Expert consensus document: Consensus statement on best practice management regarding the use of intravesical immunotherapy with BCG for bladder cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-04

AUTHORS

Ashish M. Kamat, Thomas W. Flaig, H. Barton Grossman, Badrinath Konety, Donald Lamm, Michael A. O'Donnell, Edward Uchio, Jason A. Efstathiou, John A. Taylor

ABSTRACT

Multiple clinical trials have demonstrated that intravesical Bacillus Calmette-Guérin (BCG) treatment reduces recurrences and progression in patients with non-muscle-invasive bladder cancer (NMIBC). However, although BCG has been in use for almost 40 years, this agent is often underutilized and practice patterns of administration vary. This neglect is most likely caused by uncertainties about the optimal use of BCG, including unawareness of optimal treatment schedules and about patient populations that most benefit from BCG treatment. To address this deficit, a focus group of specialized urologic oncologists (urologists, medical oncologists and radiation oncologists) reviewed the current guidelines and clinical evidence, discussed their experiences and formed a consensus regarding the optimal use of BCG in the management of patients with NIMBC. The experts concluded that continuing therapy with 3-week BCG maintenance is superior to induction treatment only and is the single most important factor in improving outcomes in patients with NMIBC. They also concluded that a reliable alternative to radical cystectomy in truly BCG-refractory disease remains the subject of clinical trials. In addition, definitions for common terms of BCG failure, such as BCG-refractory and BCG-intolerant, have been formulated. More... »

PAGES

225-235

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nrurol.2015.58

DOI

http://dx.doi.org/10.1038/nrurol.2015.58

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049087417

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25800393


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