Amyotrophic lateral sclerosis—a model of corticofugal axonal spread View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-11-12

AUTHORS

Heiko Braak, Johannes Brettschneider, Albert C. Ludolph, Virginia M. Lee, John Q. Trojanowski, Kelly Del Tredici

ABSTRACT

Prion-like propagation of pathogenic proteins has been suggested to underlie several neurodegenerative diseases. In this Perspectives article, Braak et al. posit that progressive lesions in amyotrophic lateral sclerosis (ALS) spread through cell-to-cell transfer of 43-kDA transactive response DNA-binding protein, mainly through cortical neuronal projections to other brain areas and the spinal cord. This model could have important implications for our understanding of ALS and approach to treatment. More... »

PAGES

708-714

References to SciGraph publications

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  • 2011-11-30. Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration in NATURE REVIEWS NEUROSCIENCE
  • 2007-09-05. TDP-43-immunoreactive neuronal and glial inclusions in the neostriatum in amyotrophic lateral sclerosis with and without dementia in ACTA NEUROPATHOLOGICA
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  • 2005-03-08. Cognitive function in bulbar– and spinal–onset amyotrophic lateral sclerosis in JOURNAL OF NEUROLOGY
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  • 2003-06-15. Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging in NATURE NEUROSCIENCE
  • 2011-06-05. A harmonized classification system for FTLD-TDP pathology in ACTA NEUROPATHOLOGICA
  • 2013-09-04. Self-propagation of pathogenic protein aggregates in neurodegenerative diseases in NATURE
  • 2010-10-12. Cell-to-cell transmission of non-prion protein aggregates in NATURE REVIEWS NEUROLOGY
  • 2010-03-03. Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis in ACTA NEUROPATHOLOGICA
  • 2012-11-30. Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice in SCIENTIFIC REPORTS
  • 2003-05. Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen in JOURNAL OF NEURAL TRANSMISSION
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrneurol.2013.221

    DOI

    http://dx.doi.org/10.1038/nrneurol.2013.221

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1036666613

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24217521


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