The skin microbiome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-03-16

AUTHORS

Elizabeth A. Grice, Julia A. Segre

ABSTRACT

Key PointsThe skin is a physical barrier against invasion by pathogenic organisms and foreign substances. The skin is also an ecosystem, host to a microbial milieu that, for the most part, is harmless.The habitat of the skin varies topographically and is likely to be associated with variation in the colonizing microbiota. Factors contributing to variation in the skin microbiota include the density of hair follicles and glands (sweat or sebaceous), host factors (such as age and sex) and environmental factors (such as occupation, climate and hygiene).Analysing skin bacterial microbiota by sequencing of 16S ribosomal RNA genes reveals a greater diversity of organisms than has been found by culture-based methods.The microenvironment of the skin site sampled determines to a large extent the colonization by the predominant species, the temporal variation and the interpersonal variation. Propionibacterium spp. predominate in sebaceous areas, Corynebacterium and Staphylococcus spp. predominate in moist areas, and dry areas exhibit the greatest amount of diversity.Compared with other mucosal microbiomes, the skin microbiome shows the greatest variability over time and harbours the greatest phylogenetic diversity.The cutaneous immune system modulates colonization by the microbiota and is also vital during infection and wounding. Dysregulation of the skin immune response is evident in several skin disorders.A wide range of skin disorders are postulated to arise in part owing to a microbial component. These disorders include atopic dermatitis, acne, seborrhoeic dermatitis and chronic wounds. Additionally, commensal bacteria (for example, Staphylococcus epidermidis) can become pathogenic and cause invasive infection. More... »

PAGES

244-253

References to SciGraph publications

  • 1982-09. Sex, constancy, and skin bacteria in ARCHIVES OF DERMATOLOGICAL RESEARCH
  • 2004-09. Epithelial cells pay a Toll for protection in NATURE MEDICINE
  • 2010-03-29. Medically important bacterial–fungal interactions in NATURE REVIEWS MICROBIOLOGY
  • 2010-05. Staphylococcus epidermidis Esp inhibits Staphylococcus aureus biofilm formation and nasal colonization in NATURE
  • 2006-10. Reconstructing the early evolution of Fungi using a six-gene phylogeny in NATURE
  • 2009-12-15. Defining the healthy "core microbiome" of oral microbial communities in BMC MICROBIOLOGY
  • 2010-09-21. Evaluation of the bacterial diversity of Pressure ulcers using bTEFAP pyrosequencing in BMC MEDICAL GENOMICS
  • 2008-03-06. Survey of bacterial diversity in chronic wounds using Pyrosequencing, DGGE, and full ribosome shotgun sequencing in BMC MICROBIOLOGY
  • 2007-03-30. The skin barrier as an innate immune element in SEMINARS IN IMMUNOPATHOLOGY
  • 2009-08. Staphylococcus epidermidis — the 'accidental' pathogen in NATURE REVIEWS MICROBIOLOGY
  • 2010-03-25. Bacterial diversity in the oral cavity of 10 healthy individuals in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 1980-09. Characterization of serum-independent polymorphonuclear leukocyte chemotactic factors produced byPropionibacterium acnes in INFLAMMATION
  • 2006-12. An obesity-associated gut microbiome with increased capacity for energy harvest in NATURE
  • 2009-11-22. Commensal bacteria regulate TLR3-dependent inflammation following skin injury in NATURE MEDICINE
  • 2002-03. Getting under the skin of epidermal morphogenesis in NATURE REVIEWS GENETICS
  • Journal

    TITLE

    Nature Reviews Microbiology

    ISSUE

    4

    VOLUME

    9

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrmicro2537

    DOI

    http://dx.doi.org/10.1038/nrmicro2537

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1032159307

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21407241


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