Abnormal neural oscillations and synchrony in schizophrenia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-02

AUTHORS

Peter J. Uhlhaas, Wolf Singer

ABSTRACT

Converging evidence from electrophysiological, physiological and anatomical studies suggests that abnormalities in the synchronized oscillatory activity of neurons may have a central role in the pathophysiology of schizophrenia. Neural oscillations are a fundamental mechanism for the establishment of precise temporal relationships between neuronal responses that are in turn relevant for memory, perception and consciousness. In patients with schizophrenia, the synchronization of beta- and gamma-band activity is abnormal, suggesting a crucial role for dysfunctional oscillations in the generation of the cognitive deficits and other symptoms of the disorder. Dysfunctional oscillations may arise owing to anomalies in the brain's rhythm-generating networks of GABA (gamma-aminobutyric acid) interneurons and in cortico-cortical connections. More... »

PAGES

100

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nrn2774

DOI

http://dx.doi.org/10.1038/nrn2774

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032123172

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20087360


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