Cellular mechanisms that control mistranslation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-12

AUTHORS

Noah M. Reynolds, Beth A. Lazazzera, Michael Ibba

ABSTRACT

Mistranslation broadly encompasses the introduction of errors during any step of protein synthesis, leading to the incorporation of an amino acid that is different from the one encoded by the gene. Recent research has vastly enhanced our understanding of the mechanisms that control mistranslation at the molecular level and has led to the discovery that the rates of mistranslation in vivo are not fixed but instead are variable. In this Review we describe the different steps in translation quality control and their variations under different growth conditions and between species though a comparison of in vitro and in vivo findings. This provides new insights as to why mistranslation can have both positive and negative effects on growth and viability. More... »

PAGES

849

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nrmicro2472

DOI

http://dx.doi.org/10.1038/nrmicro2472

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031748419

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21079633


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