Angiotensin-converting enzyme in innate and adaptive immunity View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-03-26

AUTHORS

Kenneth E. Bernstein, Zakir Khan, Jorge F. Giani, Duo-Yao Cao, Ellen A. Bernstein, Xiao Z. Shen

ABSTRACT

Key PointsAngiotensin-converting enzyme (ACE) expression by myeloid cells is increased in response to infection.Forced ACE overexpression in mouse macrophages increases their ability to respond to infection and some tumour models, which is in part mediated by increased levels of nitric oxide, superoxide (O2−) and pro-inflammatory cytokines.Forced ACE overexpression in neutrophils increases their response to infection by increasing NADPH oxidase-dependent production of O2−.The effects of ACE overexpression are not mediated by angiotensin II, any other angiotensin peptides or the type 1 angiotensin II receptor but instead by unknown ACE substrate(s) or product(s).No known immunological framework can currently explain the effects of ACE overexpression, but an as yet unrecognized pathway capable of stimulating myeloid function beyond levels achievable by wild-type cells must exist. More... »

PAGES

325-336

References to SciGraph publications

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  • 2014-03-10. Myeloid expression of angiotensin-converting enzyme facilitates myeloid maturation and inhibits the development of myeloid-derived suppressor cells in LABORATORY INVESTIGATION
  • 2014-04-24. Angiotensin II and Vascular Injury in CURRENT HYPERTENSION REPORTS
  • 1995-05. Male–female differences in fertility and blood pressure in ACE-deficient mice in NATURE
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  • 2013-05-18. Rediscovering ACE: novel insights into the many roles of the angiotensin-converting enzyme in JOURNAL OF MOLECULAR MEDICINE
  • 2014-04-27. Development of therapies for autoimmune disease at Stanford: a tale of multiple shots and one goal in IMMUNOLOGIC RESEARCH
  • 2016-05-27. Neutrophil migration in infection and wound repair: going forward in reverse in NATURE REVIEWS IMMUNOLOGY
  • 2013-06-04. Molecular mechanisms regulating NETosis in infection and disease in SEMINARS IN IMMUNOPATHOLOGY
  • 2014-09-14. Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens in NATURE IMMUNOLOGY
  • 2017-04-10. Angiotensin-converting enzyme affects the presentation of MHC class II antigens in LABORATORY INVESTIGATION
  • 2011-10-02. The carboxypeptidase ACE shapes the MHC class I peptide repertoire in NATURE IMMUNOLOGY
  • 2005-09-13. The impact of prior outpatient ACE inhibitor use on 30-day mortality for patients hospitalized with community-acquired pneumonia in BMC PULMONARY MEDICINE
  • 2011-02-04. Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality in CELL DEATH & DIFFERENTIATION
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrneph.2018.15

    DOI

    http://dx.doi.org/10.1038/nrneph.2018.15

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1101760619

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29578208


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