'MHC-I-opathy'—unified concept for spondyloarthritis and Behçet disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-12

AUTHORS

Dennis McGonagle, Sibel Zehra Aydin, Ahmet Gül, Alfred Mahr, Haner Direskeneli

ABSTRACT

The spondyloarthropathies comprise ankylosing spondylitis (AS), reactive arthritis, psoriatic arthritis (PsA) and arthritis associated with inflammatory bowel disease. In this Perspectives article, we describe how Behçet disease and several clinically distinct spondyloarthropathies-all associated with MHC class I (MHC-I) alleles such as HLA-B(*)51, HLA-C(*)0602 and HLA-B(*)27 and epistatic ERAP-1 interactions-have a shared immunopathogenetic basis. As a unifying concept, we propose that barrier dysfunction in environmentally exposed organs such as the skin, and aberrant innate immune reactions at sites of mechanical stress, can often trigger secondary adaptive immune CD8(+) T-cell responses with prominent neutrophilic inflammation that culminate in exacerbation and recurrence of these diseases. Of note, these 'MHC-I-opathies' show a differential immunopathology, probably reflecting antigenic differences within target tissues: HLA-B(*)51 is linked to ocular and mucocutaneous disease but not gut involvement, and HLA-C(*)0602 is linked to type I psoriasis but not scalp or nail disease. More... »

PAGES

731-740

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrrheum.2015.147

    DOI

    http://dx.doi.org/10.1038/nrrheum.2015.147

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1008336506

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26526644


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