Novel metal-binding proteins by design View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-05

AUTHORS

M Klemba, K H Gardner, S Marino, N D Clarke, L Regan

ABSTRACT

We describe the successful design of a tetrahedral His3Cys Zn(II)-binding site in a small protein of known structure: the B1 domain of Streptococcal protein G. The B1 variants containing the novel metal-binding site were characterized using a combination of optical absorption, circular dichroism and NMR spectroscopies. The results indicate that the designed proteins bind Zn(II) with high affinity and tetrahedral coordination geometry, and that the overall secondary and tertiary structure of the B1 domain is maintained. More... »

PAGES

368-373

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsb0595-368

DOI

http://dx.doi.org/10.1038/nsb0595-368

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005014952

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7664093


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Binding Sites", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cadmium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Circular Dichroism", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cobalt", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cysteine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histidine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin G", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Spectroscopy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Metalloproteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Conformation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thermodynamics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Zinc", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Molecular Biophysics & Biochemistry Yale University, New Haven, Connecticut 06520, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Klemba", 
        "givenName": "M", 
        "id": "sg:person.01045434713.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045434713.53"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Gardner", 
        "givenName": "K H", 
        "id": "sg:person.01257224143.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257224143.37"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Marino", 
        "givenName": "S", 
        "id": "sg:person.01161175744.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161175744.26"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Clarke", 
        "givenName": "N D", 
        "type": "Person"
      }, 
      {
        "familyName": "Regan", 
        "givenName": "L", 
        "id": "sg:person.01005073131.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005073131.30"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0076-6879(93)27004-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000604432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0021889891004399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014885043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1091-994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018917983", 
          "https://doi.org/10.1038/nbt1091-994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.bb.22.060193.001353", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020105496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.84.14.4841", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021941073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/367660a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024274521", 
          "https://doi.org/10.1038/367660a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0076-6879(83)91010-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035948946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/362267a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047849556", 
          "https://doi.org/10.1038/362267a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-2836(80)90282-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047849632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/362367a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053458783", 
          "https://doi.org/10.1038/362367a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00147a006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055162594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00184a020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055164267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00476a001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055177644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00489a012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055178049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00501a003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055178370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ic00058a030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055540189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja00036a072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055701047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja00174a039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055711461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja00192a050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055713029"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1871600", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062511231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2116666", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062522815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3047872", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062585349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079453679", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1995-05", 
    "datePublishedReg": "1995-05-01", 
    "description": "We describe the successful design of a tetrahedral His3Cys Zn(II)-binding site in a small protein of known structure: the B1 domain of Streptococcal protein G. The B1 variants containing the novel metal-binding site were characterized using a combination of optical absorption, circular dichroism and NMR spectroscopies. The results indicate that the designed proteins bind Zn(II) with high affinity and tetrahedral coordination geometry, and that the overall secondary and tertiary structure of the B1 domain is maintained.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nsb0595-368", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1295033", 
        "issn": [
          "1545-9993", 
          "2331-365X"
        ], 
        "name": "Nature Structural & Molecular Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "2"
      }
    ], 
    "name": "Novel metal-binding proteins by design", 
    "pagination": "368-373", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "17e599fe78710db897a5cacccedf79b42725047d50879b7679c7300d5a826432"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7664093"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9421566"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nsb0595-368"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1005014952"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nsb0595-368", 
      "https://app.dimensions.ai/details/publication/pub.1005014952"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:13", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000434.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/nsb0595-368"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nsb0595-368'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nsb0595-368'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nsb0595-368'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nsb0595-368'


 

This table displays all metadata directly associated to this object as RDF triples.

224 TRIPLES      21 PREDICATES      67 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nsb0595-368 schema:about N013b3144dd5f4bc19187c22a01adc7ca
2 N09b2f8cc6928400382c53e0bb73aac74
3 N1344e603eff74beab1307a286b4e5f6f
4 N3a42f3bb33ad477c89231100577841b1
5 N46beec0892f740b5987548ac87f20de3
6 N4c6b368e65aa453fa61b01a2b07699fe
7 N5b6d5a13cd494fec9455d8330973a85b
8 N5c8ffd3df1364f4cab7feccaef2271eb
9 N85712fd6c4234b088d7992f13b2e576a
10 N86f2faf8294340dc976a16ae70c150c6
11 N8a599f1bb1ef4faca1990c9bd4005676
12 Nb518ff33fe56497c96dbb330ab6e7727
13 Nc44d1987bebc4660918794241439b301
14 Nd39ad96bd24c4765b9cbc13b0cac365c
15 Neb46253bb8e7459f8135a0ed09b4002e
16 anzsrc-for:06
17 anzsrc-for:0601
18 schema:author Nbe9ff91a28764581ab354f02d68659a5
19 schema:citation sg:pub.10.1038/362267a0
20 sg:pub.10.1038/362367a0
21 sg:pub.10.1038/367660a0
22 sg:pub.10.1038/nbt1091-994
23 https://app.dimensions.ai/details/publication/pub.1079453679
24 https://doi.org/10.1016/0022-2836(80)90282-x
25 https://doi.org/10.1016/0076-6879(93)27004-z
26 https://doi.org/10.1016/s0076-6879(83)91010-8
27 https://doi.org/10.1021/bi00147a006
28 https://doi.org/10.1021/bi00184a020
29 https://doi.org/10.1021/bi00476a001
30 https://doi.org/10.1021/bi00489a012
31 https://doi.org/10.1021/bi00501a003
32 https://doi.org/10.1021/ic00058a030
33 https://doi.org/10.1021/ja00036a072
34 https://doi.org/10.1021/ja00174a039
35 https://doi.org/10.1021/ja00192a050
36 https://doi.org/10.1073/pnas.84.14.4841
37 https://doi.org/10.1107/s0021889891004399
38 https://doi.org/10.1126/science.1871600
39 https://doi.org/10.1126/science.2116666
40 https://doi.org/10.1126/science.3047872
41 https://doi.org/10.1146/annurev.bb.22.060193.001353
42 schema:datePublished 1995-05
43 schema:datePublishedReg 1995-05-01
44 schema:description We describe the successful design of a tetrahedral His3Cys Zn(II)-binding site in a small protein of known structure: the B1 domain of Streptococcal protein G. The B1 variants containing the novel metal-binding site were characterized using a combination of optical absorption, circular dichroism and NMR spectroscopies. The results indicate that the designed proteins bind Zn(II) with high affinity and tetrahedral coordination geometry, and that the overall secondary and tertiary structure of the B1 domain is maintained.
45 schema:genre research_article
46 schema:inLanguage en
47 schema:isAccessibleForFree false
48 schema:isPartOf Nae3ce6ea3b3040658de690eb3b3aefc0
49 Nd7f0a2391a86474b81d3c78b29c36927
50 sg:journal.1295033
51 schema:name Novel metal-binding proteins by design
52 schema:pagination 368-373
53 schema:productId N02d9f3f29ace4e28b1d6f2eaa03b148a
54 N2cc092ccf95d4f8d945717e3c54f606e
55 N527ba20dbadf4c82911d53d0ae1beec2
56 N82852d0e2cdd4d3ab93cce3223b63347
57 Nc699eef01a7546158d3fbd47de688ebd
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005014952
59 https://doi.org/10.1038/nsb0595-368
60 schema:sdDatePublished 2019-04-10T23:13
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher N69e577ff69ef468bbf0fa5bd5ec23cd6
63 schema:url http://www.nature.com/articles/nsb0595-368
64 sgo:license sg:explorer/license/
65 sgo:sdDataset articles
66 rdf:type schema:ScholarlyArticle
67 N013b3144dd5f4bc19187c22a01adc7ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Zinc
69 rdf:type schema:DefinedTerm
70 N02d9f3f29ace4e28b1d6f2eaa03b148a schema:name doi
71 schema:value 10.1038/nsb0595-368
72 rdf:type schema:PropertyValue
73 N09b2f8cc6928400382c53e0bb73aac74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Cadmium
75 rdf:type schema:DefinedTerm
76 N1084cf91e4b34d738d3eb44b111dba7e schema:familyName Clarke
77 schema:givenName N D
78 rdf:type schema:Person
79 N1344e603eff74beab1307a286b4e5f6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Molecular Sequence Data
81 rdf:type schema:DefinedTerm
82 N2cc092ccf95d4f8d945717e3c54f606e schema:name readcube_id
83 schema:value 17e599fe78710db897a5cacccedf79b42725047d50879b7679c7300d5a826432
84 rdf:type schema:PropertyValue
85 N361355c6aa904b1783641297ba8d3a5b rdf:first sg:person.01005073131.30
86 rdf:rest rdf:nil
87 N3a42f3bb33ad477c89231100577841b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Cysteine
89 rdf:type schema:DefinedTerm
90 N46beec0892f740b5987548ac87f20de3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Circular Dichroism
92 rdf:type schema:DefinedTerm
93 N4c6b368e65aa453fa61b01a2b07699fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Models, Molecular
95 rdf:type schema:DefinedTerm
96 N527ba20dbadf4c82911d53d0ae1beec2 schema:name pubmed_id
97 schema:value 7664093
98 rdf:type schema:PropertyValue
99 N5b6d5a13cd494fec9455d8330973a85b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Magnetic Resonance Spectroscopy
101 rdf:type schema:DefinedTerm
102 N5c8ffd3df1364f4cab7feccaef2271eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Binding Sites
104 rdf:type schema:DefinedTerm
105 N62b1289adb9f42d7a12e5ace8610b7f0 rdf:first sg:person.01257224143.37
106 rdf:rest Na11c12d7888a454f85bf9317d79a0f34
107 N69e577ff69ef468bbf0fa5bd5ec23cd6 schema:name Springer Nature - SN SciGraph project
108 rdf:type schema:Organization
109 N82852d0e2cdd4d3ab93cce3223b63347 schema:name dimensions_id
110 schema:value pub.1005014952
111 rdf:type schema:PropertyValue
112 N85712fd6c4234b088d7992f13b2e576a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Protein Conformation
114 rdf:type schema:DefinedTerm
115 N86f2faf8294340dc976a16ae70c150c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Immunoglobulin G
117 rdf:type schema:DefinedTerm
118 N8a599f1bb1ef4faca1990c9bd4005676 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Thermodynamics
120 rdf:type schema:DefinedTerm
121 Na11c12d7888a454f85bf9317d79a0f34 rdf:first sg:person.01161175744.26
122 rdf:rest Na1abf0550b654aa89cb05feb688f808d
123 Na1abf0550b654aa89cb05feb688f808d rdf:first N1084cf91e4b34d738d3eb44b111dba7e
124 rdf:rest N361355c6aa904b1783641297ba8d3a5b
125 Nae3ce6ea3b3040658de690eb3b3aefc0 schema:volumeNumber 2
126 rdf:type schema:PublicationVolume
127 Nb518ff33fe56497c96dbb330ab6e7727 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Cobalt
129 rdf:type schema:DefinedTerm
130 Nbe9ff91a28764581ab354f02d68659a5 rdf:first sg:person.01045434713.53
131 rdf:rest N62b1289adb9f42d7a12e5ace8610b7f0
132 Nc44d1987bebc4660918794241439b301 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Amino Acid Sequence
134 rdf:type schema:DefinedTerm
135 Nc699eef01a7546158d3fbd47de688ebd schema:name nlm_unique_id
136 schema:value 9421566
137 rdf:type schema:PropertyValue
138 Nd39ad96bd24c4765b9cbc13b0cac365c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Histidine
140 rdf:type schema:DefinedTerm
141 Nd7f0a2391a86474b81d3c78b29c36927 schema:issueNumber 5
142 rdf:type schema:PublicationIssue
143 Neb46253bb8e7459f8135a0ed09b4002e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Metalloproteins
145 rdf:type schema:DefinedTerm
146 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
147 schema:name Biological Sciences
148 rdf:type schema:DefinedTerm
149 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
150 schema:name Biochemistry and Cell Biology
151 rdf:type schema:DefinedTerm
152 sg:journal.1295033 schema:issn 1545-9993
153 2331-365X
154 schema:name Nature Structural & Molecular Biology
155 rdf:type schema:Periodical
156 sg:person.01005073131.30 schema:familyName Regan
157 schema:givenName L
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005073131.30
159 rdf:type schema:Person
160 sg:person.01045434713.53 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
161 schema:familyName Klemba
162 schema:givenName M
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045434713.53
164 rdf:type schema:Person
165 sg:person.01161175744.26 schema:familyName Marino
166 schema:givenName S
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161175744.26
168 rdf:type schema:Person
169 sg:person.01257224143.37 schema:familyName Gardner
170 schema:givenName K H
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257224143.37
172 rdf:type schema:Person
173 sg:pub.10.1038/362267a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047849556
174 https://doi.org/10.1038/362267a0
175 rdf:type schema:CreativeWork
176 sg:pub.10.1038/362367a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053458783
177 https://doi.org/10.1038/362367a0
178 rdf:type schema:CreativeWork
179 sg:pub.10.1038/367660a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024274521
180 https://doi.org/10.1038/367660a0
181 rdf:type schema:CreativeWork
182 sg:pub.10.1038/nbt1091-994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018917983
183 https://doi.org/10.1038/nbt1091-994
184 rdf:type schema:CreativeWork
185 https://app.dimensions.ai/details/publication/pub.1079453679 schema:CreativeWork
186 https://doi.org/10.1016/0022-2836(80)90282-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047849632
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/0076-6879(93)27004-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1000604432
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/s0076-6879(83)91010-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035948946
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1021/bi00147a006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055162594
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1021/bi00184a020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055164267
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1021/bi00476a001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055177644
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1021/bi00489a012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055178049
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1021/bi00501a003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055178370
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1021/ic00058a030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055540189
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1021/ja00036a072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055701047
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1021/ja00174a039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055711461
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1021/ja00192a050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055713029
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1073/pnas.84.14.4841 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021941073
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1107/s0021889891004399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014885043
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1126/science.1871600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062511231
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1126/science.2116666 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062522815
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1126/science.3047872 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062585349
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1146/annurev.bb.22.060193.001353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020105496
221 rdf:type schema:CreativeWork
222 https://www.grid.ac/institutes/grid.47100.32 schema:alternateName Yale University
223 schema:name Department of Molecular Biophysics & Biochemistry Yale University, New Haven, Connecticut 06520, USA.
224 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...