Pathogenesis of prion diseases: current status and future outlook View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-10

AUTHORS

Adriano Aguzzi, Mathias Heikenwalder

ABSTRACT

The prion, a conformational variant of a host protein, is the infectious particle responsible for transmissible spongiform encephalopathy (TSE), a fatal neurodegenerative disease of humans and animals. The principal target of prion pathology is the brain, yet most TSEs also display prion replication at extra-cerebral locations, including secondary lymphoid organs and sites of chronic inflammation. Despite significant progress in our understanding of this infectious agent, many fundamental questions relating to the nature of the prion, including the mechanism of replication and the molecular events underlying brain damage, remain unanswered. Here we focus on the unresolved issues pertaining to prion pathogenesis, particularly on the role played by the immune system. More... »

PAGES

765-775

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    http://scigraph.springernature.com/pub.10.1038/nrmicro1492

    DOI

    http://dx.doi.org/10.1038/nrmicro1492

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035807768

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16980938


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