Biologics for the treatment of autoimmune renal diseases View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-04

AUTHORS

Stephen R. Holdsworth, Poh-Yi Gan, A. Richard Kitching

ABSTRACT

Biological therapeutics (biologics) that target autoimmune responses and inflammatory injury pathways have a marked beneficial impact on the management of many chronic diseases, including rheumatoid arthritis, psoriasis, inflammatory bowel disease, and ankylosing spondylitis. Accumulating data suggest that a growing number of renal diseases result from autoimmune injury - including lupus nephritis, IgA nephropathy, anti-neutrophil cytoplasmic antibody-associated glomerulonephritis, autoimmune (formerly idiopathic) membranous nephropathy, anti-glomerular basement membrane glomerulonephritis, and C3 nephropathy - and one can speculate that biologics might also be applicable to these diseases. As many autoimmune renal diseases are relatively uncommon, with long natural histories and diverse outcomes, clinical trials that aim to validate potentially useful biologics are difficult to design and/or perform. Some excellent consortia are undertaking cohort studies and clinical trials, but more multicentre international collaborations are needed to advance the introduction of new biologics to patients with autoimmune renal disorders. This Review discusses the key molecules that direct injurious inflammation and the biologics that are available to modulate them. The opportunities and challenges for the introduction of relevant biologics into treatment protocols for autoimmune renal diseases are also discussed. More... »

PAGES

217

References to SciGraph publications

  • 2014-07. Eculizumab therapy in a patient with dense-deposit disease associated with partial lipodystropy in PEDIATRIC NEPHROLOGY
  • 2003-11. Regulation by CD25+ lymphocytes of autoantigen-specific T-cell responses in Goodpasture's (anti-GBM) disease in KIDNEY INTERNATIONAL
  • 1979-02. Crescentic glomerulonephritis without immune deposits: Clinicopathologic features in KIDNEY INTERNATIONAL
  • 1999-04. Th1 and Th2 T helper cell subsets affect patterns of injury and outcomes in glomerulonephritis in KIDNEY INTERNATIONAL
  • 2014-06. Rituximab fails where eculizumab restores renal function in C3nef-related DDD in PEDIATRIC NEPHROLOGY
  • 2013-11. Evolution of immunoglobulin deposition in C3-dominant membranoproliferative glomerulopathy in PEDIATRIC NEPHROLOGY
  • 2010-09. B-lymphocyte activating factor levels are increased in patients with Wegener’s granulomatosis and inversely correlated with ANCA titer in CLINICAL RHEUMATOLOGY
  • 2013-07. Regulation of TNF-α with a focus on rheumatoid arthritis in IMMUNOLOGY AND CELL BIOLOGY
  • 2007-04. Inhibition of complement factor C5 protects against anti-myeloperoxidase antibody-mediated glomerulonephritis in mice in KIDNEY INTERNATIONAL
  • 2008-10. Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis in NATURE MEDICINE
  • 2014-11. The etiology of glomerulonephritis: roles of infection and autoimmunity in KIDNEY INTERNATIONAL
  • 1988-01. Tumour necrosis factor-α in murine autoimmune 'lupus' nephritis in NATURE
  • 2015-04. Podocyte dysfunction in atypical haemolytic uraemic syndrome in NATURE REVIEWS NEPHROLOGY
  • 2012-08. Acquired and genetic complement abnormalities play a critical role in dense deposit disease and other C3 glomerulopathies in KIDNEY INTERNATIONAL
  • 1999-11. The HLA complex in Goodpasture's disease: A model for analyzing susceptibility to autoimmunity in KIDNEY INTERNATIONAL
  • 2012-09. B-cell depletion in the treatment of lupus nephritis in NATURE REVIEWS NEPHROLOGY
  • 2012-02. Atacicept in combination with MMF and corticosteroids in lupus nephritis: results of a prematurely terminated trial in ARTHRITIS RESEARCH & THERAPY
  • 2012-08. C3 glomerulonephritis: clinicopathological findings, complement abnormalities, glomerular proteomic profile, treatment, and follow-up in KIDNEY INTERNATIONAL
  • 2006-07. B cells move to centre stage: novel opportunities for autoimmune disease treatment in NATURE REVIEWS DRUG DISCOVERY
  • 2013-10. Eculizumab and recurrent C3 glomerulonephritis in PEDIATRIC NEPHROLOGY
  • 2013-12. C3 glomerulopathy: consensus report in KIDNEY INTERNATIONAL
  • 2008-01. Rituximab treatment of idiopathic membranous nephropathy in KIDNEY INTERNATIONAL
  • 2012-06. Chapter 13: Pauci-immune focal and segmental necrotizing glomerulonephritis in KIDNEY INTERNATIONAL SUPPLEMENTS
  • 2012-06. Chapter 14: Anti-glomerular basement membrane antibody glomerulonephritis in KIDNEY INTERNATIONAL SUPPLEMENTS
  • 2010-08. C3 glomerulopathy: a new classification in NATURE REVIEWS NEPHROLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrneph.2016.18

    DOI

    http://dx.doi.org/10.1038/nrneph.2016.18

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1007649073

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26949177


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Anti-Glomerular Basement Membrane Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Autoimmune Diseases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biological Products", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glomerulonephritis, IGA", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glomerulonephritis, Membranous", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunologic Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Kidney Diseases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lupus Nephritis", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Monash Health", 
              "id": "https://www.grid.ac/institutes/grid.419789.a", 
              "name": [
                "Department of Medicine, Centre for Inflammatory Diseases, Monash University, VIC 3800, Australia.", 
                "Department of Nephrology, Monash Health, 246 Clayton Road, Clayton, Melbourne, VIC 3168, Australia."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Holdsworth", 
            "givenName": "Stephen R.", 
            "id": "sg:person.01131260677.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131260677.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Monash University", 
              "id": "https://www.grid.ac/institutes/grid.1002.3", 
              "name": [
                "Department of Medicine, Centre for Inflammatory Diseases, Monash University, VIC 3800, Australia."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gan", 
            "givenName": "Poh-Yi", 
            "id": "sg:person.0707425666.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707425666.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Monash Health", 
              "id": "https://www.grid.ac/institutes/grid.419789.a", 
              "name": [
                "Department of Medicine, Centre for Inflammatory Diseases, Monash University, VIC 3800, Australia.", 
                "Department of Nephrology, Monash Health, 246 Clayton Road, Clayton, Melbourne, VIC 3168, Australia."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kitching", 
            "givenName": "A. Richard", 
            "id": "sg:person.0700603677.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700603677.38"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1056/nejmoa0810457", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000251144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.semnephrol.2011.06.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000825444"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.34359", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001205015"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/14651858.cd002922.pub3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001234111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.4559", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002596815"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/annrheumdis-2014-eular.3974", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002874402"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199707173370301", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003086894"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.kint.2015.12.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003207786"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.38260", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003529057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1046/j.1523-1755.2003.00259.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004405762", 
              "https://doi.org/10.1046/j.1523-1755.2003.00259.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1523-1755.2003.00259.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004405762"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2015060612", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004837905"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2015060612", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004837905"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.190.11.1697", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005101826"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ki.2013.377", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005163409", 
              "https://doi.org/10.1038/ki.2013.377"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.semnephrol.2013.08.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005461113"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0337679100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005749429"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.autrev.2009.08.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006079818"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ki.1979.24", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006561866", 
              "https://doi.org/10.1038/ki.1979.24"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci13876", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006600454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa041884", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006803264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd2085", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006848433", 
              "https://doi.org/10.1038/nrd2085"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd2085", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006848433", 
              "https://doi.org/10.1038/nrd2085"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000430849", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007263225"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ndt/gfs262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009112158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0909905", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009247104"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/ar3738", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009439269", 
              "https://doi.org/10.1186/ar3738"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2012070705", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009686633"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2012070705", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009686633"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2011121186", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010051952"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2011121186", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010051952"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2009.10.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010202033"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/annrheumdis-2013-203348", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010225448"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/mabs.2.1.10789", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010266144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ki.5002103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010550614", 
              "https://doi.org/10.1038/sj.ki.5002103"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.177.1.69", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010772550"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000319655", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010866292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/00365513.2011.652158", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011284973"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.38790", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011389288"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.semnephrol.2011.06.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012222669"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00467-013-2503-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012617355", 
              "https://doi.org/10.1007/s00467-013-2503-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.semarthrit.2015.02.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012781245"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/09629350400003100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012956032"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2008.05.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013070429"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.38037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014040548"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2215/cjn.06041108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014173867"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/0471142735.im1526s106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014493023"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1404231", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014688727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/nep.12530", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014875921"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0961203310395802", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014892911"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0961203310395802", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014892911"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0961203310395802", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014892911"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2215/cjn.05140512", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015768010"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.166.3.798", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016051734"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9440(10)62952-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016379541"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2215/cjn.01180307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016514206"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molimm.2015.01.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016879291"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm198806233182504", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017392435"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaut.2012.05.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017644148"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci31720", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018161580"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2014121195", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018577616"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2014121195", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018577616"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1517/13543784.17.9.1267", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018772882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20030286", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019022554"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmjopen-2013-003573", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019729187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.1874", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020010437", 
              "https://doi.org/10.1038/nm.1874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thx.2006.076513", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020914319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thx.2006.076513", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020914319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/annrheumdis-2013-204164", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021335386"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2008080891", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021967845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2008080891", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021967845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/kisup.2012.26", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022519635", 
              "https://doi.org/10.1038/kisup.2012.26"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2010050536", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022583059"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2010050536", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022583059"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2010-07-294249", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022664307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2011030304", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022774150"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2011030304", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022774150"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrneph.2012.141", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022827679", 
              "https://doi.org/10.1038/nrneph.2012.141"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10067-010-1526-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023159752", 
              "https://doi.org/10.1007/s10067-010-1526-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10067-010-1526-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023159752", 
              "https://doi.org/10.1007/s10067-010-1526-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/kisup.2012.27", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024851361", 
              "https://doi.org/10.1038/kisup.2012.27"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/jir.2008.0027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024851893"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ki.2014.49", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025158820", 
              "https://doi.org/10.1038/ki.2014.49"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2008050497", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025609397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2008050497", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025609397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.autrev.2013.07.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025674060"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrneph.2010.85", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025976520", 
              "https://doi.org/10.1038/nrneph.2010.85"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrneph.2010.85", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025976520", 
              "https://doi.org/10.1038/nrneph.2010.85"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1409354", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026104672"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1529-0131(200105)44:5<1149::aid-anr197>3.0.co;2-f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026381601"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0909169", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027355308"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.274.16.11267", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027783149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrneph.2014.250", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027840533", 
              "https://doi.org/10.1038/nrneph.2014.250"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.semnephrol.2007.02.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027914632"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00467-013-2748-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027939914", 
              "https://doi.org/10.1007/s00467-013-2748-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.194.4.417", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028419152"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmc1111953", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028512912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ndt/gfq187", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028596961"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ndt/gfq187", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028596961"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2147/dddt.s49778", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028800667"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(10)61354-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028914094"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/ard.61.6.559", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029758838"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2010.03.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029759090"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199711203372106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030293646"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(08)60453-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030759765"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.106.2.191", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030833671"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/rheumatology/41.10.1126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030835263"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1300269", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031381963"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/icb.2013.15", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031852459", 
              "https://doi.org/10.1038/icb.2013.15"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/qjmed/89.12.903", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032238595"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/0471142735.im1527s107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032455948"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmra1108178", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032681183"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/cei.12287", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032785507"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci38468", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033179827"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci38468", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033179827"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1108735", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033434785"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2013020143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033949576"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2013020143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033949576"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ki.2012.212", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034063404", 
              "https://doi.org/10.1038/ki.2012.212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2249.1992.tb05860.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034097646"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/annrheumdis-2014-206090", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034264665"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/rheumatology/41.11.1303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034519082"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ki.5002628", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034720925", 
              "https://doi.org/10.1038/sj.ki.5002628"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2215/cjn.12901211", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035397126"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20021553", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036754305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(12)61566-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036822805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2005060616", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037039385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2005060616", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037039385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ppul.22884", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037373047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00467-013-2711-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037518601", 
              "https://doi.org/10.1007/s00467-013-2711-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0910500", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037844276"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2215/cjn.01080905", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038083969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmra1004965", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038098608"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1208981", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038836296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaut.2005.08.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039022915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2007091052", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040259921"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2007091052", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040259921"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-6143.2011.03923.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041110857"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00467-013-2565-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041465742", 
              "https://doi.org/10.1007/s00467-013-2565-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cytogfr.2013.04.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041592245"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ndt/gfs319", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041695723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2005010096", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042294058"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2005010096", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042294058"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2013010026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042479677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2013010026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042479677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.21869", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042637139"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci72270", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042904706"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.192.5.681", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042914936"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmc1106619", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043193847"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2013010045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043252234"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2013010045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043252234"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20021996", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043729147"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/ard.2005.042416", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044253021"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mnh.0b013e32835da24c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044703034"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mnh.0b013e32835da24c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044703034"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2010111125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044887314"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2010111125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044887314"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.27221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045050471"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.27221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045050471"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/annrheumdis-2015-eular.2916", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045448345"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ki.2012.63", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045948666", 
              "https://doi.org/10.1038/ki.2012.63"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa044396", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047160581"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa044397", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047413416"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1046/j.1523-1755.1999.00720.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047474097", 
              "https://doi.org/10.1046/j.1523-1755.1999.00720.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmc1112273", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047915300"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000368592", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048923837"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000319656", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049033928"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molimm.2015.03.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049283562"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1046/j.1523-1755.1999.00369.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049544773", 
              "https://doi.org/10.1046/j.1523-1755.1999.00369.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2353/ajpath.2008.070131", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049851151"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/bor.0b013e32834d85ce", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050422547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/bor.0b013e32834d85ce", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050422547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/331356a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050954154", 
              "https://doi.org/10.1038/331356a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.autrev.2011.05.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051101540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3181/00379727-100-24736", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051146252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3181/00379727-100-24736", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051146252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2215/cjn.05080610", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051372200"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.186.1.131", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051770127"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.186.1.131", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051770127"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0601094103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051976893"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2007020166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052277923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2007020166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052277923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.34362", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053222569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/bcp.12864", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053329232"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2006121348", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053536356"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2006121348", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053536356"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.asn.0000091381.60059.fb", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060319347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.asn.0000091381.60059.fb", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060319347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.asn.0000091381.60059.fb", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060319347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.asn.0000091588.80007.0e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060319351"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.asn.0000091588.80007.0e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060319351"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.asn.0000091588.80007.0e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060319351"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.asn.0000114554.67106.28", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060319517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.asn.0000114554.67106.28", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060319517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.asn.0000114554.67106.28", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060319517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.7520604", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062647417"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci15918", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063415457"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1191/0961203304lu1032oa", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064154418"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1191/0961203304lu1032oa", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064154418"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1191/0961203304lu1032oa", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064154418"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2015020149", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068243434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2015020149", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068243434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2015020149", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068243434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/1381612821666150316115727", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069170307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3904/kjim.1994.9.1.1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071556328"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5301/jn.5000218", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072753340"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5301/jn.5000278", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072753400"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.173.1.136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1076855492"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.175.8.5370", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077123900"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.177.8.5687", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077303911"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077612381", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078034835", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078149273", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078549898", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1203200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078713655"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1203548", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078721126"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078761086", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079203817", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082400456", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082503455", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082688919", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082736831", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000422410", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082757575"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082790645", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-04", 
        "datePublishedReg": "2016-04-01", 
        "description": "Biological therapeutics (biologics) that target autoimmune responses and inflammatory injury pathways have a marked beneficial impact on the management of many chronic diseases, including rheumatoid arthritis, psoriasis, inflammatory bowel disease, and ankylosing spondylitis. Accumulating data suggest that a growing number of renal diseases result from autoimmune injury - including lupus nephritis, IgA nephropathy, anti-neutrophil cytoplasmic antibody-associated glomerulonephritis, autoimmune (formerly idiopathic) membranous nephropathy, anti-glomerular basement membrane glomerulonephritis, and C3 nephropathy - and one can speculate that biologics might also be applicable to these diseases. As many autoimmune renal diseases are relatively uncommon, with long natural histories and diverse outcomes, clinical trials that aim to validate potentially useful biologics are difficult to design and/or perform. Some excellent consortia are undertaking cohort studies and clinical trials, but more multicentre international collaborations are needed to advance the introduction of new biologics to patients with autoimmune renal disorders. This Review discusses the key molecules that direct injurious inflammation and the biologics that are available to modulate them. The opportunities and challenges for the introduction of relevant biologics into treatment protocols for autoimmune renal diseases are also discussed. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nrneph.2016.18", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.6736516", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6734877", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6735020", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6730264", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6728319", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1294907", 
            "issn": [
              "1759-5061", 
              "1759-507X"
            ], 
            "name": "Nature Reviews Nephrology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "12"
          }
        ], 
        "name": "Biologics for the treatment of autoimmune renal diseases", 
        "pagination": "217", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "246f4f98af80309ecbe67a51f4e8c0081b2f8376d421f0804da05c5fe3f0e2ba"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "26949177"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101500081"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nrneph.2016.18"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1007649073"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nrneph.2016.18", 
          "https://app.dimensions.ai/details/publication/pub.1007649073"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T15:40", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000442.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/nrneph.2016.18"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nrneph.2016.18'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrneph.2016.18'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrneph.2016.18'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nrneph.2016.18'


     

    This table displays all metadata directly associated to this object as RDF triples.

    699 TRIPLES      21 PREDICATES      222 URIs      30 LITERALS      18 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nrneph.2016.18 schema:about N1d62368292864f99b29e189d668c4890
    2 N3bd2e21c2c2d4583b855447ede5405de
    3 N3e2ed9f07466462db03136750ece3ee0
    4 N46a725eb2e0645d1a0c8b4abd5e1790a
    5 N93aa6e7c12e64ccda37b6c30c1abc13b
    6 N9ca49101348f47949d7d448b1b99a8ce
    7 Na59ae4cb5f3648b1bc501f39fab85326
    8 Nb87a451f71bf43e981faed1aef745480
    9 Nf1e5c096013a4b1493cd0a28e30d1cac
    10 anzsrc-for:11
    11 anzsrc-for:1107
    12 schema:author Ncc0c82e1f0ca4d0ead99a7a5b982c745
    13 schema:citation sg:pub.10.1007/s00467-013-2503-y
    14 sg:pub.10.1007/s00467-013-2565-x
    15 sg:pub.10.1007/s00467-013-2711-5
    16 sg:pub.10.1007/s00467-013-2748-5
    17 sg:pub.10.1007/s10067-010-1526-z
    18 sg:pub.10.1038/331356a0
    19 sg:pub.10.1038/icb.2013.15
    20 sg:pub.10.1038/ki.1979.24
    21 sg:pub.10.1038/ki.2012.212
    22 sg:pub.10.1038/ki.2012.63
    23 sg:pub.10.1038/ki.2013.377
    24 sg:pub.10.1038/ki.2014.49
    25 sg:pub.10.1038/kisup.2012.26
    26 sg:pub.10.1038/kisup.2012.27
    27 sg:pub.10.1038/nm.1874
    28 sg:pub.10.1038/nrd2085
    29 sg:pub.10.1038/nrneph.2010.85
    30 sg:pub.10.1038/nrneph.2012.141
    31 sg:pub.10.1038/nrneph.2014.250
    32 sg:pub.10.1038/sj.ki.5002103
    33 sg:pub.10.1038/sj.ki.5002628
    34 sg:pub.10.1046/j.1523-1755.1999.00369.x
    35 sg:pub.10.1046/j.1523-1755.1999.00720.x
    36 sg:pub.10.1046/j.1523-1755.2003.00259.x
    37 sg:pub.10.1186/ar3738
    38 https://app.dimensions.ai/details/publication/pub.1077612381
    39 https://app.dimensions.ai/details/publication/pub.1078034835
    40 https://app.dimensions.ai/details/publication/pub.1078149273
    41 https://app.dimensions.ai/details/publication/pub.1078549898
    42 https://app.dimensions.ai/details/publication/pub.1078761086
    43 https://app.dimensions.ai/details/publication/pub.1079203817
    44 https://app.dimensions.ai/details/publication/pub.1082400456
    45 https://app.dimensions.ai/details/publication/pub.1082503455
    46 https://app.dimensions.ai/details/publication/pub.1082688919
    47 https://app.dimensions.ai/details/publication/pub.1082736831
    48 https://app.dimensions.ai/details/publication/pub.1082790645
    49 https://doi.org/10.1002/0471142735.im1526s106
    50 https://doi.org/10.1002/0471142735.im1527s107
    51 https://doi.org/10.1002/14651858.cd002922.pub3
    52 https://doi.org/10.1002/1529-0131(200105)44:5<1149::aid-anr197>3.0.co;2-f
    53 https://doi.org/10.1002/art.21869
    54 https://doi.org/10.1002/art.27221
    55 https://doi.org/10.1002/art.34359
    56 https://doi.org/10.1002/art.34362
    57 https://doi.org/10.1002/art.38037
    58 https://doi.org/10.1002/art.38260
    59 https://doi.org/10.1002/art.38790
    60 https://doi.org/10.1002/path.4559
    61 https://doi.org/10.1002/ppul.22884
    62 https://doi.org/10.1016/j.autrev.2009.08.007
    63 https://doi.org/10.1016/j.autrev.2011.05.001
    64 https://doi.org/10.1016/j.autrev.2013.07.002
    65 https://doi.org/10.1016/j.cytogfr.2013.04.003
    66 https://doi.org/10.1016/j.jaci.2008.05.024
    67 https://doi.org/10.1016/j.jaci.2009.10.014
    68 https://doi.org/10.1016/j.jaci.2010.03.028
    69 https://doi.org/10.1016/j.jaut.2005.08.004
    70 https://doi.org/10.1016/j.jaut.2012.05.003
    71 https://doi.org/10.1016/j.kint.2015.12.003
    72 https://doi.org/10.1016/j.molimm.2015.01.028
    73 https://doi.org/10.1016/j.molimm.2015.03.012
    74 https://doi.org/10.1016/j.semarthrit.2015.02.002
    75 https://doi.org/10.1016/j.semnephrol.2007.02.002
    76 https://doi.org/10.1016/j.semnephrol.2011.06.005
    77 https://doi.org/10.1016/j.semnephrol.2011.06.006
    78 https://doi.org/10.1016/j.semnephrol.2013.08.008
    79 https://doi.org/10.1016/s0002-9440(10)62952-5
    80 https://doi.org/10.1016/s0140-6736(08)60453-5
    81 https://doi.org/10.1016/s0140-6736(10)61354-2
    82 https://doi.org/10.1016/s0140-6736(12)61566-9
    83 https://doi.org/10.1046/j.1523-1755.2003.00259.x
    84 https://doi.org/10.1056/nejm198806233182504
    85 https://doi.org/10.1056/nejm199707173370301
    86 https://doi.org/10.1056/nejm199711203372106
    87 https://doi.org/10.1056/nejmc1106619
    88 https://doi.org/10.1056/nejmc1111953
    89 https://doi.org/10.1056/nejmc1112273
    90 https://doi.org/10.1056/nejmoa041884
    91 https://doi.org/10.1056/nejmoa044396
    92 https://doi.org/10.1056/nejmoa044397
    93 https://doi.org/10.1056/nejmoa0810457
    94 https://doi.org/10.1056/nejmoa0909169
    95 https://doi.org/10.1056/nejmoa0909905
    96 https://doi.org/10.1056/nejmoa0910500
    97 https://doi.org/10.1056/nejmoa1108735
    98 https://doi.org/10.1056/nejmoa1208981
    99 https://doi.org/10.1056/nejmoa1404231
    100 https://doi.org/10.1056/nejmoa1409354
    101 https://doi.org/10.1056/nejmra1004965
    102 https://doi.org/10.1056/nejmra1108178
    103 https://doi.org/10.1073/pnas.0337679100
    104 https://doi.org/10.1073/pnas.0601094103
    105 https://doi.org/10.1074/jbc.274.16.11267
    106 https://doi.org/10.1080/09629350400003100
    107 https://doi.org/10.1084/jem.106.2.191
    108 https://doi.org/10.1084/jem.166.3.798
    109 https://doi.org/10.1084/jem.177.1.69
    110 https://doi.org/10.1084/jem.186.1.131
    111 https://doi.org/10.1084/jem.190.11.1697
    112 https://doi.org/10.1084/jem.192.5.681
    113 https://doi.org/10.1084/jem.194.4.417
    114 https://doi.org/10.1084/jem.20021553
    115 https://doi.org/10.1084/jem.20021996
    116 https://doi.org/10.1084/jem.20030286
    117 https://doi.org/10.1089/jir.2008.0027
    118 https://doi.org/10.1093/ndt/gfq187
    119 https://doi.org/10.1093/ndt/gfs262
    120 https://doi.org/10.1093/ndt/gfs319
    121 https://doi.org/10.1093/qjmed/89.12.903
    122 https://doi.org/10.1093/rheumatology/41.10.1126
    123 https://doi.org/10.1093/rheumatology/41.11.1303
    124 https://doi.org/10.1097/01.asn.0000091381.60059.fb
    125 https://doi.org/10.1097/01.asn.0000091588.80007.0e
    126 https://doi.org/10.1097/01.asn.0000114554.67106.28
    127 https://doi.org/10.1097/bor.0b013e32834d85ce
    128 https://doi.org/10.1097/mnh.0b013e32835da24c
    129 https://doi.org/10.1111/bcp.12864
    130 https://doi.org/10.1111/cei.12287
    131 https://doi.org/10.1111/j.1365-2249.1992.tb05860.x
    132 https://doi.org/10.1111/j.1600-6143.2011.03923.x
    133 https://doi.org/10.1111/nep.12530
    134 https://doi.org/10.1126/science.7520604
    135 https://doi.org/10.1136/annrheumdis-2013-203348
    136 https://doi.org/10.1136/annrheumdis-2013-204164
    137 https://doi.org/10.1136/annrheumdis-2014-206090
    138 https://doi.org/10.1136/annrheumdis-2014-eular.3974
    139 https://doi.org/10.1136/annrheumdis-2015-eular.2916
    140 https://doi.org/10.1136/ard.2005.042416
    141 https://doi.org/10.1136/ard.61.6.559
    142 https://doi.org/10.1136/bmjopen-2013-003573
    143 https://doi.org/10.1136/thx.2006.076513
    144 https://doi.org/10.1159/000319655
    145 https://doi.org/10.1159/000319656
    146 https://doi.org/10.1159/000368592
    147 https://doi.org/10.1159/000422410
    148 https://doi.org/10.1159/000430849
    149 https://doi.org/10.1172/jci13876
    150 https://doi.org/10.1172/jci15918
    151 https://doi.org/10.1172/jci31720
    152 https://doi.org/10.1172/jci38468
    153 https://doi.org/10.1172/jci72270
    154 https://doi.org/10.1177/0961203310395802
    155 https://doi.org/10.1182/blood-2010-07-294249
    156 https://doi.org/10.1191/0961203304lu1032oa
    157 https://doi.org/10.1517/13543784.17.9.1267
    158 https://doi.org/10.1681/asn.2005010096
    159 https://doi.org/10.1681/asn.2005060616
    160 https://doi.org/10.1681/asn.2006121348
    161 https://doi.org/10.1681/asn.2007020166
    162 https://doi.org/10.1681/asn.2007091052
    163 https://doi.org/10.1681/asn.2008050497
    164 https://doi.org/10.1681/asn.2008080891
    165 https://doi.org/10.1681/asn.2010050536
    166 https://doi.org/10.1681/asn.2010111125
    167 https://doi.org/10.1681/asn.2011030304
    168 https://doi.org/10.1681/asn.2011121186
    169 https://doi.org/10.1681/asn.2012070705
    170 https://doi.org/10.1681/asn.2013010026
    171 https://doi.org/10.1681/asn.2013010045
    172 https://doi.org/10.1681/asn.2013020143
    173 https://doi.org/10.1681/asn.2014121195
    174 https://doi.org/10.1681/asn.2015020149
    175 https://doi.org/10.1681/asn.2015060612
    176 https://doi.org/10.2147/dddt.s49778
    177 https://doi.org/10.2174/1381612821666150316115727
    178 https://doi.org/10.2215/cjn.01080905
    179 https://doi.org/10.2215/cjn.01180307
    180 https://doi.org/10.2215/cjn.05080610
    181 https://doi.org/10.2215/cjn.05140512
    182 https://doi.org/10.2215/cjn.06041108
    183 https://doi.org/10.2215/cjn.12901211
    184 https://doi.org/10.2353/ajpath.2008.070131
    185 https://doi.org/10.3109/00365513.2011.652158
    186 https://doi.org/10.3181/00379727-100-24736
    187 https://doi.org/10.3904/kjim.1994.9.1.1
    188 https://doi.org/10.4049/jimmunol.1203200
    189 https://doi.org/10.4049/jimmunol.1203548
    190 https://doi.org/10.4049/jimmunol.1300269
    191 https://doi.org/10.4049/jimmunol.173.1.136
    192 https://doi.org/10.4049/jimmunol.175.8.5370
    193 https://doi.org/10.4049/jimmunol.177.8.5687
    194 https://doi.org/10.4161/mabs.2.1.10789
    195 https://doi.org/10.5301/jn.5000218
    196 https://doi.org/10.5301/jn.5000278
    197 schema:datePublished 2016-04
    198 schema:datePublishedReg 2016-04-01
    199 schema:description Biological therapeutics (biologics) that target autoimmune responses and inflammatory injury pathways have a marked beneficial impact on the management of many chronic diseases, including rheumatoid arthritis, psoriasis, inflammatory bowel disease, and ankylosing spondylitis. Accumulating data suggest that a growing number of renal diseases result from autoimmune injury - including lupus nephritis, IgA nephropathy, anti-neutrophil cytoplasmic antibody-associated glomerulonephritis, autoimmune (formerly idiopathic) membranous nephropathy, anti-glomerular basement membrane glomerulonephritis, and C3 nephropathy - and one can speculate that biologics might also be applicable to these diseases. As many autoimmune renal diseases are relatively uncommon, with long natural histories and diverse outcomes, clinical trials that aim to validate potentially useful biologics are difficult to design and/or perform. Some excellent consortia are undertaking cohort studies and clinical trials, but more multicentre international collaborations are needed to advance the introduction of new biologics to patients with autoimmune renal disorders. This Review discusses the key molecules that direct injurious inflammation and the biologics that are available to modulate them. The opportunities and challenges for the introduction of relevant biologics into treatment protocols for autoimmune renal diseases are also discussed.
    200 schema:genre research_article
    201 schema:inLanguage en
    202 schema:isAccessibleForFree false
    203 schema:isPartOf N438d3bd1b0194eec90f4452ec64389a0
    204 N6fa72bd27eeb4994bbfbe495f2184766
    205 sg:journal.1294907
    206 schema:name Biologics for the treatment of autoimmune renal diseases
    207 schema:pagination 217
    208 schema:productId N00f4d9f40f2d4f68b9efd9c48f3ad48c
    209 N438c16b89d774811a8b007494c01a58f
    210 Nafbaa786b9664cdc8c97bcad245d1fa8
    211 Nb6476e92064a4248ad1ddfc875a171da
    212 Nee3b5fac2e78479484fb0f2314e4a8ea
    213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007649073
    214 https://doi.org/10.1038/nrneph.2016.18
    215 schema:sdDatePublished 2019-04-10T15:40
    216 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    217 schema:sdPublisher Nd17a10bfe2364812a8c3808ef7550051
    218 schema:url https://www.nature.com/articles/nrneph.2016.18
    219 sgo:license sg:explorer/license/
    220 sgo:sdDataset articles
    221 rdf:type schema:ScholarlyArticle
    222 N00f4d9f40f2d4f68b9efd9c48f3ad48c schema:name readcube_id
    223 schema:value 246f4f98af80309ecbe67a51f4e8c0081b2f8376d421f0804da05c5fe3f0e2ba
    224 rdf:type schema:PropertyValue
    225 N1d62368292864f99b29e189d668c4890 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    226 schema:name Kidney Diseases
    227 rdf:type schema:DefinedTerm
    228 N344c37b7dc864ae9b7cc076c2a5f3aea rdf:first sg:person.0707425666.79
    229 rdf:rest Naafd00da91a7412bab6de4ddc7feca1a
    230 N3bd2e21c2c2d4583b855447ede5405de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    231 schema:name Humans
    232 rdf:type schema:DefinedTerm
    233 N3e2ed9f07466462db03136750ece3ee0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    234 schema:name Biological Products
    235 rdf:type schema:DefinedTerm
    236 N438c16b89d774811a8b007494c01a58f schema:name dimensions_id
    237 schema:value pub.1007649073
    238 rdf:type schema:PropertyValue
    239 N438d3bd1b0194eec90f4452ec64389a0 schema:volumeNumber 12
    240 rdf:type schema:PublicationVolume
    241 N46a725eb2e0645d1a0c8b4abd5e1790a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    242 schema:name Glomerulonephritis, Membranous
    243 rdf:type schema:DefinedTerm
    244 N6fa72bd27eeb4994bbfbe495f2184766 schema:issueNumber 4
    245 rdf:type schema:PublicationIssue
    246 N93aa6e7c12e64ccda37b6c30c1abc13b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    247 schema:name Autoimmune Diseases
    248 rdf:type schema:DefinedTerm
    249 N9ca49101348f47949d7d448b1b99a8ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    250 schema:name Immunologic Factors
    251 rdf:type schema:DefinedTerm
    252 Na59ae4cb5f3648b1bc501f39fab85326 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    253 schema:name Lupus Nephritis
    254 rdf:type schema:DefinedTerm
    255 Naafd00da91a7412bab6de4ddc7feca1a rdf:first sg:person.0700603677.38
    256 rdf:rest rdf:nil
    257 Nafbaa786b9664cdc8c97bcad245d1fa8 schema:name nlm_unique_id
    258 schema:value 101500081
    259 rdf:type schema:PropertyValue
    260 Nb6476e92064a4248ad1ddfc875a171da schema:name doi
    261 schema:value 10.1038/nrneph.2016.18
    262 rdf:type schema:PropertyValue
    263 Nb87a451f71bf43e981faed1aef745480 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    264 schema:name Anti-Glomerular Basement Membrane Disease
    265 rdf:type schema:DefinedTerm
    266 Ncc0c82e1f0ca4d0ead99a7a5b982c745 rdf:first sg:person.01131260677.45
    267 rdf:rest N344c37b7dc864ae9b7cc076c2a5f3aea
    268 Nd17a10bfe2364812a8c3808ef7550051 schema:name Springer Nature - SN SciGraph project
    269 rdf:type schema:Organization
    270 Nee3b5fac2e78479484fb0f2314e4a8ea schema:name pubmed_id
    271 schema:value 26949177
    272 rdf:type schema:PropertyValue
    273 Nf1e5c096013a4b1493cd0a28e30d1cac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    274 schema:name Glomerulonephritis, IGA
    275 rdf:type schema:DefinedTerm
    276 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    277 schema:name Medical and Health Sciences
    278 rdf:type schema:DefinedTerm
    279 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    280 schema:name Immunology
    281 rdf:type schema:DefinedTerm
    282 sg:grant.6728319 http://pending.schema.org/fundedItem sg:pub.10.1038/nrneph.2016.18
    283 rdf:type schema:MonetaryGrant
    284 sg:grant.6730264 http://pending.schema.org/fundedItem sg:pub.10.1038/nrneph.2016.18
    285 rdf:type schema:MonetaryGrant
    286 sg:grant.6734877 http://pending.schema.org/fundedItem sg:pub.10.1038/nrneph.2016.18
    287 rdf:type schema:MonetaryGrant
    288 sg:grant.6735020 http://pending.schema.org/fundedItem sg:pub.10.1038/nrneph.2016.18
    289 rdf:type schema:MonetaryGrant
    290 sg:grant.6736516 http://pending.schema.org/fundedItem sg:pub.10.1038/nrneph.2016.18
    291 rdf:type schema:MonetaryGrant
    292 sg:journal.1294907 schema:issn 1759-5061
    293 1759-507X
    294 schema:name Nature Reviews Nephrology
    295 rdf:type schema:Periodical
    296 sg:person.01131260677.45 schema:affiliation https://www.grid.ac/institutes/grid.419789.a
    297 schema:familyName Holdsworth
    298 schema:givenName Stephen R.
    299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131260677.45
    300 rdf:type schema:Person
    301 sg:person.0700603677.38 schema:affiliation https://www.grid.ac/institutes/grid.419789.a
    302 schema:familyName Kitching
    303 schema:givenName A. Richard
    304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700603677.38
    305 rdf:type schema:Person
    306 sg:person.0707425666.79 schema:affiliation https://www.grid.ac/institutes/grid.1002.3
    307 schema:familyName Gan
    308 schema:givenName Poh-Yi
    309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707425666.79
    310 rdf:type schema:Person
    311 sg:pub.10.1007/s00467-013-2503-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1012617355
    312 https://doi.org/10.1007/s00467-013-2503-y
    313 rdf:type schema:CreativeWork
    314 sg:pub.10.1007/s00467-013-2565-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041465742
    315 https://doi.org/10.1007/s00467-013-2565-x
    316 rdf:type schema:CreativeWork
    317 sg:pub.10.1007/s00467-013-2711-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037518601
    318 https://doi.org/10.1007/s00467-013-2711-5
    319 rdf:type schema:CreativeWork
    320 sg:pub.10.1007/s00467-013-2748-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027939914
    321 https://doi.org/10.1007/s00467-013-2748-5
    322 rdf:type schema:CreativeWork
    323 sg:pub.10.1007/s10067-010-1526-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1023159752
    324 https://doi.org/10.1007/s10067-010-1526-z
    325 rdf:type schema:CreativeWork
    326 sg:pub.10.1038/331356a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050954154
    327 https://doi.org/10.1038/331356a0
    328 rdf:type schema:CreativeWork
    329 sg:pub.10.1038/icb.2013.15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031852459
    330 https://doi.org/10.1038/icb.2013.15
    331 rdf:type schema:CreativeWork
    332 sg:pub.10.1038/ki.1979.24 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006561866
    333 https://doi.org/10.1038/ki.1979.24
    334 rdf:type schema:CreativeWork
    335 sg:pub.10.1038/ki.2012.212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034063404
    336 https://doi.org/10.1038/ki.2012.212
    337 rdf:type schema:CreativeWork
    338 sg:pub.10.1038/ki.2012.63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045948666
    339 https://doi.org/10.1038/ki.2012.63
    340 rdf:type schema:CreativeWork
    341 sg:pub.10.1038/ki.2013.377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005163409
    342 https://doi.org/10.1038/ki.2013.377
    343 rdf:type schema:CreativeWork
    344 sg:pub.10.1038/ki.2014.49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025158820
    345 https://doi.org/10.1038/ki.2014.49
    346 rdf:type schema:CreativeWork
    347 sg:pub.10.1038/kisup.2012.26 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022519635
    348 https://doi.org/10.1038/kisup.2012.26
    349 rdf:type schema:CreativeWork
    350 sg:pub.10.1038/kisup.2012.27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024851361
    351 https://doi.org/10.1038/kisup.2012.27
    352 rdf:type schema:CreativeWork
    353 sg:pub.10.1038/nm.1874 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020010437
    354 https://doi.org/10.1038/nm.1874
    355 rdf:type schema:CreativeWork
    356 sg:pub.10.1038/nrd2085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006848433
    357 https://doi.org/10.1038/nrd2085
    358 rdf:type schema:CreativeWork
    359 sg:pub.10.1038/nrneph.2010.85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025976520
    360 https://doi.org/10.1038/nrneph.2010.85
    361 rdf:type schema:CreativeWork
    362 sg:pub.10.1038/nrneph.2012.141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022827679
    363 https://doi.org/10.1038/nrneph.2012.141
    364 rdf:type schema:CreativeWork
    365 sg:pub.10.1038/nrneph.2014.250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027840533
    366 https://doi.org/10.1038/nrneph.2014.250
    367 rdf:type schema:CreativeWork
    368 sg:pub.10.1038/sj.ki.5002103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010550614
    369 https://doi.org/10.1038/sj.ki.5002103
    370 rdf:type schema:CreativeWork
    371 sg:pub.10.1038/sj.ki.5002628 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034720925
    372 https://doi.org/10.1038/sj.ki.5002628
    373 rdf:type schema:CreativeWork
    374 sg:pub.10.1046/j.1523-1755.1999.00369.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049544773
    375 https://doi.org/10.1046/j.1523-1755.1999.00369.x
    376 rdf:type schema:CreativeWork
    377 sg:pub.10.1046/j.1523-1755.1999.00720.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047474097
    378 https://doi.org/10.1046/j.1523-1755.1999.00720.x
    379 rdf:type schema:CreativeWork
    380 sg:pub.10.1046/j.1523-1755.2003.00259.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004405762
    381 https://doi.org/10.1046/j.1523-1755.2003.00259.x
    382 rdf:type schema:CreativeWork
    383 sg:pub.10.1186/ar3738 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009439269
    384 https://doi.org/10.1186/ar3738
    385 rdf:type schema:CreativeWork
    386 https://app.dimensions.ai/details/publication/pub.1077612381 schema:CreativeWork
    387 https://app.dimensions.ai/details/publication/pub.1078034835 schema:CreativeWork
    388 https://app.dimensions.ai/details/publication/pub.1078149273 schema:CreativeWork
    389 https://app.dimensions.ai/details/publication/pub.1078549898 schema:CreativeWork
    390 https://app.dimensions.ai/details/publication/pub.1078761086 schema:CreativeWork
    391 https://app.dimensions.ai/details/publication/pub.1079203817 schema:CreativeWork
    392 https://app.dimensions.ai/details/publication/pub.1082400456 schema:CreativeWork
    393 https://app.dimensions.ai/details/publication/pub.1082503455 schema:CreativeWork
    394 https://app.dimensions.ai/details/publication/pub.1082688919 schema:CreativeWork
    395 https://app.dimensions.ai/details/publication/pub.1082736831 schema:CreativeWork
    396 https://app.dimensions.ai/details/publication/pub.1082790645 schema:CreativeWork
    397 https://doi.org/10.1002/0471142735.im1526s106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014493023
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1002/0471142735.im1527s107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032455948
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1002/14651858.cd002922.pub3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001234111
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1002/1529-0131(200105)44:5<1149::aid-anr197>3.0.co;2-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1026381601
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1002/art.21869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042637139
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1002/art.27221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045050471
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1002/art.34359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001205015
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1002/art.34362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053222569
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1002/art.38037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014040548
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1002/art.38260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003529057
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1002/art.38790 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011389288
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1002/path.4559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002596815
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1002/ppul.22884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037373047
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1016/j.autrev.2009.08.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006079818
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1016/j.autrev.2011.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051101540
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1016/j.autrev.2013.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025674060
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1016/j.cytogfr.2013.04.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041592245
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1016/j.jaci.2008.05.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013070429
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1016/j.jaci.2009.10.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010202033
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1016/j.jaci.2010.03.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029759090
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1016/j.jaut.2005.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039022915
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1016/j.jaut.2012.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017644148
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1016/j.kint.2015.12.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003207786
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1016/j.molimm.2015.01.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016879291
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1016/j.molimm.2015.03.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049283562
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.1016/j.semarthrit.2015.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012781245
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.1016/j.semnephrol.2007.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027914632
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.1016/j.semnephrol.2011.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000825444
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.1016/j.semnephrol.2011.06.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012222669
    454 rdf:type schema:CreativeWork
    455 https://doi.org/10.1016/j.semnephrol.2013.08.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005461113
    456 rdf:type schema:CreativeWork
    457 https://doi.org/10.1016/s0002-9440(10)62952-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016379541
    458 rdf:type schema:CreativeWork
    459 https://doi.org/10.1016/s0140-6736(08)60453-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030759765
    460 rdf:type schema:CreativeWork
    461 https://doi.org/10.1016/s0140-6736(10)61354-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028914094
    462 rdf:type schema:CreativeWork
    463 https://doi.org/10.1016/s0140-6736(12)61566-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036822805
    464 rdf:type schema:CreativeWork
    465 https://doi.org/10.1046/j.1523-1755.2003.00259.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004405762
    466 rdf:type schema:CreativeWork
    467 https://doi.org/10.1056/nejm198806233182504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017392435
    468 rdf:type schema:CreativeWork
    469 https://doi.org/10.1056/nejm199707173370301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003086894
    470 rdf:type schema:CreativeWork
    471 https://doi.org/10.1056/nejm199711203372106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030293646
    472 rdf:type schema:CreativeWork
    473 https://doi.org/10.1056/nejmc1106619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043193847
    474 rdf:type schema:CreativeWork
    475 https://doi.org/10.1056/nejmc1111953 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028512912
    476 rdf:type schema:CreativeWork
    477 https://doi.org/10.1056/nejmc1112273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047915300
    478 rdf:type schema:CreativeWork
    479 https://doi.org/10.1056/nejmoa041884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006803264
    480 rdf:type schema:CreativeWork
    481 https://doi.org/10.1056/nejmoa044396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047160581
    482 rdf:type schema:CreativeWork
    483 https://doi.org/10.1056/nejmoa044397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047413416
    484 rdf:type schema:CreativeWork
    485 https://doi.org/10.1056/nejmoa0810457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000251144
    486 rdf:type schema:CreativeWork
    487 https://doi.org/10.1056/nejmoa0909169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027355308
    488 rdf:type schema:CreativeWork
    489 https://doi.org/10.1056/nejmoa0909905 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009247104
    490 rdf:type schema:CreativeWork
    491 https://doi.org/10.1056/nejmoa0910500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037844276
    492 rdf:type schema:CreativeWork
    493 https://doi.org/10.1056/nejmoa1108735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033434785
    494 rdf:type schema:CreativeWork
    495 https://doi.org/10.1056/nejmoa1208981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038836296
    496 rdf:type schema:CreativeWork
    497 https://doi.org/10.1056/nejmoa1404231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014688727
    498 rdf:type schema:CreativeWork
    499 https://doi.org/10.1056/nejmoa1409354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026104672
    500 rdf:type schema:CreativeWork
    501 https://doi.org/10.1056/nejmra1004965 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038098608
    502 rdf:type schema:CreativeWork
    503 https://doi.org/10.1056/nejmra1108178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032681183
    504 rdf:type schema:CreativeWork
    505 https://doi.org/10.1073/pnas.0337679100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005749429
    506 rdf:type schema:CreativeWork
    507 https://doi.org/10.1073/pnas.0601094103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051976893
    508 rdf:type schema:CreativeWork
    509 https://doi.org/10.1074/jbc.274.16.11267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027783149
    510 rdf:type schema:CreativeWork
    511 https://doi.org/10.1080/09629350400003100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012956032
    512 rdf:type schema:CreativeWork
    513 https://doi.org/10.1084/jem.106.2.191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030833671
    514 rdf:type schema:CreativeWork
    515 https://doi.org/10.1084/jem.166.3.798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016051734
    516 rdf:type schema:CreativeWork
    517 https://doi.org/10.1084/jem.177.1.69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010772550
    518 rdf:type schema:CreativeWork
    519 https://doi.org/10.1084/jem.186.1.131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051770127
    520 rdf:type schema:CreativeWork
    521 https://doi.org/10.1084/jem.190.11.1697 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005101826
    522 rdf:type schema:CreativeWork
    523 https://doi.org/10.1084/jem.192.5.681 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042914936
    524 rdf:type schema:CreativeWork
    525 https://doi.org/10.1084/jem.194.4.417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028419152
    526 rdf:type schema:CreativeWork
    527 https://doi.org/10.1084/jem.20021553 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036754305
    528 rdf:type schema:CreativeWork
    529 https://doi.org/10.1084/jem.20021996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043729147
    530 rdf:type schema:CreativeWork
    531 https://doi.org/10.1084/jem.20030286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019022554
    532 rdf:type schema:CreativeWork
    533 https://doi.org/10.1089/jir.2008.0027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024851893
    534 rdf:type schema:CreativeWork
    535 https://doi.org/10.1093/ndt/gfq187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028596961
    536 rdf:type schema:CreativeWork
    537 https://doi.org/10.1093/ndt/gfs262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009112158
    538 rdf:type schema:CreativeWork
    539 https://doi.org/10.1093/ndt/gfs319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041695723
    540 rdf:type schema:CreativeWork
    541 https://doi.org/10.1093/qjmed/89.12.903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032238595
    542 rdf:type schema:CreativeWork
    543 https://doi.org/10.1093/rheumatology/41.10.1126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030835263
    544 rdf:type schema:CreativeWork
    545 https://doi.org/10.1093/rheumatology/41.11.1303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034519082
    546 rdf:type schema:CreativeWork
    547 https://doi.org/10.1097/01.asn.0000091381.60059.fb schema:sameAs https://app.dimensions.ai/details/publication/pub.1060319347
    548 rdf:type schema:CreativeWork
    549 https://doi.org/10.1097/01.asn.0000091588.80007.0e schema:sameAs https://app.dimensions.ai/details/publication/pub.1060319351
    550 rdf:type schema:CreativeWork
    551 https://doi.org/10.1097/01.asn.0000114554.67106.28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060319517
    552 rdf:type schema:CreativeWork
    553 https://doi.org/10.1097/bor.0b013e32834d85ce schema:sameAs https://app.dimensions.ai/details/publication/pub.1050422547
    554 rdf:type schema:CreativeWork
    555 https://doi.org/10.1097/mnh.0b013e32835da24c schema:sameAs https://app.dimensions.ai/details/publication/pub.1044703034
    556 rdf:type schema:CreativeWork
    557 https://doi.org/10.1111/bcp.12864 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053329232
    558 rdf:type schema:CreativeWork
    559 https://doi.org/10.1111/cei.12287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032785507
    560 rdf:type schema:CreativeWork
    561 https://doi.org/10.1111/j.1365-2249.1992.tb05860.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034097646
    562 rdf:type schema:CreativeWork
    563 https://doi.org/10.1111/j.1600-6143.2011.03923.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041110857
    564 rdf:type schema:CreativeWork
    565 https://doi.org/10.1111/nep.12530 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014875921
    566 rdf:type schema:CreativeWork
    567 https://doi.org/10.1126/science.7520604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062647417
    568 rdf:type schema:CreativeWork
    569 https://doi.org/10.1136/annrheumdis-2013-203348 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010225448
    570 rdf:type schema:CreativeWork
    571 https://doi.org/10.1136/annrheumdis-2013-204164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021335386
    572 rdf:type schema:CreativeWork
    573 https://doi.org/10.1136/annrheumdis-2014-206090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034264665
    574 rdf:type schema:CreativeWork
    575 https://doi.org/10.1136/annrheumdis-2014-eular.3974 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002874402
    576 rdf:type schema:CreativeWork
    577 https://doi.org/10.1136/annrheumdis-2015-eular.2916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045448345
    578 rdf:type schema:CreativeWork
    579 https://doi.org/10.1136/ard.2005.042416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044253021
    580 rdf:type schema:CreativeWork
    581 https://doi.org/10.1136/ard.61.6.559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029758838
    582 rdf:type schema:CreativeWork
    583 https://doi.org/10.1136/bmjopen-2013-003573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019729187
    584 rdf:type schema:CreativeWork
    585 https://doi.org/10.1136/thx.2006.076513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020914319
    586 rdf:type schema:CreativeWork
    587 https://doi.org/10.1159/000319655 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010866292
    588 rdf:type schema:CreativeWork
    589 https://doi.org/10.1159/000319656 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049033928
    590 rdf:type schema:CreativeWork
    591 https://doi.org/10.1159/000368592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048923837
    592 rdf:type schema:CreativeWork
    593 https://doi.org/10.1159/000422410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082757575
    594 rdf:type schema:CreativeWork
    595 https://doi.org/10.1159/000430849 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007263225
    596 rdf:type schema:CreativeWork
    597 https://doi.org/10.1172/jci13876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006600454
    598 rdf:type schema:CreativeWork
    599 https://doi.org/10.1172/jci15918 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063415457
    600 rdf:type schema:CreativeWork
    601 https://doi.org/10.1172/jci31720 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018161580
    602 rdf:type schema:CreativeWork
    603 https://doi.org/10.1172/jci38468 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033179827
    604 rdf:type schema:CreativeWork
    605 https://doi.org/10.1172/jci72270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042904706
    606 rdf:type schema:CreativeWork
    607 https://doi.org/10.1177/0961203310395802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014892911
    608 rdf:type schema:CreativeWork
    609 https://doi.org/10.1182/blood-2010-07-294249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022664307
    610 rdf:type schema:CreativeWork
    611 https://doi.org/10.1191/0961203304lu1032oa schema:sameAs https://app.dimensions.ai/details/publication/pub.1064154418
    612 rdf:type schema:CreativeWork
    613 https://doi.org/10.1517/13543784.17.9.1267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018772882
    614 rdf:type schema:CreativeWork
    615 https://doi.org/10.1681/asn.2005010096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042294058
    616 rdf:type schema:CreativeWork
    617 https://doi.org/10.1681/asn.2005060616 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037039385
    618 rdf:type schema:CreativeWork
    619 https://doi.org/10.1681/asn.2006121348 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053536356
    620 rdf:type schema:CreativeWork
    621 https://doi.org/10.1681/asn.2007020166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052277923
    622 rdf:type schema:CreativeWork
    623 https://doi.org/10.1681/asn.2007091052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040259921
    624 rdf:type schema:CreativeWork
    625 https://doi.org/10.1681/asn.2008050497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025609397
    626 rdf:type schema:CreativeWork
    627 https://doi.org/10.1681/asn.2008080891 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021967845
    628 rdf:type schema:CreativeWork
    629 https://doi.org/10.1681/asn.2010050536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022583059
    630 rdf:type schema:CreativeWork
    631 https://doi.org/10.1681/asn.2010111125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044887314
    632 rdf:type schema:CreativeWork
    633 https://doi.org/10.1681/asn.2011030304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022774150
    634 rdf:type schema:CreativeWork
    635 https://doi.org/10.1681/asn.2011121186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010051952
    636 rdf:type schema:CreativeWork
    637 https://doi.org/10.1681/asn.2012070705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009686633
    638 rdf:type schema:CreativeWork
    639 https://doi.org/10.1681/asn.2013010026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042479677
    640 rdf:type schema:CreativeWork
    641 https://doi.org/10.1681/asn.2013010045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043252234
    642 rdf:type schema:CreativeWork
    643 https://doi.org/10.1681/asn.2013020143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033949576
    644 rdf:type schema:CreativeWork
    645 https://doi.org/10.1681/asn.2014121195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018577616
    646 rdf:type schema:CreativeWork
    647 https://doi.org/10.1681/asn.2015020149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068243434
    648 rdf:type schema:CreativeWork
    649 https://doi.org/10.1681/asn.2015060612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004837905
    650 rdf:type schema:CreativeWork
    651 https://doi.org/10.2147/dddt.s49778 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028800667
    652 rdf:type schema:CreativeWork
    653 https://doi.org/10.2174/1381612821666150316115727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069170307
    654 rdf:type schema:CreativeWork
    655 https://doi.org/10.2215/cjn.01080905 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038083969
    656 rdf:type schema:CreativeWork
    657 https://doi.org/10.2215/cjn.01180307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016514206
    658 rdf:type schema:CreativeWork
    659 https://doi.org/10.2215/cjn.05080610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051372200
    660 rdf:type schema:CreativeWork
    661 https://doi.org/10.2215/cjn.05140512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015768010
    662 rdf:type schema:CreativeWork
    663 https://doi.org/10.2215/cjn.06041108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014173867
    664 rdf:type schema:CreativeWork
    665 https://doi.org/10.2215/cjn.12901211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035397126
    666 rdf:type schema:CreativeWork
    667 https://doi.org/10.2353/ajpath.2008.070131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049851151
    668 rdf:type schema:CreativeWork
    669 https://doi.org/10.3109/00365513.2011.652158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011284973
    670 rdf:type schema:CreativeWork
    671 https://doi.org/10.3181/00379727-100-24736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051146252
    672 rdf:type schema:CreativeWork
    673 https://doi.org/10.3904/kjim.1994.9.1.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071556328
    674 rdf:type schema:CreativeWork
    675 https://doi.org/10.4049/jimmunol.1203200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078713655
    676 rdf:type schema:CreativeWork
    677 https://doi.org/10.4049/jimmunol.1203548 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078721126
    678 rdf:type schema:CreativeWork
    679 https://doi.org/10.4049/jimmunol.1300269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031381963
    680 rdf:type schema:CreativeWork
    681 https://doi.org/10.4049/jimmunol.173.1.136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076855492
    682 rdf:type schema:CreativeWork
    683 https://doi.org/10.4049/jimmunol.175.8.5370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077123900
    684 rdf:type schema:CreativeWork
    685 https://doi.org/10.4049/jimmunol.177.8.5687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077303911
    686 rdf:type schema:CreativeWork
    687 https://doi.org/10.4161/mabs.2.1.10789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010266144
    688 rdf:type schema:CreativeWork
    689 https://doi.org/10.5301/jn.5000218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072753340
    690 rdf:type schema:CreativeWork
    691 https://doi.org/10.5301/jn.5000278 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072753400
    692 rdf:type schema:CreativeWork
    693 https://www.grid.ac/institutes/grid.1002.3 schema:alternateName Monash University
    694 schema:name Department of Medicine, Centre for Inflammatory Diseases, Monash University, VIC 3800, Australia.
    695 rdf:type schema:Organization
    696 https://www.grid.ac/institutes/grid.419789.a schema:alternateName Monash Health
    697 schema:name Department of Medicine, Centre for Inflammatory Diseases, Monash University, VIC 3800, Australia.
    698 Department of Nephrology, Monash Health, 246 Clayton Road, Clayton, Melbourne, VIC 3168, Australia.
    699 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...