Not just amyloid: physiological functions of the amyloid precursor protein family View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-03-31

AUTHORS

Ulrike C. Müller, Thomas Deller, Martin Korte

ABSTRACT

Key PointsAmyloid precursor protein (APP) and the APP-like proteins APLP1 and APLP2 form the mammalian APP gene family. They have important physiological functions in the peripheral and central nervous systems, some of which are still emerging.APP family members share a similar structure and have partially overlapping functions. Their processing by canonical and non-canonical secretases results in numerous biologically active fragments, which mediate distinct and even opposing functions.Membrane-bound APP family members interact in cis or in trans, which enables them to function as cell-adhesion molecules. Large numbers of extracellular and intracellular binding partners have been identified, and this Review summarizes those that are involved in physiological pathways in vivo.Biological functions in which APP family members are involved include nervous system development, the formation and function of the neuromuscular junction, synaptogenesis, dendritic complexity and spine density, axonal growth and guidance, and synaptic functions, including synaptic plasticity, learning and memory.α-Secretase cleavage of APP releases the neuroprotective and neurotrophic fragment APPsα. It upregulates protective pathways, inhibits neuronal apoptosis, increases neuronal resistance to brain injuries and has a crucial role in synaptic plasticity, learning and memory.Increasing APPsα levels may be of therapeutic value. Pharmacotherapeutic and gene-therapeutic approaches could complement amyloid-targeting strategies. More... »

PAGES

281-298

References to SciGraph publications

  • 2014-08-28. Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway in CELL DEATH & DISEASE
  • 2015-11-04. Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer’s disease mouse model in ACTA NEUROPATHOLOGICA
  • 2008-02-17. A TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesis in NATURE CELL BIOLOGY
  • 2014-12-08. The role of protein clearance mechanisms in organismal ageing and age-related diseases in NATURE COMMUNICATIONS
  • 1998-10-22. Hypersensitivity to seizures in β-amyloid precursor protein deficient mice in CELL DEATH & DIFFERENTIATION
  • 2016-04-30. Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology in ACTA NEUROPATHOLOGICA
  • 2016-08-03. Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis in NATURE
  • 2005-10-09. Regulation of cholesterol and sphingomyelin metabolism by amyloid-β and presenilin in NATURE CELL BIOLOGY
  • 2011-11-16. Roles of amyloid precursor protein family members in neuroprotection, stress signaling and aging in EXPERIMENTAL BRAIN RESEARCH
  • 2013-06-06. Time-dependent changes in gene expression induced by secreted amyloid precursor protein-alpha in the rat hippocampus in BMC GENOMICS
  • 2011-11-11. Functional consequences of the lack of amyloid precursor protein in the mouse dentate gyrus in vivo in EXPERIMENTAL BRAIN RESEARCH
  • 2015-11-02. Modulation of BAG3 Expression and Proteasomal Activity by sAPPα Does Not Require Membrane-Tethered Holo-APP in MOLECULAR NEUROBIOLOGY
  • 2016-06-08. Amyloid Precursor-Like Protein 2 deletion-induced retinal synaptopathy related to congenital stationary night blindness: structural, functional and molecular characteristics in MOLECULAR BRAIN
  • 2001-07. A gene trap insertion reveals that amyloid precursor protein expression is a very early event in murine embryogenesis in DEVELOPMENT GENES AND EVOLUTION
  • 2015-11-09. Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease in NATURE COMMUNICATIONS
  • 1987-02. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor in NATURE
  • 2016-02-19. Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site in MOLECULAR NEURODEGENERATION
  • 2009-02. APP binds DR6 to trigger axon pruning and neuron death via distinct caspases in NATURE
  • 1999-04. Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2014-11-29. Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity in ACTA NEUROPATHOLOGICA
  • 1997-05. Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein in NATURE
  • 2014-03-31. Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression in ACTA NEUROPATHOLOGICA COMMUNICATIONS
  • 2005-06-15. Traumatic brain injury: cause or risk of Alzheimer’s disease? A review of experimental studies in JOURNAL OF NEURAL TRANSMISSION
  • 2009-07-14. The interactome of the amyloid β precursor protein family members is shaped by phosphorylation of their intracellular domains in MOLECULAR NEURODEGENERATION
  • 2014-10-07. The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes in ACTA NEUROPATHOLOGICA
  • 2008-06-23. Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1 in NEURAL DEVELOPMENT
  • 2012-01. Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation in NATURE COMMUNICATIONS
  • 2008-06-22. Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory in NATURE MEDICINE
  • 2015-08-31. η-Secretase processing of APP inhibits neuronal activity in the hippocampus in NATURE
  • 2002-02-28. α-Secretase ADAM10 as Well as αAPPs Is Reduced in Platelets and CSF of Alzheimer Disease Patients in MOLECULAR MEDICINE
  • 2015-12-07. Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway in NATURE NEUROSCIENCE
  • 2016-05-11. FE65 and FE65L1 share common synaptic functions and genetically interact with the APP family in neuromuscular junction formation in SCIENTIFIC REPORTS
  • 2011-10-04. Regulation of alpha-secretase ADAM10 expression and activity in EXPERIMENTAL BRAIN RESEARCH
  • 2014-01-11. Trafficking regulation of proteins in Alzheimer’s disease in MOLECULAR NEURODEGENERATION
  • 2011-03-24. Comparative transcriptome profiling of amyloid precursor protein family members in the adult cortex in BMC GENOMICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrn.2017.29

    DOI

    http://dx.doi.org/10.1038/nrn.2017.29

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1084129770

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28360418


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Amyloid beta-Protein Precursor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Brain", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Ruprecht-Karls University Heidelberg, Institute of Pharmacy and Molecular Biotechnology, Bioinformatics and Functional Genomics, Im Neuenheimer Feld 364, D-69120, Heidelberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Ruprecht-Karls University Heidelberg, Institute of Pharmacy and Molecular Biotechnology, Bioinformatics and Functional Genomics, Im Neuenheimer Feld 364, D-69120, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "M\u00fcller", 
            "givenName": "Ulrike C.", 
            "id": "sg:person.0606446602.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606446602.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Goethe University Frankfurt, Institute of Clinical Neuroanatomy, Neuroscience Center, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7839.5", 
              "name": [
                "Goethe University Frankfurt, Institute of Clinical Neuroanatomy, Neuroscience Center, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Deller", 
            "givenName": "Thomas", 
            "id": "sg:person.01125311260.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125311260.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Helmholtz Centre for Infection Research, Neuroinflammation and Neurodegeneration Group, Inhoffenstrasse 7, 38124, Braunschweig, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7490.a", 
              "name": [
                "TU Braunschweig, Zoological Institute, Cellular Neurobiology, Spielmannstrasse 7, D-38106, Raunschweig, Germany", 
                "Helmholtz Centre for Infection Research, Neuroinflammation and Neurodegeneration Group, Inhoffenstrasse 7, 38124, Braunschweig, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Korte", 
            "givenName": "Martin", 
            "id": "sg:person.01165136477.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165136477.16"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nn.4188", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013238841", 
              "https://doi.org/10.1038/nn.4188"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13024-016-0084-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022855605", 
              "https://doi.org/10.1186/s13024-016-0084-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-14-376", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017814513", 
              "https://doi.org/10.1186/1471-2164-14-376"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature19076", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001112315", 
              "https://doi.org/10.1038/nature19076"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00221-011-2911-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028958656", 
              "https://doi.org/10.1007/s00221-011-2911-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12035-015-9501-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032036886", 
              "https://doi.org/10.1007/s12035-015-9501-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13041-016-0245-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028802033", 
              "https://doi.org/10.1186/s13041-016-0245-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-12-160", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038108762", 
              "https://doi.org/10.1186/1471-2164-12-160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cddis.2014.352", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012801112", 
              "https://doi.org/10.1038/cddis.2014.352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1782", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013028078", 
              "https://doi.org/10.1038/nm1782"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/325733a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021444222", 
              "https://doi.org/10.1038/325733a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4400391", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043098484", 
              "https://doi.org/10.1038/sj.cdd.4400391"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1749-8104-3-15", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040054870", 
              "https://doi.org/10.1186/1749-8104-3-15"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s004270100158", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030588545", 
              "https://doi.org/10.1007/s004270100158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms1781", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050782814", 
              "https://doi.org/10.1038/ncomms1781"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2051-5960-2-36", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045374950", 
              "https://doi.org/10.1186/2051-5960-2-36"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1313", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005119282", 
              "https://doi.org/10.1038/ncb1313"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms6659", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020334275", 
              "https://doi.org/10.1038/ncomms6659"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00702-005-0326-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028959995", 
              "https://doi.org/10.1007/s00702-005-0326-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00221-011-2885-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050571745", 
              "https://doi.org/10.1007/s00221-011-2885-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00221-011-2932-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053429131", 
              "https://doi.org/10.1007/s00221-011-2932-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1750-1326-4-28", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047562055", 
              "https://doi.org/10.1186/1750-1326-4-28"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/387500a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017890171", 
              "https://doi.org/10.1038/387500a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14864", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039281345", 
              "https://doi.org/10.1038/nature14864"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/7562", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032547864", 
              "https://doi.org/10.1038/7562"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07767", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030496745", 
              "https://doi.org/10.1038/nature07767"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-014-1347-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046113535", 
              "https://doi.org/10.1007/s00401-014-1347-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-016-1577-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047037670", 
              "https://doi.org/10.1007/s00401-016-1577-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep25652", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049150423", 
              "https://doi.org/10.1038/srep25652"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms9762", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043640902", 
              "https://doi.org/10.1038/ncomms9762"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf03402076", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075075017", 
              "https://doi.org/10.1007/bf03402076"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-014-1368-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006671477", 
              "https://doi.org/10.1007/s00401-014-1368-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1690", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052415980", 
              "https://doi.org/10.1038/ncb1690"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1750-1326-9-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035275576", 
              "https://doi.org/10.1186/1750-1326-9-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-015-1498-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020214627", 
              "https://doi.org/10.1007/s00401-015-1498-9"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-03-31", 
        "datePublishedReg": "2017-03-31", 
        "description": "Key PointsAmyloid precursor protein (APP) and the APP-like proteins APLP1 and APLP2 form the mammalian APP gene family. They have important physiological functions in the peripheral and central nervous systems, some of which are still emerging.APP family members share a similar structure and have partially overlapping functions. Their processing by canonical and non-canonical secretases results in numerous biologically active fragments, which mediate distinct and even opposing functions.Membrane-bound APP family members interact in cis or in trans, which enables them to function as cell-adhesion molecules. Large numbers of extracellular and intracellular binding partners have been identified, and this Review summarizes those that are involved in physiological pathways in vivo.Biological functions in which APP family members are involved include nervous system development, the formation and function of the neuromuscular junction, synaptogenesis, dendritic complexity and spine density, axonal growth and guidance, and synaptic functions, including synaptic plasticity, learning and memory.\u03b1-Secretase cleavage of APP releases the neuroprotective and neurotrophic fragment APPs\u03b1. It upregulates protective pathways, inhibits neuronal apoptosis, increases neuronal resistance to brain injuries and has a crucial role in synaptic plasticity, learning and memory.Increasing APPs\u03b1 levels may be of therapeutic value. Pharmacotherapeutic and gene-therapeutic approaches could complement amyloid-targeting strategies.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/nrn.2017.29", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1023608", 
            "issn": [
              "1471-003X", 
              "1471-0048"
            ], 
            "name": "Nature Reviews Neuroscience", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "18"
          }
        ], 
        "keywords": [
          "APP family members", 
          "amyloid precursor protein family", 
          "physiological functions", 
          "APP gene family", 
          "nervous system development", 
          "important physiological functions", 
          "gene family", 
          "protein family", 
          "family members", 
          "cell adhesion molecule", 
          "synaptic plasticity", 
          "biological functions", 
          "physiological pathways", 
          "precursor protein", 
          "secretase cleavage", 
          "gene therapeutic approaches", 
          "synaptic function", 
          "central nervous system", 
          "active fragment", 
          "protective pathways", 
          "axonal growth", 
          "neuronal apoptosis", 
          "neuromuscular junction", 
          "dendritic complexity", 
          "pathway", 
          "spine density", 
          "neuronal resistance", 
          "brain injury", 
          "crucial role", 
          "nervous system", 
          "plasticity", 
          "therapeutic value", 
          "secretase results", 
          "members", 
          "family", 
          "APLP1", 
          "APLP2", 
          "protein", 
          "similar structure", 
          "apoptosis", 
          "function", 
          "system development", 
          "membrane", 
          "large number", 
          "cleavage", 
          "synaptogenesis", 
          "fragments", 
          "APPs\u03b1", 
          "vivo", 
          "injury", 
          "growth", 
          "molecules", 
          "role", 
          "trans", 
          "partners", 
          "review", 
          "resistance", 
          "junction", 
          "formation", 
          "development", 
          "levels", 
          "cis", 
          "structure", 
          "number", 
          "guidance", 
          "memory", 
          "strategies", 
          "apps", 
          "density", 
          "results", 
          "complexity", 
          "system", 
          "values", 
          "processing", 
          "approach", 
          "learning"
        ], 
        "name": "Not just amyloid: physiological functions of the amyloid precursor protein family", 
        "pagination": "281-298", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1084129770"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nrn.2017.29"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28360418"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nrn.2017.29", 
          "https://app.dimensions.ai/details/publication/pub.1084129770"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-05-10T10:17", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_743.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/nrn.2017.29"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nrn.2017.29'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrn.2017.29'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrn.2017.29'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nrn.2017.29'


     

    This table displays all metadata directly associated to this object as RDF triples.

    319 TRIPLES      22 PREDICATES      142 URIs      99 LITERALS      12 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nrn.2017.29 schema:about N0b5fb914dd9843479b71da5d18e77e70
    2 N2bc17c3ad7d34887a86bcee52e7e93ce
    3 N3a67217902d84dd391f7037c0a4190d3
    4 Nb849f67f5f034ff1a92315b12148a22d
    5 Nf885003b5ac545ee94bbfef348f48500
    6 anzsrc-for:11
    7 anzsrc-for:1109
    8 schema:author Nbc45803c5d214ec6bf950d84cffb6c8c
    9 schema:citation sg:pub.10.1007/bf03402076
    10 sg:pub.10.1007/s00221-011-2885-7
    11 sg:pub.10.1007/s00221-011-2911-9
    12 sg:pub.10.1007/s00221-011-2932-4
    13 sg:pub.10.1007/s00401-014-1347-2
    14 sg:pub.10.1007/s00401-014-1368-x
    15 sg:pub.10.1007/s00401-015-1498-9
    16 sg:pub.10.1007/s00401-016-1577-6
    17 sg:pub.10.1007/s004270100158
    18 sg:pub.10.1007/s00702-005-0326-0
    19 sg:pub.10.1007/s12035-015-9501-y
    20 sg:pub.10.1038/325733a0
    21 sg:pub.10.1038/387500a0
    22 sg:pub.10.1038/7562
    23 sg:pub.10.1038/cddis.2014.352
    24 sg:pub.10.1038/nature07767
    25 sg:pub.10.1038/nature14864
    26 sg:pub.10.1038/nature19076
    27 sg:pub.10.1038/ncb1313
    28 sg:pub.10.1038/ncb1690
    29 sg:pub.10.1038/ncomms1781
    30 sg:pub.10.1038/ncomms6659
    31 sg:pub.10.1038/ncomms9762
    32 sg:pub.10.1038/nm1782
    33 sg:pub.10.1038/nn.4188
    34 sg:pub.10.1038/sj.cdd.4400391
    35 sg:pub.10.1038/srep25652
    36 sg:pub.10.1186/1471-2164-12-160
    37 sg:pub.10.1186/1471-2164-14-376
    38 sg:pub.10.1186/1749-8104-3-15
    39 sg:pub.10.1186/1750-1326-4-28
    40 sg:pub.10.1186/1750-1326-9-6
    41 sg:pub.10.1186/2051-5960-2-36
    42 sg:pub.10.1186/s13024-016-0084-5
    43 sg:pub.10.1186/s13041-016-0245-z
    44 schema:datePublished 2017-03-31
    45 schema:datePublishedReg 2017-03-31
    46 schema:description Key PointsAmyloid precursor protein (APP) and the APP-like proteins APLP1 and APLP2 form the mammalian APP gene family. They have important physiological functions in the peripheral and central nervous systems, some of which are still emerging.APP family members share a similar structure and have partially overlapping functions. Their processing by canonical and non-canonical secretases results in numerous biologically active fragments, which mediate distinct and even opposing functions.Membrane-bound APP family members interact in cis or in trans, which enables them to function as cell-adhesion molecules. Large numbers of extracellular and intracellular binding partners have been identified, and this Review summarizes those that are involved in physiological pathways in vivo.Biological functions in which APP family members are involved include nervous system development, the formation and function of the neuromuscular junction, synaptogenesis, dendritic complexity and spine density, axonal growth and guidance, and synaptic functions, including synaptic plasticity, learning and memory.α-Secretase cleavage of APP releases the neuroprotective and neurotrophic fragment APPsα. It upregulates protective pathways, inhibits neuronal apoptosis, increases neuronal resistance to brain injuries and has a crucial role in synaptic plasticity, learning and memory.Increasing APPsα levels may be of therapeutic value. Pharmacotherapeutic and gene-therapeutic approaches could complement amyloid-targeting strategies.
    47 schema:genre article
    48 schema:inLanguage en
    49 schema:isAccessibleForFree false
    50 schema:isPartOf Nb2130371b9be461c9eb0fea5ff4f5cc1
    51 Ned81b253643046b78174dc5b57875a19
    52 sg:journal.1023608
    53 schema:keywords APLP1
    54 APLP2
    55 APP family members
    56 APP gene family
    57 APPsα
    58 active fragment
    59 amyloid precursor protein family
    60 apoptosis
    61 approach
    62 apps
    63 axonal growth
    64 biological functions
    65 brain injury
    66 cell adhesion molecule
    67 central nervous system
    68 cis
    69 cleavage
    70 complexity
    71 crucial role
    72 dendritic complexity
    73 density
    74 development
    75 family
    76 family members
    77 formation
    78 fragments
    79 function
    80 gene family
    81 gene therapeutic approaches
    82 growth
    83 guidance
    84 important physiological functions
    85 injury
    86 junction
    87 large number
    88 learning
    89 levels
    90 members
    91 membrane
    92 memory
    93 molecules
    94 nervous system
    95 nervous system development
    96 neuromuscular junction
    97 neuronal apoptosis
    98 neuronal resistance
    99 number
    100 partners
    101 pathway
    102 physiological functions
    103 physiological pathways
    104 plasticity
    105 precursor protein
    106 processing
    107 protective pathways
    108 protein
    109 protein family
    110 resistance
    111 results
    112 review
    113 role
    114 secretase cleavage
    115 secretase results
    116 similar structure
    117 spine density
    118 strategies
    119 structure
    120 synaptic function
    121 synaptic plasticity
    122 synaptogenesis
    123 system
    124 system development
    125 therapeutic value
    126 trans
    127 values
    128 vivo
    129 schema:name Not just amyloid: physiological functions of the amyloid precursor protein family
    130 schema:pagination 281-298
    131 schema:productId N189b66293ae5452eb268d5a0fe9a4dc5
    132 N3889852a6e064bd4a1c8b4e7c5e8f70f
    133 N8e8ee6306473429a920054f1c3d7fa63
    134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084129770
    135 https://doi.org/10.1038/nrn.2017.29
    136 schema:sdDatePublished 2022-05-10T10:17
    137 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    138 schema:sdPublisher Nb8d09fa702194b9584fc705b17f5bfaa
    139 schema:url https://doi.org/10.1038/nrn.2017.29
    140 sgo:license sg:explorer/license/
    141 sgo:sdDataset articles
    142 rdf:type schema:ScholarlyArticle
    143 N0b5fb914dd9843479b71da5d18e77e70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Brain
    145 rdf:type schema:DefinedTerm
    146 N189b66293ae5452eb268d5a0fe9a4dc5 schema:name dimensions_id
    147 schema:value pub.1084129770
    148 rdf:type schema:PropertyValue
    149 N278853133e8b4e629367b6b2433e2caa rdf:first sg:person.01165136477.16
    150 rdf:rest rdf:nil
    151 N2bc17c3ad7d34887a86bcee52e7e93ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Amyloid beta-Protein Precursor
    153 rdf:type schema:DefinedTerm
    154 N3889852a6e064bd4a1c8b4e7c5e8f70f schema:name pubmed_id
    155 schema:value 28360418
    156 rdf:type schema:PropertyValue
    157 N3a67217902d84dd391f7037c0a4190d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Mice
    159 rdf:type schema:DefinedTerm
    160 N552187c4a2574dedab2b5e9ac124060e rdf:first sg:person.01125311260.54
    161 rdf:rest N278853133e8b4e629367b6b2433e2caa
    162 N8e8ee6306473429a920054f1c3d7fa63 schema:name doi
    163 schema:value 10.1038/nrn.2017.29
    164 rdf:type schema:PropertyValue
    165 Nb2130371b9be461c9eb0fea5ff4f5cc1 schema:issueNumber 5
    166 rdf:type schema:PublicationIssue
    167 Nb849f67f5f034ff1a92315b12148a22d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Animals
    169 rdf:type schema:DefinedTerm
    170 Nb8d09fa702194b9584fc705b17f5bfaa schema:name Springer Nature - SN SciGraph project
    171 rdf:type schema:Organization
    172 Nbc45803c5d214ec6bf950d84cffb6c8c rdf:first sg:person.0606446602.48
    173 rdf:rest N552187c4a2574dedab2b5e9ac124060e
    174 Ned81b253643046b78174dc5b57875a19 schema:volumeNumber 18
    175 rdf:type schema:PublicationVolume
    176 Nf885003b5ac545ee94bbfef348f48500 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Humans
    178 rdf:type schema:DefinedTerm
    179 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    180 schema:name Medical and Health Sciences
    181 rdf:type schema:DefinedTerm
    182 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    183 schema:name Neurosciences
    184 rdf:type schema:DefinedTerm
    185 sg:journal.1023608 schema:issn 1471-003X
    186 1471-0048
    187 schema:name Nature Reviews Neuroscience
    188 schema:publisher Springer Nature
    189 rdf:type schema:Periodical
    190 sg:person.01125311260.54 schema:affiliation grid-institutes:grid.7839.5
    191 schema:familyName Deller
    192 schema:givenName Thomas
    193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125311260.54
    194 rdf:type schema:Person
    195 sg:person.01165136477.16 schema:affiliation grid-institutes:grid.7490.a
    196 schema:familyName Korte
    197 schema:givenName Martin
    198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165136477.16
    199 rdf:type schema:Person
    200 sg:person.0606446602.48 schema:affiliation grid-institutes:grid.7700.0
    201 schema:familyName Müller
    202 schema:givenName Ulrike C.
    203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606446602.48
    204 rdf:type schema:Person
    205 sg:pub.10.1007/bf03402076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075075017
    206 https://doi.org/10.1007/bf03402076
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1007/s00221-011-2885-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050571745
    209 https://doi.org/10.1007/s00221-011-2885-7
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1007/s00221-011-2911-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028958656
    212 https://doi.org/10.1007/s00221-011-2911-9
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1007/s00221-011-2932-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053429131
    215 https://doi.org/10.1007/s00221-011-2932-4
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1007/s00401-014-1347-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046113535
    218 https://doi.org/10.1007/s00401-014-1347-2
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1007/s00401-014-1368-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006671477
    221 https://doi.org/10.1007/s00401-014-1368-x
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1007/s00401-015-1498-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020214627
    224 https://doi.org/10.1007/s00401-015-1498-9
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1007/s00401-016-1577-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047037670
    227 https://doi.org/10.1007/s00401-016-1577-6
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1007/s004270100158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030588545
    230 https://doi.org/10.1007/s004270100158
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1007/s00702-005-0326-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028959995
    233 https://doi.org/10.1007/s00702-005-0326-0
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1007/s12035-015-9501-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1032036886
    236 https://doi.org/10.1007/s12035-015-9501-y
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1038/325733a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021444222
    239 https://doi.org/10.1038/325733a0
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1038/387500a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017890171
    242 https://doi.org/10.1038/387500a0
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1038/7562 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032547864
    245 https://doi.org/10.1038/7562
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1038/cddis.2014.352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012801112
    248 https://doi.org/10.1038/cddis.2014.352
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1038/nature07767 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030496745
    251 https://doi.org/10.1038/nature07767
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1038/nature14864 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039281345
    254 https://doi.org/10.1038/nature14864
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1038/nature19076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001112315
    257 https://doi.org/10.1038/nature19076
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1038/ncb1313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005119282
    260 https://doi.org/10.1038/ncb1313
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1038/ncb1690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052415980
    263 https://doi.org/10.1038/ncb1690
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1038/ncomms1781 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050782814
    266 https://doi.org/10.1038/ncomms1781
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1038/ncomms6659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020334275
    269 https://doi.org/10.1038/ncomms6659
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1038/ncomms9762 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043640902
    272 https://doi.org/10.1038/ncomms9762
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1038/nm1782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013028078
    275 https://doi.org/10.1038/nm1782
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1038/nn.4188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013238841
    278 https://doi.org/10.1038/nn.4188
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1038/sj.cdd.4400391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043098484
    281 https://doi.org/10.1038/sj.cdd.4400391
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1038/srep25652 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049150423
    284 https://doi.org/10.1038/srep25652
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1186/1471-2164-12-160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038108762
    287 https://doi.org/10.1186/1471-2164-12-160
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1186/1471-2164-14-376 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017814513
    290 https://doi.org/10.1186/1471-2164-14-376
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1186/1749-8104-3-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040054870
    293 https://doi.org/10.1186/1749-8104-3-15
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1186/1750-1326-4-28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047562055
    296 https://doi.org/10.1186/1750-1326-4-28
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1186/1750-1326-9-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035275576
    299 https://doi.org/10.1186/1750-1326-9-6
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1186/2051-5960-2-36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045374950
    302 https://doi.org/10.1186/2051-5960-2-36
    303 rdf:type schema:CreativeWork
    304 sg:pub.10.1186/s13024-016-0084-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022855605
    305 https://doi.org/10.1186/s13024-016-0084-5
    306 rdf:type schema:CreativeWork
    307 sg:pub.10.1186/s13041-016-0245-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1028802033
    308 https://doi.org/10.1186/s13041-016-0245-z
    309 rdf:type schema:CreativeWork
    310 grid-institutes:grid.7490.a schema:alternateName Helmholtz Centre for Infection Research, Neuroinflammation and Neurodegeneration Group, Inhoffenstrasse 7, 38124, Braunschweig, Germany
    311 schema:name Helmholtz Centre for Infection Research, Neuroinflammation and Neurodegeneration Group, Inhoffenstrasse 7, 38124, Braunschweig, Germany
    312 TU Braunschweig, Zoological Institute, Cellular Neurobiology, Spielmannstrasse 7, D-38106, Raunschweig, Germany
    313 rdf:type schema:Organization
    314 grid-institutes:grid.7700.0 schema:alternateName Ruprecht-Karls University Heidelberg, Institute of Pharmacy and Molecular Biotechnology, Bioinformatics and Functional Genomics, Im Neuenheimer Feld 364, D-69120, Heidelberg, Germany
    315 schema:name Ruprecht-Karls University Heidelberg, Institute of Pharmacy and Molecular Biotechnology, Bioinformatics and Functional Genomics, Im Neuenheimer Feld 364, D-69120, Heidelberg, Germany
    316 rdf:type schema:Organization
    317 grid-institutes:grid.7839.5 schema:alternateName Goethe University Frankfurt, Institute of Clinical Neuroanatomy, Neuroscience Center, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany
    318 schema:name Goethe University Frankfurt, Institute of Clinical Neuroanatomy, Neuroscience Center, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany
    319 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...