The gut microbiota, bacterial metabolites and colorectal cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-09-08

AUTHORS

Petra Louis, Georgina L. Hold, Harry J. Flint

ABSTRACT

Key PointsDietary intake has an important effect on the gut environment, much of which is mediated by the metabolic activities of the intestinal microbiota on dietary compounds. Different microbial metabolites have the potential to promote and protect against colorectal cancer (CRC).Accumulating evidence suggests that microbial-derived short chain fatty acids control inflammation and regulatory T cell populations. This involves the inhibition of host histone deacetylases and interactions with cell surface receptors.Multiple species in the gut microbiota have complex roles in releasing and converting diet-derived phytochemicals and host-derived bile acids and glycoconjugates, all of which influence the overall microbial metabolome.Alterations in the composition of the gut microbiota can be detected both in faecal samples and in tumour-associated communities that are associated with CRC. Although many of these changes may be consequential, some specific pathogens seem to contribute to causation and disease progression.It is unlikely that the aetiology of CRC can be ascribed to the presence and activities of single pathogenic species, and it is proposed that the cumulative effects of microbial metabolites should be considered to better predict and prevent cancer progression. More... »

PAGES

661-672

References to SciGraph publications

  • 2009-08-23. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses in NATURE MEDICINE
  • 2011-07-14. Abundance and diversity of mucosa-associated hydrogenotrophic microbes in the healthy human colon in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2013-05-15. Co-occurrence of anaerobic bacteria in colorectal carcinomas in MICROBIOME
  • 2013-10-17. The microbiome and cancer in NATURE REVIEWS CANCER
  • 2013-10-24. Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms in NATURE REVIEWS CANCER
  • 2005-12-01. Increased Risk of Intestinal Cancer in Crohn's Disease: A Meta-Analysis of Population-Based Cohort Studies in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2013-12-11. Diet rapidly and reproducibly alters the human gut microbiome in NATURE
  • 2014-02-20. Phylogenetic distribution of three pathways for propionate production within the human gut microbiota in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2012-06-25. A bacterial driver–passenger model for colorectal cancer: beyond the usual suspects in NATURE REVIEWS MICROBIOLOGY
  • 2012-05-15. Contributions of the microbial hydrogen economy to colonic homeostasis in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2012-02-23. The gut anaerobe Faecalibacterium prausnitzii uses an extracellular electron shuttle to grow at oxic–anoxic interphases in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2013-08-28. Richness of human gut microbiome correlates with metabolic markers in NATURE
  • 2012-09-04. The role of the gut microbiota in nutrition and health in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2012-05-24. Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2004-01. The strict anaerobe Bacteroides fragilis grows in and benefits from nanomolar concentrations of oxygen in NATURE
  • 2011-08-18. Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2013-11-13. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells in NATURE
  • 2013-11-13. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation in NATURE
  • 2003-06-01. Is There a True “shift” to the Right Colon in the Incidence of Colorectal Cancer? in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 1997-08. Colonic Sulfide in Pathogenesis and Treatment of Ulcerative Colitis in DIGESTIVE DISEASES AND SCIENCES
  • 2012-02-21. IBD—what role do Proteobacteria play? in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2012-06-13. Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10−/− mice in NATURE
  • 2010-08-05. Dominant and diet-responsive groups of bacteria within the human colonic microbiota in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2013-08-28. Dietary intervention impact on gut microbial gene richness in NATURE
  • 2014-04-24. Impact of diet and individual variation on intestinal microbiota composition and fermentation products in obese men in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2012-11-07. Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth in NATURE
  • 2001-12. Intestinal bacterial β-glucuronidase activity of patients with colon cancer in ARCHIVES OF PHARMACAL RESEARCH
  • 2007-03-01. Alteration of Sulfate and Hydrogen Metabolism in the Human Colon by Changing Intestinal Transit Rate in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2013-06-06. A metabolomic view of how the human gut microbiota impacts the host metabolome using humanized and gnotobiotic mice in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2013-06-26. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome in NATURE
  • 1997. Carbohydrate Fermentation, Energy Transduction and Gas Metabolism in the Human Large Intestine in GASTROINTESTINAL MICROBIOLOGY
  • 2009-10. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43 in NATURE
  • Journal

    TITLE

    Nature Reviews Microbiology

    ISSUE

    10

    VOLUME

    12

    Identifiers

    URI

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    DOI

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    PUBMED

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    45 schema:description Key PointsDietary intake has an important effect on the gut environment, much of which is mediated by the metabolic activities of the intestinal microbiota on dietary compounds. Different microbial metabolites have the potential to promote and protect against colorectal cancer (CRC).Accumulating evidence suggests that microbial-derived short chain fatty acids control inflammation and regulatory T cell populations. This involves the inhibition of host histone deacetylases and interactions with cell surface receptors.Multiple species in the gut microbiota have complex roles in releasing and converting diet-derived phytochemicals and host-derived bile acids and glycoconjugates, all of which influence the overall microbial metabolome.Alterations in the composition of the gut microbiota can be detected both in faecal samples and in tumour-associated communities that are associated with CRC. Although many of these changes may be consequential, some specific pathogens seem to contribute to causation and disease progression.It is unlikely that the aetiology of CRC can be ascribed to the presence and activities of single pathogenic species, and it is proposed that the cumulative effects of microbial metabolites should be considered to better predict and prevent cancer progression.
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