Prospects of immune checkpoint modulators in the treatment of glioblastoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-09

AUTHORS

Matthias Preusser, Michael Lim, David A. Hafler, David A. Reardon, John H. Sampson

ABSTRACT

Glioblastoma is the most common primary brain tumour in adults. Prognosis is poor: even with the current gold-standard first-line treatment—maximal safe resection and combination of radiotherapy with temozolomide chemotherapy—the median overall survival time is only approximately 15-17 months, because the tumour recurs in virtually all patients, and no commonly accepted standard treatment for recurrent disease exists. Several targeted agents have failed to improve patient outcomes in glioblastoma. Immunotherapy with immune checkpoint inhibitors such as ipilimumab, nivolumab, and pembrolizumab has provided relevant clinical improvements in other advanced tumours for which conventional therapies have had limited success, making immunotherapy an appealing strategy in glioblastoma. This Review summarizes current knowledge on immune checkpoint modulators and evaluates their potential role in glioblastoma on the basis of preclinical studies and emerging clinical data. Furthermore, we discuss challenges that need to be considered in the clinical development of drugs that target immune checkpoint pathways in glioblastoma, such as specific properties of the immune system in the CNS, issues with radiological response assessment, and potential interactions with established and emerging treatment strategies. More... »

PAGES

504-514

References to SciGraph publications

  • 2014-01. The prognostic value of Foxp3+ tumor-infiltrating lymphocytes in patients with glioblastoma in JOURNAL OF NEURO-ONCOLOGY
  • 2014-05. Efficacy and safety of ipilimumab in patients with advanced melanoma and brain metastases in JOURNAL OF NEURO-ONCOLOGY
  • 2007-01. Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma in NATURE MEDICINE
  • 2014-08. A vaccine targeting mutant IDH1 induces antitumour immunity in NATURE
  • 2013-09. Immunotherapy at Large: Balancing tumor immunity and inflammatory pathology in NATURE MEDICINE
  • 2014-12. Neuro-oncology: A step towards clinical blood biomarkers of glioblastoma in NATURE REVIEWS NEUROLOGY
  • 2014-12. Response assessment in metastatic melanoma treated with ipilimumab and bevacizumab: CT tumor size and density as markers for response and outcome in JOURNAL FOR IMMUNOTHERAPY OF CANCER
  • 2014-01. Programmed death ligand-1 expression in non-small cell lung cancer in LABORATORY INVESTIGATION
  • 2002-05. Dexamethasone treatment in patients with brain metastases and primary brain tumors: do the benefits outweigh the side-effects? in SUPPORTIVE CARE IN CANCER
  • 2013-07. Mutational heterogeneity in cancer and the search for new cancer-associated genes in NATURE
  • 2015-07. Biomarkers for glioma immunotherapy: the next generation in JOURNAL OF NEURO-ONCOLOGY
  • 2012-04. The blockade of immune checkpoints in cancer immunotherapy in NATURE REVIEWS CANCER
  • 2014-05. Tumour-infiltrating CD4+ and CD8+ lymphocytes as predictors of clinical outcome in glioma in BRITISH JOURNAL OF CANCER
  • 2015-07. Structural and functional features of central nervous system lymphatic vessels in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrneurol.2015.139

    DOI

    http://dx.doi.org/10.1038/nrneurol.2015.139

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1045057880

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26260659


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Brain Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Clinical Trials as Topic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glioblastoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunologic Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunotherapy", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Medical University of Vienna", 
              "id": "https://www.grid.ac/institutes/grid.22937.3d", 
              "name": [
                "Department of Medicine I and Comprehensive Cancer Centre CNS Tumours Unit, Medical University of Vienna, Waehringer Guertel 18\u201320, 1090 Vienna, Austria."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Preusser", 
            "givenName": "Matthias", 
            "id": "sg:person.01247463220.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247463220.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Johns Hopkins University", 
              "id": "https://www.grid.ac/institutes/grid.21107.35", 
              "name": [
                "Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lim", 
            "givenName": "Michael", 
            "id": "sg:person.01233314250.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233314250.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Neurology, Yale School of Medicine, Yale New Haven Hospital, 15 York Street, PO Box 208018, New Haven, CT 06520, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hafler", 
            "givenName": "David A.", 
            "id": "sg:person.0720414633.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720414633.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dana\u2013Farber Cancer Institute", 
              "id": "https://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "Center for Neuro-Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Dana 2134, Boston, MA 02215, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Reardon", 
            "givenName": "David A.", 
            "id": "sg:person.01334047606.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334047606.77"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Duke University", 
              "id": "https://www.grid.ac/institutes/grid.26009.3d", 
              "name": [
                "Division of Neurosurgery, 220 Sands Building, Research Drive, Duke University School of Medicine, Durham, NC 27705, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sampson", 
            "givenName": "John H.", 
            "id": "sg:person.01127256465.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127256465.77"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature14432", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000736772", 
              "https://doi.org/10.1038/nature14432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.2980", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001783473"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2013.51.4802", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002061814"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3335", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002198629", 
              "https://doi.org/10.1038/nm.3335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11060-015-1746-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002579319", 
              "https://doi.org/10.1007/s11060-015-1746-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1076514", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003163159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(12)70090-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003673495"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2326-6066.cir-13-0028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004343764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-13-3271", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004953031"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00520-001-0333-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005830681", 
              "https://doi.org/10.1007/s00520-001-0333-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2012/492920", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005974874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2013.07.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006498518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/2162402x.2015.1057388", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006736286"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-11-1620", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006976153"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.4794-04.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007498527"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/neuonc/nou212", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007801267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2147/ott.s4833", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007878666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2013.08.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008514979"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.2009.00771.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008563862"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.2009.00771.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008563862"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2014.59.0703", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009621823"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrneurol.2014.208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009832934", 
              "https://doi.org/10.1038/nrneurol.2014.208"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20082429", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010107580"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(12)70324-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010195671"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/neuonc/noq157", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010254555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2011/732413", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010794620"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.14791/btrt.2013.1.1.2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011261217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(14)60958-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012632588"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/neuonc/nov071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012818242"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1411087", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014862127"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0059082", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016248318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13387", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016354360", 
              "https://doi.org/10.1038/nature13387"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4155/tde.14.114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016876066"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2010/689171", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018385459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/neuonc/nou223", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019576806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-05-3773", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020419107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1406498", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020435459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12213", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021761707", 
              "https://doi.org/10.1038/nature12213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40425-014-0040-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022897953", 
              "https://doi.org/10.1186/s40425-014-0040-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40425-014-0040-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022897953", 
              "https://doi.org/10.1186/s40425-014-0040-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1302369", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024659470"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/labinvest.2013.130", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024707845", 
              "https://doi.org/10.1038/labinvest.2013.130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1504030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024843336"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci35180", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025112763"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdq013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025653897"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fimmu.2013.00053", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025662395"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2008.10.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026558254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/neuonc/nou348", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026946190"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11060-013-1314-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027346751", 
              "https://doi.org/10.1007/s11060-013-1314-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11060-013-1314-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027346751", 
              "https://doi.org/10.1007/s11060-013-1314-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-14-0514", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027650074"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.clineuro.2013.12.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028177765"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-09-1624", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028571226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0192623310391482", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028688186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0192623310391482", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028688186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/theoncologist.2012-0483", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029091889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-09-2376", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029992849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2326-6066.cir-14-0039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030280412"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/wco.0000000000000144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030702082"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/wco.0000000000000144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030702082"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scitranslmed.3009095", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030864998"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1586/14737175.2013.857603", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031078385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mds258", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031103729"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/ijms15010927", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031119695"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2011/160250", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031777754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-13-0895", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033750005"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.26.6650", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033812582"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-11-0774", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034057657"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1530/eje-10-0833", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034298017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1517/14712598.2011.540563", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034418047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/neuonc/nou307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034634150"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2014.162", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035077389", 
              "https://doi.org/10.1038/bjc.2014.162"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-06-2070", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035218301"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-13-0551", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035326911"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-12-3314", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035649201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1308345", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036201464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/his.12537", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037223091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1517", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039360772", 
              "https://doi.org/10.1038/nm1517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1517", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039360772", 
              "https://doi.org/10.1038/nm1517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1530/eje-12-0167", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041133776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.cco.0000142076.52721.b3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041825320"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.cco.0000142076.52721.b3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041825320"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1305133", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042841008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1200690", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042896583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2013/186563", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042947898"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.26.3541", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043187529"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jneuroim.2010.04.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044500647"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.200939274", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044753373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1003081", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045586298"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-07-0047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045655350"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(14)70011-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046267258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/neuonc/noq169", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047523365"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3239", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047946992", 
              "https://doi.org/10.1038/nrc3239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11060-014-1400-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048201517", 
              "https://doi.org/10.1007/s11060-014-1400-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1308573", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048225580"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-07-0187", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049037424"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijrobp.2012.12.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049460853"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(15)70054-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049970377"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0101764", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050988859"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa043330", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052112015"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1003466", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052212829"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aaa1348", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062665078"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aaa1348", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062665078"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1215/15228517-2007-010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064414279"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/092986712800099811", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069162469"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/onci.24436", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072306426"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/onci.28780", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072306690"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5414/np300698", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072837799"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074712934", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076595667", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.14694/edbook_am.2012.32.174", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078845845"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-09", 
        "datePublishedReg": "2015-09-01", 
        "description": "Glioblastoma is the most common primary brain tumour in adults. Prognosis is poor: even with the current gold-standard first-line treatment\u2014maximal safe resection and combination of radiotherapy with temozolomide chemotherapy\u2014the median overall survival time is only approximately 15-17 months, because the tumour recurs in virtually all patients, and no commonly accepted standard treatment for recurrent disease exists. Several targeted agents have failed to improve patient outcomes in glioblastoma. Immunotherapy with immune checkpoint inhibitors such as ipilimumab, nivolumab, and pembrolizumab has provided relevant clinical improvements in other advanced tumours for which conventional therapies have had limited success, making immunotherapy an appealing strategy in glioblastoma. This Review summarizes current knowledge on immune checkpoint modulators and evaluates their potential role in glioblastoma on the basis of preclinical studies and emerging clinical data. Furthermore, we discuss challenges that need to be considered in the clinical development of drugs that target immune checkpoint pathways in glioblastoma, such as specific properties of the immune system in the CNS, issues with radiological response assessment, and potential interactions with established and emerging treatment strategies.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nrneurol.2015.139", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2482377", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3803237", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2623831", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2695808", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3802599", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2695720", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2623803", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2434988", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2435036", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1036166", 
            "issn": [
              "1759-4758", 
              "1759-4766"
            ], 
            "name": "Nature Reviews Neurology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "9", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "11"
          }
        ], 
        "name": "Prospects of immune checkpoint modulators in the treatment of glioblastoma", 
        "pagination": "504-514", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "d6a00315d5589ac717eba2cb38d84b5ed70817ff2f065a94372b7aefa1a087a2"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "26260659"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101500072"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nrneurol.2015.139"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1045057880"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nrneurol.2015.139", 
          "https://app.dimensions.ai/details/publication/pub.1045057880"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T19:45", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000426.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/nrneurol/journal/v11/n9/full/nrneurol.2015.139.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nrneurol.2015.139'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrneurol.2015.139'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrneurol.2015.139'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nrneurol.2015.139'


     

    This table displays all metadata directly associated to this object as RDF triples.

    475 TRIPLES      21 PREDICATES      139 URIs      28 LITERALS      16 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nrneurol.2015.139 schema:about N5c26e9a71f474b5fab65062defb0626a
    2 N669a1357494e4e44bed481967bc94286
    3 N6a789749c6b4475ba7863a0dea2985b7
    4 N6fe1e1940da040d3a0753406321ec697
    5 N738a1412267b4bbe92c5cf8467b44bc1
    6 N99a0a52e4a134562914cf01f3cecf6f8
    7 Nb35915f0b47c4478bc1a756ee6222788
    8 anzsrc-for:11
    9 anzsrc-for:1112
    10 schema:author N2877457a9dea49fc8711809089335077
    11 schema:citation sg:pub.10.1007/s00520-001-0333-0
    12 sg:pub.10.1007/s11060-013-1314-0
    13 sg:pub.10.1007/s11060-014-1400-y
    14 sg:pub.10.1007/s11060-015-1746-9
    15 sg:pub.10.1038/bjc.2014.162
    16 sg:pub.10.1038/labinvest.2013.130
    17 sg:pub.10.1038/nature12213
    18 sg:pub.10.1038/nature13387
    19 sg:pub.10.1038/nature14432
    20 sg:pub.10.1038/nm.3335
    21 sg:pub.10.1038/nm1517
    22 sg:pub.10.1038/nrc3239
    23 sg:pub.10.1038/nrneurol.2014.208
    24 sg:pub.10.1186/s40425-014-0040-2
    25 https://app.dimensions.ai/details/publication/pub.1074712934
    26 https://app.dimensions.ai/details/publication/pub.1076595667
    27 https://doi.org/10.1002/eji.200939274
    28 https://doi.org/10.1016/j.ccr.2013.08.001
    29 https://doi.org/10.1016/j.clineuro.2013.12.004
    30 https://doi.org/10.1016/j.ejca.2008.10.026
    31 https://doi.org/10.1016/j.ijrobp.2012.12.025
    32 https://doi.org/10.1016/j.immuni.2013.07.012
    33 https://doi.org/10.1016/j.jneuroim.2010.04.003
    34 https://doi.org/10.1016/s0140-6736(14)60958-2
    35 https://doi.org/10.1016/s1470-2045(12)70090-6
    36 https://doi.org/10.1016/s1470-2045(12)70324-8
    37 https://doi.org/10.1016/s1470-2045(14)70011-7
    38 https://doi.org/10.1016/s1470-2045(15)70054-9
    39 https://doi.org/10.1056/nejmoa043330
    40 https://doi.org/10.1056/nejmoa1003466
    41 https://doi.org/10.1056/nejmoa1200690
    42 https://doi.org/10.1056/nejmoa1302369
    43 https://doi.org/10.1056/nejmoa1305133
    44 https://doi.org/10.1056/nejmoa1308345
    45 https://doi.org/10.1056/nejmoa1308573
    46 https://doi.org/10.1056/nejmoa1406498
    47 https://doi.org/10.1056/nejmoa1411087
    48 https://doi.org/10.1056/nejmoa1504030
    49 https://doi.org/10.1080/2162402x.2015.1057388
    50 https://doi.org/10.1084/jem.20082429
    51 https://doi.org/10.1093/annonc/mdq013
    52 https://doi.org/10.1093/annonc/mds258
    53 https://doi.org/10.1093/neuonc/noq157
    54 https://doi.org/10.1093/neuonc/noq169
    55 https://doi.org/10.1093/neuonc/nou212
    56 https://doi.org/10.1093/neuonc/nou223
    57 https://doi.org/10.1093/neuonc/nou307
    58 https://doi.org/10.1093/neuonc/nou348
    59 https://doi.org/10.1093/neuonc/nov071
    60 https://doi.org/10.1097/01.cco.0000142076.52721.b3
    61 https://doi.org/10.1097/wco.0000000000000144
    62 https://doi.org/10.1111/his.12537
    63 https://doi.org/10.1111/j.1600-065x.2009.00771.x
    64 https://doi.org/10.1126/science.1076514
    65 https://doi.org/10.1126/science.aaa1348
    66 https://doi.org/10.1126/scitranslmed.3009095
    67 https://doi.org/10.1155/2010/689171
    68 https://doi.org/10.1155/2011/160250
    69 https://doi.org/10.1155/2011/732413
    70 https://doi.org/10.1155/2012/492920
    71 https://doi.org/10.1155/2013/186563
    72 https://doi.org/10.1158/0008-5472.can-05-3773
    73 https://doi.org/10.1158/0008-5472.can-11-1620
    74 https://doi.org/10.1158/1078-0432.ccr-06-2070
    75 https://doi.org/10.1158/1078-0432.ccr-07-0187
    76 https://doi.org/10.1158/1078-0432.ccr-09-1624
    77 https://doi.org/10.1158/1078-0432.ccr-09-2376
    78 https://doi.org/10.1158/1078-0432.ccr-11-0774
    79 https://doi.org/10.1158/1078-0432.ccr-12-3314
    80 https://doi.org/10.1158/1078-0432.ccr-13-0551
    81 https://doi.org/10.1158/1078-0432.ccr-13-0895
    82 https://doi.org/10.1158/1078-0432.ccr-13-3271
    83 https://doi.org/10.1158/1078-0432.ccr-14-0514
    84 https://doi.org/10.1158/1535-7163.mct-07-0047
    85 https://doi.org/10.1158/2326-6066.cir-13-0028
    86 https://doi.org/10.1158/2326-6066.cir-14-0039
    87 https://doi.org/10.1172/jci35180
    88 https://doi.org/10.1177/0192623310391482
    89 https://doi.org/10.1200/jco.2009.26.3541
    90 https://doi.org/10.1200/jco.2009.26.6650
    91 https://doi.org/10.1200/jco.2013.51.4802
    92 https://doi.org/10.1200/jco.2014.59.0703
    93 https://doi.org/10.1215/15228517-2007-010
    94 https://doi.org/10.1371/journal.pone.0059082
    95 https://doi.org/10.1371/journal.pone.0101764
    96 https://doi.org/10.14694/edbook_am.2012.32.174
    97 https://doi.org/10.14791/btrt.2013.1.1.2
    98 https://doi.org/10.1517/14712598.2011.540563
    99 https://doi.org/10.1523/jneurosci.4794-04.2005
    100 https://doi.org/10.1530/eje-10-0833
    101 https://doi.org/10.1530/eje-12-0167
    102 https://doi.org/10.1586/14737175.2013.857603
    103 https://doi.org/10.1634/theoncologist.2012-0483
    104 https://doi.org/10.18632/oncotarget.2980
    105 https://doi.org/10.2147/ott.s4833
    106 https://doi.org/10.2174/092986712800099811
    107 https://doi.org/10.3389/fimmu.2013.00053
    108 https://doi.org/10.3390/ijms15010927
    109 https://doi.org/10.4049/jimmunol.1003081
    110 https://doi.org/10.4155/tde.14.114
    111 https://doi.org/10.4161/onci.24436
    112 https://doi.org/10.4161/onci.28780
    113 https://doi.org/10.5414/np300698
    114 schema:datePublished 2015-09
    115 schema:datePublishedReg 2015-09-01
    116 schema:description Glioblastoma is the most common primary brain tumour in adults. Prognosis is poor: even with the current gold-standard first-line treatment—maximal safe resection and combination of radiotherapy with temozolomide chemotherapy—the median overall survival time is only approximately 15-17 months, because the tumour recurs in virtually all patients, and no commonly accepted standard treatment for recurrent disease exists. Several targeted agents have failed to improve patient outcomes in glioblastoma. Immunotherapy with immune checkpoint inhibitors such as ipilimumab, nivolumab, and pembrolizumab has provided relevant clinical improvements in other advanced tumours for which conventional therapies have had limited success, making immunotherapy an appealing strategy in glioblastoma. This Review summarizes current knowledge on immune checkpoint modulators and evaluates their potential role in glioblastoma on the basis of preclinical studies and emerging clinical data. Furthermore, we discuss challenges that need to be considered in the clinical development of drugs that target immune checkpoint pathways in glioblastoma, such as specific properties of the immune system in the CNS, issues with radiological response assessment, and potential interactions with established and emerging treatment strategies.
    117 schema:genre research_article
    118 schema:inLanguage en
    119 schema:isAccessibleForFree true
    120 schema:isPartOf N93a30e2167e142a980e265b9a98208e1
    121 Ne3bdcb2a9bf846eeab7e6834cdc760b0
    122 sg:journal.1036166
    123 schema:name Prospects of immune checkpoint modulators in the treatment of glioblastoma
    124 schema:pagination 504-514
    125 schema:productId N05f39f306ac04102b2fdc871f73b5323
    126 N258417c588374103806dc2f7e28258d9
    127 N5dc94c9cebec4df782cd2a72bee8d386
    128 Nb10b20848a9844b0b2504520936f1ee0
    129 Nf3c28527c0aa415f9b51b0a45b7c0d46
    130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045057880
    131 https://doi.org/10.1038/nrneurol.2015.139
    132 schema:sdDatePublished 2019-04-10T19:45
    133 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    134 schema:sdPublisher N3e2318e6df1d4a5f9cb3128bb891db3c
    135 schema:url http://www.nature.com/nrneurol/journal/v11/n9/full/nrneurol.2015.139.html
    136 sgo:license sg:explorer/license/
    137 sgo:sdDataset articles
    138 rdf:type schema:ScholarlyArticle
    139 N05f39f306ac04102b2fdc871f73b5323 schema:name nlm_unique_id
    140 schema:value 101500072
    141 rdf:type schema:PropertyValue
    142 N258417c588374103806dc2f7e28258d9 schema:name dimensions_id
    143 schema:value pub.1045057880
    144 rdf:type schema:PropertyValue
    145 N2877457a9dea49fc8711809089335077 rdf:first sg:person.01247463220.45
    146 rdf:rest Nb888da8fc96d4f6289958878e967b859
    147 N3e2318e6df1d4a5f9cb3128bb891db3c schema:name Springer Nature - SN SciGraph project
    148 rdf:type schema:Organization
    149 N5c26e9a71f474b5fab65062defb0626a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Brain Neoplasms
    151 rdf:type schema:DefinedTerm
    152 N5dc94c9cebec4df782cd2a72bee8d386 schema:name pubmed_id
    153 schema:value 26260659
    154 rdf:type schema:PropertyValue
    155 N669a1357494e4e44bed481967bc94286 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Humans
    157 rdf:type schema:DefinedTerm
    158 N6a789749c6b4475ba7863a0dea2985b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name Immunologic Factors
    160 rdf:type schema:DefinedTerm
    161 N6fe1e1940da040d3a0753406321ec697 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Clinical Trials as Topic
    163 rdf:type schema:DefinedTerm
    164 N738a1412267b4bbe92c5cf8467b44bc1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Animals
    166 rdf:type schema:DefinedTerm
    167 N755a8befd3a74b8599e01f95def5f42b rdf:first sg:person.01334047606.77
    168 rdf:rest Ne1e7c48eddc145a48656e3aadd5e9bee
    169 N785f232659084d44adb618dcc36212fc rdf:first sg:person.0720414633.14
    170 rdf:rest N755a8befd3a74b8599e01f95def5f42b
    171 N84b50d9a8f8f418e9968094d6044418e schema:name Department of Neurology, Yale School of Medicine, Yale New Haven Hospital, 15 York Street, PO Box 208018, New Haven, CT 06520, USA.
    172 rdf:type schema:Organization
    173 N93a30e2167e142a980e265b9a98208e1 schema:issueNumber 9
    174 rdf:type schema:PublicationIssue
    175 N99a0a52e4a134562914cf01f3cecf6f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Immunotherapy
    177 rdf:type schema:DefinedTerm
    178 Nb10b20848a9844b0b2504520936f1ee0 schema:name doi
    179 schema:value 10.1038/nrneurol.2015.139
    180 rdf:type schema:PropertyValue
    181 Nb35915f0b47c4478bc1a756ee6222788 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Glioblastoma
    183 rdf:type schema:DefinedTerm
    184 Nb888da8fc96d4f6289958878e967b859 rdf:first sg:person.01233314250.47
    185 rdf:rest N785f232659084d44adb618dcc36212fc
    186 Ne1e7c48eddc145a48656e3aadd5e9bee rdf:first sg:person.01127256465.77
    187 rdf:rest rdf:nil
    188 Ne3bdcb2a9bf846eeab7e6834cdc760b0 schema:volumeNumber 11
    189 rdf:type schema:PublicationVolume
    190 Nf3c28527c0aa415f9b51b0a45b7c0d46 schema:name readcube_id
    191 schema:value d6a00315d5589ac717eba2cb38d84b5ed70817ff2f065a94372b7aefa1a087a2
    192 rdf:type schema:PropertyValue
    193 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    194 schema:name Medical and Health Sciences
    195 rdf:type schema:DefinedTerm
    196 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    197 schema:name Oncology and Carcinogenesis
    198 rdf:type schema:DefinedTerm
    199 sg:grant.2434988 http://pending.schema.org/fundedItem sg:pub.10.1038/nrneurol.2015.139
    200 rdf:type schema:MonetaryGrant
    201 sg:grant.2435036 http://pending.schema.org/fundedItem sg:pub.10.1038/nrneurol.2015.139
    202 rdf:type schema:MonetaryGrant
    203 sg:grant.2482377 http://pending.schema.org/fundedItem sg:pub.10.1038/nrneurol.2015.139
    204 rdf:type schema:MonetaryGrant
    205 sg:grant.2623803 http://pending.schema.org/fundedItem sg:pub.10.1038/nrneurol.2015.139
    206 rdf:type schema:MonetaryGrant
    207 sg:grant.2623831 http://pending.schema.org/fundedItem sg:pub.10.1038/nrneurol.2015.139
    208 rdf:type schema:MonetaryGrant
    209 sg:grant.2695720 http://pending.schema.org/fundedItem sg:pub.10.1038/nrneurol.2015.139
    210 rdf:type schema:MonetaryGrant
    211 sg:grant.2695808 http://pending.schema.org/fundedItem sg:pub.10.1038/nrneurol.2015.139
    212 rdf:type schema:MonetaryGrant
    213 sg:grant.3802599 http://pending.schema.org/fundedItem sg:pub.10.1038/nrneurol.2015.139
    214 rdf:type schema:MonetaryGrant
    215 sg:grant.3803237 http://pending.schema.org/fundedItem sg:pub.10.1038/nrneurol.2015.139
    216 rdf:type schema:MonetaryGrant
    217 sg:journal.1036166 schema:issn 1759-4758
    218 1759-4766
    219 schema:name Nature Reviews Neurology
    220 rdf:type schema:Periodical
    221 sg:person.01127256465.77 schema:affiliation https://www.grid.ac/institutes/grid.26009.3d
    222 schema:familyName Sampson
    223 schema:givenName John H.
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127256465.77
    225 rdf:type schema:Person
    226 sg:person.01233314250.47 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
    227 schema:familyName Lim
    228 schema:givenName Michael
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233314250.47
    230 rdf:type schema:Person
    231 sg:person.01247463220.45 schema:affiliation https://www.grid.ac/institutes/grid.22937.3d
    232 schema:familyName Preusser
    233 schema:givenName Matthias
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247463220.45
    235 rdf:type schema:Person
    236 sg:person.01334047606.77 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
    237 schema:familyName Reardon
    238 schema:givenName David A.
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334047606.77
    240 rdf:type schema:Person
    241 sg:person.0720414633.14 schema:affiliation N84b50d9a8f8f418e9968094d6044418e
    242 schema:familyName Hafler
    243 schema:givenName David A.
    244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720414633.14
    245 rdf:type schema:Person
    246 sg:pub.10.1007/s00520-001-0333-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005830681
    247 https://doi.org/10.1007/s00520-001-0333-0
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1007/s11060-013-1314-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027346751
    250 https://doi.org/10.1007/s11060-013-1314-0
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1007/s11060-014-1400-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1048201517
    253 https://doi.org/10.1007/s11060-014-1400-y
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1007/s11060-015-1746-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002579319
    256 https://doi.org/10.1007/s11060-015-1746-9
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1038/bjc.2014.162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035077389
    259 https://doi.org/10.1038/bjc.2014.162
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1038/labinvest.2013.130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024707845
    262 https://doi.org/10.1038/labinvest.2013.130
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1038/nature12213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021761707
    265 https://doi.org/10.1038/nature12213
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1038/nature13387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016354360
    268 https://doi.org/10.1038/nature13387
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1038/nature14432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000736772
    271 https://doi.org/10.1038/nature14432
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1038/nm.3335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002198629
    274 https://doi.org/10.1038/nm.3335
    275 rdf:type schema:CreativeWork
    276 sg:pub.10.1038/nm1517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039360772
    277 https://doi.org/10.1038/nm1517
    278 rdf:type schema:CreativeWork
    279 sg:pub.10.1038/nrc3239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047946992
    280 https://doi.org/10.1038/nrc3239
    281 rdf:type schema:CreativeWork
    282 sg:pub.10.1038/nrneurol.2014.208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009832934
    283 https://doi.org/10.1038/nrneurol.2014.208
    284 rdf:type schema:CreativeWork
    285 sg:pub.10.1186/s40425-014-0040-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022897953
    286 https://doi.org/10.1186/s40425-014-0040-2
    287 rdf:type schema:CreativeWork
    288 https://app.dimensions.ai/details/publication/pub.1074712934 schema:CreativeWork
    289 https://app.dimensions.ai/details/publication/pub.1076595667 schema:CreativeWork
    290 https://doi.org/10.1002/eji.200939274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044753373
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1016/j.ccr.2013.08.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008514979
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1016/j.clineuro.2013.12.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028177765
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1016/j.ejca.2008.10.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026558254
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1016/j.ijrobp.2012.12.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049460853
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1016/j.immuni.2013.07.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006498518
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1016/j.jneuroim.2010.04.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044500647
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1016/s0140-6736(14)60958-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012632588
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1016/s1470-2045(12)70090-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003673495
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1016/s1470-2045(12)70324-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010195671
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1016/s1470-2045(14)70011-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046267258
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1016/s1470-2045(15)70054-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049970377
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1056/nejmoa043330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052112015
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1056/nejmoa1003466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052212829
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1056/nejmoa1200690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042896583
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1056/nejmoa1302369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024659470
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1056/nejmoa1305133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042841008
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1056/nejmoa1308345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036201464
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1056/nejmoa1308573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048225580
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1056/nejmoa1406498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020435459
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1056/nejmoa1411087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014862127
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1056/nejmoa1504030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024843336
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1080/2162402x.2015.1057388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006736286
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1084/jem.20082429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010107580
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1093/annonc/mdq013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025653897
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1093/annonc/mds258 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031103729
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1093/neuonc/noq157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010254555
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1093/neuonc/noq169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047523365
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1093/neuonc/nou212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007801267
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1093/neuonc/nou223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019576806
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1093/neuonc/nou307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034634150
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1093/neuonc/nou348 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026946190
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1093/neuonc/nov071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012818242
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1097/01.cco.0000142076.52721.b3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041825320
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1097/wco.0000000000000144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030702082
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1111/his.12537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037223091
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1111/j.1600-065x.2009.00771.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008563862
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1126/science.1076514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003163159
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1126/science.aaa1348 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062665078
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1126/scitranslmed.3009095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030864998
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1155/2010/689171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018385459
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1155/2011/160250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031777754
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1155/2011/732413 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010794620
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1155/2012/492920 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005974874
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1155/2013/186563 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042947898
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1158/0008-5472.can-05-3773 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020419107
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1158/0008-5472.can-11-1620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006976153
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1158/1078-0432.ccr-06-2070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035218301
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1158/1078-0432.ccr-07-0187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049037424
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1158/1078-0432.ccr-09-1624 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028571226
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1158/1078-0432.ccr-09-2376 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029992849
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1158/1078-0432.ccr-11-0774 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034057657
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1158/1078-0432.ccr-12-3314 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035649201
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.1158/1078-0432.ccr-13-0551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035326911
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.1158/1078-0432.ccr-13-0895 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033750005
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.1158/1078-0432.ccr-13-3271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004953031
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.1158/1078-0432.ccr-14-0514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027650074
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.1158/1535-7163.mct-07-0047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045655350
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.1158/2326-6066.cir-13-0028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004343764
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.1158/2326-6066.cir-14-0039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030280412
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.1172/jci35180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025112763
    411 rdf:type schema:CreativeWork
    412 https://doi.org/10.1177/0192623310391482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028688186
    413 rdf:type schema:CreativeWork
    414 https://doi.org/10.1200/jco.2009.26.3541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043187529
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.1200/jco.2009.26.6650 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033812582
    417 rdf:type schema:CreativeWork
    418 https://doi.org/10.1200/jco.2013.51.4802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002061814
    419 rdf:type schema:CreativeWork
    420 https://doi.org/10.1200/jco.2014.59.0703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009621823
    421 rdf:type schema:CreativeWork
    422 https://doi.org/10.1215/15228517-2007-010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064414279
    423 rdf:type schema:CreativeWork
    424 https://doi.org/10.1371/journal.pone.0059082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016248318
    425 rdf:type schema:CreativeWork
    426 https://doi.org/10.1371/journal.pone.0101764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050988859
    427 rdf:type schema:CreativeWork
    428 https://doi.org/10.14694/edbook_am.2012.32.174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078845845
    429 rdf:type schema:CreativeWork
    430 https://doi.org/10.14791/btrt.2013.1.1.2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011261217
    431 rdf:type schema:CreativeWork
    432 https://doi.org/10.1517/14712598.2011.540563 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034418047
    433 rdf:type schema:CreativeWork
    434 https://doi.org/10.1523/jneurosci.4794-04.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007498527
    435 rdf:type schema:CreativeWork
    436 https://doi.org/10.1530/eje-10-0833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034298017
    437 rdf:type schema:CreativeWork
    438 https://doi.org/10.1530/eje-12-0167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041133776
    439 rdf:type schema:CreativeWork
    440 https://doi.org/10.1586/14737175.2013.857603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031078385
    441 rdf:type schema:CreativeWork
    442 https://doi.org/10.1634/theoncologist.2012-0483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029091889
    443 rdf:type schema:CreativeWork
    444 https://doi.org/10.18632/oncotarget.2980 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001783473
    445 rdf:type schema:CreativeWork
    446 https://doi.org/10.2147/ott.s4833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007878666
    447 rdf:type schema:CreativeWork
    448 https://doi.org/10.2174/092986712800099811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069162469
    449 rdf:type schema:CreativeWork
    450 https://doi.org/10.3389/fimmu.2013.00053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025662395
    451 rdf:type schema:CreativeWork
    452 https://doi.org/10.3390/ijms15010927 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031119695
    453 rdf:type schema:CreativeWork
    454 https://doi.org/10.4049/jimmunol.1003081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045586298
    455 rdf:type schema:CreativeWork
    456 https://doi.org/10.4155/tde.14.114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016876066
    457 rdf:type schema:CreativeWork
    458 https://doi.org/10.4161/onci.24436 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072306426
    459 rdf:type schema:CreativeWork
    460 https://doi.org/10.4161/onci.28780 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072306690
    461 rdf:type schema:CreativeWork
    462 https://doi.org/10.5414/np300698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072837799
    463 rdf:type schema:CreativeWork
    464 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
    465 schema:name Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA.
    466 rdf:type schema:Organization
    467 https://www.grid.ac/institutes/grid.22937.3d schema:alternateName Medical University of Vienna
    468 schema:name Department of Medicine I and Comprehensive Cancer Centre CNS Tumours Unit, Medical University of Vienna, Waehringer Guertel 18–20, 1090 Vienna, Austria.
    469 rdf:type schema:Organization
    470 https://www.grid.ac/institutes/grid.26009.3d schema:alternateName Duke University
    471 schema:name Division of Neurosurgery, 220 Sands Building, Research Drive, Duke University School of Medicine, Durham, NC 27705, USA.
    472 rdf:type schema:Organization
    473 https://www.grid.ac/institutes/grid.65499.37 schema:alternateName Dana–Farber Cancer Institute
    474 schema:name Center for Neuro-Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Dana 2134, Boston, MA 02215, USA.
    475 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...