Toll-like receptors and chronic inflammation in rheumatic diseases: new developments View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-06

AUTHORS

Leo A. B. Joosten, Shahla Abdollahi-Roodsaz, Charles A. Dinarello, Luke O'Neill, Mihai G. Netea

ABSTRACT

In the past few years, new developments have been reported on the role of Toll-like receptors (TLRs) in chronic inflammation in rheumatic diseases. The inhibitory function of TLR10 has been demonstrated. Receptors that enhance the function of TLRs, and several TLR inhibitors, have been identified. In addition, the role of the microbiome and TLRs in the onset of rheumatic diseases has been reported. We review novel insights on the role of TLRs in several inflammatory joint diseases, including rheumatoid arthritis, systemic lupus erythematosus, gout and Lyme arthritis, with a focus on the signalling mechanisms mediated by the Toll-IL-1 receptor (TIR) domain, the exogenous and endogenous ligands of TLRs, and the current and future therapeutic strategies to target TLR signalling in rheumatic diseases. More... »

PAGES

344-357

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrrheum.2016.61

    DOI

    http://dx.doi.org/10.1038/nrrheum.2016.61

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27170508


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    698 rdf:type schema:Organization
     




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