Bacteriocins — a viable alternative to antibiotics? View Full Text


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Article Info

DATE

2012-12-24

AUTHORS

Paul D. Cotter, R. Paul Ross, Colin Hill

ABSTRACT

Key PointsSolutions are urgently required for the growing number of infections caused by antibiotic-resistant bacteria and to address the fact that broad-spectrum antibiotics can considerably harm the commensal human microbiota.Bacteriocins are potential alternatives to traditional antibiotics. These peptides, which are produced by many bacteria, can have a high potency and a low toxicity, can be produced in situ by probiotics and can be bioengineered. Both broad- and narrow-spectrum bacteriocins exist.Bacteriocins function through different mechanisms that are frequently distinct from those used by antibiotics. Bacteriocins can be broadly classified into those that target the cell membrane and those that function within the cell, targeting DNA, RNA and protein metabolism.Resistance to bacteriocins is a potential problem. In some cases, resistance arises at a sufficiently low rate to allow commercialization of the peptide in its natural form. In other cases, knowledge of the potential resistance mechanisms could be crucial for minimizing the emergence of resistance when clinical applications commence.Many bacteriocins possess properties which suggest that these peptides could be of value in clinical settings. However, to date, the primary focus for their use has been on animal, rather than human, health.A lack of sufficient investment has been a significant problem with respect to the medical application of bacteriocins. Notably, however, there is evidence to suggest that issue is finally being addressed. More... »

PAGES

95-105

References to SciGraph publications

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  • 2011-08-24. Stop the killing of beneficial bacteria in NATURE
  • 2006-04-01. Bacteriocins Pep5 and Epidermin Inhibit Staphylococcus epidermidis Adhesion to Catheters in CURRENT MICROBIOLOGY
  • 2007-09. Antibacterial Evaluations of Thiazomycin in THE JOURNAL OF ANTIBIOTICS
  • 2010-12-12. Elucidation of the Molecular Mechanisms of Action of the Natural Antimicrobial Peptide Subtilosin Against the Bacterial Vaginosis-associated Pathogen Gardnerella vaginalis in PROBIOTICS AND ANTIMICROBIAL PROTEINS
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1038/nrmicro2937

    DOI

    http://dx.doi.org/10.1038/nrmicro2937

    DIMENSIONS

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    https://www.ncbi.nlm.nih.gov/pubmed/23268227


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