100 years of Lewy pathology View Full Text


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Article Info

DATE

2012-11-27

AUTHORS

Michel Goedert, Maria Grazia Spillantini, Kelly Del Tredici, Heiko Braak

ABSTRACT

In 1912, Fritz Heinrich Lewy identified the intracellular inclusions that are characteristic of Parkinson disease (PD). Here, Goedert and colleagues present an overview of Lewy's life, including the events leading up to the discovery of the inclusion bodies that now bear his name. They go on to discuss the central role of Lewy pathology in PD and other neurodegenerative disorders, and the research that has elucidated the mechanisms through which α-synuclein aggregation causes neuronal dysfunction and death. More... »

PAGES

13-24

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrneurol.2012.242

    DOI

    http://dx.doi.org/10.1038/nrneurol.2012.242

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23183883


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