Imaging tau and amyloid-β proteinopathies in Alzheimer disease and other conditions View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-02-16

AUTHORS

Victor L. Villemagne, Vincent Doré, Samantha C. Burnham, Colin L. Masters, Christopher C. Rowe

ABSTRACT

Most neurodegenerative disorders are associated with aggregated protein deposits. In the case of Alzheimer disease (AD), extracellular amyloid-β (Aβ) aggregates and intracellular tau neurofibrillary tangles are the two neuropathological hallmarks of the disease. Aβ-PET imaging has already been approved for clinical use and is being used in clinical trials of anti-Aβ therapies both for patient recruitment and as an outcome measure. These studies have shown that Aβ accumulation is a protracted process that can extend for more than 2 decades before the onset of clinical AD. This Review describes how in vivo brain imaging of Aβ pathology has revolutionized the evaluation of patients with clinical AD by providing robust and reproducible statements of global or regional brain Aβ burden and enabling the monitoring of disease progression. The role of selective tau imaging is discussed, focusing on how longitudinal tau and Aβ imaging studies might reveal the various effects (sequential and/or parallel, independent and/or synergistic) of these proteins on progression, cognition and other disease-specific biomarkers of neurodegeneration. Finally, imaging studies are discussed in the context of elucidating the respective roles of Aβ and tau in AD and in advancing our understanding of the relationship and/or interplay between these two proteinopathies. More... »

PAGES

225

References to SciGraph publications

  • 2011-10. In vivo demonstration of amyloid burden in posterior cortical atrophy: a case series with PET and CSF findings in JOURNAL OF NEUROLOGY
  • 2012-04. Using PET with 18F-AV-45 (florbetapir) to quantify brain amyloid load in a clinical environment in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2011-10. Amyloid imaging in prodromal Alzheimer's disease in ALZHEIMER'S RESEARCH & THERAPY
  • 2015-05. PART is part of Alzheimer disease in ACTA NEUROPATHOLOGICA
  • 2016-12. An autoradiographic evaluation of AV-1451 Tau PET in dementia in ACTA NEUROPATHOLOGICA COMMUNICATIONS
  • 2017-05. Tau aggregation influences cognition and hippocampal atrophy in the absence of beta-amyloid: a clinico-imaging-pathological study of primary age-related tauopathy (PART) in ACTA NEUROPATHOLOGICA
  • 2018-07. Longitudinal changes of tau PET imaging in relation to hypometabolism in prodromal and Alzheimer’s disease dementia in MOLECULAR PSYCHIATRY
  • 2010-05. Frontotemporal lobar degeneration in CNS DRUGS
  • 2010-06. Pro: Can biomarkers be gold standards in Alzheimer's disease? in ALZHEIMER'S RESEARCH & THERAPY
  • 2017-10. [F-18]-AV-1451 binding correlates with postmortem neurofibrillary tangle Braak staging in ACTA NEUROPATHOLOGICA
  • 2014-09. Florbetapir F 18 amyloid PET and 36-month cognitive decline:a prospective multicenter study in MOLECULAR PSYCHIATRY
  • 2014-05. In vivo evaluation of a novel tau imaging tracer for Alzheimer’s disease in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2009-04. Challenges in the conduct of disease-modifying trials in ad: Practical experience from a phase 2 trial of TAU-aggregation inhibitor therapy in THE JOURNAL OF NUTRITION, HEALTH & AGING
  • 2013-04. An In Vivo Evaluation of Cerebral Cortical Amyloid with [18F]Flutemetamol Using Positron Emission Tomography Compared with Parietal Biopsy Samples in Living Normal Pressure Hydrocephalus Patients in MOLECULAR IMAGING AND BIOLOGY
  • 2007-04. Biomarkers of neurodegeneration for diagnosis and monitoring therapeutics in NATURE REVIEWS DRUG DISCOVERY
  • 2013-11. Longitudinal change in CSF Tau and Aβ biomarkers for up to 48 months in ADNI in ACTA NEUROPATHOLOGICA
  • 2017-12. Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain in ALZHEIMER'S RESEARCH & THERAPY
  • 2017-11. 18F-Florbetaben PET beta-amyloid binding expressed in Centiloids in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2013-02. 18F-florbetaben Aβ imaging in mild cognitive impairment in ALZHEIMER'S RESEARCH & THERAPY
  • 2014-12. Primary age-related tauopathy (PART): a common pathology associated with human aging in ACTA NEUROPATHOLOGICA
  • 2014. Neuropathology in MULTIPLE SYSTEM ATROPHY
  • 2001-10. Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage alzheimer’s disease in JOURNAL OF MOLECULAR NEUROSCIENCE
  • 2014-02. Breast cancer detection using high-resolution breast PET compared to whole-body PET or PET/CT in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2014-12. PART and SNAP in ACTA NEUROPATHOLOGICA
  • 2008-01. In vivo amyloid imaging with PET in frontotemporal dementia in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2015-05. PART, a distinct tauopathy, different from classical sporadic Alzheimer disease in ACTA NEUROPATHOLOGICA
  • 2011-09. The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics in NATURE REVIEWS DRUG DISCOVERY
  • 2008-08. The ART of Loss: Aβ Imaging in the Evaluation of Alzheimer’s Disease and other Dementias in MOLECULAR NEUROBIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrneurol.2018.9

    DOI

    http://dx.doi.org/10.1038/nrneurol.2018.9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1101077599

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29449700


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Florey Institute of Neuroscience and Mental Health", 
              "id": "https://www.grid.ac/institutes/grid.418025.a", 
              "name": [
                "Department of Molecular Imaging and Therapy, Centre for PET, Austin Health, Heidelberg, Victoria, Australia.", 
                "Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia.", 
                "The Florey Institute of Neuroscience and Mental Health and University of Melbourne, Parkville, Victoria, Australia."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Villemagne", 
            "givenName": "Victor L.", 
            "id": "sg:person.014745210673.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014745210673.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Austin Health", 
              "id": "https://www.grid.ac/institutes/grid.410678.c", 
              "name": [
                "Department of Molecular Imaging and Therapy, Centre for PET, Austin Health, Heidelberg, Victoria, Australia.", 
                "CSIRO, Health and Biosecurity Flagship, The Australian eHealth Research Centre, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dor\u00e9", 
            "givenName": "Vincent", 
            "id": "sg:person.0600065374.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600065374.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CSIRO Health and Biosecurity", 
              "id": "https://www.grid.ac/institutes/grid.492989.7", 
              "name": [
                "eHealth, CSIRO Health and Biosecurity, Melbourne, Parkville, Victoria, Australia."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Burnham", 
            "givenName": "Samantha C.", 
            "id": "sg:person.01066450464.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066450464.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Florey Institute of Neuroscience and Mental Health", 
              "id": "https://www.grid.ac/institutes/grid.418025.a", 
              "name": [
                "The Florey Institute of Neuroscience and Mental Health and University of Melbourne, Parkville, Victoria, Australia."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Masters", 
            "givenName": "Colin L.", 
            "id": "sg:person.0643473627.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643473627.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Florey Institute of Neuroscience and Mental Health", 
              "id": "https://www.grid.ac/institutes/grid.418025.a", 
              "name": [
                "Department of Molecular Imaging and Therapy, Centre for PET, Austin Health, Heidelberg, Victoria, Australia.", 
                "Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia.", 
                "The Florey Institute of Neuroscience and Mental Health and University of Melbourne, Parkville, Victoria, Australia."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rowe", 
            "givenName": "Christopher C.", 
            "id": "sg:person.01210677130.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210677130.28"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.3233/jad-150247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000171418"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.283.12.1571", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001167675"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.22608", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002043918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.21843", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002050736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.21843", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002050736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awr044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002146991"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archneurol.2007.23", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002715139"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.3669-09.2009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002736466"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jalz.2011.04.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002950568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1474-4422(09)70299-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003108805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000163927", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003200530"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archneur.64.3.noc60123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003509907"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.21955", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003944440"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1474-4422(14)70090-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004039747"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.21451", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004561483"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archneurol.2011.535", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004855546"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1474-4422(13)70044-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005017445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m501285200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005020995"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/b978-0-12-394816-8.00002-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005304186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.22628", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006022678"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40478-016-0315-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006093437", 
              "https://doi.org/10.1186/s40478-016-0315-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40478-016-0315-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006093437", 
              "https://doi.org/10.1186/s40478-016-0315-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0900345106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006130429"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neurobiolaging.2012.06.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007010312"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neurobiolaging.2006.09.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007695507"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2967/jnumed.114.148981", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008088660"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-7091-0687-7_3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008416385", 
              "https://doi.org/10.1007/978-3-7091-0687-7_3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/alzrt41", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008491941", 
              "https://doi.org/10.1186/alzrt41"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2016.01.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009123709"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.dadm.2016.12.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009187571"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.22068", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009203901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd3505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009624842", 
              "https://doi.org/10.1038/nrd3505"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.0730-07.2007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010620750"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.0305-1846.2003.00481.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010948922"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-8993(99)01466-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011212764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2006.03989.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011396068"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.22333", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012322349"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1474-4422(08)70001-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012432155"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1474-4422(11)70077-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012606695"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awr216", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012796794"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jamaneurol.2014.2031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012826894"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.24844", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013259503"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archneurol.2011.1538", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013423205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1474-4422(16)30125-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013569569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jnnp.2007.127878", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013600692"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1474-4422(14)70252-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014649642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-015-1407-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014650794", 
              "https://doi.org/10.1007/s00401-015-1407-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-015-1390-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014972059", 
              "https://doi.org/10.1007/s00401-015-1390-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-015-1390-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014972059", 
              "https://doi.org/10.1007/s00401-015-1390-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.24321", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014986615"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1474-4422(13)70194-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015055172"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.24546", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015127175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2967/jnumed.111.089730", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015444921"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.2010.2008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015450809"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jalz.2011.03.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015460770"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-013-2553-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015830116", 
              "https://doi.org/10.1007/s00259-013-2553-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2013.07.037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016306106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neurobiolaging.2010.03.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016806438"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12603-009-0046-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016828839", 
              "https://doi.org/10.1007/s12603-009-0046-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12603-009-0046-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016828839", 
              "https://doi.org/10.1007/s12603-009-0046-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jamaneurol.2014.4144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017346285"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-014-1362-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017495710", 
              "https://doi.org/10.1007/s00401-014-1362-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-014-1362-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017495710", 
              "https://doi.org/10.1007/s00401-014-1362-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bmcl.2008.12.069", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017514730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/emmm.200900048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017577260"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0000000000002923", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017625707"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0000000000002923", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017625707"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuropsychologia.2008.02.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017806350"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jalz.2011.03.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018411398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0197-4580(97)00056-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018951481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1474-4422(10)70043-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019191546"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1531-8249(199903)45:3<358::aid-ana12>3.0.co;2-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019306016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0022-510x(70)90063-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019350526"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0022-510x(70)90063-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019350526"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.20009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019367853"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awm238", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019773913"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd2176", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019893204", 
              "https://doi.org/10.1038/nrd2176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.24040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019934103"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2967/jnumed.108.058529", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020264059"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awn107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020269912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neurobiolaging.2007.03.029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020422385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1134108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020426292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jalz.2015.02.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020606984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/alzrt88", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020989647", 
              "https://doi.org/10.1186/alzrt88"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/ene.13164", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021209701"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/nen.0b013e31824b211b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021810233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cpet.2009.12.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022137858"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awv191", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022260671"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awr066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023334786"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.23908", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023439990"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archneurol.2011.150", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023756040"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1474-4422(12)70142-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023875103"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00415-011-6030-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024186776", 
              "https://doi.org/10.1007/s00415-011-6030-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0197-4580(00)00173-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024254186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jamaneurol.2013.1062", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025084978"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jalz.2011.03.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025279802"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awn016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025352748"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scitranslmed.3002609", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025584955"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neulet.2007.03.064", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025966122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jnnp-2014-308094", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027209137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.nbd.2010.10.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027457741"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2796.2004.01380.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027683931"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awp062", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028065595"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neurobiolaging.2005.07.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028320315"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neurobiolaging.2005.07.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028320315"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-011-2021-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028393977", 
              "https://doi.org/10.1007/s00259-011-2021-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.nucmedbio.2012.03.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028521726"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.21164", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028666580"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12035-008-8019-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028903939", 
              "https://doi.org/10.1007/s12035-008-8019-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archneurol.2009.285", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028973239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archneurol.2011.77", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029066171"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2967/jnumed.109.063305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029411711"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0158460", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029549776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/1440-1681.12598", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029804036"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archneurol.2011.70", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029833183"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroimage.2007.09.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030311365"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archneur.56.3.303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030365018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0531-5565(02)00141-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030998113"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0166-2236(96)01030-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031070780"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/cn500103u", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031168861"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.2015.4669", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031264828"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jalz.2013.01.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031642676"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1385/jmn:17:2:101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031691219", 
              "https://doi.org/10.1385/jmn:17:2:101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.20730", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031718949"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.20730", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031718949"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11307-012-0583-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031995292", 
              "https://doi.org/10.1007/s11307-012-0583-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2013.12.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032944547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archneurol.2010.357", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034446097"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awm336", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034818309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jamaneurol.2014.4829", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035611656"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-014-1349-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036179092", 
              "https://doi.org/10.1007/s00401-014-1349-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jnnp.2008.171496", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036233629"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0166-2236(02)02037-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036832085"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.22099", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037017380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2990.2003.00545.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037212011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.parkreldis.2007.07.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037994539"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/alzrt158", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038107278", 
              "https://doi.org/10.1186/alzrt158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/aws125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038222252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jalz.2016.02.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038834094"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jalz.2016.02.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038834094"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jalz.2016.02.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038834094"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neurobiolaging.2010.04.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039551403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000259035.98480.ed", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039897238"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000259035.98480.ed", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039897238"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hbm.22927", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040015027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neurobiolaging.2015.10.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040072691"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awt142", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040124857"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archneur.64.8.1140", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040467341"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archneur.65.11.1509", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040961566"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1586/14737159.4.1.63", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041598426"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1474-4422(12)70015-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043289055"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.20889", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043584475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jalz.2011.07.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043691942"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awn320", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043963301"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awp326", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044172509"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2014.9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044329471", 
              "https://doi.org/10.1038/mp.2014.9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1474-4422(10)70223-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044499508"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0058816", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045500685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000109754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046193315"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biopsych.2011.04.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046508499"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/mds.26851", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046642007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jamaneurol.2016.2078", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046777311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/11533100-000000000-00000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047040889", 
              "https://doi.org/10.2165/11533100-000000000-00000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/11533100-000000000-00000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047040889", 
              "https://doi.org/10.2165/11533100-000000000-00000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neurobiolaging.2011.09.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048451358"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scitranslmed.aaf2362", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048536310"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.24825", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048664011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archneur.1985.04060100083029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049843631"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.semnuclmed.2011.03.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050222585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2967/jnumed.109.064360", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050232947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.24517", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050357746"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jalz.2014.07.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050435075"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.24706", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050769314"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awp214", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050846973"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awp214", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050846973"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archneurol.2011.153", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050971746"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-007-0523-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051012934", 
              "https://doi.org/10.1007/s00259-007-0523-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-007-0523-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051012934", 
              "https://doi.org/10.1007/s00259-007-0523-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neurobiolaging.2011.11.029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051801056"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000335381", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051859247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.22248", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052165065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-013-2681-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052642973", 
              "https://doi.org/10.1007/s00259-013-2681-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awn061", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052800839"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-013-1151-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052998440", 
              "https://doi.org/10.1007/s00401-013-1151-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.278.16.1349", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054161541"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acs.jmedchem.6b00166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055100047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm050166g", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055949459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm050166g", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055949459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/aww041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059445113"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/aww139", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059445172"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/aww334", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059445324"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnen/64.5.420", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059822152"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scitranslmed.3007941", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062688220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.con.0000429181.60095.99", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064344158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.con.0000429181.60095.99", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064344158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.con.0000429181.60095.99", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064344158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000228230.26044.a4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064348348"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000228230.26044.a4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064348348"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000228230.26044.a4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064348348"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000244749.20056.d4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064348717"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000244749.20056.d4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064348717"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000244749.20056.d4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064348717"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000256373.39415.b1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064348989"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000256373.39415.b1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064348989"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000256373.39415.b1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064348989"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000256373.39415.b1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064348989"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000261919.22630.ea", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064349201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000261919.22630.ea", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064349201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000261919.22630.ea", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064349201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000326146.60732.d6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064350547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000326146.60732.d6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064350547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000326146.60732.d6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064350547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0000000000002892", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064353673"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0000000000002892", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064353673"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0000000000002892", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064353673"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3181b23564", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064354537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3181b23564", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064354537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3181b23564", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064354537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3181c918b5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064354929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3181c918b5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064354929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3181c918b5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064354929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3181c918b5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064354929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3181d3e3e9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064355101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3181d3e3e9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064355101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3181d3e3e9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064355101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e31823b9c5e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064356650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e31823b9c5e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064356650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e31823b9c5e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064356650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e318246d67a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064356739"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e318246d67a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064356739"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e318246d67a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064356739"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3182661f74", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064357163"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3182661f74", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064357163"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3182661f74", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064357163"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3182661f74", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064357163"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3182840bbe", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064357577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3182840bbe", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064357577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3182840bbe", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064357577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3182840bbe", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064357577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3182872830", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064357602"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3182872830", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064357602"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3182872830", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064357602"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3182918ca6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064357722"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3182918ca6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064357722"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3182918ca6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064357722"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3182a8418b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064358023"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3182a8418b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064358023"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3182a8418b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064358023"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.38.11.1688", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064367511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.52.6.1158", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064377351"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/156720510790274446", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069188931"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/156720511795745375", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069189054"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2967/jnumed.115.171595", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070928465"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074651193", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077373311", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3233/jad-122059", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078660394"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3233/jpd-130247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078808602"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082765991", 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-017-1681-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083534962", 
              "https://doi.org/10.1007/s00401-017-1681-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-017-1681-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083534962", 
              "https://doi.org/10.1007/s00401-017-1681-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2967/jnumed.116.185199", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083862224"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jamaneurol.2016.5755", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084005987"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13195-017-0253-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084252361", 
              "https://doi.org/10.1186/s13195-017-0253-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13195-017-0253-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084252361", 
              "https://doi.org/10.1186/s13195-017-0253-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2017.108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085417603", 
              "https://doi.org/10.1038/mp.2017.108"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2017.108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085417603", 
              "https://doi.org/10.1038/mp.2017.108"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2017.108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085417603", 
              "https://doi.org/10.1038/mp.2017.108"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2967/jnumed.117.190082", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085464448"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-017-1740-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085993567", 
              "https://doi.org/10.1007/s00401-017-1740-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-017-1740-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085993567", 
              "https://doi.org/10.1007/s00401-017-1740-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-017-3749-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086122668", 
              "https://doi.org/10.1007/s00259-017-3749-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-017-3749-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086122668", 
              "https://doi.org/10.1007/s00259-017-3749-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acs.jmedchem.7b00632", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090388851"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.25060", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092085054"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-02-16", 
        "datePublishedReg": "2018-02-16", 
        "description": "Most neurodegenerative disorders are associated with aggregated protein deposits. In the case of Alzheimer disease (AD), extracellular amyloid-\u03b2 (A\u03b2) aggregates and intracellular tau neurofibrillary tangles are the two neuropathological hallmarks of the disease. A\u03b2-PET imaging has already been approved for clinical use and is being used in clinical trials of anti-A\u03b2 therapies both for patient recruitment and as an outcome measure. These studies have shown that A\u03b2 accumulation is a protracted process that can extend for more than 2 decades before the onset of clinical AD. This Review describes how in vivo brain imaging of A\u03b2 pathology has revolutionized the evaluation of patients with clinical AD by providing robust and reproducible statements of global or regional brain A\u03b2 burden and enabling the monitoring of disease progression. The role of selective tau imaging is discussed, focusing on how longitudinal tau and A\u03b2 imaging studies might reveal the various effects (sequential and/or parallel, independent and/or synergistic) of these proteins on progression, cognition and other disease-specific biomarkers of neurodegeneration. Finally, imaging studies are discussed in the context of elucidating the respective roles of A\u03b2 and tau in AD and in advancing our understanding of the relationship and/or interplay between these two proteinopathies.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nrneurol.2018.9", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.6722695", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6734612", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6733444", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1036166", 
            "issn": [
              "1759-4758", 
              "1759-4766"
            ], 
            "name": "Nature Reviews Neurology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "14"
          }
        ], 
        "name": "Imaging tau and amyloid-\u03b2 proteinopathies in Alzheimer disease and other conditions", 
        "pagination": "225", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "c3a1772c3b5da04c727dc3c16240a0dbbfd946a0f0403c4db4d5521c111c2530"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29449700"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101500072"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nrneurol.2018.9"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1101077599"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nrneurol.2018.9", 
          "https://app.dimensions.ai/details/publication/pub.1101077599"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T16:44", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000519.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/nrneurol.2018.9"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nrneurol.2018.9'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrneurol.2018.9'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrneurol.2018.9'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nrneurol.2018.9'


     

    This table displays all metadata directly associated to this object as RDF triples.

    779 TRIPLES      21 PREDICATES      242 URIs      20 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nrneurol.2018.9 schema:about anzsrc-for:11
    2 anzsrc-for:1109
    3 schema:author N70e6319bb22440d7b722e0970d325004
    4 schema:citation sg:pub.10.1007/978-3-7091-0687-7_3
    5 sg:pub.10.1007/s00259-007-0523-1
    6 sg:pub.10.1007/s00259-011-2021-8
    7 sg:pub.10.1007/s00259-013-2553-1
    8 sg:pub.10.1007/s00259-013-2681-7
    9 sg:pub.10.1007/s00259-017-3749-6
    10 sg:pub.10.1007/s00401-013-1151-4
    11 sg:pub.10.1007/s00401-014-1349-0
    12 sg:pub.10.1007/s00401-014-1362-3
    13 sg:pub.10.1007/s00401-015-1390-7
    14 sg:pub.10.1007/s00401-015-1407-2
    15 sg:pub.10.1007/s00401-017-1681-2
    16 sg:pub.10.1007/s00401-017-1740-8
    17 sg:pub.10.1007/s00415-011-6030-0
    18 sg:pub.10.1007/s11307-012-0583-x
    19 sg:pub.10.1007/s12035-008-8019-y
    20 sg:pub.10.1007/s12603-009-0046-5
    21 sg:pub.10.1038/mp.2014.9
    22 sg:pub.10.1038/mp.2017.108
    23 sg:pub.10.1038/nrd2176
    24 sg:pub.10.1038/nrd3505
    25 sg:pub.10.1186/alzrt158
    26 sg:pub.10.1186/alzrt41
    27 sg:pub.10.1186/alzrt88
    28 sg:pub.10.1186/s13195-017-0253-y
    29 sg:pub.10.1186/s40478-016-0315-6
    30 sg:pub.10.1385/jmn:17:2:101
    31 sg:pub.10.2165/11533100-000000000-00000
    32 https://app.dimensions.ai/details/publication/pub.1074651193
    33 https://app.dimensions.ai/details/publication/pub.1077373311
    34 https://app.dimensions.ai/details/publication/pub.1082765991
    35 https://doi.org/10.1001/archneur.1985.04060100083029
    36 https://doi.org/10.1001/archneur.56.3.303
    37 https://doi.org/10.1001/archneur.64.3.noc60123
    38 https://doi.org/10.1001/archneur.64.8.1140
    39 https://doi.org/10.1001/archneur.65.11.1509
    40 https://doi.org/10.1001/archneurol.2007.23
    41 https://doi.org/10.1001/archneurol.2009.285
    42 https://doi.org/10.1001/archneurol.2010.357
    43 https://doi.org/10.1001/archneurol.2011.150
    44 https://doi.org/10.1001/archneurol.2011.153
    45 https://doi.org/10.1001/archneurol.2011.1538
    46 https://doi.org/10.1001/archneurol.2011.535
    47 https://doi.org/10.1001/archneurol.2011.70
    48 https://doi.org/10.1001/archneurol.2011.77
    49 https://doi.org/10.1001/jama.2010.2008
    50 https://doi.org/10.1001/jama.2015.4669
    51 https://doi.org/10.1001/jama.278.16.1349
    52 https://doi.org/10.1001/jama.283.12.1571
    53 https://doi.org/10.1001/jamaneurol.2013.1062
    54 https://doi.org/10.1001/jamaneurol.2014.2031
    55 https://doi.org/10.1001/jamaneurol.2014.4144
    56 https://doi.org/10.1001/jamaneurol.2014.4829
    57 https://doi.org/10.1001/jamaneurol.2016.2078
    58 https://doi.org/10.1001/jamaneurol.2016.5755
    59 https://doi.org/10.1002/1531-8249(199903)45:3<358::aid-ana12>3.0.co;2-x
    60 https://doi.org/10.1002/ana.20009
    61 https://doi.org/10.1002/ana.20730
    62 https://doi.org/10.1002/ana.20889
    63 https://doi.org/10.1002/ana.21164
    64 https://doi.org/10.1002/ana.21451
    65 https://doi.org/10.1002/ana.21843
    66 https://doi.org/10.1002/ana.21955
    67 https://doi.org/10.1002/ana.22068
    68 https://doi.org/10.1002/ana.22099
    69 https://doi.org/10.1002/ana.22248
    70 https://doi.org/10.1002/ana.22333
    71 https://doi.org/10.1002/ana.22608
    72 https://doi.org/10.1002/ana.22628
    73 https://doi.org/10.1002/ana.23908
    74 https://doi.org/10.1002/ana.24040
    75 https://doi.org/10.1002/ana.24321
    76 https://doi.org/10.1002/ana.24517
    77 https://doi.org/10.1002/ana.24546
    78 https://doi.org/10.1002/ana.24706
    79 https://doi.org/10.1002/ana.24825
    80 https://doi.org/10.1002/ana.24844
    81 https://doi.org/10.1002/ana.25060
    82 https://doi.org/10.1002/emmm.200900048
    83 https://doi.org/10.1002/hbm.22927
    84 https://doi.org/10.1002/mds.26851
    85 https://doi.org/10.1016/0022-510x(70)90063-8
    86 https://doi.org/10.1016/b978-0-12-394816-8.00002-7
    87 https://doi.org/10.1016/j.biopsych.2011.04.023
    88 https://doi.org/10.1016/j.bmcl.2008.12.069
    89 https://doi.org/10.1016/j.cpet.2009.12.008
    90 https://doi.org/10.1016/j.dadm.2016.12.001
    91 https://doi.org/10.1016/j.jalz.2011.03.003
    92 https://doi.org/10.1016/j.jalz.2011.03.005
    93 https://doi.org/10.1016/j.jalz.2011.03.008
    94 https://doi.org/10.1016/j.jalz.2011.04.011
    95 https://doi.org/10.1016/j.jalz.2011.07.003
    96 https://doi.org/10.1016/j.jalz.2013.01.002
    97 https://doi.org/10.1016/j.jalz.2014.07.003
    98 https://doi.org/10.1016/j.jalz.2015.02.004
    99 https://doi.org/10.1016/j.jalz.2016.02.002
    100 https://doi.org/10.1016/j.nbd.2010.10.005
    101 https://doi.org/10.1016/j.neulet.2007.03.064
    102 https://doi.org/10.1016/j.neurobiolaging.2005.07.003
    103 https://doi.org/10.1016/j.neurobiolaging.2006.09.008
    104 https://doi.org/10.1016/j.neurobiolaging.2007.03.029
    105 https://doi.org/10.1016/j.neurobiolaging.2010.03.011
    106 https://doi.org/10.1016/j.neurobiolaging.2010.04.007
    107 https://doi.org/10.1016/j.neurobiolaging.2011.09.005
    108 https://doi.org/10.1016/j.neurobiolaging.2011.11.029
    109 https://doi.org/10.1016/j.neurobiolaging.2012.06.014
    110 https://doi.org/10.1016/j.neurobiolaging.2015.10.013
    111 https://doi.org/10.1016/j.neuroimage.2007.09.020
    112 https://doi.org/10.1016/j.neuron.2013.07.037
    113 https://doi.org/10.1016/j.neuron.2013.12.003
    114 https://doi.org/10.1016/j.neuron.2016.01.028
    115 https://doi.org/10.1016/j.neuropsychologia.2008.02.008
    116 https://doi.org/10.1016/j.nucmedbio.2012.03.001
    117 https://doi.org/10.1016/j.parkreldis.2007.07.010
    118 https://doi.org/10.1016/s0006-8993(99)01466-3
    119 https://doi.org/10.1016/s0166-2236(02)02037-4
    120 https://doi.org/10.1016/s0166-2236(96)01030-2
    121 https://doi.org/10.1016/s0197-4580(00)00173-1
    122 https://doi.org/10.1016/s0197-4580(97)00056-0
    123 https://doi.org/10.1016/s0531-5565(02)00141-9
    124 https://doi.org/10.1016/s1474-4422(08)70001-2
    125 https://doi.org/10.1016/s1474-4422(09)70299-6
    126 https://doi.org/10.1016/s1474-4422(10)70043-0
    127 https://doi.org/10.1016/s1474-4422(10)70223-4
    128 https://doi.org/10.1016/s1474-4422(11)70077-1
    129 https://doi.org/10.1016/s1474-4422(12)70015-7
    130 https://doi.org/10.1016/s1474-4422(12)70142-4
    131 https://doi.org/10.1016/s1474-4422(13)70044-9
    132 https://doi.org/10.1016/s1474-4422(13)70194-7
    133 https://doi.org/10.1016/s1474-4422(14)70090-0
    134 https://doi.org/10.1016/s1474-4422(14)70252-2
    135 https://doi.org/10.1016/s1474-4422(16)30125-9
    136 https://doi.org/10.1021/acs.jmedchem.6b00166
    137 https://doi.org/10.1021/acs.jmedchem.7b00632
    138 https://doi.org/10.1021/cn500103u
    139 https://doi.org/10.1021/jm050166g
    140 https://doi.org/10.1046/j.0305-1846.2003.00481.x
    141 https://doi.org/10.1053/j.semnuclmed.2011.03.001
    142 https://doi.org/10.1073/pnas.0900345106
    143 https://doi.org/10.1074/jbc.m501285200
    144 https://doi.org/10.1093/brain/awm238
    145 https://doi.org/10.1093/brain/awm336
    146 https://doi.org/10.1093/brain/awn016
    147 https://doi.org/10.1093/brain/awn061
    148 https://doi.org/10.1093/brain/awn107
    149 https://doi.org/10.1093/brain/awn320
    150 https://doi.org/10.1093/brain/awp062
    151 https://doi.org/10.1093/brain/awp214
    152 https://doi.org/10.1093/brain/awp326
    153 https://doi.org/10.1093/brain/awr044
    154 https://doi.org/10.1093/brain/awr066
    155 https://doi.org/10.1093/brain/awr216
    156 https://doi.org/10.1093/brain/aws125
    157 https://doi.org/10.1093/brain/awt142
    158 https://doi.org/10.1093/brain/awv191
    159 https://doi.org/10.1093/brain/aww041
    160 https://doi.org/10.1093/brain/aww139
    161 https://doi.org/10.1093/brain/aww334
    162 https://doi.org/10.1093/jnen/64.5.420
    163 https://doi.org/10.1097/nen.0b013e31824b211b
    164 https://doi.org/10.1111/1440-1681.12598
    165 https://doi.org/10.1111/ene.13164
    166 https://doi.org/10.1111/j.1365-2796.2004.01380.x
    167 https://doi.org/10.1111/j.1365-2990.2003.00545.x
    168 https://doi.org/10.1111/j.1471-4159.2006.03989.x
    169 https://doi.org/10.1126/science.1134108
    170 https://doi.org/10.1126/scitranslmed.3002609
    171 https://doi.org/10.1126/scitranslmed.3007941
    172 https://doi.org/10.1126/scitranslmed.aaf2362
    173 https://doi.org/10.1136/jnnp-2014-308094
    174 https://doi.org/10.1136/jnnp.2007.127878
    175 https://doi.org/10.1136/jnnp.2008.171496
    176 https://doi.org/10.1159/000109754
    177 https://doi.org/10.1159/000163927
    178 https://doi.org/10.1159/000335381
    179 https://doi.org/10.1212/01.con.0000429181.60095.99
    180 https://doi.org/10.1212/01.wnl.0000228230.26044.a4
    181 https://doi.org/10.1212/01.wnl.0000244749.20056.d4
    182 https://doi.org/10.1212/01.wnl.0000256373.39415.b1
    183 https://doi.org/10.1212/01.wnl.0000259035.98480.ed
    184 https://doi.org/10.1212/01.wnl.0000261919.22630.ea
    185 https://doi.org/10.1212/01.wnl.0000326146.60732.d6
    186 https://doi.org/10.1212/wnl.0000000000002892
    187 https://doi.org/10.1212/wnl.0000000000002923
    188 https://doi.org/10.1212/wnl.0b013e3181b23564
    189 https://doi.org/10.1212/wnl.0b013e3181c918b5
    190 https://doi.org/10.1212/wnl.0b013e3181d3e3e9
    191 https://doi.org/10.1212/wnl.0b013e31823b9c5e
    192 https://doi.org/10.1212/wnl.0b013e318246d67a
    193 https://doi.org/10.1212/wnl.0b013e3182661f74
    194 https://doi.org/10.1212/wnl.0b013e3182840bbe
    195 https://doi.org/10.1212/wnl.0b013e3182872830
    196 https://doi.org/10.1212/wnl.0b013e3182918ca6
    197 https://doi.org/10.1212/wnl.0b013e3182a8418b
    198 https://doi.org/10.1212/wnl.38.11.1688
    199 https://doi.org/10.1212/wnl.52.6.1158
    200 https://doi.org/10.1371/journal.pone.0058816
    201 https://doi.org/10.1371/journal.pone.0158460
    202 https://doi.org/10.1523/jneurosci.0730-07.2007
    203 https://doi.org/10.1523/jneurosci.3669-09.2009
    204 https://doi.org/10.1586/14737159.4.1.63
    205 https://doi.org/10.2174/156720510790274446
    206 https://doi.org/10.2174/156720511795745375
    207 https://doi.org/10.2967/jnumed.108.058529
    208 https://doi.org/10.2967/jnumed.109.063305
    209 https://doi.org/10.2967/jnumed.109.064360
    210 https://doi.org/10.2967/jnumed.111.089730
    211 https://doi.org/10.2967/jnumed.114.148981
    212 https://doi.org/10.2967/jnumed.115.171595
    213 https://doi.org/10.2967/jnumed.116.185199
    214 https://doi.org/10.2967/jnumed.117.190082
    215 https://doi.org/10.3233/jad-122059
    216 https://doi.org/10.3233/jad-150247
    217 https://doi.org/10.3233/jpd-130247
    218 schema:datePublished 2018-02-16
    219 schema:datePublishedReg 2018-02-16
    220 schema:description Most neurodegenerative disorders are associated with aggregated protein deposits. In the case of Alzheimer disease (AD), extracellular amyloid-β (Aβ) aggregates and intracellular tau neurofibrillary tangles are the two neuropathological hallmarks of the disease. Aβ-PET imaging has already been approved for clinical use and is being used in clinical trials of anti-Aβ therapies both for patient recruitment and as an outcome measure. These studies have shown that Aβ accumulation is a protracted process that can extend for more than 2 decades before the onset of clinical AD. This Review describes how in vivo brain imaging of Aβ pathology has revolutionized the evaluation of patients with clinical AD by providing robust and reproducible statements of global or regional brain Aβ burden and enabling the monitoring of disease progression. The role of selective tau imaging is discussed, focusing on how longitudinal tau and Aβ imaging studies might reveal the various effects (sequential and/or parallel, independent and/or synergistic) of these proteins on progression, cognition and other disease-specific biomarkers of neurodegeneration. Finally, imaging studies are discussed in the context of elucidating the respective roles of Aβ and tau in AD and in advancing our understanding of the relationship and/or interplay between these two proteinopathies.
    221 schema:genre research_article
    222 schema:inLanguage en
    223 schema:isAccessibleForFree false
    224 schema:isPartOf N2537084b466f468f8b8b22944de24415
    225 Nb2963dd7f0884e26844c995ab5932cf7
    226 sg:journal.1036166
    227 schema:name Imaging tau and amyloid-β proteinopathies in Alzheimer disease and other conditions
    228 schema:pagination 225
    229 schema:productId N0b24abd6a85b4b4d868ae9aa20832b65
    230 N2b8c34c5a06740409c5e55f6aeec4e48
    231 N3f80ebd071f84ee89d61c19c9100207c
    232 N514a80207d114c1a9ffad345e15ef27b
    233 N82a168af2e084190967eda0b9df17f11
    234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101077599
    235 https://doi.org/10.1038/nrneurol.2018.9
    236 schema:sdDatePublished 2019-04-10T16:44
    237 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    238 schema:sdPublisher N4b56f164308a4e82967ec0436a3abc6c
    239 schema:url https://www.nature.com/articles/nrneurol.2018.9
    240 sgo:license sg:explorer/license/
    241 sgo:sdDataset articles
    242 rdf:type schema:ScholarlyArticle
    243 N0b24abd6a85b4b4d868ae9aa20832b65 schema:name pubmed_id
    244 schema:value 29449700
    245 rdf:type schema:PropertyValue
    246 N18ea3fca50754e27bf8c458941abb133 rdf:first sg:person.0600065374.11
    247 rdf:rest N476d63ca630a466cb6fea057c9b4abf4
    248 N2537084b466f468f8b8b22944de24415 schema:issueNumber 4
    249 rdf:type schema:PublicationIssue
    250 N2b8c34c5a06740409c5e55f6aeec4e48 schema:name nlm_unique_id
    251 schema:value 101500072
    252 rdf:type schema:PropertyValue
    253 N3c0f4be596894eec910e4b4cb351460b rdf:first sg:person.01210677130.28
    254 rdf:rest rdf:nil
    255 N3f80ebd071f84ee89d61c19c9100207c schema:name doi
    256 schema:value 10.1038/nrneurol.2018.9
    257 rdf:type schema:PropertyValue
    258 N476d63ca630a466cb6fea057c9b4abf4 rdf:first sg:person.01066450464.06
    259 rdf:rest Nc8847962204d40939519a28f897fba9b
    260 N4b56f164308a4e82967ec0436a3abc6c schema:name Springer Nature - SN SciGraph project
    261 rdf:type schema:Organization
    262 N514a80207d114c1a9ffad345e15ef27b schema:name dimensions_id
    263 schema:value pub.1101077599
    264 rdf:type schema:PropertyValue
    265 N70e6319bb22440d7b722e0970d325004 rdf:first sg:person.014745210673.17
    266 rdf:rest N18ea3fca50754e27bf8c458941abb133
    267 N82a168af2e084190967eda0b9df17f11 schema:name readcube_id
    268 schema:value c3a1772c3b5da04c727dc3c16240a0dbbfd946a0f0403c4db4d5521c111c2530
    269 rdf:type schema:PropertyValue
    270 Nb2963dd7f0884e26844c995ab5932cf7 schema:volumeNumber 14
    271 rdf:type schema:PublicationVolume
    272 Nc8847962204d40939519a28f897fba9b rdf:first sg:person.0643473627.24
    273 rdf:rest N3c0f4be596894eec910e4b4cb351460b
    274 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    275 schema:name Medical and Health Sciences
    276 rdf:type schema:DefinedTerm
    277 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    278 schema:name Neurosciences
    279 rdf:type schema:DefinedTerm
    280 sg:grant.6722695 http://pending.schema.org/fundedItem sg:pub.10.1038/nrneurol.2018.9
    281 rdf:type schema:MonetaryGrant
    282 sg:grant.6733444 http://pending.schema.org/fundedItem sg:pub.10.1038/nrneurol.2018.9
    283 rdf:type schema:MonetaryGrant
    284 sg:grant.6734612 http://pending.schema.org/fundedItem sg:pub.10.1038/nrneurol.2018.9
    285 rdf:type schema:MonetaryGrant
    286 sg:journal.1036166 schema:issn 1759-4758
    287 1759-4766
    288 schema:name Nature Reviews Neurology
    289 rdf:type schema:Periodical
    290 sg:person.01066450464.06 schema:affiliation https://www.grid.ac/institutes/grid.492989.7
    291 schema:familyName Burnham
    292 schema:givenName Samantha C.
    293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066450464.06
    294 rdf:type schema:Person
    295 sg:person.01210677130.28 schema:affiliation https://www.grid.ac/institutes/grid.418025.a
    296 schema:familyName Rowe
    297 schema:givenName Christopher C.
    298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210677130.28
    299 rdf:type schema:Person
    300 sg:person.014745210673.17 schema:affiliation https://www.grid.ac/institutes/grid.418025.a
    301 schema:familyName Villemagne
    302 schema:givenName Victor L.
    303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014745210673.17
    304 rdf:type schema:Person
    305 sg:person.0600065374.11 schema:affiliation https://www.grid.ac/institutes/grid.410678.c
    306 schema:familyName Doré
    307 schema:givenName Vincent
    308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600065374.11
    309 rdf:type schema:Person
    310 sg:person.0643473627.24 schema:affiliation https://www.grid.ac/institutes/grid.418025.a
    311 schema:familyName Masters
    312 schema:givenName Colin L.
    313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643473627.24
    314 rdf:type schema:Person
    315 sg:pub.10.1007/978-3-7091-0687-7_3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008416385
    316 https://doi.org/10.1007/978-3-7091-0687-7_3
    317 rdf:type schema:CreativeWork
    318 sg:pub.10.1007/s00259-007-0523-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051012934
    319 https://doi.org/10.1007/s00259-007-0523-1
    320 rdf:type schema:CreativeWork
    321 sg:pub.10.1007/s00259-011-2021-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028393977
    322 https://doi.org/10.1007/s00259-011-2021-8
    323 rdf:type schema:CreativeWork
    324 sg:pub.10.1007/s00259-013-2553-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015830116
    325 https://doi.org/10.1007/s00259-013-2553-1
    326 rdf:type schema:CreativeWork
    327 sg:pub.10.1007/s00259-013-2681-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052642973
    328 https://doi.org/10.1007/s00259-013-2681-7
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1007/s00259-017-3749-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086122668
    331 https://doi.org/10.1007/s00259-017-3749-6
    332 rdf:type schema:CreativeWork
    333 sg:pub.10.1007/s00401-013-1151-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052998440
    334 https://doi.org/10.1007/s00401-013-1151-4
    335 rdf:type schema:CreativeWork
    336 sg:pub.10.1007/s00401-014-1349-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036179092
    337 https://doi.org/10.1007/s00401-014-1349-0
    338 rdf:type schema:CreativeWork
    339 sg:pub.10.1007/s00401-014-1362-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017495710
    340 https://doi.org/10.1007/s00401-014-1362-3
    341 rdf:type schema:CreativeWork
    342 sg:pub.10.1007/s00401-015-1390-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014972059
    343 https://doi.org/10.1007/s00401-015-1390-7
    344 rdf:type schema:CreativeWork
    345 sg:pub.10.1007/s00401-015-1407-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014650794
    346 https://doi.org/10.1007/s00401-015-1407-2
    347 rdf:type schema:CreativeWork
    348 sg:pub.10.1007/s00401-017-1681-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083534962
    349 https://doi.org/10.1007/s00401-017-1681-2
    350 rdf:type schema:CreativeWork
    351 sg:pub.10.1007/s00401-017-1740-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085993567
    352 https://doi.org/10.1007/s00401-017-1740-8
    353 rdf:type schema:CreativeWork
    354 sg:pub.10.1007/s00415-011-6030-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024186776
    355 https://doi.org/10.1007/s00415-011-6030-0
    356 rdf:type schema:CreativeWork
    357 sg:pub.10.1007/s11307-012-0583-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031995292
    358 https://doi.org/10.1007/s11307-012-0583-x
    359 rdf:type schema:CreativeWork
    360 sg:pub.10.1007/s12035-008-8019-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1028903939
    361 https://doi.org/10.1007/s12035-008-8019-y
    362 rdf:type schema:CreativeWork
    363 sg:pub.10.1007/s12603-009-0046-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016828839
    364 https://doi.org/10.1007/s12603-009-0046-5
    365 rdf:type schema:CreativeWork
    366 sg:pub.10.1038/mp.2014.9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044329471
    367 https://doi.org/10.1038/mp.2014.9
    368 rdf:type schema:CreativeWork
    369 sg:pub.10.1038/mp.2017.108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085417603
    370 https://doi.org/10.1038/mp.2017.108
    371 rdf:type schema:CreativeWork
    372 sg:pub.10.1038/nrd2176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019893204
    373 https://doi.org/10.1038/nrd2176
    374 rdf:type schema:CreativeWork
    375 sg:pub.10.1038/nrd3505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009624842
    376 https://doi.org/10.1038/nrd3505
    377 rdf:type schema:CreativeWork
    378 sg:pub.10.1186/alzrt158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038107278
    379 https://doi.org/10.1186/alzrt158
    380 rdf:type schema:CreativeWork
    381 sg:pub.10.1186/alzrt41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008491941
    382 https://doi.org/10.1186/alzrt41
    383 rdf:type schema:CreativeWork
    384 sg:pub.10.1186/alzrt88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020989647
    385 https://doi.org/10.1186/alzrt88
    386 rdf:type schema:CreativeWork
    387 sg:pub.10.1186/s13195-017-0253-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1084252361
    388 https://doi.org/10.1186/s13195-017-0253-y
    389 rdf:type schema:CreativeWork
    390 sg:pub.10.1186/s40478-016-0315-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006093437
    391 https://doi.org/10.1186/s40478-016-0315-6
    392 rdf:type schema:CreativeWork
    393 sg:pub.10.1385/jmn:17:2:101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031691219
    394 https://doi.org/10.1385/jmn:17:2:101
    395 rdf:type schema:CreativeWork
    396 sg:pub.10.2165/11533100-000000000-00000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047040889
    397 https://doi.org/10.2165/11533100-000000000-00000
    398 rdf:type schema:CreativeWork
    399 https://app.dimensions.ai/details/publication/pub.1074651193 schema:CreativeWork
    400 https://app.dimensions.ai/details/publication/pub.1077373311 schema:CreativeWork
    401 https://app.dimensions.ai/details/publication/pub.1082765991 schema:CreativeWork
    402 https://doi.org/10.1001/archneur.1985.04060100083029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049843631
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.1001/archneur.56.3.303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030365018
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.1001/archneur.64.3.noc60123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003509907
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.1001/archneur.64.8.1140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040467341
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.1001/archneur.65.11.1509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040961566
    411 rdf:type schema:CreativeWork
    412 https://doi.org/10.1001/archneurol.2007.23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002715139
    413 rdf:type schema:CreativeWork
    414 https://doi.org/10.1001/archneurol.2009.285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028973239
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.1001/archneurol.2010.357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034446097
    417 rdf:type schema:CreativeWork
    418 https://doi.org/10.1001/archneurol.2011.150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023756040
    419 rdf:type schema:CreativeWork
    420 https://doi.org/10.1001/archneurol.2011.153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050971746
    421 rdf:type schema:CreativeWork
    422 https://doi.org/10.1001/archneurol.2011.1538 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013423205
    423 rdf:type schema:CreativeWork
    424 https://doi.org/10.1001/archneurol.2011.535 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004855546
    425 rdf:type schema:CreativeWork
    426 https://doi.org/10.1001/archneurol.2011.70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029833183
    427 rdf:type schema:CreativeWork
    428 https://doi.org/10.1001/archneurol.2011.77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029066171
    429 rdf:type schema:CreativeWork
    430 https://doi.org/10.1001/jama.2010.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015450809
    431 rdf:type schema:CreativeWork
    432 https://doi.org/10.1001/jama.2015.4669 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031264828
    433 rdf:type schema:CreativeWork
    434 https://doi.org/10.1001/jama.278.16.1349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054161541
    435 rdf:type schema:CreativeWork
    436 https://doi.org/10.1001/jama.283.12.1571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001167675
    437 rdf:type schema:CreativeWork
    438 https://doi.org/10.1001/jamaneurol.2013.1062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025084978
    439 rdf:type schema:CreativeWork
    440 https://doi.org/10.1001/jamaneurol.2014.2031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012826894
    441 rdf:type schema:CreativeWork
    442 https://doi.org/10.1001/jamaneurol.2014.4144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017346285
    443 rdf:type schema:CreativeWork
    444 https://doi.org/10.1001/jamaneurol.2014.4829 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035611656
    445 rdf:type schema:CreativeWork
    446 https://doi.org/10.1001/jamaneurol.2016.2078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046777311
    447 rdf:type schema:CreativeWork
    448 https://doi.org/10.1001/jamaneurol.2016.5755 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084005987
    449 rdf:type schema:CreativeWork
    450 https://doi.org/10.1002/1531-8249(199903)45:3<358::aid-ana12>3.0.co;2-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019306016
    451 rdf:type schema:CreativeWork
    452 https://doi.org/10.1002/ana.20009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019367853
    453 rdf:type schema:CreativeWork
    454 https://doi.org/10.1002/ana.20730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031718949
    455 rdf:type schema:CreativeWork
    456 https://doi.org/10.1002/ana.20889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043584475
    457 rdf:type schema:CreativeWork
    458 https://doi.org/10.1002/ana.21164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028666580
    459 rdf:type schema:CreativeWork
    460 https://doi.org/10.1002/ana.21451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004561483
    461 rdf:type schema:CreativeWork
    462 https://doi.org/10.1002/ana.21843 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002050736
    463 rdf:type schema:CreativeWork
    464 https://doi.org/10.1002/ana.21955 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003944440
    465 rdf:type schema:CreativeWork
    466 https://doi.org/10.1002/ana.22068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009203901
    467 rdf:type schema:CreativeWork
    468 https://doi.org/10.1002/ana.22099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037017380
    469 rdf:type schema:CreativeWork
    470 https://doi.org/10.1002/ana.22248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052165065
    471 rdf:type schema:CreativeWork
    472 https://doi.org/10.1002/ana.22333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012322349
    473 rdf:type schema:CreativeWork
    474 https://doi.org/10.1002/ana.22608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002043918
    475 rdf:type schema:CreativeWork
    476 https://doi.org/10.1002/ana.22628 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006022678
    477 rdf:type schema:CreativeWork
    478 https://doi.org/10.1002/ana.23908 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023439990
    479 rdf:type schema:CreativeWork
    480 https://doi.org/10.1002/ana.24040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019934103
    481 rdf:type schema:CreativeWork
    482 https://doi.org/10.1002/ana.24321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014986615
    483 rdf:type schema:CreativeWork
    484 https://doi.org/10.1002/ana.24517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050357746
    485 rdf:type schema:CreativeWork
    486 https://doi.org/10.1002/ana.24546 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015127175
    487 rdf:type schema:CreativeWork
    488 https://doi.org/10.1002/ana.24706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050769314
    489 rdf:type schema:CreativeWork
    490 https://doi.org/10.1002/ana.24825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048664011
    491 rdf:type schema:CreativeWork
    492 https://doi.org/10.1002/ana.24844 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013259503
    493 rdf:type schema:CreativeWork
    494 https://doi.org/10.1002/ana.25060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092085054
    495 rdf:type schema:CreativeWork
    496 https://doi.org/10.1002/emmm.200900048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017577260
    497 rdf:type schema:CreativeWork
    498 https://doi.org/10.1002/hbm.22927 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040015027
    499 rdf:type schema:CreativeWork
    500 https://doi.org/10.1002/mds.26851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046642007
    501 rdf:type schema:CreativeWork
    502 https://doi.org/10.1016/0022-510x(70)90063-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019350526
    503 rdf:type schema:CreativeWork
    504 https://doi.org/10.1016/b978-0-12-394816-8.00002-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005304186
    505 rdf:type schema:CreativeWork
    506 https://doi.org/10.1016/j.biopsych.2011.04.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046508499
    507 rdf:type schema:CreativeWork
    508 https://doi.org/10.1016/j.bmcl.2008.12.069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017514730
    509 rdf:type schema:CreativeWork
    510 https://doi.org/10.1016/j.cpet.2009.12.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022137858
    511 rdf:type schema:CreativeWork
    512 https://doi.org/10.1016/j.dadm.2016.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009187571
    513 rdf:type schema:CreativeWork
    514 https://doi.org/10.1016/j.jalz.2011.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018411398
    515 rdf:type schema:CreativeWork
    516 https://doi.org/10.1016/j.jalz.2011.03.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015460770
    517 rdf:type schema:CreativeWork
    518 https://doi.org/10.1016/j.jalz.2011.03.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025279802
    519 rdf:type schema:CreativeWork
    520 https://doi.org/10.1016/j.jalz.2011.04.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002950568
    521 rdf:type schema:CreativeWork
    522 https://doi.org/10.1016/j.jalz.2011.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043691942
    523 rdf:type schema:CreativeWork
    524 https://doi.org/10.1016/j.jalz.2013.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031642676
    525 rdf:type schema:CreativeWork
    526 https://doi.org/10.1016/j.jalz.2014.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050435075
    527 rdf:type schema:CreativeWork
    528 https://doi.org/10.1016/j.jalz.2015.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020606984
    529 rdf:type schema:CreativeWork
    530 https://doi.org/10.1016/j.jalz.2016.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038834094
    531 rdf:type schema:CreativeWork
    532 https://doi.org/10.1016/j.nbd.2010.10.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027457741
    533 rdf:type schema:CreativeWork
    534 https://doi.org/10.1016/j.neulet.2007.03.064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025966122
    535 rdf:type schema:CreativeWork
    536 https://doi.org/10.1016/j.neurobiolaging.2005.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028320315
    537 rdf:type schema:CreativeWork
    538 https://doi.org/10.1016/j.neurobiolaging.2006.09.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007695507
    539 rdf:type schema:CreativeWork
    540 https://doi.org/10.1016/j.neurobiolaging.2007.03.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020422385
    541 rdf:type schema:CreativeWork
    542 https://doi.org/10.1016/j.neurobiolaging.2010.03.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016806438
    543 rdf:type schema:CreativeWork
    544 https://doi.org/10.1016/j.neurobiolaging.2010.04.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039551403
    545 rdf:type schema:CreativeWork
    546 https://doi.org/10.1016/j.neurobiolaging.2011.09.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048451358
    547 rdf:type schema:CreativeWork
    548 https://doi.org/10.1016/j.neurobiolaging.2011.11.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051801056
    549 rdf:type schema:CreativeWork
    550 https://doi.org/10.1016/j.neurobiolaging.2012.06.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007010312
    551 rdf:type schema:CreativeWork
    552 https://doi.org/10.1016/j.neurobiolaging.2015.10.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040072691
    553 rdf:type schema:CreativeWork
    554 https://doi.org/10.1016/j.neuroimage.2007.09.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030311365
    555 rdf:type schema:CreativeWork
    556 https://doi.org/10.1016/j.neuron.2013.07.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016306106
    557 rdf:type schema:CreativeWork
    558 https://doi.org/10.1016/j.neuron.2013.12.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032944547
    559 rdf:type schema:CreativeWork
    560 https://doi.org/10.1016/j.neuron.2016.01.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009123709
    561 rdf:type schema:CreativeWork
    562 https://doi.org/10.1016/j.neuropsychologia.2008.02.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017806350
    563 rdf:type schema:CreativeWork
    564 https://doi.org/10.1016/j.nucmedbio.2012.03.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028521726
    565 rdf:type schema:CreativeWork
    566 https://doi.org/10.1016/j.parkreldis.2007.07.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037994539
    567 rdf:type schema:CreativeWork
    568 https://doi.org/10.1016/s0006-8993(99)01466-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011212764
    569 rdf:type schema:CreativeWork
    570 https://doi.org/10.1016/s0166-2236(02)02037-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036832085
    571 rdf:type schema:CreativeWork
    572 https://doi.org/10.1016/s0166-2236(96)01030-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031070780
    573 rdf:type schema:CreativeWork
    574 https://doi.org/10.1016/s0197-4580(00)00173-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024254186
    575 rdf:type schema:CreativeWork
    576 https://doi.org/10.1016/s0197-4580(97)00056-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018951481
    577 rdf:type schema:CreativeWork
    578 https://doi.org/10.1016/s0531-5565(02)00141-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030998113
    579 rdf:type schema:CreativeWork
    580 https://doi.org/10.1016/s1474-4422(08)70001-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012432155
    581 rdf:type schema:CreativeWork
    582 https://doi.org/10.1016/s1474-4422(09)70299-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003108805
    583 rdf:type schema:CreativeWork
    584 https://doi.org/10.1016/s1474-4422(10)70043-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019191546
    585 rdf:type schema:CreativeWork
    586 https://doi.org/10.1016/s1474-4422(10)70223-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044499508
    587 rdf:type schema:CreativeWork
    588 https://doi.org/10.1016/s1474-4422(11)70077-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012606695
    589 rdf:type schema:CreativeWork
    590 https://doi.org/10.1016/s1474-4422(12)70015-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043289055
    591 rdf:type schema:CreativeWork
    592 https://doi.org/10.1016/s1474-4422(12)70142-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023875103
    593 rdf:type schema:CreativeWork
    594 https://doi.org/10.1016/s1474-4422(13)70044-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005017445
    595 rdf:type schema:CreativeWork
    596 https://doi.org/10.1016/s1474-4422(13)70194-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015055172
    597 rdf:type schema:CreativeWork
    598 https://doi.org/10.1016/s1474-4422(14)70090-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004039747
    599 rdf:type schema:CreativeWork
    600 https://doi.org/10.1016/s1474-4422(14)70252-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014649642
    601 rdf:type schema:CreativeWork
    602 https://doi.org/10.1016/s1474-4422(16)30125-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013569569
    603 rdf:type schema:CreativeWork
    604 https://doi.org/10.1021/acs.jmedchem.6b00166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055100047
    605 rdf:type schema:CreativeWork
    606 https://doi.org/10.1021/acs.jmedchem.7b00632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090388851
    607 rdf:type schema:CreativeWork
    608 https://doi.org/10.1021/cn500103u schema:sameAs https://app.dimensions.ai/details/publication/pub.1031168861
    609 rdf:type schema:CreativeWork
    610 https://doi.org/10.1021/jm050166g schema:sameAs https://app.dimensions.ai/details/publication/pub.1055949459
    611 rdf:type schema:CreativeWork
    612 https://doi.org/10.1046/j.0305-1846.2003.00481.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010948922
    613 rdf:type schema:CreativeWork
    614 https://doi.org/10.1053/j.semnuclmed.2011.03.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050222585
    615 rdf:type schema:CreativeWork
    616 https://doi.org/10.1073/pnas.0900345106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006130429
    617 rdf:type schema:CreativeWork
    618 https://doi.org/10.1074/jbc.m501285200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005020995
    619 rdf:type schema:CreativeWork
    620 https://doi.org/10.1093/brain/awm238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019773913
    621 rdf:type schema:CreativeWork
    622 https://doi.org/10.1093/brain/awm336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034818309
    623 rdf:type schema:CreativeWork
    624 https://doi.org/10.1093/brain/awn016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025352748
    625 rdf:type schema:CreativeWork
    626 https://doi.org/10.1093/brain/awn061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052800839
    627 rdf:type schema:CreativeWork
    628 https://doi.org/10.1093/brain/awn107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020269912
    629 rdf:type schema:CreativeWork
    630 https://doi.org/10.1093/brain/awn320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043963301
    631 rdf:type schema:CreativeWork
    632 https://doi.org/10.1093/brain/awp062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028065595
    633 rdf:type schema:CreativeWork
    634 https://doi.org/10.1093/brain/awp214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050846973
    635 rdf:type schema:CreativeWork
    636 https://doi.org/10.1093/brain/awp326 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044172509
    637 rdf:type schema:CreativeWork
    638 https://doi.org/10.1093/brain/awr044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002146991
    639 rdf:type schema:CreativeWork
    640 https://doi.org/10.1093/brain/awr066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023334786
    641 rdf:type schema:CreativeWork
    642 https://doi.org/10.1093/brain/awr216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012796794
    643 rdf:type schema:CreativeWork
    644 https://doi.org/10.1093/brain/aws125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038222252
    645 rdf:type schema:CreativeWork
    646 https://doi.org/10.1093/brain/awt142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040124857
    647 rdf:type schema:CreativeWork
    648 https://doi.org/10.1093/brain/awv191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022260671
    649 rdf:type schema:CreativeWork
    650 https://doi.org/10.1093/brain/aww041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059445113
    651 rdf:type schema:CreativeWork
    652 https://doi.org/10.1093/brain/aww139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059445172
    653 rdf:type schema:CreativeWork
    654 https://doi.org/10.1093/brain/aww334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059445324
    655 rdf:type schema:CreativeWork
    656 https://doi.org/10.1093/jnen/64.5.420 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059822152
    657 rdf:type schema:CreativeWork
    658 https://doi.org/10.1097/nen.0b013e31824b211b schema:sameAs https://app.dimensions.ai/details/publication/pub.1021810233
    659 rdf:type schema:CreativeWork
    660 https://doi.org/10.1111/1440-1681.12598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029804036
    661 rdf:type schema:CreativeWork
    662 https://doi.org/10.1111/ene.13164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021209701
    663 rdf:type schema:CreativeWork
    664 https://doi.org/10.1111/j.1365-2796.2004.01380.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027683931
    665 rdf:type schema:CreativeWork
    666 https://doi.org/10.1111/j.1365-2990.2003.00545.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037212011
    667 rdf:type schema:CreativeWork
    668 https://doi.org/10.1111/j.1471-4159.2006.03989.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011396068
    669 rdf:type schema:CreativeWork
    670 https://doi.org/10.1126/science.1134108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020426292
    671 rdf:type schema:CreativeWork
    672 https://doi.org/10.1126/scitranslmed.3002609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025584955
    673 rdf:type schema:CreativeWork
    674 https://doi.org/10.1126/scitranslmed.3007941 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062688220
    675 rdf:type schema:CreativeWork
    676 https://doi.org/10.1126/scitranslmed.aaf2362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048536310
    677 rdf:type schema:CreativeWork
    678 https://doi.org/10.1136/jnnp-2014-308094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027209137
    679 rdf:type schema:CreativeWork
    680 https://doi.org/10.1136/jnnp.2007.127878 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013600692
    681 rdf:type schema:CreativeWork
    682 https://doi.org/10.1136/jnnp.2008.171496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036233629
    683 rdf:type schema:CreativeWork
    684 https://doi.org/10.1159/000109754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046193315
    685 rdf:type schema:CreativeWork
    686 https://doi.org/10.1159/000163927 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003200530
    687 rdf:type schema:CreativeWork
    688 https://doi.org/10.1159/000335381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051859247
    689 rdf:type schema:CreativeWork
    690 https://doi.org/10.1212/01.con.0000429181.60095.99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064344158
    691 rdf:type schema:CreativeWork
    692 https://doi.org/10.1212/01.wnl.0000228230.26044.a4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064348348
    693 rdf:type schema:CreativeWork
    694 https://doi.org/10.1212/01.wnl.0000244749.20056.d4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064348717
    695 rdf:type schema:CreativeWork
    696 https://doi.org/10.1212/01.wnl.0000256373.39415.b1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064348989
    697 rdf:type schema:CreativeWork
    698 https://doi.org/10.1212/01.wnl.0000259035.98480.ed schema:sameAs https://app.dimensions.ai/details/publication/pub.1039897238
    699 rdf:type schema:CreativeWork
    700 https://doi.org/10.1212/01.wnl.0000261919.22630.ea schema:sameAs https://app.dimensions.ai/details/publication/pub.1064349201
    701 rdf:type schema:CreativeWork
    702 https://doi.org/10.1212/01.wnl.0000326146.60732.d6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064350547
    703 rdf:type schema:CreativeWork
    704 https://doi.org/10.1212/wnl.0000000000002892 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064353673
    705 rdf:type schema:CreativeWork
    706 https://doi.org/10.1212/wnl.0000000000002923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017625707
    707 rdf:type schema:CreativeWork
    708 https://doi.org/10.1212/wnl.0b013e3181b23564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064354537
    709 rdf:type schema:CreativeWork
    710 https://doi.org/10.1212/wnl.0b013e3181c918b5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064354929
    711 rdf:type schema:CreativeWork
    712 https://doi.org/10.1212/wnl.0b013e3181d3e3e9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064355101
    713 rdf:type schema:CreativeWork
    714 https://doi.org/10.1212/wnl.0b013e31823b9c5e schema:sameAs https://app.dimensions.ai/details/publication/pub.1064356650
    715 rdf:type schema:CreativeWork
    716 https://doi.org/10.1212/wnl.0b013e318246d67a schema:sameAs https://app.dimensions.ai/details/publication/pub.1064356739
    717 rdf:type schema:CreativeWork
    718 https://doi.org/10.1212/wnl.0b013e3182661f74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064357163
    719 rdf:type schema:CreativeWork
    720 https://doi.org/10.1212/wnl.0b013e3182840bbe schema:sameAs https://app.dimensions.ai/details/publication/pub.1064357577
    721 rdf:type schema:CreativeWork
    722 https://doi.org/10.1212/wnl.0b013e3182872830 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064357602
    723 rdf:type schema:CreativeWork
    724 https://doi.org/10.1212/wnl.0b013e3182918ca6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064357722
    725 rdf:type schema:CreativeWork
    726 https://doi.org/10.1212/wnl.0b013e3182a8418b schema:sameAs https://app.dimensions.ai/details/publication/pub.1064358023
    727 rdf:type schema:CreativeWork
    728 https://doi.org/10.1212/wnl.38.11.1688 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064367511
    729 rdf:type schema:CreativeWork
    730 https://doi.org/10.1212/wnl.52.6.1158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064377351
    731 rdf:type schema:CreativeWork
    732 https://doi.org/10.1371/journal.pone.0058816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045500685
    733 rdf:type schema:CreativeWork
    734 https://doi.org/10.1371/journal.pone.0158460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029549776
    735 rdf:type schema:CreativeWork
    736 https://doi.org/10.1523/jneurosci.0730-07.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010620750
    737 rdf:type schema:CreativeWork
    738 https://doi.org/10.1523/jneurosci.3669-09.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002736466
    739 rdf:type schema:CreativeWork
    740 https://doi.org/10.1586/14737159.4.1.63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041598426
    741 rdf:type schema:CreativeWork
    742 https://doi.org/10.2174/156720510790274446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069188931
    743 rdf:type schema:CreativeWork
    744 https://doi.org/10.2174/156720511795745375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069189054
    745 rdf:type schema:CreativeWork
    746 https://doi.org/10.2967/jnumed.108.058529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020264059
    747 rdf:type schema:CreativeWork
    748 https://doi.org/10.2967/jnumed.109.063305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029411711
    749 rdf:type schema:CreativeWork
    750 https://doi.org/10.2967/jnumed.109.064360 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050232947
    751 rdf:type schema:CreativeWork
    752 https://doi.org/10.2967/jnumed.111.089730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015444921
    753 rdf:type schema:CreativeWork
    754 https://doi.org/10.2967/jnumed.114.148981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008088660
    755 rdf:type schema:CreativeWork
    756 https://doi.org/10.2967/jnumed.115.171595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070928465
    757 rdf:type schema:CreativeWork
    758 https://doi.org/10.2967/jnumed.116.185199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083862224
    759 rdf:type schema:CreativeWork
    760 https://doi.org/10.2967/jnumed.117.190082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085464448
    761 rdf:type schema:CreativeWork
    762 https://doi.org/10.3233/jad-122059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078660394
    763 rdf:type schema:CreativeWork
    764 https://doi.org/10.3233/jad-150247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000171418
    765 rdf:type schema:CreativeWork
    766 https://doi.org/10.3233/jpd-130247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078808602
    767 rdf:type schema:CreativeWork
    768 https://www.grid.ac/institutes/grid.410678.c schema:alternateName Austin Health
    769 schema:name CSIRO, Health and Biosecurity Flagship, The Australian eHealth Research Centre, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
    770 Department of Molecular Imaging and Therapy, Centre for PET, Austin Health, Heidelberg, Victoria, Australia.
    771 rdf:type schema:Organization
    772 https://www.grid.ac/institutes/grid.418025.a schema:alternateName Florey Institute of Neuroscience and Mental Health
    773 schema:name Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia.
    774 Department of Molecular Imaging and Therapy, Centre for PET, Austin Health, Heidelberg, Victoria, Australia.
    775 The Florey Institute of Neuroscience and Mental Health and University of Melbourne, Parkville, Victoria, Australia.
    776 rdf:type schema:Organization
    777 https://www.grid.ac/institutes/grid.492989.7 schema:alternateName CSIRO Health and Biosecurity
    778 schema:name eHealth, CSIRO Health and Biosecurity, Melbourne, Parkville, Victoria, Australia.
    779 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...