Bacteriocins — a viable alternative to antibiotics? View Full Text


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Article Info

DATE

2012-12-24

AUTHORS

Paul D. Cotter, R. Paul Ross, Colin Hill

ABSTRACT

Key PointsSolutions are urgently required for the growing number of infections caused by antibiotic-resistant bacteria and to address the fact that broad-spectrum antibiotics can considerably harm the commensal human microbiota.Bacteriocins are potential alternatives to traditional antibiotics. These peptides, which are produced by many bacteria, can have a high potency and a low toxicity, can be produced in situ by probiotics and can be bioengineered. Both broad- and narrow-spectrum bacteriocins exist.Bacteriocins function through different mechanisms that are frequently distinct from those used by antibiotics. Bacteriocins can be broadly classified into those that target the cell membrane and those that function within the cell, targeting DNA, RNA and protein metabolism.Resistance to bacteriocins is a potential problem. In some cases, resistance arises at a sufficiently low rate to allow commercialization of the peptide in its natural form. In other cases, knowledge of the potential resistance mechanisms could be crucial for minimizing the emergence of resistance when clinical applications commence.Many bacteriocins possess properties which suggest that these peptides could be of value in clinical settings. However, to date, the primary focus for their use has been on animal, rather than human, health.A lack of sufficient investment has been a significant problem with respect to the medical application of bacteriocins. Notably, however, there is evidence to suggest that issue is finally being addressed. More... »

PAGES

95-105

References to SciGraph publications

  • 2012-10-10. Activity of the thiopeptide antibiotic nosiheptide against contemporary strains of methicillin-resistant Staphylococcus aureus in THE JOURNAL OF ANTIBIOTICS
  • 2011-01-02. Sublancin is not a lantibiotic but an S-linked glycopeptide in NATURE CHEMICAL BIOLOGY
  • 2011-04-06. Fix the antibiotics pipeline in NATURE
  • 2010-09-24. Sources of novel antibiotics—aside the common roads in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2011-04-06. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease in NATURE
  • 2012-04-19. Generation of an actagardine A variant library through saturation mutagenesis in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2005-10. Bacteriocins: developing innate immunity for food in NATURE REVIEWS MICROBIOLOGY
  • 2010-11-30. In silico analysis highlights the frequency and diversity of type 1 lantibiotic gene clusters in genome sequenced bacteria in BMC GENOMICS
  • 2010-11-16. Identification of Lactobacillus plantarum genes modulating the cytokine response of human peripheral blood mononuclear cells in BMC MICROBIOLOGY
  • 2002-08. Genetically modified Streptococcus mutans for the prevention of dental caries in ANTONIE VAN LEEUWENHOEK
  • 2006-04. Parasitism of Iron-siderophore Receptors of Escherichia Coli by the Siderophore-peptide Microcin E492m and its Unmodified Counterpart in BIOMETALS
  • 2010-02-27. Cyanobactins—ribosomal cyclic peptides produced by cyanobacteria in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2012-01-20. RNA therapeutics: beyond RNA interference and antisense oligonucleotides in NATURE REVIEWS DRUG DISCOVERY
  • 2011-05-17. AS-48 bacteriocin: close to perfection in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2011-02-28. Shifting the balance: antibiotic effects on host–microbiota mutualism in NATURE REVIEWS MICROBIOLOGY
  • 2011-08-24. Stop the killing of beneficial bacteria in NATURE
  • 2006-04-01. Bacteriocins Pep5 and Epidermin Inhibit Staphylococcus epidermidis Adhesion to Catheters in CURRENT MICROBIOLOGY
  • 2007-09. Antibacterial Evaluations of Thiazomycin in THE JOURNAL OF ANTIBIOTICS
  • 2010-12-12. Elucidation of the Molecular Mechanisms of Action of the Natural Antimicrobial Peptide Subtilosin Against the Bacterial Vaginosis-associated Pathogen Gardnerella vaginalis in PROBIOTICS AND ANTIMICROBIAL PROTEINS
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    http://scigraph.springernature.com/pub.10.1038/nrmicro2937

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    http://dx.doi.org/10.1038/nrmicro2937

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    https://www.ncbi.nlm.nih.gov/pubmed/23268227


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