2004-02
AUTHORSJames B. Kaper, James P. Nataro, Harry L. T. Mobley
ABSTRACTKey PointsIn addition to being an important member of the normal intestinal microflora of humans and other mammals, the species Escherichia coli contains many pathotypes that cause a variety of diseases. At least six different pathotypes cause enteric disease, such as diarrhoea or dysentery, and other pathotypes cause extra-intestinal infections, including urinary tract infections and meningitis.Virulence factors of E. coli can affect a wide range of eukaryotic cellular processes, including cell signalling, ion secretion, protein synthesis, mitosis, cytoskeletal function and mitochondrial function.Virulence factors of pathogenic E. coli are frequently encoded on genetic elements such as plasmids, bacteriophage, transposons and pathogenicity islands that can be mobilized into different strains to create novel combinations of virulence factors.The genomic structure of the E. coli pathotypes that have been sequenced so far show a striking mosaic pattern, with 2,000 genes present in 247 islands in one pathotype that are not present in K-12. Up to 0.53 MB of DNA present in K-12 can also be absent from pathogenic E. coli.Genes that encode virulence factors of pathogenic E. coli are regulated by both pathotype-specific regulators that are absent from commensal E. coli, and by 'housekeeping' regulators that are present in commensal E. coli. More... »
PAGES123-140
http://scigraph.springernature.com/pub.10.1038/nrmicro818
DOIhttp://dx.doi.org/10.1038/nrmicro818
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1011876605
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/15040260
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Genetics",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical Microbiology",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Bacterial Adhesion",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Diarrhea",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Escherichia coli",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Expression Regulation, Bacterial",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Meningitis, Bacterial",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Shiga Toxins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Urinary Tract Infections",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Virulence Factors",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Microbiology and Immunology, University of Maryland School of Medicine, 21201, Baltimore, Maryland, USA",
"id": "http://www.grid.ac/institutes/grid.411024.2",
"name": [
"Center for Vaccine Development, University of Maryland School of Medicine, 21201, Baltimore, Maryland, USA",
"Department of Microbiology and Immunology, University of Maryland School of Medicine, 21201, Baltimore, Maryland, USA"
],
"type": "Organization"
},
"familyName": "Kaper",
"givenName": "James B.",
"id": "sg:person.01065173365.11",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065173365.11"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pediatrics, University of Maryland School of Medicine, 21201, Baltimore, Maryland, USA",
"id": "http://www.grid.ac/institutes/grid.411024.2",
"name": [
"Center for Vaccine Development, University of Maryland School of Medicine, 21201, Baltimore, Maryland, USA",
"Department of Pediatrics, University of Maryland School of Medicine, 21201, Baltimore, Maryland, USA"
],
"type": "Organization"
},
"familyName": "Nataro",
"givenName": "James P.",
"id": "sg:person.01037567240.37",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037567240.37"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Microbiology and Immunology, University of Maryland School of Medicine, 21201, Baltimore, Maryland, USA",
"id": "http://www.grid.ac/institutes/grid.411024.2",
"name": [
"Department of Microbiology and Immunology, University of Maryland School of Medicine, 21201, Baltimore, Maryland, USA"
],
"type": "Organization"
},
"familyName": "Mobley",
"givenName": "Harry L. T.",
"id": "sg:person.01027770150.45",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027770150.45"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/14087",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049527734",
"https://doi.org/10.1038/14087"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35074106",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046017863",
"https://doi.org/10.1038/35074106"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35015091",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047653020",
"https://doi.org/10.1038/35015091"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-3-662-09217-0_4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002239617",
"https://doi.org/10.1007/978-3-662-09217-0_4"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf01569828",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027844733",
"https://doi.org/10.1007/bf01569828"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/358167a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039743712",
"https://doi.org/10.1038/358167a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35054089",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020385479",
"https://doi.org/10.1038/35054089"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00467-001-0783-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053714360",
"https://doi.org/10.1007/s00467-001-0783-0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35017546",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018110892",
"https://doi.org/10.1038/35017546"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1203/00006450-199609000-00009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064208517",
"https://doi.org/10.1203/00006450-199609000-00009"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/356252a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045567991",
"https://doi.org/10.1038/356252a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-3-662-09217-0_2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028884081",
"https://doi.org/10.1007/978-3-662-09217-0_2"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-3-662-09217-0_3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019680329",
"https://doi.org/10.1007/978-3-662-09217-0_3"
],
"type": "CreativeWork"
}
],
"datePublished": "2004-02",
"datePublishedReg": "2004-02-01",
"description": "Key PointsIn addition to being an important member of the normal intestinal microflora of humans and other mammals, the species Escherichia coli contains many pathotypes that cause a variety of diseases. At least six different pathotypes cause enteric disease, such as diarrhoea or dysentery, and other pathotypes cause extra-intestinal infections, including urinary tract infections and meningitis.Virulence factors of E. coli can affect a wide range of eukaryotic cellular processes, including cell signalling, ion secretion, protein synthesis, mitosis, cytoskeletal function and mitochondrial function.Virulence factors of pathogenic E. coli are frequently encoded on genetic elements such as plasmids, bacteriophage, transposons and pathogenicity islands that can be mobilized into different strains to create novel combinations of virulence factors.The genomic structure of the E. coli pathotypes that have been sequenced so far show a striking mosaic pattern, with 2,000 genes present in 247 islands in one pathotype that are not present in K-12. Up to 0.53 MB of DNA present in K-12 can also be absent from pathogenic E. coli.Genes that encode virulence factors of pathogenic E. coli are regulated by both pathotype-specific regulators that are absent from commensal E. coli, and by 'housekeeping' regulators that are present in commensal E. coli.",
"genre": "article",
"id": "sg:pub.10.1038/nrmicro818",
"isAccessibleForFree": false,
"isFundedItemOf": [
{
"id": "sg:grant.2633792",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1032854",
"issn": [
"1740-1526",
"1740-1534"
],
"name": "Nature Reviews Microbiology",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "2"
}
],
"keywords": [
"virulence factors",
"pathogenic E. coli",
"E. coli",
"eukaryotic cellular processes",
"Escherichia coli",
"commensal E. coli",
"species Escherichia coli",
"Key PointsIn addition",
"genomic structure",
"cytoskeletal function",
"cellular processes",
"cell signaling",
"genetic elements",
"pathogenic Escherichia coli",
"pathogenicity island",
"urinary tract infection",
"mitochondrial function",
"normal intestinal microflora",
"protein synthesis",
"DNA present",
"E. coli pathotypes",
"different pathotypes",
"extra-intestinal infections",
"pathotypes",
"coli",
"important member",
"tract infections",
"variety of diseases",
"genes",
"mosaic pattern",
"intestinal microflora",
"regulator",
"ion secretion",
"coli pathotypes",
"enteric disease",
"different strains",
"infection",
"disease",
"islands",
"mammals",
"transposon",
"mitosis",
"signaling",
"plasmid",
"bacteriophages",
"meningitis",
"housekeeping",
"diarrhea",
"factors",
"novel combination",
"secretion",
"function",
"MB",
"dysentery",
"microflora",
"members",
"wide range",
"strains",
"humans",
"patterns",
"variety",
"synthesis",
"structure",
"addition",
"combination",
"elements",
"process",
"present",
"range"
],
"name": "Pathogenic Escherichia coli",
"pagination": "123-140",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1011876605"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/nrmicro818"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"15040260"
]
}
],
"sameAs": [
"https://doi.org/10.1038/nrmicro818",
"https://app.dimensions.ai/details/publication/pub.1011876605"
],
"sdDataset": "articles",
"sdDatePublished": "2022-10-01T06:32",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_380.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/nrmicro818"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nrmicro818'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrmicro818'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrmicro818'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nrmicro818'
This table displays all metadata directly associated to this object as RDF triples.
249 TRIPLES
21 PREDICATES
120 URIs
97 LITERALS
17 BLANK NODES