-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006126487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.85.6.1907", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007216350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmbi.1994.1582", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010002758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(91)90331-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014976156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(91)90331-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014976156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/384419a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015456573", 
          "https://doi.org/10.1038/384419a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.bi.61.070192.002131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015688577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.21.9765", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016692069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bip.1978.360170803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017763589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(78)90812-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018148263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-2776(08)60671-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020018159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(93)80226-k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021519079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/348411a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023911798", 
          "https://doi.org/10.1038/348411a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.89.5.1705", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025336691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/348419a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025743531", 
          "https://doi.org/10.1038/348419a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-065x.1992.tb00623.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025839243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830230310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028908154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/360232a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032121467", 
          "https://doi.org/10.1038/360232a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/abio.1994.1390", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033490686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.iy.04.040186.002223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035669767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-291x(92)91296-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037679523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bip.1980.360190303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038610786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0959-440x(92)90147-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041217345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0959-440x(92)90147-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041217345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.196904921", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042959669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bip.360270109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045132095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/366421a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047054116", 
          "https://doi.org/10.1038/366421a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.89.13.5872", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047400269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830190610", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051488961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-3233(08)60063-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051619703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/prot.340160309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052473485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/prot.340160309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052473485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ar50133a001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055151409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc00030a014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055153045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00519a032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055179183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja00087a007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055705709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja00466a064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055734800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/intimm/5.1.47", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059711809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7529940", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062647446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076080209", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076626828", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077322220", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077525191", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077890404", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078380237", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078808721", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082393136", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082696430", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082794105", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082837485", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1996-05", 
    "datePublishedReg": "1996-05-01", 
    "description": "We have designed synthetic peptide inhibitors of the interaction between IgE and its high affinity receptor, Fc epsilon RI. The structure of the second domain of CD2 was used as a modelling template for the second alpha-chain domain of Fc epsilon RI, the C-C' loop of which has been implicated in the interaction with IgE. An L-amino acid peptide and a retro-enantiomeric D-amino acid peptide were designed to mimic the conformation of the C-C' region. Both peptides were cyclized by disulphide bond formation between terminal cysteine residues, and show mirror image symmetry by circular dichroism analysis. The C-C' peptide mimics act as competitive inhibitors of IgE binding. The cyclic L- and retro D-peptides exhibited KDs of approximately 3 microM and 11 microM, respectively, for IgE. Further, the peptides inhibit IgE-mediated mast cell degranulation, an in vitro model of an allergic response.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nsb0596-419", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1295033", 
        "issn": [
          "1545-9993", 
          "2331-365X"
        ], 
        "name": "Nature Structural & Molecular Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "3"
      }
    ], 
    "name": "Structure based design and characterization of peptides that inhibit IgE binding to its high-affinity receptor", 
    "pagination": "419", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e11938696b8c17c1b678204ed3bf12cea7e2f25d4c0cde8c55216730c7e9a9c0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8612071"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9421566"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nsb0596-419"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1047252894"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nsb0596-419", 
      "https://app.dimensions.ai/details/publication/pub.1047252894"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:49", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000442.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nsb0596-419"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nsb0596-419'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nsb0596-419'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nsb0596-419'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nsb0596-419'


 

This table displays all metadata directly associated to this object as RDF triples.

332 TRIPLES      21 PREDICATES      100 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nsb0596-419 schema:about N0b0813d0b75c4a98b9caf0d103e141b8
2 N42edfd92bfc841eaae229a5a60782534
3 N43af1796b86d4c8c8edabd842d6ce5f7
4 N461a0eb1be354bc293ea69b3d816ebc3
5 N4b6e610735e042659fcd04629f65ac92
6 N51b6aae3ae724ec49103d6aa276ca0f3
7 N56378242ab05421b9c620b7f7461f7c9
8 N667fa15d79c84a43892f2771583381af
9 N6746ead8d86044029f84b56232895042
10 N68242b5341154c4eb52f96477972ab64
11 N6dbe4f9e5cf4412b96fc1af5d301d15d
12 N89aab71272104d39a15839a141568c92
13 N9a32e336fe874af89dcecc6f1d214fc7
14 Na047d90286c94d579ca34f69934cdde9
15 Na94ae820d904415ca55be1fd26e7c60b
16 Na9e5cbca6044418ab2b628208b60f723
17 Nac4fc74aa15d4f25a1af3046f0f20fa5
18 Nb398399ca7a04e22b399bcfbf21f450e
19 Nbe6faa6fc7794d04bb77eb30742b472d
20 anzsrc-for:06
21 anzsrc-for:0601
22 schema:author N26ea586a5ba44eb79ba04a6fa74127bc
23 schema:citation sg:pub.10.1038/348411a0
24 sg:pub.10.1038/348419a0
25 sg:pub.10.1038/360232a0
26 sg:pub.10.1038/366421a0
27 sg:pub.10.1038/368744a0
28 sg:pub.10.1038/384419a0
29 https://app.dimensions.ai/details/publication/pub.1076080209
30 https://app.dimensions.ai/details/publication/pub.1076626828
31 https://app.dimensions.ai/details/publication/pub.1077322220
32 https://app.dimensions.ai/details/publication/pub.1077525191
33 https://app.dimensions.ai/details/publication/pub.1077890404
34 https://app.dimensions.ai/details/publication/pub.1078380237
35 https://app.dimensions.ai/details/publication/pub.1078808721
36 https://app.dimensions.ai/details/publication/pub.1082393136
37 https://app.dimensions.ai/details/publication/pub.1082696430
38 https://app.dimensions.ai/details/publication/pub.1082794105
39 https://app.dimensions.ai/details/publication/pub.1082837485
40 https://doi.org/10.1002/anie.196904921
41 https://doi.org/10.1002/bip.1978.360170606
42 https://doi.org/10.1002/bip.1978.360170803
43 https://doi.org/10.1002/bip.1980.360190303
44 https://doi.org/10.1002/bip.360270109
45 https://doi.org/10.1002/eji.1830190610
46 https://doi.org/10.1002/eji.1830230310
47 https://doi.org/10.1002/prot.340160309
48 https://doi.org/10.1006/abio.1994.1390
49 https://doi.org/10.1006/jmbi.1994.1582
50 https://doi.org/10.1016/0003-2697(78)90812-6
51 https://doi.org/10.1016/0006-291x(92)91296-3
52 https://doi.org/10.1016/0014-5793(92)81333-h
53 https://doi.org/10.1016/0014-5793(93)80226-k
54 https://doi.org/10.1016/0022-1759(91)90331-9
55 https://doi.org/10.1016/0263-7855(93)87009-t
56 https://doi.org/10.1016/0959-440x(92)90147-y
57 https://doi.org/10.1016/s0065-2776(08)60671-9
58 https://doi.org/10.1016/s0065-3233(08)60063-7
59 https://doi.org/10.1016/s0065-3233(08)60375-7
60 https://doi.org/10.1021/ar50133a001
61 https://doi.org/10.1021/bc00030a014
62 https://doi.org/10.1021/bi00519a032
63 https://doi.org/10.1021/ja00087a007
64 https://doi.org/10.1021/ja00466a064
65 https://doi.org/10.1073/pnas.85.6.1907
66 https://doi.org/10.1073/pnas.89.13.5872
67 https://doi.org/10.1073/pnas.89.5.1705
68 https://doi.org/10.1073/pnas.91.21.9765
69 https://doi.org/10.1093/intimm/5.1.47
70 https://doi.org/10.1107/s0021889892009944
71 https://doi.org/10.1111/j.1600-065x.1992.tb00623.x
72 https://doi.org/10.1126/science.7529940
73 https://doi.org/10.1146/annurev.bi.61.070192.002131
74 https://doi.org/10.1146/annurev.iy.04.040186.002223
75 schema:datePublished 1996-05
76 schema:datePublishedReg 1996-05-01
77 schema:description We have designed synthetic peptide inhibitors of the interaction between IgE and its high affinity receptor, Fc epsilon RI. The structure of the second domain of CD2 was used as a modelling template for the second alpha-chain domain of Fc epsilon RI, the C-C' loop of which has been implicated in the interaction with IgE. An L-amino acid peptide and a retro-enantiomeric D-amino acid peptide were designed to mimic the conformation of the C-C' region. Both peptides were cyclized by disulphide bond formation between terminal cysteine residues, and show mirror image symmetry by circular dichroism analysis. The C-C' peptide mimics act as competitive inhibitors of IgE binding. The cyclic L- and retro D-peptides exhibited KDs of approximately 3 microM and 11 microM, respectively, for IgE. Further, the peptides inhibit IgE-mediated mast cell degranulation, an in vitro model of an allergic response.
78 schema:genre research_article
79 schema:inLanguage en
80 schema:isAccessibleForFree false
81 schema:isPartOf N4d8326d467fd46e698ffafb5aa98388f
82 N8ffb2f27623642ccbb371ea6cf7f2f65
83 sg:journal.1295033
84 schema:name Structure based design and characterization of peptides that inhibit IgE binding to its high-affinity receptor
85 schema:pagination 419
86 schema:productId Na95a86084cea4a4b9127391a5f1d5a4b
87 Nb340a3657bb74798aaaf37d30a0b9212
88 Nd7149d6c306d466f9da4157c3d7c0757
89 Nd93acdfdf4174bcb84bb36f72b1f9f69
90 Nd97bab6e6b944a37a150bff8d86ee6fe
91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047252894
92 https://doi.org/10.1038/nsb0596-419
93 schema:sdDatePublished 2019-04-10T14:49
94 schema:sdLicense https://scigraph.springernature.com/explorer/license/
95 schema:sdPublisher Ncd4ffccca562468fa3ba7d16e0bedbd8
96 schema:url https://www.nature.com/articles/nsb0596-419
97 sgo:license sg:explorer/license/
98 sgo:sdDataset articles
99 rdf:type schema:ScholarlyArticle
100 N0b0813d0b75c4a98b9caf0d103e141b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Hypersensitivity
102 rdf:type schema:DefinedTerm
103 N1dcb50325aa74b10874a1d1fe8b7d026 rdf:first sg:person.01365227327.84
104 rdf:rest Nd87a52806eaf49cfb383306b2565436e
105 N26ea586a5ba44eb79ba04a6fa74127bc rdf:first sg:person.0662147671.90
106 rdf:rest N82a1a64dd180479ab6e0b97f97e9febd
107 N42edfd92bfc841eaae229a5a60782534 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Rats
109 rdf:type schema:DefinedTerm
110 N43af1796b86d4c8c8edabd842d6ce5f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Receptors, IgE
112 rdf:type schema:DefinedTerm
113 N461a0eb1be354bc293ea69b3d816ebc3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Animals
115 rdf:type schema:DefinedTerm
116 N4b6e610735e042659fcd04629f65ac92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Immunoglobulin E
118 rdf:type schema:DefinedTerm
119 N4d8326d467fd46e698ffafb5aa98388f schema:volumeNumber 3
120 rdf:type schema:PublicationVolume
121 N51b6aae3ae724ec49103d6aa276ca0f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Protein Conformation
123 rdf:type schema:DefinedTerm
124 N56378242ab05421b9c620b7f7461f7c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Protein Binding
126 rdf:type schema:DefinedTerm
127 N667fa15d79c84a43892f2771583381af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Mast Cells
129 rdf:type schema:DefinedTerm
130 N6746ead8d86044029f84b56232895042 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Molecular Sequence Data
132 rdf:type schema:DefinedTerm
133 N68242b5341154c4eb52f96477972ab64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Molecular Mimicry
135 rdf:type schema:DefinedTerm
136 N6dbe4f9e5cf4412b96fc1af5d301d15d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Anti-Allergic Agents
138 rdf:type schema:DefinedTerm
139 N82a1a64dd180479ab6e0b97f97e9febd rdf:first sg:person.01205647402.96
140 rdf:rest Neadf61d09832457db280c85f5757e097
141 N89aab71272104d39a15839a141568c92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Humans
143 rdf:type schema:DefinedTerm
144 N8ffb2f27623642ccbb371ea6cf7f2f65 schema:issueNumber 5
145 rdf:type schema:PublicationIssue
146 N9a32e336fe874af89dcecc6f1d214fc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Models, Molecular
148 rdf:type schema:DefinedTerm
149 Na047d90286c94d579ca34f69934cdde9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Peptides, Cyclic
151 rdf:type schema:DefinedTerm
152 Na94ae820d904415ca55be1fd26e7c60b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Computer Simulation
154 rdf:type schema:DefinedTerm
155 Na95a86084cea4a4b9127391a5f1d5a4b schema:name readcube_id
156 schema:value e11938696b8c17c1b678204ed3bf12cea7e2f25d4c0cde8c55216730c7e9a9c0
157 rdf:type schema:PropertyValue
158 Na9e5cbca6044418ab2b628208b60f723 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Biosensing Techniques
160 rdf:type schema:DefinedTerm
161 Nac4fc74aa15d4f25a1af3046f0f20fa5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Cell Degranulation
163 rdf:type schema:DefinedTerm
164 Nb340a3657bb74798aaaf37d30a0b9212 schema:name pubmed_id
165 schema:value 8612071
166 rdf:type schema:PropertyValue
167 Nb398399ca7a04e22b399bcfbf21f450e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Amino Acid Sequence
169 rdf:type schema:DefinedTerm
170 Nbe6faa6fc7794d04bb77eb30742b472d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Drug Design
172 rdf:type schema:DefinedTerm
173 Ncd4ffccca562468fa3ba7d16e0bedbd8 schema:name Springer Nature - SN SciGraph project
174 rdf:type schema:Organization
175 Nd7149d6c306d466f9da4157c3d7c0757 schema:name doi
176 schema:value 10.1038/nsb0596-419
177 rdf:type schema:PropertyValue
178 Nd87a52806eaf49cfb383306b2565436e rdf:first sg:person.01041421406.36
179 rdf:rest Nf5d5222ab42f45d9b66ae9f5939cfec7
180 Nd93acdfdf4174bcb84bb36f72b1f9f69 schema:name dimensions_id
181 schema:value pub.1047252894
182 rdf:type schema:PropertyValue
183 Nd97bab6e6b944a37a150bff8d86ee6fe schema:name nlm_unique_id
184 schema:value 9421566
185 rdf:type schema:PropertyValue
186 Neadf61d09832457db280c85f5757e097 rdf:first sg:person.01055705537.78
187 rdf:rest Nf34e202a87b949ee9b6d0e9010cdf36c
188 Nf34e202a87b949ee9b6d0e9010cdf36c rdf:first sg:person.01072606406.40
189 rdf:rest N1dcb50325aa74b10874a1d1fe8b7d026
190 Nf5d5222ab42f45d9b66ae9f5939cfec7 rdf:first sg:person.01062203557.39
191 rdf:rest rdf:nil
192 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
193 schema:name Biological Sciences
194 rdf:type schema:DefinedTerm
195 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
196 schema:name Biochemistry and Cell Biology
197 rdf:type schema:DefinedTerm
198 sg:journal.1295033 schema:issn 1545-9993
199 2331-365X
200 schema:name Nature Structural & Molecular Biology
201 rdf:type schema:Periodical
202 sg:person.01041421406.36 schema:familyName Gould
203 schema:givenName H J
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041421406.36
205 rdf:type schema:Person
206 sg:person.01055705537.78 schema:familyName Mackay
207 schema:givenName G A
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055705537.78
209 rdf:type schema:Person
210 sg:person.01062203557.39 schema:familyName Sutton
211 schema:givenName B J
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062203557.39
213 rdf:type schema:Person
214 sg:person.01072606406.40 schema:familyName Jameson
215 schema:givenName B A
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072606406.40
217 rdf:type schema:Person
218 sg:person.01205647402.96 schema:familyName Beavil
219 schema:givenName A J
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205647402.96
221 rdf:type schema:Person
222 sg:person.01365227327.84 schema:familyName Korngold
223 schema:givenName R
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365227327.84
225 rdf:type schema:Person
226 sg:person.0662147671.90 schema:affiliation https://www.grid.ac/institutes/grid.13097.3c
227 schema:familyName McDonnell
228 schema:givenName J M
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662147671.90
230 rdf:type schema:Person
231 sg:pub.10.1038/348411a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023911798
232 https://doi.org/10.1038/348411a0
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/348419a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025743531
235 https://doi.org/10.1038/348419a0
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/360232a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032121467
238 https://doi.org/10.1038/360232a0
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/366421a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047054116
241 https://doi.org/10.1038/366421a0
242 rdf:type schema:CreativeWork
243 sg:pub.10.1038/368744a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000663713
244 https://doi.org/10.1038/368744a0
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/384419a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015456573
247 https://doi.org/10.1038/384419a0
248 rdf:type schema:CreativeWork
249 https://app.dimensions.ai/details/publication/pub.1076080209 schema:CreativeWork
250 https://app.dimensions.ai/details/publication/pub.1076626828 schema:CreativeWork
251 https://app.dimensions.ai/details/publication/pub.1077322220 schema:CreativeWork
252 https://app.dimensions.ai/details/publication/pub.1077525191 schema:CreativeWork
253 https://app.dimensions.ai/details/publication/pub.1077890404 schema:CreativeWork
254 https://app.dimensions.ai/details/publication/pub.1078380237 schema:CreativeWork
255 https://app.dimensions.ai/details/publication/pub.1078808721 schema:CreativeWork
256 https://app.dimensions.ai/details/publication/pub.1082393136 schema:CreativeWork
257 https://app.dimensions.ai/details/publication/pub.1082696430 schema:CreativeWork
258 https://app.dimensions.ai/details/publication/pub.1082794105 schema:CreativeWork
259 https://app.dimensions.ai/details/publication/pub.1082837485 schema:CreativeWork
260 https://doi.org/10.1002/anie.196904921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042959669
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1002/bip.1978.360170606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004798764
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1002/bip.1978.360170803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017763589
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1002/bip.1980.360190303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038610786
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1002/bip.360270109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045132095
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1002/eji.1830190610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051488961
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1002/eji.1830230310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028908154
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1002/prot.340160309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052473485
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1006/abio.1994.1390 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033490686
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1006/jmbi.1994.1582 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010002758
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/0003-2697(78)90812-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018148263
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/0006-291x(92)91296-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037679523
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/0014-5793(92)81333-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1004498760
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/0014-5793(93)80226-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1021519079
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/0022-1759(91)90331-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014976156
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/0263-7855(93)87009-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1001021383
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/0959-440x(92)90147-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1041217345
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/s0065-2776(08)60671-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020018159
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/s0065-3233(08)60063-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051619703
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/s0065-3233(08)60375-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006126487
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1021/ar50133a001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055151409
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1021/bc00030a014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055153045
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1021/bi00519a032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055179183
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1021/ja00087a007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055705709
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1021/ja00466a064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055734800
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1073/pnas.85.6.1907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007216350
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1073/pnas.89.13.5872 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047400269
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1073/pnas.89.5.1705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025336691
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1073/pnas.91.21.9765 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016692069
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1093/intimm/5.1.47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059711809
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1107/s0021889892009944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003451988
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1111/j.1600-065x.1992.tb00623.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025839243
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1126/science.7529940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062647446
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1146/annurev.bi.61.070192.002131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015688577
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1146/annurev.iy.04.040186.002223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035669767
329 rdf:type schema:CreativeWork
330 https://www.grid.ac/institutes/grid.13097.3c schema:alternateName King's College London
331 schema:name The Randall Institute, King's College London, UK.
332 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...