Prokaryotic toxin–antitoxin stress response loci View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-05

AUTHORS

Kenn Gerdes, Susanne K Christensen, Anders Løbner-Olesen

ABSTRACT

Although toxin-antitoxin gene cassettes were first found in plasmids, recent database mining has shown that these loci are abundant in free-living prokaryotes, including many pathogenic bacteria. For example, Mycobacterium tuberculosis has 38 chromosomal toxin-antitoxin loci, including 3 relBE and 9 mazEF loci. RelE and MazF are toxins that cleave mRNA in response to nutritional stress. RelE cleaves mRNAs that are positioned at the ribosomal A-site, between the second and third nucleotides of the A-site codon. It has been proposed that toxin-antitoxin loci function in bacterial programmed cell death, but evidence now indicates that these loci provide a control mechanism that helps free-living prokaryotes cope with nutritional stress. More... »

PAGES

371-382

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nrmicro1147

DOI

http://dx.doi.org/10.1038/nrmicro1147

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034055556

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15864262


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