Lactate in the brain: from metabolic end-product to signalling molecule View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-03-08

AUTHORS

Pierre J. Magistretti, Igor Allaman

ABSTRACT

Much research has shown that lactate produced by astrocytes serves as a neuronal energy substrate. In this Review, Magistretti and Allaman describe this model as well as recent evidence that lactate also modulates neuronal properties, including excitability and plasticity, thus helping to set the 'homeostatic tone' of the nervous system.

PAGES

235-249

References to SciGraph publications

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  • 2008-10-29. Brain metabolism dictates the polarity of astrocyte control over arterioles in NATURE
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  • 2004-06-18. Relationship between L-glutamate-regulated intracellular Na+ dynamics and ATP hydrolysis in astrocytes in JOURNAL OF NEURAL TRANSMISSION
  • 2017-05-02. Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism in NATURE COMMUNICATIONS
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  • 2010-02-03. Changes in Central Sodium and not Osmolarity or Lactate Induce Panic-Like Responses in a Model of Panic Disorder in NEUROPSYCHOPHARMACOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrn.2018.19

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    http://dx.doi.org/10.1038/nrn.2018.19

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