The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-02

AUTHORS

Gunilla B Karlsson Hedestam, Ron A M Fouchier, Sanjay Phogat, Dennis R Burton, Joseph Sodroski, Richard T Wyatt

ABSTRACT

The ability to elicit broadly neutralizing antibody responses against HIV-1 is a crucial goal for a prophylactic HIV-1 vaccine. Here, we discuss the difficulties of achieving broad HIV-1 neutralization in the context of both the effective annual human influenza virus vaccine and the need to develop a pandemic influenza vaccine. Immunogen-design strategies are underway to target functionally conserved regions of the HIV-1 envelope glycoproteins, and similar strategies might be applicable to pandemic influenza virus vaccine development. Efforts to develop broadly neutralizing vaccines against either HIV-1 or influenza virus might establish a paradigm for future vaccines against highly variable pathogens. More... »

PAGES

143-155

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nrmicro1819

DOI

http://dx.doi.org/10.1038/nrmicro1819

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031201834

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18197170


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