Ontology type: schema:ScholarlyArticle
2017-03-31
AUTHORSUlrike C. Müller, Thomas Deller, Martin Korte
ABSTRACTKey PointsAmyloid precursor protein (APP) and the APP-like proteins APLP1 and APLP2 form the mammalian APP gene family. They have important physiological functions in the peripheral and central nervous systems, some of which are still emerging.APP family members share a similar structure and have partially overlapping functions. Their processing by canonical and non-canonical secretases results in numerous biologically active fragments, which mediate distinct and even opposing functions.Membrane-bound APP family members interact in cis or in trans, which enables them to function as cell-adhesion molecules. Large numbers of extracellular and intracellular binding partners have been identified, and this Review summarizes those that are involved in physiological pathways in vivo.Biological functions in which APP family members are involved include nervous system development, the formation and function of the neuromuscular junction, synaptogenesis, dendritic complexity and spine density, axonal growth and guidance, and synaptic functions, including synaptic plasticity, learning and memory.α-Secretase cleavage of APP releases the neuroprotective and neurotrophic fragment APPsα. It upregulates protective pathways, inhibits neuronal apoptosis, increases neuronal resistance to brain injuries and has a crucial role in synaptic plasticity, learning and memory.Increasing APPsα levels may be of therapeutic value. Pharmacotherapeutic and gene-therapeutic approaches could complement amyloid-targeting strategies. More... »
PAGES281-298
http://scigraph.springernature.com/pub.10.1038/nrn.2017.29
DOIhttp://dx.doi.org/10.1038/nrn.2017.29
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1084129770
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/28360418
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Neurosciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Amyloid beta-Protein Precursor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Brain",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Ruprecht-Karls University Heidelberg, Institute of Pharmacy and Molecular Biotechnology, Bioinformatics and Functional Genomics, Im Neuenheimer Feld 364, D-69120, Heidelberg, Germany",
"id": "http://www.grid.ac/institutes/grid.7700.0",
"name": [
"Ruprecht-Karls University Heidelberg, Institute of Pharmacy and Molecular Biotechnology, Bioinformatics and Functional Genomics, Im Neuenheimer Feld 364, D-69120, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "M\u00fcller",
"givenName": "Ulrike C.",
"id": "sg:person.0606446602.48",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606446602.48"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Goethe University Frankfurt, Institute of Clinical Neuroanatomy, Neuroscience Center, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany",
"id": "http://www.grid.ac/institutes/grid.7839.5",
"name": [
"Goethe University Frankfurt, Institute of Clinical Neuroanatomy, Neuroscience Center, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany"
],
"type": "Organization"
},
"familyName": "Deller",
"givenName": "Thomas",
"id": "sg:person.01125311260.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125311260.54"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Helmholtz Centre for Infection Research, Neuroinflammation and Neurodegeneration Group, Inhoffenstrasse 7, 38124, Braunschweig, Germany",
"id": "http://www.grid.ac/institutes/grid.7490.a",
"name": [
"TU Braunschweig, Zoological Institute, Cellular Neurobiology, Spielmannstrasse 7, D-38106, Raunschweig, Germany",
"Helmholtz Centre for Infection Research, Neuroinflammation and Neurodegeneration Group, Inhoffenstrasse 7, 38124, Braunschweig, Germany"
],
"type": "Organization"
},
"familyName": "Korte",
"givenName": "Martin",
"id": "sg:person.01165136477.16",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165136477.16"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/nn.4188",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013238841",
"https://doi.org/10.1038/nn.4188"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s13024-016-0084-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022855605",
"https://doi.org/10.1186/s13024-016-0084-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1471-2164-14-376",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017814513",
"https://doi.org/10.1186/1471-2164-14-376"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature19076",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001112315",
"https://doi.org/10.1038/nature19076"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00221-011-2911-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028958656",
"https://doi.org/10.1007/s00221-011-2911-9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12035-015-9501-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032036886",
"https://doi.org/10.1007/s12035-015-9501-y"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s13041-016-0245-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028802033",
"https://doi.org/10.1186/s13041-016-0245-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1471-2164-12-160",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038108762",
"https://doi.org/10.1186/1471-2164-12-160"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/cddis.2014.352",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012801112",
"https://doi.org/10.1038/cddis.2014.352"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm1782",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013028078",
"https://doi.org/10.1038/nm1782"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/325733a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021444222",
"https://doi.org/10.1038/325733a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.cdd.4400391",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043098484",
"https://doi.org/10.1038/sj.cdd.4400391"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1749-8104-3-15",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040054870",
"https://doi.org/10.1186/1749-8104-3-15"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s004270100158",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030588545",
"https://doi.org/10.1007/s004270100158"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncomms1781",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050782814",
"https://doi.org/10.1038/ncomms1781"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/2051-5960-2-36",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045374950",
"https://doi.org/10.1186/2051-5960-2-36"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncb1313",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005119282",
"https://doi.org/10.1038/ncb1313"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncomms6659",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020334275",
"https://doi.org/10.1038/ncomms6659"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00702-005-0326-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028959995",
"https://doi.org/10.1007/s00702-005-0326-0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00221-011-2885-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050571745",
"https://doi.org/10.1007/s00221-011-2885-7"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00221-011-2932-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053429131",
"https://doi.org/10.1007/s00221-011-2932-4"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1750-1326-4-28",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047562055",
"https://doi.org/10.1186/1750-1326-4-28"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/387500a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017890171",
"https://doi.org/10.1038/387500a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature14864",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039281345",
"https://doi.org/10.1038/nature14864"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/7562",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032547864",
"https://doi.org/10.1038/7562"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature07767",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030496745",
"https://doi.org/10.1038/nature07767"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00401-014-1347-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046113535",
"https://doi.org/10.1007/s00401-014-1347-2"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00401-016-1577-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047037670",
"https://doi.org/10.1007/s00401-016-1577-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/srep25652",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049150423",
"https://doi.org/10.1038/srep25652"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncomms9762",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043640902",
"https://doi.org/10.1038/ncomms9762"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf03402076",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1075075017",
"https://doi.org/10.1007/bf03402076"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00401-014-1368-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006671477",
"https://doi.org/10.1007/s00401-014-1368-x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncb1690",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052415980",
"https://doi.org/10.1038/ncb1690"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1750-1326-9-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035275576",
"https://doi.org/10.1186/1750-1326-9-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00401-015-1498-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020214627",
"https://doi.org/10.1007/s00401-015-1498-9"
],
"type": "CreativeWork"
}
],
"datePublished": "2017-03-31",
"datePublishedReg": "2017-03-31",
"description": "Key PointsAmyloid precursor protein (APP) and the APP-like proteins APLP1 and APLP2 form the mammalian APP gene family. They have important physiological functions in the peripheral and central nervous systems, some of which are still emerging.APP family members share a similar structure and have partially overlapping functions. Their processing by canonical and non-canonical secretases results in numerous biologically active fragments, which mediate distinct and even opposing functions.Membrane-bound APP family members interact in cis or in trans, which enables them to function as cell-adhesion molecules. Large numbers of extracellular and intracellular binding partners have been identified, and this Review summarizes those that are involved in physiological pathways in vivo.Biological functions in which APP family members are involved include nervous system development, the formation and function of the neuromuscular junction, synaptogenesis, dendritic complexity and spine density, axonal growth and guidance, and synaptic functions, including synaptic plasticity, learning and memory.\u03b1-Secretase cleavage of APP releases the neuroprotective and neurotrophic fragment APPs\u03b1. It upregulates protective pathways, inhibits neuronal apoptosis, increases neuronal resistance to brain injuries and has a crucial role in synaptic plasticity, learning and memory.Increasing APPs\u03b1 levels may be of therapeutic value. Pharmacotherapeutic and gene-therapeutic approaches could complement amyloid-targeting strategies.",
"genre": "article",
"id": "sg:pub.10.1038/nrn.2017.29",
"inLanguage": "en",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1023608",
"issn": [
"1471-003X",
"1471-0048"
],
"name": "Nature Reviews Neuroscience",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "5",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "18"
}
],
"keywords": [
"APP family members",
"amyloid precursor protein family",
"physiological functions",
"APP gene family",
"nervous system development",
"important physiological functions",
"gene family",
"protein family",
"family members",
"cell adhesion molecule",
"synaptic plasticity",
"biological functions",
"physiological pathways",
"precursor protein",
"secretase cleavage",
"gene therapeutic approaches",
"synaptic function",
"central nervous system",
"active fragment",
"protective pathways",
"axonal growth",
"neuronal apoptosis",
"neuromuscular junction",
"dendritic complexity",
"pathway",
"spine density",
"neuronal resistance",
"brain injury",
"crucial role",
"nervous system",
"plasticity",
"therapeutic value",
"secretase results",
"members",
"family",
"APLP1",
"APLP2",
"protein",
"similar structure",
"apoptosis",
"function",
"system development",
"membrane",
"large number",
"cleavage",
"synaptogenesis",
"fragments",
"APPs\u03b1",
"vivo",
"injury",
"growth",
"molecules",
"role",
"trans",
"partners",
"review",
"resistance",
"junction",
"formation",
"development",
"levels",
"cis",
"structure",
"number",
"guidance",
"memory",
"strategies",
"apps",
"density",
"results",
"complexity",
"system",
"values",
"processing",
"approach",
"learning"
],
"name": "Not just amyloid: physiological functions of the amyloid precursor protein family",
"pagination": "281-298",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1084129770"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/nrn.2017.29"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"28360418"
]
}
],
"sameAs": [
"https://doi.org/10.1038/nrn.2017.29",
"https://app.dimensions.ai/details/publication/pub.1084129770"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-10T10:17",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_743.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/nrn.2017.29"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nrn.2017.29'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrn.2017.29'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrn.2017.29'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nrn.2017.29'
This table displays all metadata directly associated to this object as RDF triples.
319 TRIPLES
22 PREDICATES
142 URIs
99 LITERALS
12 BLANK NODES