An updated evolutionary classification of CRISPR–Cas systems View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-11

AUTHORS

Kira S. Makarova, Yuri I. Wolf, Omer S. Alkhnbashi, Fabrizio Costa, Shiraz A. Shah, Sita J. Saunders, Rodolphe Barrangou, Stan J. J. Brouns, Emmanuelle Charpentier, Daniel H. Haft, Philippe Horvath, Sylvain Moineau, Francisco J. M. Mojica, Rebecca M. Terns, Michael P. Terns, Malcolm F. White, Alexander F. Yakunin, Roger A. Garrett, John van der Oost, Rolf Backofen, Eugene V. Koonin

ABSTRACT

The evolution of CRISPR-cas loci, which encode adaptive immune systems in archaea and bacteria, involves rapid changes, in particular numerous rearrangements of the locus architecture and horizontal transfer of complete loci or individual modules. These dynamics complicate straightforward phylogenetic classification, but here we present an approach combining the analysis of signature protein families and features of the architecture of cas loci that unambiguously partitions most CRISPR-cas loci into distinct classes, types and subtypes. The new classification retains the overall structure of the previous version but is expanded to now encompass two classes, five types and 16 subtypes. The relative stability of the classification suggests that the most prevalent variants of CRISPR-Cas systems are already known. However, the existence of rare, currently unclassifiable variants implies that additional types and subtypes remain to be characterized. More... »

PAGES

722-736

References to SciGraph publications

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  • Journal

    TITLE

    Nature Reviews Microbiology

    ISSUE

    11

    VOLUME

    13

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrmicro3569

    DOI

    http://dx.doi.org/10.1038/nrmicro3569

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1010036058

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26411297


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