Artemisinin resistance: current status and scenarios for containment View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-04

AUTHORS

Arjen M. Dondorp, Shunmay Yeung, Lisa White, Chea Nguon, Nicholas P.J. Day, Duong Socheat, Lorenz von Seidlein

ABSTRACT

Artemisinin combination therapies are the first-line treatments for uncomplicated Plasmodium falciparum malaria in most malaria-endemic countries. Recently, partial artemisinin-resistant P. falciparum malaria has emerged on the Cambodia-Thailand border. Exposure of the parasite population to artemisinin monotherapies in subtherapeutic doses for over 30 years, and the availability of substandard artemisinins, have probably been the main driving force in the selection of the resistant phenotype in the region. A multifaceted containment programme has recently been launched, including early diagnosis and appropriate treatment, decreasing drug pressure, optimising vector control, targeting the mobile population, strengthening management and surveillance systems, and operational research. Mathematical modelling can be a useful tool to evaluate possible strategies for containment. More... »

PAGES

272

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nrmicro2331

DOI

http://dx.doi.org/10.1038/nrmicro2331

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003849904

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20208550


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