Ontology type: schema:ScholarlyArticle
2013-07
AUTHORSRalf Bartenschlager, Volker Lohmann, Francois Penin
ABSTRACTThe availability of the first molecular clone of the hepatitis C virus (HCV) genome allowed the identification and biochemical characterization of two viral enzymes that are targets for antiviral therapy: the protease NS3-4A and the RNA-dependent RNA polymerase NS5B. With the advent of cell culture systems that can recapitulate either the intracellular steps of the viral replication cycle or the complete cycle, additional drug targets have been identified, most notably the phosphoprotein NS5A, but also host cell factors that promote viral replication, such as cyclophilin A. Here, we review insights into the structures of these proteins and the mechanisms by which they contribute to the HCV replication cycle, and discuss how these insights have facilitated the development of new, directly acting antiviral compounds that have started to enter the clinic. More... »
PAGES482-496
http://scigraph.springernature.com/pub.10.1038/nrmicro3046
DOIhttp://dx.doi.org/10.1038/nrmicro3046
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/23748342
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JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nrmicro3046'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrmicro3046'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrmicro3046'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nrmicro3046'
This table displays all metadata directly associated to this object as RDF triples.
617 TRIPLES
21 PREDICATES
196 URIs
30 LITERALS
18 BLANK NODES